JP2017505114A5 - - Google Patents
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- Publication number
- JP2017505114A5 JP2017505114A5 JP2016538525A JP2016538525A JP2017505114A5 JP 2017505114 A5 JP2017505114 A5 JP 2017505114A5 JP 2016538525 A JP2016538525 A JP 2016538525A JP 2016538525 A JP2016538525 A JP 2016538525A JP 2017505114 A5 JP2017505114 A5 JP 2017505114A5
- Authority
- JP
- Japan
- Prior art keywords
- residue
- modified serpin
- rcl
- serpin
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1322091.8 | 2013-12-13 | ||
| GBGB1322091.8A GB201322091D0 (en) | 2013-12-13 | 2013-12-13 | Modified serpins for the treatment of bleeding disorders |
| PCT/EP2014/077783 WO2015086854A1 (en) | 2013-12-13 | 2014-12-15 | Modified serpins for the treatment of bleeding disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018204779A Division JP6723319B2 (ja) | 2013-12-13 | 2018-10-31 | 出血性障害の治療に対する改変セルピン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017505114A JP2017505114A (ja) | 2017-02-16 |
| JP2017505114A5 true JP2017505114A5 (enExample) | 2018-06-28 |
| JP6431541B2 JP6431541B2 (ja) | 2018-11-28 |
Family
ID=50030900
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538525A Active JP6431541B2 (ja) | 2013-12-13 | 2014-12-15 | 出血性障害の治療に対する改変セルピン |
| JP2018204779A Expired - Fee Related JP6723319B2 (ja) | 2013-12-13 | 2018-10-31 | 出血性障害の治療に対する改変セルピン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018204779A Expired - Fee Related JP6723319B2 (ja) | 2013-12-13 | 2018-10-31 | 出血性障害の治療に対する改変セルピン |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9982035B2 (enExample) |
| EP (2) | EP3434689A1 (enExample) |
| JP (2) | JP6431541B2 (enExample) |
| KR (2) | KR101954945B1 (enExample) |
| CN (2) | CN110330563B (enExample) |
| AU (2) | AU2014363359B2 (enExample) |
| CA (1) | CA2933508C (enExample) |
| CY (1) | CY1121267T1 (enExample) |
| DK (1) | DK3080157T3 (enExample) |
| EA (1) | EA034050B1 (enExample) |
| ES (1) | ES2704058T3 (enExample) |
| GB (1) | GB201322091D0 (enExample) |
| HR (1) | HRP20182138T1 (enExample) |
| HU (1) | HUE042763T2 (enExample) |
| IL (2) | IL246180B (enExample) |
| LT (1) | LT3080157T (enExample) |
| MX (1) | MX357941B (enExample) |
| NZ (1) | NZ721918A (enExample) |
| PL (1) | PL3080157T3 (enExample) |
| PT (1) | PT3080157T (enExample) |
| RS (1) | RS58191B1 (enExample) |
| SI (1) | SI3080157T1 (enExample) |
| SM (1) | SMT201900016T1 (enExample) |
| TR (1) | TR201819781T4 (enExample) |
| WO (1) | WO2015086854A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100183558A1 (en) | 2008-10-17 | 2010-07-22 | Zhennan Lai | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| GB201322091D0 (en) | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
| EP3319631A4 (en) | 2015-07-08 | 2019-01-09 | American Gene Technologies International Inc. | HIV PREMUNICATION AND IMMUNOTHERAPY |
| CN116064678A (zh) | 2016-01-15 | 2023-05-05 | 美国基因技术国际有限公司 | 用于活化γ-δT细胞的方法和组合物 |
| WO2017139065A1 (en) | 2016-02-08 | 2017-08-17 | American Gene Technologies International Inc. | Hiv vaccination and immunotherapy |
| WO2017156311A2 (en) | 2016-03-09 | 2017-09-14 | American Gene Technologies International Inc. | Combination vectors and methods for treating cancer |
| EP3468617A4 (en) | 2016-06-08 | 2020-01-22 | American Gene Technologies International Inc. | SYSTEM FOR THE NON-INTEGRAL VIRAL ISSUE AND PROCEDURE RELATING TO IT |
| AU2017292582C1 (en) | 2016-07-08 | 2021-11-11 | American Gene Technologies International Inc. | HIV pre-immunization and immunotherapy |
| WO2018154044A1 (en) * | 2017-02-23 | 2018-08-30 | Umc Utrecht Holding B.V. | Modified serpins for the treatment of bradykinin-mediated disease |
| US11820999B2 (en) | 2017-04-03 | 2023-11-21 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
