PT3080157T - Serpinas modificadas para o tratamento de distúrbios de sangramento - Google Patents

Serpinas modificadas para o tratamento de distúrbios de sangramento

Info

Publication number
PT3080157T
PT3080157T PT14827185T PT14827185T PT3080157T PT 3080157 T PT3080157 T PT 3080157T PT 14827185 T PT14827185 T PT 14827185T PT 14827185 T PT14827185 T PT 14827185T PT 3080157 T PT3080157 T PT 3080157T
Authority
PT
Portugal
Prior art keywords
treatment
bleeding disorders
modified serpins
serpins
modified
Prior art date
Application number
PT14827185T
Other languages
English (en)
Inventor
Andrew Huntington James
Polderdijk Stéphanie
Baglin Trevor
Original Assignee
Cambridge Entpr Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Entpr Ltd filed Critical Cambridge Entpr Ltd
Publication of PT3080157T publication Critical patent/PT3080157T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
PT14827185T 2013-12-13 2014-12-15 Serpinas modificadas para o tratamento de distúrbios de sangramento PT3080157T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1322091.8A GB201322091D0 (en) 2013-12-13 2013-12-13 Modified serpins for the treatment of bleeding disorders

Publications (1)

Publication Number Publication Date
PT3080157T true PT3080157T (pt) 2019-01-11

Family

ID=50030900

Family Applications (1)

Application Number Title Priority Date Filing Date
PT14827185T PT3080157T (pt) 2013-12-13 2014-12-15 Serpinas modificadas para o tratamento de distúrbios de sangramento

Country Status (24)

Country Link
US (2) US9982035B2 (pt)
EP (2) EP3080157B1 (pt)
JP (2) JP6431541B2 (pt)
KR (2) KR101954945B1 (pt)
CN (2) CN110330563B (pt)
AU (2) AU2014363359B2 (pt)
CA (1) CA2933508C (pt)
CY (1) CY1121267T1 (pt)
DK (1) DK3080157T3 (pt)
EA (1) EA034050B1 (pt)
ES (1) ES2704058T3 (pt)
GB (1) GB201322091D0 (pt)
HR (1) HRP20182138T1 (pt)
HU (1) HUE042763T2 (pt)
IL (2) IL246180B (pt)
LT (1) LT3080157T (pt)
MX (1) MX357941B (pt)
NZ (1) NZ721918A (pt)
PL (1) PL3080157T3 (pt)
PT (1) PT3080157T (pt)
RS (1) RS58191B1 (pt)
SI (1) SI3080157T1 (pt)
TR (1) TR201819781T4 (pt)
WO (1) WO2015086854A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100183558A1 (en) 2008-10-17 2010-07-22 Zhennan Lai Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
EP3319631A4 (en) 2015-07-08 2019-01-09 American Gene Technologies International Inc. HIV PREMUNICATION AND IMMUNOTHERAPY
EP3426777B1 (en) 2016-03-09 2022-02-16 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
WO2017213697A1 (en) 2016-06-08 2017-12-14 American Gene Technologies International Inc. Non-integrating viral delivery system and methods related thereto
JP6971492B2 (ja) 2016-07-08 2021-11-24 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド Ｈｉｖ予備免疫化および免疫療法
US11851474B2 (en) * 2017-02-23 2023-12-26 Preclinics Gesellschaft Für Präklinische Forschung Mbh Modified serpins for the treatment of bradykinin-mediated disease
US11820999B2 (en) 2017-04-03 2023-11-21 American Gene Technologies International Inc. Compositions and methods for treating phenylketonuria
RU2663464C1 (ru) * 2018-02-26 2018-08-06 Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" Комбинаторная терапия для лечения геморрагического шока
CN110051830A (zh) * 2019-03-14 2019-07-26 苏州新凝生物医药科技有限公司 一种protease nexin II\KPI蛋白突变体的应用
US20240051991A1 (en) * 2021-04-20 2024-02-15 University Of Louisville Recombinant Miropin
WO2023118150A1 (en) 2021-12-22 2023-06-29 Royal College Of Surgeons In Ireland A conjugate for use in localising a molecule to the vascular endothelium.

