JP6431541B2 - 出血性障害の治療に対する改変セルピン - Google Patents

出血性障害の治療に対する改変セルピン Download PDF

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Publication number
JP6431541B2
JP6431541B2 JP2016538525A JP2016538525A JP6431541B2 JP 6431541 B2 JP6431541 B2 JP 6431541B2 JP 2016538525 A JP2016538525 A JP 2016538525A JP 2016538525 A JP2016538525 A JP 2016538525A JP 6431541 B2 JP6431541 B2 JP 6431541B2
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residue
serpin
thrombin
inhibition
apc
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Japanese (ja)
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JP2017505114A (ja
JP2017505114A5 (enExample
Inventor
ジェームズ アンドリュー ハンティントン
ジェームズ アンドリュー ハンティントン
ステファニー ポルダーデイク
ステファニー ポルダーデイク
トレヴァー バグリン
トレヴァー バグリン
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Cambridge Enterprise Ltd
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Cambridge Enterprise Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2016538525A 2013-12-13 2014-12-15 出血性障害の治療に対する改変セルピン Active JP6431541B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1322091.8 2013-12-13
GBGB1322091.8A GB201322091D0 (en) 2013-12-13 2013-12-13 Modified serpins for the treatment of bleeding disorders
PCT/EP2014/077783 WO2015086854A1 (en) 2013-12-13 2014-12-15 Modified serpins for the treatment of bleeding disorders

Related Child Applications (1)

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JP2018204779A Division JP6723319B2 (ja) 2013-12-13 2018-10-31 出血性障害の治療に対する改変セルピン

Publications (3)

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JP2017505114A JP2017505114A (ja) 2017-02-16
JP2017505114A5 JP2017505114A5 (enExample) 2018-06-28
JP6431541B2 true JP6431541B2 (ja) 2018-11-28

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JP2016538525A Active JP6431541B2 (ja) 2013-12-13 2014-12-15 出血性障害の治療に対する改変セルピン
JP2018204779A Expired - Fee Related JP6723319B2 (ja) 2013-12-13 2018-10-31 出血性障害の治療に対する改変セルピン

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US (2) US9982035B2 (enExample)
EP (2) EP3434689A1 (enExample)
JP (2) JP6431541B2 (enExample)
KR (2) KR101954945B1 (enExample)
CN (2) CN110330563B (enExample)
AU (2) AU2014363359B2 (enExample)
CA (1) CA2933508C (enExample)
CY (1) CY1121267T1 (enExample)
DK (1) DK3080157T3 (enExample)
EA (1) EA034050B1 (enExample)
ES (1) ES2704058T3 (enExample)
GB (1) GB201322091D0 (enExample)
HR (1) HRP20182138T1 (enExample)
HU (1) HUE042763T2 (enExample)
IL (2) IL246180B (enExample)
LT (1) LT3080157T (enExample)
MX (1) MX357941B (enExample)
NZ (1) NZ721918A (enExample)
PL (1) PL3080157T3 (enExample)
PT (1) PT3080157T (enExample)
RS (1) RS58191B1 (enExample)
SI (1) SI3080157T1 (enExample)
SM (1) SMT201900016T1 (enExample)
TR (1) TR201819781T4 (enExample)
WO (1) WO2015086854A1 (enExample)

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CN116064678A (zh) 2016-01-15 2023-05-05 美国基因技术国际有限公司 用于活化γ-δT细胞的方法和组合物
WO2017139065A1 (en) 2016-02-08 2017-08-17 American Gene Technologies International Inc. Hiv vaccination and immunotherapy
WO2017156311A2 (en) 2016-03-09 2017-09-14 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
EP3468617A4 (en) 2016-06-08 2020-01-22 American Gene Technologies International Inc. SYSTEM FOR THE NON-INTEGRAL VIRAL ISSUE AND PROCEDURE RELATING TO IT
AU2017292582C1 (en) 2016-07-08 2021-11-11 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
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RU2663464C1 (ru) * 2018-02-26 2018-08-06 Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" Комбинаторная терапия для лечения геморрагического шока
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CN110051830A (zh) * 2019-03-14 2019-07-26 苏州新凝生物医药科技有限公司 一种protease nexin II\KPI蛋白突变体的应用
EP4326869A4 (en) * 2021-04-20 2025-12-10 Univ Of Louisville RECOMBINATING MICRO-NECK
US20250066436A1 (en) 2021-12-22 2025-02-27 Royal College Of Surgeons In Ireland A conjugate for use in localising a molecule to the vascular endothelium
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Also Published As

Publication number Publication date
TR201819781T4 (tr) 2019-01-21
EA034050B1 (ru) 2019-12-23
ES2704058T3 (es) 2019-03-14
AU2014363359B2 (en) 2019-01-03
CY1121267T1 (el) 2020-05-29
WO2015086854A1 (en) 2015-06-18
JP6723319B2 (ja) 2020-07-15
JP2019037242A (ja) 2019-03-14
KR20160092025A (ko) 2016-08-03
US20160311887A1 (en) 2016-10-27
HRP20182138T1 (hr) 2019-02-08
EP3080157B1 (en) 2018-10-03
MX357941B (es) 2018-07-31
PL3080157T3 (pl) 2019-03-29
US20180273610A1 (en) 2018-09-27
CA2933508C (en) 2021-04-06
HUE042763T2 (hu) 2019-07-29
LT3080157T (lt) 2018-12-10
US9982035B2 (en) 2018-05-29
PT3080157T (pt) 2019-01-11
CA2933508A1 (en) 2015-06-18
AU2014363359A1 (en) 2016-07-21
GB201322091D0 (en) 2014-01-29
BR112016013591A2 (pt) 2017-10-03
NZ721918A (en) 2019-12-20
US10351619B2 (en) 2019-07-16
SMT201900016T1 (it) 2019-02-28
CN105992771A (zh) 2016-10-05
CN110330563B (zh) 2024-03-29
RS58191B1 (sr) 2019-03-29
SI3080157T1 (sl) 2018-12-31
KR102186924B1 (ko) 2020-12-04
CN110330563A (zh) 2019-10-15
JP2017505114A (ja) 2017-02-16
EP3434689A1 (en) 2019-01-30
DK3080157T3 (en) 2018-12-17
IL246180A0 (en) 2016-07-31
CN105992771B (zh) 2019-08-23
EA201691235A1 (ru) 2016-12-30
AU2018279054A1 (en) 2019-01-17
EP3080157A1 (en) 2016-10-19
KR20190022945A (ko) 2019-03-06
IL246180B (en) 2018-11-29
MX2016007711A (es) 2016-12-09
IL262879A (en) 2018-12-31
KR101954945B1 (ko) 2019-03-07

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