| RU2663464C1 (ru) * | 2018-02-26 | 2018-08-06 | Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" | Комбинаторная терапия для лечения геморрагического шока |
| CA3117961A1 (en) * | 2018-10-29 | 2020-05-07 | Spin Therapeutics, Llc | Compositions and methods for alpha-1-antitrypsin disorders |
| CN110051830A (zh) * | 2019-03-14 | 2019-07-26 | 苏州新凝生物医药科技有限公司 | 一种protease nexin II\KPI蛋白突变体的应用 |
| EP4326869A4 (en) * | 2021-04-20 | 2025-12-10 | Univ Of Louisville | RECOMBINATING MICRO-NECK |
| US20250066436A1 (en) | 2021-12-22 | 2025-02-27 | Royal College Of Surgeons In Ireland | A conjugate for use in localising a molecule to the vascular endothelium |
| EP4707391A1 (en) * | 2024-09-10 | 2026-03-11 | e-therapeutics PLC | Nucleic acid compounds for zpi inhibition |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4711848A (en) | 1984-03-14 | 1987-12-08 | Zymogenetics, Inc. | Site specific mutagenesis in alpha-1-antitrypsin |
| FR2599752B1 (fr) | 1986-06-10 | 1989-11-03 | Transgene Sa | Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine |
| DE3705745A1 (de) | 1987-02-23 | 1988-09-01 | Behringwerke Ag | Protein c-inhibitor (pci) als pharmazeutikum und in vitro-diagnostikum, verfahren zur herstellung eines solchen pharmazeutikums oder diagnostikums sowie ein mittel enthaltend pci |
| US5612194A (en) | 1989-06-23 | 1997-03-18 | Trustees Of The University Of Pennsylvania | Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors |
| IE902276A1 (en) | 1989-06-26 | 1991-01-16 | Akzo Nv | Serpin variants |
| US6566493B1 (en) | 1996-11-19 | 2003-05-20 | The University Of Vermont | Peptidomimetics containing 6-peptidylamino-1-naphthalenesulfonamide moieties |
| WO2001055390A1 (en) | 2000-01-28 | 2001-08-02 | Human Genome Sciences, Inc. | Human serpin polynucleotides, polypeptides, and antibodies |
| JP2002010783A (ja) | 2000-06-29 | 2002-01-15 | Jcr Pharmaceuticals Co Ltd | 改変型ヒトプロテインｃインヒビター |
| US6924267B2 (en) | 2001-09-18 | 2005-08-02 | Suomen Punainen Risti Veripalvelu | Methods and active substances for protecting organs |
| JP2003093063A (ja) | 2001-09-20 | 2003-04-02 | Jcr Pharmaceuticals Co Ltd | 改変型ヒトプロテインｃインヒビター |
| WO2003039585A1 (en) | 2001-11-09 | 2003-05-15 | Novo Nordisk Health Care Ag | Pharmaceutical composition comprising factor vii polypeptides and protein c inhibitors |
| FR2836143B1 (fr) | 2002-02-21 | 2004-04-16 | Servier Lab | Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| ES2504365T3 (es) | 2002-12-05 | 2014-10-08 | Zz Biotech L.L.C. | La actividad neuroprotectora de la proteína C activada es independiente de su actividad anticoagulante |
| WO2004056309A2 (en) | 2002-12-05 | 2004-07-08 | Socratech L.L.C. | Neuroprotective activity of activated protein c is independent of its anticoagulant activity |
| WO2006090282A2 (en) * | 2005-02-28 | 2006-08-31 | Universite De Lausanne | Recombinant inhibitor proteins of an hk14 protease and use thereof |
| US8106002B2 (en) | 2005-04-18 | 2012-01-31 | Chugai Seiyaku Kabushiki Kaisha | Anti-cancer agent comprising protein C inhibitor |
| US8333076B2 (en) * | 2005-12-15 | 2012-12-18 | Gulfstream Aerospace Corporation | Isentropic compression inlet for supersonic aircraft |
| SG175602A1 (en) * | 2006-07-05 | 2011-11-28 | Catalyst Biosciences Inc | Protease screening methods and proteases identified thereby |
| WO2008059043A2 (en) | 2006-11-16 | 2008-05-22 | Crucell Holland B.V. | Combination of coagulation factor viii with apc-resistant factor v |
| EP2081589B1 (en) | 2006-11-16 | 2010-10-06 | Crucell Holland B.V. | Complementation of factor xi deficiency by factor v mutants |
| WO2008059009A2 (en) | 2006-11-16 | 2008-05-22 | Crucell Holland B.V. | Factor v mutants for hemostasis in hemophilia |