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711848A (en) 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
FR2599752B1 (fr) 1986-06-10 1989-11-03 Transgene Sa Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine
DE3705745A1 (de) 1987-02-23 1988-09-01 Behringwerke Ag Protein c-inhibitor (pci) als pharmazeutikum und in vitro-diagnostikum, verfahren zur herstellung eines solchen pharmazeutikums oder diagnostikums sowie ein mittel enthaltend pci
US5612194A (en) 1989-06-23 1997-03-18 Trustees Of The University Of Pennsylvania Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors
IE902276A1 (en) 1989-06-26 1991-01-16 Akzo Nv Serpin variants
US6566493B1 (en) 1996-11-19 2003-05-20 The University Of Vermont Peptidomimetics containing 6-peptidylamino-1-naphthalenesulfonamide moieties
WO2001055390A1 (en) 2000-01-28 2001-08-02 Human Genome Sciences, Inc. Human serpin polynucleotides, polypeptides, and antibodies
JP2002010783A (ja) 2000-06-29 2002-01-15 Jcr Pharmaceuticals Co Ltd 改変型ヒトプロテインｃインヒビター
US6924267B2 (en) 2001-09-18 2005-08-02 Suomen Punainen Risti Veripalvelu Methods and active substances for protecting organs
JP2003093063A (ja) 2001-09-20 2003-04-02 Jcr Pharmaceuticals Co Ltd 改変型ヒトプロテインｃインヒビター
EP1446150A1 (en) 2001-11-09 2004-08-18 Novo Nordisk Health Care AG Pharmaceutical composition comprising factor vii polypeptides and protein c inhibitors
FR2836143B1 (fr) 2002-02-21 2004-04-16 Servier Lab Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2004056309A2 (en) 2002-12-05 2004-07-08 Socratech L.L.C. Neuroprotective activity of activated protein c is independent of its anticoagulant activity
ES2504365T3 (es) 2002-12-05 2014-10-08 Zz Biotech L.L.C. La actividad neuroprotectora de la proteína C activada es independiente de su actividad anticoagulante
WO2006090282A2 (en) * 2005-02-28 2006-08-31 Universite De Lausanne Recombinant inhibitor proteins of an hk14 protease and use thereof
EP1894574A4 (en) 2005-04-18 2011-05-18 Univ Mie ANTICANCER AGENT COMPRISING A PROTEIN C INHIBITOR
ES2726752T3 (es) * 2005-12-15 2019-10-09 Gulfstream Aerospace Corp Entrada de compresión isentrópica para aviones supersónicos
SG175602A1 (en) * 2006-07-05 2011-11-28 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby
US20100144620A1 (en) 2006-11-16 2010-06-10 Crucell Holland B.V. Complementation of factor xi deficeincy by factor v mutants
WO2008059009A2 (en) 2006-11-16 2008-05-22 Crucell Holland B.V. Factor v mutants for hemostasis in hemophilia
WO2008059043A2 (en) 2006-11-16 2008-05-22 Crucell Holland B.V. Combination of coagulation factor viii with apc-resistant factor v
ATE539764T1 (de) 2007-07-20 2012-01-15 Univ Paris Sud Xi Verwendung mutierter antithrombine zur behandlung oder verhinderung von gerinnungserkrankungen
GB0714649D0 (en) 2007-07-27 2007-09-05 Univ Leuven Kath Novel viral replication inhibitors
KR101856210B1 (ko) 2007-10-26 2018-05-09 오클라호마 메디컬 리써치 화운데이션 활성 및 비활성 단백질 ｃ에 대한 모노클로날 항체
EP2055783A1 (en) * 2007-10-30 2009-05-06 VIB vzw Insect inhibiting plant serpin mutants
AU2008319183B2 (en) 2007-11-01 2014-09-04 University Of Rochester Recombinant factor VIII having increased stability
CN101977626A (zh) * 2008-01-21 2011-02-16 德莫迪斯公司 丝氨酸蛋白酶抑制剂在治疗皮肤病中的用途
WO2010081878A1 (en) 2009-01-16 2010-07-22 Universite Paris-Sud Xi Mutated antithrombins, a process for preparing the same and their use as drugs
CN102439044B (zh) * 2009-04-22 2014-08-13 阿特根公司 通过体内持续释放维持的体内半衰期增加的融合蛋白质或融合肽以及使用所述融合蛋白质或融合肽增加体内半衰期的方法
WO2011123830A2 (en) * 2010-04-02 2011-10-06 Amunix Operating Inc. Alpha 1-antitrypsin compositions and methods of making and using same
US9127274B2 (en) 2012-04-26 2015-09-08 Alnylam Pharmaceuticals, Inc. Serpinc1 iRNA compositions and methods of use thereof
EP2996713B1 (en) 2013-05-15 2019-10-02 Mor Research Applications Ltd. Compositions and methods for treating post-operative complications of cardiopulmonary surgery
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
US11851474B2 (en) * 2017-02-23 2023-12-26 Preclinics Gesellschaft Für Präklinische Forschung Mbh Modified serpins for the treatment of bradykinin-mediated disease

