JP2017505114A5 - - Google Patents
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- Publication number
- JP2017505114A5 JP2017505114A5 JP2016538525A JP2016538525A JP2017505114A5 JP 2017505114 A5 JP2017505114 A5 JP 2017505114A5 JP 2016538525 A JP2016538525 A JP 2016538525A JP 2016538525 A JP2016538525 A JP 2016538525A JP 2017505114 A5 JP2017505114 A5 JP 2017505114A5
- Authority
- JP
- Japan
- Prior art keywords
- residue
- modified serpin
- rcl
- serpin
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1322091.8A GB201322091D0 (en) | 2013-12-13 | 2013-12-13 | Modified serpins for the treatment of bleeding disorders |
| GB1322091.8 | 2013-12-13 | ||
| PCT/EP2014/077783 WO2015086854A1 (en) | 2013-12-13 | 2014-12-15 | Modified serpins for the treatment of bleeding disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018204779A Division JP6723319B2 (ja) | 2013-12-13 | 2018-10-31 | 出血性障害の治療に対する改変セルピン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017505114A JP2017505114A (ja) | 2017-02-16 |
| JP2017505114A5 true JP2017505114A5 (enExample) | 2018-06-28 |
| JP6431541B2 JP6431541B2 (ja) | 2018-11-28 |
Family
ID=50030900
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538525A Active JP6431541B2 (ja) | 2013-12-13 | 2014-12-15 | 出血性障害の治療に対する改変セルピン |
| JP2018204779A Expired - Fee Related JP6723319B2 (ja) | 2013-12-13 | 2018-10-31 | 出血性障害の治療に対する改変セルピン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018204779A Expired - Fee Related JP6723319B2 (ja) | 2013-12-13 | 2018-10-31 | 出血性障害の治療に対する改変セルピン |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9982035B2 (enExample) |
| EP (2) | EP3080157B1 (enExample) |
| JP (2) | JP6431541B2 (enExample) |
| KR (2) | KR102186924B1 (enExample) |
| CN (2) | CN110330563B (enExample) |
| AU (2) | AU2014363359B2 (enExample) |
| CA (1) | CA2933508C (enExample) |
| CY (1) | CY1121267T1 (enExample) |
| DK (1) | DK3080157T3 (enExample) |
| EA (1) | EA034050B1 (enExample) |
| ES (1) | ES2704058T3 (enExample) |
| GB (1) | GB201322091D0 (enExample) |
| HR (1) | HRP20182138T1 (enExample) |
| HU (1) | HUE042763T2 (enExample) |
| IL (2) | IL246180B (enExample) |
| LT (1) | LT3080157T (enExample) |
| MX (1) | MX357941B (enExample) |
| NZ (1) | NZ721918A (enExample) |
| PL (1) | PL3080157T3 (enExample) |
| PT (1) | PT3080157T (enExample) |
| RS (1) | RS58191B1 (enExample) |
| SI (1) | SI3080157T1 (enExample) |
| SM (1) | SMT201900016T1 (enExample) |
| TR (1) | TR201819781T4 (enExample) |
| WO (1) | WO2015086854A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010045659A1 (en) | 2008-10-17 | 2010-04-22 | American Gene Technologies International Inc. | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| GB201322091D0 (en) | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
| US11980663B2 (en) | 2015-07-08 | 2024-05-14 | American Gene Technologies International Inc. | HIV pre-immunization and immunotherapy |
| IL297238B2 (en) | 2016-01-15 | 2024-08-01 | American Gene Tech Int Inc | Methods and preparations for gamma-delta T-cell activation |
| JP7153332B2 (ja) | 2016-02-08 | 2022-10-14 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Ｈｉｖワクチン接種および免疫療法 |
| ES2911448T3 (es) | 2016-03-09 | 2022-05-19 | American Gene Tech Int Inc | Vectores combinados y métodos para el tratamiento del cáncer |
| WO2017213697A1 (en) | 2016-06-08 | 2017-12-14 | American Gene Technologies International Inc. | Non-integrating viral delivery system and methods related thereto |
| CA3028982A1 (en) | 2016-07-08 | 2018-01-11 | American Gene Technologies International Inc. | Hiv pre-immunization and immunotherapy |
| WO2018154044A1 (en) * | 2017-02-23 | 2018-08-30 | Umc Utrecht Holding B.V. | Modified serpins for the treatment of bradykinin-mediated disease |