| JP2010533684A (ja) | 2007-07-20 | 2010-10-28 | ユニベルシテ パリ サッド １１ | 血液凝固異常の治療又は予防のための変異アンチトロンビンの使用 |
| GB0714649D0 (en) | 2007-07-27 | 2007-09-05 | Univ Leuven Kath | Novel viral replication inhibitors |
| WO2009055669A2 (en) | 2007-10-26 | 2009-04-30 | Oklahoma Medical Research Foundation | Monoclonal antibodies against activated and unactivated protein c |
| EP2055783A1 (en) * | 2007-10-30 | 2009-05-06 | VIB vzw | Insect inhibiting plant serpin mutants |
| CN101965409A (zh) | 2007-11-01 | 2011-02-02 | 罗切斯特大学 | 具有增加的稳定性的重组因子viii |
| CN101977626A (zh) * | 2008-01-21 | 2011-02-16 | 德莫迪斯公司 | 丝氨酸蛋白酶抑制剂在治疗皮肤病中的用途 |
| WO2010081878A1 (en) | 2009-01-16 | 2010-07-22 | Universite Paris-Sud Xi | Mutated antithrombins, a process for preparing the same and their use as drugs |
| JP5727459B2 (ja) * | 2009-04-22 | 2015-06-03 | アルテオゼン， インクＡｌｔｅｏｇｅｎ， Ｉｎｃ | 体内持続性を維持することにより体内半減期が増加したタンパク質またはペプチド融合体 |
| US8557961B2 (en) * | 2010-04-02 | 2013-10-15 | Amunix Operating Inc. | Alpha 1-antitrypsin compositions and methods of making and using same |
| US9127274B2 (en) | 2012-04-26 | 2015-09-08 | Alnylam Pharmaceuticals, Inc. | Serpinc1 iRNA compositions and methods of use thereof |
| EP2996713B1 (en) | 2013-05-15 | 2019-10-02 | Mor Research Applications Ltd. | Compositions and methods for treating post-operative complications of cardiopulmonary surgery |
| GB201322091D0 (en) | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
| WO2018154044A1 (en) * | 2017-02-23 | 2018-08-30 | Umc Utrecht Holding B.V. | Modified serpins for the treatment of bradykinin-mediated disease |
-
2013
- 2013-12-13 GB GBGB1322091.8A patent/GB201322091D0/en not_active Ceased
-
2014
- 2014-12-15 EA EA201691235A patent/EA034050B1/ru unknown
- 2014-12-15 CN CN201910704484.0A patent/CN110330563B/zh active Active
- 2014-12-15 MX MX2016007711A patent/MX357941B/es active IP Right Grant
- 2014-12-15 EP EP18190334.5A patent/EP3434689A1/en not_active Withdrawn
- 2014-12-15 CN CN201480075522.6A patent/CN105992771B/zh active Active
- 2014-12-15 ES ES14827185T patent/ES2704058T3/es active Active
- 2014-12-15 WO PCT/EP2014/077783 patent/WO2015086854A1/en not_active Ceased
- 2014-12-15 SM SM20190016T patent/SMT201900016T1/it unknown
- 2014-12-15 PT PT14827185T patent/PT3080157T/pt unknown
- 2014-12-15 PL PL14827185T patent/PL3080157T3/pl unknown
- 2014-12-15 NZ NZ721918A patent/NZ721918A/en unknown
- 2014-12-15 DK DK14827185.1T patent/DK3080157T3/en active
- 2014-12-15 KR KR1020167018756A patent/KR101954945B1/ko active Active
- 2014-12-15 RS RS20181470A patent/RS58191B1/sr unknown
- 2014-12-15 SI SI201430967T patent/SI3080157T1/sl unknown
- 2014-12-15 US US15/103,420 patent/US9982035B2/en active Active
- 2014-12-15 HU HUE14827185A patent/HUE042763T2/hu unknown
- 2014-12-15 HR HRP20182138TT patent/HRP20182138T1/hr unknown
- 2014-12-15 JP JP2016538525A patent/JP6431541B2/ja active Active
- 2014-12-15 CA CA2933508A patent/CA2933508C/en active Active
- 2014-12-15 AU AU2014363359A patent/AU2014363359B2/en active Active
- 2014-12-15 TR TR2018/19781T patent/TR201819781T4/tr unknown
- 2014-12-15 LT LTEP14827185.1T patent/LT3080157T/lt unknown
- 2014-12-15 KR KR1020197006015A patent/KR102186924B1/ko active Active
- 2014-12-15 EP EP14827185.1A patent/EP3080157B1/en active Active
-
2016
- 2016-06-13 IL IL246180A patent/IL246180B/en active IP Right Grant
-
2018
- 2018-05-04 US US15/971,692 patent/US10351619B2/en active Active
- 2018-10-31 JP JP2018204779A patent/JP6723319B2/ja not_active Expired - Fee Related
- 2018-11-08 IL IL262879A patent/IL262879A/en unknown
- 2018-12-17 AU AU2018279054A patent/AU2018279054A1/en not_active Abandoned
- 2018-12-27 CY CY20181101396T patent/CY1121267T1/el unknown
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