JP2017505114A5 - - Google Patents
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- Publication number
- JP2017505114A5 JP2017505114A5 JP2016538525A JP2016538525A JP2017505114A5 JP 2017505114 A5 JP2017505114 A5 JP 2017505114A5 JP 2016538525 A JP2016538525 A JP 2016538525A JP 2016538525 A JP2016538525 A JP 2016538525A JP 2017505114 A5 JP2017505114 A5 JP 2017505114A5
- Authority
- JP
- Japan
- Prior art keywords
- residue
- modified serpin
- rcl
- serpin
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000008847 Serpin Human genes 0.000 claims 39
- 108050000761 Serpin Proteins 0.000 claims 39
- 239000003001 serine protease inhibitor Substances 0.000 claims 39
- 230000035772 mutation Effects 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 102100030500 Heparin cofactor 2 Human genes 0.000 claims 3
- 102100024078 Plasma serine protease inhibitor Human genes 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 102100022977 Antithrombin-III Human genes 0.000 claims 2
- 102100033299 Glia-derived nexin Human genes 0.000 claims 2
- 108090000481 Heparin Cofactor II Proteins 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 108010001953 Protein C Inhibitor Proteins 0.000 claims 2
- 229940122929 Protein C inhibitor Drugs 0.000 claims 2
- 108090000190 Thrombin Proteins 0.000 claims 2
- 208000031169 hemorrhagic disease Diseases 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 229960004072 thrombin Drugs 0.000 claims 2
- 102100022524 Alpha-1-antichymotrypsin Human genes 0.000 claims 1
- 102100022712 Alpha-1-antitrypsin Human genes 0.000 claims 1
- 102100035991 Alpha-2-antiplasmin Human genes 0.000 claims 1
- 108090000935 Antithrombin III Proteins 0.000 claims 1
- 206010053567 Coagulopathies Diseases 0.000 claims 1
- 101710183811 Glia-derived nexin Proteins 0.000 claims 1
- 208000031220 Hemophilia Diseases 0.000 claims 1
- 208000009292 Hemophilia A Diseases 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 claims 1
- 101000823116 Homo sapiens Alpha-1-antitrypsin Proteins 0.000 claims 1
- 101000783712 Homo sapiens Alpha-2-antiplasmin Proteins 0.000 claims 1
- 101000757319 Homo sapiens Antithrombin-III Proteins 0.000 claims 1
- 101000997803 Homo sapiens Glia-derived nexin Proteins 0.000 claims 1
- 101001082432 Homo sapiens Heparin cofactor 2 Proteins 0.000 claims 1
- 101000975003 Homo sapiens Kallistatin Proteins 0.000 claims 1
- 101001053641 Homo sapiens Plasma serine protease inhibitor Proteins 0.000 claims 1
- 102100023012 Kallistatin Human genes 0.000 claims 1
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 claims 1
- 102000010752 Plasminogen Inactivators Human genes 0.000 claims 1
- 108010077971 Plasminogen Inactivators Proteins 0.000 claims 1
- 102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 claims 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
- 101800004937 Protein C Proteins 0.000 claims 1
- 102000017975 Protein C Human genes 0.000 claims 1
- 101800001700 Saposin-D Proteins 0.000 claims 1
- 102000012607 Thrombomodulin Human genes 0.000 claims 1
- 108010079274 Thrombomodulin Proteins 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 239000004019 antithrombin Substances 0.000 claims 1
- 208000034158 bleeding Diseases 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 229940009550 c1 esterase inhibitor Drugs 0.000 claims 1
- 239000003541 chymotrypsin inhibitor Substances 0.000 claims 1
- 230000035602 clotting Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 230000023597 hemostasis Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108010025221 plasma protein Z Proteins 0.000 claims 1