| US11820999B2 (en) | 2017-04-03 | 2023-11-21 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
| RU2663464C1 (ru) * | 2018-02-26 | 2018-08-06 | Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" | Комбинаторная терапия для лечения геморрагического шока |
| WO2020092448A1 (en) * | 2018-10-29 | 2020-05-07 | Spin Therapeutics, Llc | Compositions and methods for alpha-1-antitrypsin disorders |
| CN110051830A (zh) * | 2019-03-14 | 2019-07-26 | 苏州新凝生物医药科技有限公司 | 一种protease nexin II\KPI蛋白突变体的应用 |
| EP4326869A4 (en) * | 2021-04-20 | 2025-12-10 | Univ Of Louisville | RECOMBINATING MICRO-NECK |
| EP4453012A1 (en) | 2021-12-22 | 2024-10-30 | Royal College of Surgeons in Ireland | A conjugate for use in localising a molecule to the vascular endothelium |
| EP4707391A1 (en) * | 2024-09-10 | 2026-03-11 | e-therapeutics PLC | Nucleic acid compounds for zpi inhibition |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4711848A (en) | 1984-03-14 | 1987-12-08 | Zymogenetics, Inc. | Site specific mutagenesis in alpha-1-antitrypsin |
| FR2599752B1 (fr) | 1986-06-10 | 1989-11-03 | Transgene Sa | Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine |
| DE3705745A1 (de) | 1987-02-23 | 1988-09-01 | Behringwerke Ag | Protein c-inhibitor (pci) als pharmazeutikum und in vitro-diagnostikum, verfahren zur herstellung eines solchen pharmazeutikums oder diagnostikums sowie ein mittel enthaltend pci |
| US5612194A (en) | 1989-06-23 | 1997-03-18 | Trustees Of The University Of Pennsylvania | Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors |
| IE902276A1 (en) | 1989-06-26 | 1991-01-16 | Akzo Nv | Serpin variants |
| CA2272095A1 (en) | 1996-11-19 | 1998-05-28 | Saulius Butenas | Peptidomimetics containing 6-peptidylamino-1-naphthalenesulfonamide moieties |
| WO2001055390A1 (en) | 2000-01-28 | 2001-08-02 | Human Genome Sciences, Inc. | Human serpin polynucleotides, polypeptides, and antibodies |
| JP2002010783A (ja) | 2000-06-29 | 2002-01-15 | Jcr Pharmaceuticals Co Ltd | 改変型ヒトプロテインｃインヒビター |
| US6924267B2 (en) | 2001-09-18 | 2005-08-02 | Suomen Punainen Risti Veripalvelu | Methods and active substances for protecting organs |
| JP2003093063A (ja) | 2001-09-20 | 2003-04-02 | Jcr Pharmaceuticals Co Ltd | 改変型ヒトプロテインｃインヒビター |
| WO2003039585A1 (en) | 2001-11-09 | 2003-05-15 | Novo Nordisk Health Care Ag | Pharmaceutical composition comprising factor vii polypeptides and protein c inhibitors |
| FR2836143B1 (fr) | 2002-02-21 | 2004-04-16 | Servier Lab | Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2508276C (en) | 2002-12-05 | 2018-03-27 | Socratech L.L.C. | Neuroprotective activity of activated protein c is independent of its anticoagulant activity |
| WO2004056309A2 (en) | 2002-12-05 | 2004-07-08 | Socratech L.L.C. | Neuroprotective activity of activated protein c is independent of its anticoagulant activity |
| WO2006090282A2 (en) * | 2005-02-28 | 2006-08-31 | Universite De Lausanne | Recombinant inhibitor proteins of an hk14 protease and use thereof |
| EP1894574A4 (en) | 2005-04-18 | 2011-05-18 | Univ Mie | ANTICROBIAL AGENTS WITH PROTEIN C INHIBITOR |
| EP1960266B1 (en) * | 2005-12-15 | 2019-02-20 | Gulfstream Aerospace Corporation | Isentropic compression inlet for supersonic aircraft |
| ES2372709T3 (es) * | 2006-07-05 | 2012-01-25 | Catalyst Biosciences, Inc. | Procedimientos de cribado de proteasas y proteasas identificadas por los mismos. |
| WO2008059009A2 (en) | 2006-11-16 | 2008-05-22 | Crucell Holland B.V. | Factor v mutants for hemostasis in hemophilia |
| WO2008059041A2 (en) | 2006-11-16 | 2008-05-22 | Crucell Holland B.V. | Complementation of factor xi deficiency by factor v mutants |
| WO2008059043A2 (en) | 2006-11-16 | 2008-05-22 | Crucell Holland B.V. | Combination of coagulation factor viii with apc-resistant factor v |
