TR201819781T4 - Kanama Bozukluklarının Tedavisi İçin Modifiye Serpinler - Google Patents

Kanama Bozukluklarının Tedavisi İçin Modifiye Serpinler Download PDF

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Publication number
TR201819781T4
TR201819781T4 TR2018/19781T TR201819781T TR201819781T4 TR 201819781 T4 TR201819781 T4 TR 201819781T4 TR 2018/19781 T TR2018/19781 T TR 2018/19781T TR 201819781 T TR201819781 T TR 201819781T TR 201819781 T4 TR201819781 T4 TR 201819781T4
Authority
TR
Turkey
Prior art keywords
modified
treatment
serpines
bleeding disorders
sprinkle
Prior art date
Application number
TR2018/19781T
Other languages
English (en)
Inventor
Andrew Huntington James
Polderdijk Stéphanie
Baglin Trevor
Original Assignee
Cambridge Entpr Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Entpr Ltd filed Critical Cambridge Entpr Ltd
Publication of TR201819781T4 publication Critical patent/TR201819781T4/tr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Bu buluş, antikoagülan proteazlar için artmış spesifisite göstermesi için reaktif merkez lupu (RCL) içerisinde P4, P2, P1 ve/veya P1? artıklarının modifiye edilmesi suretiyle düzenlenmiş pro-koagülan serpin molekülleriyle ilgilidir. Bu modifiye serpin molekülleri, tedavide, örneğin prokoagülanlar olarak kanama tedavisinde kullanışlı ve faydalı olabilir.
TR2018/19781T 2013-12-13 2014-12-15 Kanama Bozukluklarının Tedavisi İçin Modifiye Serpinler TR201819781T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1322091.8A GB201322091D0 (en) 2013-12-13 2013-12-13 Modified serpins for the treatment of bleeding disorders

Publications (1)

Publication Number Publication Date
TR201819781T4 true TR201819781T4 (tr) 2019-01-21

Family

ID=50030900

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/19781T TR201819781T4 (tr) 2013-12-13 2014-12-15 Kanama Bozukluklarının Tedavisi İçin Modifiye Serpinler

Country Status (24)

Country Link
US (2) US9982035B2 (tr)
EP (2) EP3434689A1 (tr)
JP (2) JP6431541B2 (tr)
KR (2) KR101954945B1 (tr)
CN (2) CN105992771B (tr)
AU (2) AU2014363359B2 (tr)
CA (1) CA2933508C (tr)
CY (1) CY1121267T1 (tr)
DK (1) DK3080157T3 (tr)
EA (1) EA034050B1 (tr)
ES (1) ES2704058T3 (tr)
GB (1) GB201322091D0 (tr)
HR (1) HRP20182138T1 (tr)
HU (1) HUE042763T2 (tr)
IL (2) IL246180B (tr)
LT (1) LT3080157T (tr)
MX (1) MX357941B (tr)
NZ (1) NZ721918A (tr)
PL (1) PL3080157T3 (tr)
PT (1) PT3080157T (tr)
RS (1) RS58191B1 (tr)
SI (1) SI3080157T1 (tr)
TR (1) TR201819781T4 (tr)
WO (1) WO2015086854A1 (tr)

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WO2017213697A1 (en) 2016-06-08 2017-12-14 American Gene Technologies International Inc. Non-integrating viral delivery system and methods related thereto
JP6971492B2 (ja) 2016-07-08 2021-11-24 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド Ｈｉｖ予備免疫化および免疫療法
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CN110051830A (zh) * 2019-03-14 2019-07-26 苏州新凝生物医药科技有限公司 一种protease nexin II\KPI蛋白突变体的应用
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Also Published As

Publication number Publication date
CN110330563A (zh) 2019-10-15
AU2014363359B2 (en) 2019-01-03
IL246180B (en) 2018-11-29
KR102186924B1 (ko) 2020-12-04
AU2014363359A1 (en) 2016-07-21
PT3080157T (pt) 2019-01-11
GB201322091D0 (en) 2014-01-29
KR20190022945A (ko) 2019-03-06
JP6431541B2 (ja) 2018-11-28
HRP20182138T1 (hr) 2019-02-08
US20160311887A1 (en) 2016-10-27
AU2018279054A1 (en) 2019-01-17
PL3080157T3 (pl) 2019-03-29
EP3080157A1 (en) 2016-10-19
EA201691235A1 (ru) 2016-12-30
ES2704058T3 (es) 2019-03-14
US10351619B2 (en) 2019-07-16
EP3080157B1 (en) 2018-10-03
DK3080157T3 (en) 2018-12-17
CA2933508A1 (en) 2015-06-18
JP2019037242A (ja) 2019-03-14
KR20160092025A (ko) 2016-08-03
CY1121267T1 (el) 2020-05-29
IL246180A0 (en) 2016-07-31
US20180273610A1 (en) 2018-09-27
RS58191B1 (sr) 2019-03-29
BR112016013591A2 (pt) 2017-10-03
CN105992771A (zh) 2016-10-05
CN105992771B (zh) 2019-08-23
KR101954945B1 (ko) 2019-03-07
HUE042763T2 (hu) 2019-07-29
EP3434689A1 (en) 2019-01-30
MX357941B (es) 2018-07-31
IL262879A (en) 2018-12-31
JP2017505114A (ja) 2017-02-16
CN110330563B (zh) 2024-03-29
EA034050B1 (ru) 2019-12-23
NZ721918A (en) 2019-12-20
SI3080157T1 (sl) 2018-12-31
LT3080157T (lt) 2018-12-10
US9982035B2 (en) 2018-05-29
JP6723319B2 (ja) 2020-07-15
WO2015086854A1 (en) 2015-06-18
CA2933508C (en) 2021-04-06
MX2016007711A (es) 2016-12-09

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