- 239000002797 plasminogen activator inhibitor Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 229960000856 protein c Drugs 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 239000002753 trypsin inhibitor Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1322091.8 | 2013-12-13 | ||
| GBGB1322091.8A GB201322091D0 (en) | 2013-12-13 | 2013-12-13 | Modified serpins for the treatment of bleeding disorders |
| PCT/EP2014/077783 WO2015086854A1 (en) | 2013-12-13 | 2014-12-15 | Modified serpins for the treatment of bleeding disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018204779A Division JP6723319B2 (ja) | 2013-12-13 | 2018-10-31 | 出血性障害の治療に対する改変セルピン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017505114A JP2017505114A (ja) | 2017-02-16 |
| JP2017505114A5 true JP2017505114A5 (enExample) | 2018-06-28 |
| JP6431541B2 JP6431541B2 (ja) | 2018-11-28 |
Family
ID=50030900
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538525A Active JP6431541B2 (ja) | 2013-12-13 | 2014-12-15 | 出血性障害の治療に対する改変セルピン |
| JP2018204779A Active JP6723319B2 (ja) | 2013-12-13 | 2018-10-31 | 出血性障害の治療に対する改変セルピン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018204779A Active JP6723319B2 (ja) | 2013-12-13 | 2018-10-31 | 出血性障害の治療に対する改変セルピン |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9982035B2 (enExample) |
| EP (2) | EP3434689A1 (enExample) |
| JP (2) | JP6431541B2 (enExample) |
| KR (2) | KR101954945B1 (enExample) |
| CN (2) | CN105992771B (enExample) |
| AU (2) | AU2014363359B2 (enExample) |
| CA (1) | CA2933508C (enExample) |
| CY (1) | CY1121267T1 (enExample) |
| DK (1) | DK3080157T3 (enExample) |
| EA (1) | EA034050B1 (enExample) |
| ES (1) | ES2704058T3 (enExample) |
| GB (1) | GB201322091D0 (enExample) |
| HR (1) | HRP20182138T1 (enExample) |
| HU (1) | HUE042763T2 (enExample) |
| IL (2) | IL246180B (enExample) |
| LT (1) | LT3080157T (enExample) |
| MX (1) | MX357941B (enExample) |
| NZ (1) | NZ721918A (enExample) |
| PL (1) | PL3080157T3 (enExample) |
| PT (1) | PT3080157T (enExample) |
| RS (1) | RS58191B1 (enExample) |
| SI (1) | SI3080157T1 (enExample) |
| SM (1) | SMT201900016T1 (enExample) |
| TR (1) | TR201819781T4 (enExample) |
| WO (1) | WO2015086854A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010045659A1 (en) | 2008-10-17 | 2010-04-22 | American Gene Technologies International Inc. | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| GB201322091D0 (en) | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
| EP3319631A4 (en) | 2015-07-08 | 2019-01-09 | American Gene Technologies International Inc. | HIV PREMUNICATION AND IMMUNOTHERAPY |
| CA3011529A1 (en) | 2016-01-15 | 2017-07-20 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta t-cells |
| US10888613B2 (en) | 2016-02-08 | 2021-01-12 | American Gene Technologies International Inc. | Method of producing cells resistant to HIV infection |
| ES2911448T3 (es) | 2016-03-09 | 2022-05-19 | American Gene Tech Int Inc | Vectores combinados y métodos para el tratamiento del cáncer |
| EP3468617A4 (en) | 2016-06-08 | 2020-01-22 | American Gene Technologies International Inc. | INTEGRATED VIRAL ADMINISTRATION SYSTEM AND RELATED METHODS |
| IL300730A (en) | 2016-07-08 | 2023-04-01 | American Gene Tech Int Inc | Pre-HIV vaccine and immunotherapy |
| WO2018154044A1 (en) * | 2017-02-23 | 2018-08-30 | Umc Utrecht Holding B.V. | Modified serpins for the treatment of bradykinin-mediated disease |
| US11820999B2 (en) | 2017-04-03 | 2023-11-21 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
| RU2663464C1 (ru) * | 2018-02-26 | 2018-08-06 | Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" | Комбинаторная терапия для лечения геморрагического шока |