Also Published As

Publication number Publication date
EP3080157B1 (en) 2018-10-03
SI3080157T1 (sl) 2018-12-31
CA2933508A1 (en) 2015-06-18
CA2933508C (en) 2021-04-06
JP2017505114A (ja) 2017-02-16
IL246180B (en) 2018-11-29
NZ721918A (en) 2019-12-20
RS58191B1 (sr) 2019-03-29
EA201691235A1 (ru) 2016-12-30
CN110330563A (zh) 2019-10-15
AU2018279054A1 (en) 2019-01-17
JP6723319B2 (ja) 2020-07-15
IL246180A0 (en) 2016-07-31
AU2014363359B2 (en) 2019-01-03
CN105992771B (zh) 2019-08-23
ES2704058T3 (es) 2019-03-14
US20160311887A1 (en) 2016-10-27
KR20160092025A (ko) 2016-08-03
JP2019037242A (ja) 2019-03-14
EP3080157A1 (en) 2016-10-19
HRP20182138T1 (hr) 2019-02-08
PL3080157T3 (pl) 2019-03-29
US20180273610A1 (en) 2018-09-27
CN105992771A (zh) 2016-10-05
DK3080157T3 (en) 2018-12-17
KR20190022945A (ko) 2019-03-06
KR101954945B1 (ko) 2019-03-07
GB201322091D0 (en) 2014-01-29
JP6431541B2 (ja) 2018-11-28
EA034050B1 (ru) 2019-12-23
WO2015086854A1 (en) 2015-06-18
MX2016007711A (es) 2016-12-09
CN110330563B (zh) 2024-03-29
TR201819781T4 (tr) 2019-01-21
EP3434689A1 (en) 2019-01-30
KR102186924B1 (ko) 2020-12-04
US10351619B2 (en) 2019-07-16
BR112016013591A2 (pt) 2017-10-03
HUE042763T2 (hu) 2019-07-29
LT3080157T (lt) 2018-12-10
US9982035B2 (en) 2018-05-29
IL262879A (en) 2018-12-31
AU2014363359A1 (en) 2016-07-21
CY1121267T1 (el) 2020-05-29
MX357941B (es) 2018-07-31

Similar Documents

Publication Publication Date Title
HRP20182138T1 (hr) Modificirani serpini za liječenje poremećaja s krvarenjem
IL243976A0 (en) kdm1a inhibitors for disease treatment
HK1222552A1 (zh) 索布替羅用於治療髓鞘形成疾病
EP3019491A4 (en) KINASE INHIBITORS FOR THE TREATMENT OF DISEASE
HK1213886A1 (zh) 用於治療心血管疾病的 -哌啶- -基苯甲酰胺衍生物
HK1220324A1 (zh) 用於治療血管緊張素相關疾病的方法、化合物和組合物
HUE061618T2 (hu) Vegyület szemrendellenességek kezelésére
IL283432A (en) Preparations, methods and systems for the treatment of skin disorders
HK1220611A1 (zh) 用於治療胃腸道病症的組成物
HK1219653A1 (zh) 治療線粒體疾病的方法
EP2989123A4 (en) METHODS AND COMPOSITIONS FOR TREATING COAGULATION DISORDERS
HK1221166A1 (zh) 炎症性病症的治療
IL277377B (en) Prohemostatic proteins for the treatment of bleeding
IL241934A (en) Inhibitory peptides for the treatment of inflammatory diseases
EP2958570A4 (en) THERAPEUTIC COMPOSITION FOR THE TREATMENT OF PERIANAL DISORDERS
EP2968550A4 (en) COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANGIOGENESIS RELATED DISORDERS
PL3016948T3 (pl) 2-acyloaminotiazole do leczenia nowotworów
GB201303721D0 (en) Compositions for treatment of sleep disorders
GB201318433D0 (en) Candidate for the treatment of epilepsy
TH1501001181A (th) องค์ประกอบสำหรับรักษาโรคสะเก็ดเงิน