| WO2009013251A1 (en) | 2007-07-20 | 2009-01-29 | Universite Paris-Sud Xi | Use of mutated antithrombins for treating or preventing coagulation disorders |
| GB0714649D0 (en) | 2007-07-27 | 2007-09-05 | Univ Leuven Kath | Novel viral replication inhibitors |
| BRPI0818865A2 (pt) | 2007-10-26 | 2015-05-05 | Oklahoma Med Res Found | Anticorpos monoclonais contra proteína c ativada. |
| EP2055783A1 (en) * | 2007-10-30 | 2009-05-06 | VIB vzw | Insect inhibiting plant serpin mutants |
| CA2703948A1 (en) | 2007-11-01 | 2009-05-07 | University Of Rochester | Recombinant factor viii having increased stability |
| AU2009207394B2 (en) * | 2008-01-21 | 2015-01-22 | Dermadis Sa | Use of serine protease inhibitors in the treatment of skin diseases |
| US8822654B2 (en) | 2009-01-16 | 2014-09-02 | Universite Paris—Sud XI | Mutated antithrombins, a process for preparing the same and their use as drugs |
| CN102439044B (zh) * | 2009-04-22 | 2014-08-13 | 阿特根公司 | 通过体内持续释放维持的体内半衰期增加的融合蛋白质或融合肽以及使用所述融合蛋白质或融合肽增加体内半衰期的方法 |
| WO2011123830A2 (en) * | 2010-04-02 | 2011-10-06 | Amunix Operating Inc. | Alpha 1-antitrypsin compositions and methods of making and using same |
| US9127274B2 (en) | 2012-04-26 | 2015-09-08 | Alnylam Pharmaceuticals, Inc. | Serpinc1 iRNA compositions and methods of use thereof |
| CN105431165A (zh) | 2013-05-15 | 2016-03-23 | 莫尔研究应用有限公司 | 用于治疗心肺手术后的术后并发症的组合物和方法 |
| GB201322091D0 (en) | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
| WO2018154044A1 (en) * | 2017-02-23 | 2018-08-30 | Umc Utrecht Holding B.V. | Modified serpins for the treatment of bradykinin-mediated disease |
-
2013
- 2013-12-13 GB GBGB1322091.8A patent/GB201322091D0/en not_active Ceased
-
2014
- 2014-12-15 SM SM20190016T patent/SMT201900016T1/it unknown
- 2014-12-15 KR KR1020197006015A patent/KR102186924B1/ko active Active
- 2014-12-15 DK DK14827185.1T patent/DK3080157T3/en active
- 2014-12-15 RS RS20181470A patent/RS58191B1/sr unknown
- 2014-12-15 ES ES14827185T patent/ES2704058T3/es active Active
- 2014-12-15 CA CA2933508A patent/CA2933508C/en active Active
- 2014-12-15 AU AU2014363359A patent/AU2014363359B2/en active Active
- 2014-12-15 EP EP14827185.1A patent/EP3080157B1/en active Active
- 2014-12-15 CN CN201910704484.0A patent/CN110330563B/zh active Active
- 2014-12-15 JP JP2016538525A patent/JP6431541B2/ja active Active
- 2014-12-15 LT LTEP14827185.1T patent/LT3080157T/lt unknown
- 2014-12-15 HU HUE14827185A patent/HUE042763T2/hu unknown
- 2014-12-15 PL PL14827185T patent/PL3080157T3/pl unknown
- 2014-12-15 CN CN201480075522.6A patent/CN105992771B/zh active Active
- 2014-12-15 KR KR1020167018756A patent/KR101954945B1/ko active Active
- 2014-12-15 EA EA201691235A patent/EA034050B1/ru unknown
- 2014-12-15 TR TR2018/19781T patent/TR201819781T4/tr unknown
- 2014-12-15 US US15/103,420 patent/US9982035B2/en active Active
- 2014-12-15 NZ NZ721918A patent/NZ721918A/en unknown
- 2014-12-15 WO PCT/EP2014/077783 patent/WO2015086854A1/en not_active Ceased
- 2014-12-15 HR HRP20182138TT patent/HRP20182138T1/hr unknown
- 2014-12-15 EP EP18190334.5A patent/EP3434689A1/en not_active Withdrawn
- 2014-12-15 SI SI201430967T patent/SI3080157T1/sl unknown
- 2014-12-15 PT PT14827185T patent/PT3080157T/pt unknown
- 2014-12-15 MX MX2016007711A patent/MX357941B/es active IP Right Grant
-
2016
- 2016-06-13 IL IL246180A patent/IL246180B/en active IP Right Grant
-
2018
- 2018-05-04 US US15/971,692 patent/US10351619B2/en active Active
- 2018-10-31 JP JP2018204779A patent/JP6723319B2/ja not_active Expired - Fee Related
- 2018-11-08 IL IL262879A patent/IL262879A/en unknown
- 2018-12-17 AU AU2018279054A patent/AU2018279054A1/en not_active Abandoned
- 2018-12-27 CY CY20181101396T patent/CY1121267T1/el unknown
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