| CN110051830A (zh) * | 2019-03-14 | 2019-07-26 | 苏州新凝生物医药科技有限公司 | 一种protease nexin II\KPI蛋白突变体的应用 |
| US20240051991A1 (en) * | 2021-04-20 | 2024-02-15 | University Of Louisville | Recombinant Miropin |
| US20250066436A1 (en) | 2021-12-22 | 2025-02-27 | Royal College Of Surgeons In Ireland | A conjugate for use in localising a molecule to the vascular endothelium |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4711848A (en) | 1984-03-14 | 1987-12-08 | Zymogenetics, Inc. | Site specific mutagenesis in alpha-1-antitrypsin |
| FR2599752B1 (fr) | 1986-06-10 | 1989-11-03 | Transgene Sa | Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine |
| DE3705745A1 (de) | 1987-02-23 | 1988-09-01 | Behringwerke Ag | Protein c-inhibitor (pci) als pharmazeutikum und in vitro-diagnostikum, verfahren zur herstellung eines solchen pharmazeutikums oder diagnostikums sowie ein mittel enthaltend pci |
| US5612194A (en) | 1989-06-23 | 1997-03-18 | Trustees Of The University Of Pennsylvania | Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors |
| IE902276A1 (en) | 1989-06-26 | 1991-01-16 | Akzo Nv | Serpin variants |
| CA2272095A1 (en) | 1996-11-19 | 1998-05-28 | Saulius Butenas | Peptidomimetics containing 6-peptidylamino-1-naphthalenesulfonamide moieties |
| WO2001055390A1 (en) | 2000-01-28 | 2001-08-02 | Human Genome Sciences, Inc. | Human serpin polynucleotides, polypeptides, and antibodies |
| JP2002010783A (ja) | 2000-06-29 | 2002-01-15 | Jcr Pharmaceuticals Co Ltd | 改変型ヒトプロテインｃインヒビター |
| US6924267B2 (en) | 2001-09-18 | 2005-08-02 | Suomen Punainen Risti Veripalvelu | Methods and active substances for protecting organs |
| JP2003093063A (ja) | 2001-09-20 | 2003-04-02 | Jcr Pharmaceuticals Co Ltd | 改変型ヒトプロテインｃインヒビター |
| WO2003039585A1 (en) | 2001-11-09 | 2003-05-15 | Novo Nordisk Health Care Ag | Pharmaceutical composition comprising factor vii polypeptides and protein c inhibitors |
| FR2836143B1 (fr) | 2002-02-21 | 2004-04-16 | Servier Lab | Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2004056309A2 (en) | 2002-12-05 | 2004-07-08 | Socratech L.L.C. | Neuroprotective activity of activated protein c is independent of its anticoagulant activity |
| EP1567199B1 (en) | 2002-12-05 | 2014-07-23 | Zz Biotech L.L.C. | Neuroprotective activity of activated protein c is independent of its anticoagulant activity |
| WO2006090282A2 (en) * | 2005-02-28 | 2006-08-31 | Universite De Lausanne | Recombinant inhibitor proteins of an hk14 protease and use thereof |
| EP1894574A4 (en) | 2005-04-18 | 2011-05-18 | Univ Mie | ANTICROBIAL AGENTS WITH PROTEIN C INHIBITOR |
| JP4846808B2 (ja) * | 2005-12-15 | 2011-12-28 | ガルフストリーム・エアロスペース・コーポレイション | 超音速航空機のための等エントロピー圧縮インレット |
| DK2046951T5 (da) * | 2006-07-05 | 2012-01-23 | Catalyst Biosciences Inc | Proteasesreeningsmetoder og proteaser identificeret dermed |
| US20100144620A1 (en) | 2006-11-16 | 2010-06-10 | Crucell Holland B.V. | Complementation of factor xi deficeincy by factor v mutants |
| WO2008059009A2 (en) | 2006-11-16 | 2008-05-22 | Crucell Holland B.V. | Factor v mutants for hemostasis in hemophilia |
| WO2008059043A2 (en) | 2006-11-16 | 2008-05-22 | Crucell Holland B.V. | Combination of coagulation factor viii with apc-resistant factor v |
| ATE539764T1 (de) | 2007-07-20 | 2012-01-15 | Univ Paris Sud Xi | Verwendung mutierter antithrombine zur behandlung oder verhinderung von gerinnungserkrankungen |
| GB0714649D0 (en) | 2007-07-27 | 2007-09-05 | Univ Leuven Kath | Novel viral replication inhibitors |
| WO2009055669A2 (en) | 2007-10-26 | 2009-04-30 | Oklahoma Medical Research Foundation | Monoclonal antibodies against activated and unactivated protein c |
| EP2055783A1 (en) * | 2007-10-30 | 2009-05-06 | VIB vzw | Insect inhibiting plant serpin mutants |
| CA2703948A1 (en) | 2007-11-01 | 2009-05-07 | University Of Rochester | Recombinant factor viii having increased stability |
| CN101977626A (zh) * | 2008-01-21 | 2011-02-16 | 德莫迪斯公司 | 丝氨酸蛋白酶抑制剂在治疗皮肤病中的用途 |
| US8822654B2 (en) | 2009-01-16 | 2014-09-02 | Universite Paris—Sud XI | Mutated antithrombins, a process for preparing the same and their use as drugs |
| EP2423233B1 (en) * | 2009-04-22 | 2015-03-11 | Alteogen, Inc | In vivo half life increased fusion protein or peptide maintained by sustained in vivo release, and method for increasing in vivo half-life using same |
| WO2011123830A2 (en) * | 2010-04-02 | 2011-10-06 | Amunix Operating Inc. | Alpha 1-antitrypsin compositions and methods of making and using same |
| US9127274B2 (en) | 2012-04-26 | 2015-09-08 | Alnylam Pharmaceuticals, Inc. | Serpinc1 iRNA compositions and methods of use thereof |
| WO2014184794A1 (en) | 2013-05-15 | 2014-11-20 | Mor Research Applications Ltd. | Compositions and methods for treating post-operative complications of cardiopulmonary surgery |
| GB201322091D0 (en) | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
| WO2018154044A1 (en) * | 2017-02-23 | 2018-08-30 | Umc Utrecht Holding B.V. | Modified serpins for the treatment of bradykinin-mediated disease |
-
2013
- 2013-12-13 GB GBGB1322091.8A patent/GB201322091D0/en not_active Ceased
-
2014
- 2014-12-15 US US15/103,420 patent/US9982035B2/en active Active
- 2014-12-15 TR TR2018/19781T patent/TR201819781T4/tr unknown
- 2014-12-15 KR KR1020167018756A patent/KR101954945B1/ko active Active
- 2014-12-15 DK DK14827185.1T patent/DK3080157T3/en active
- 2014-12-15 CN CN201480075522.6A patent/CN105992771B/zh active Active
- 2014-12-15 EP EP18190334.5A patent/EP3434689A1/en not_active Withdrawn
- 2014-12-15 NZ NZ721918A patent/NZ721918A/en unknown
- 2014-12-15 PT PT14827185T patent/PT3080157T/pt unknown
- 2014-12-15 EA EA201691235A patent/EA034050B1/ru unknown
- 2014-12-15 MX MX2016007711A patent/MX357941B/es active IP Right Grant
- 2014-12-15 KR KR1020197006015A patent/KR102186924B1/ko active Active
- 2014-12-15 CN CN201910704484.0A patent/CN110330563B/zh active Active
- 2014-12-15 EP EP14827185.1A patent/EP3080157B1/en active Active
- 2014-12-15 PL PL14827185T patent/PL3080157T3/pl unknown
- 2014-12-15 CA CA2933508A patent/CA2933508C/en active Active
- 2014-12-15 ES ES14827185T patent/ES2704058T3/es active Active
- 2014-12-15 AU AU2014363359A patent/AU2014363359B2/en active Active
- 2014-12-15 RS RS20181470A patent/RS58191B1/sr unknown
- 2014-12-15 WO PCT/EP2014/077783 patent/WO2015086854A1/en not_active Ceased
- 2014-12-15 SM SM20190016T patent/SMT201900016T1/it unknown
- 2014-12-15 LT LTEP14827185.1T patent/LT3080157T/lt unknown
- 2014-12-15 HU HUE14827185A patent/HUE042763T2/hu unknown
- 2014-12-15 JP JP2016538525A patent/JP6431541B2/ja active Active
- 2014-12-15 SI SI201430967T patent/SI3080157T1/sl unknown
- 2014-12-15 HR HRP20182138TT patent/HRP20182138T1/hr unknown
-
2016
- 2016-06-13 IL IL246180A patent/IL246180B/en active IP Right Grant
-
2018
- 2018-05-04 US US15/971,692 patent/US10351619B2/en active Active
- 2018-10-31 JP JP2018204779A patent/JP6723319B2/ja active Active
- 2018-11-08 IL IL262879A patent/IL262879A/en unknown
- 2018-12-17 AU AU2018279054A patent/AU2018279054A1/en not_active Abandoned
- 2018-12-27 CY CY20181101396T patent/CY1121267T1/el unknown
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