SI3080157T1 - Modificirani serpini za zdravljenje krvavitvenih motenj - Google Patents

Modificirani serpini za zdravljenje krvavitvenih motenj

Info

Publication number
SI3080157T1
SI3080157T1 SI201430967T SI201430967T SI3080157T1 SI 3080157 T1 SI3080157 T1 SI 3080157T1 SI 201430967 T SI201430967 T SI 201430967T SI 201430967 T SI201430967 T SI 201430967T SI 3080157 T1 SI3080157 T1 SI 3080157T1
Authority
SI
Slovenia
Prior art keywords
treatment
bleeding disorders
modified serpins
serpins
modified
Prior art date
Application number
SI201430967T
Other languages
English (en)
Inventor
James Andrew Huntington
Stephanie Polderdijk
Trevor Baglin
Original Assignee
Cambridge Enterprise Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Enterprise Limited filed Critical Cambridge Enterprise Limited
Publication of SI3080157T1 publication Critical patent/SI3080157T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
SI201430967T 2013-12-13 2014-12-15 Modificirani serpini za zdravljenje krvavitvenih motenj SI3080157T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1322091.8A GB201322091D0 (en) 2013-12-13 2013-12-13 Modified serpins for the treatment of bleeding disorders
PCT/EP2014/077783 WO2015086854A1 (en) 2013-12-13 2014-12-15 Modified serpins for the treatment of bleeding disorders
EP14827185.1A EP3080157B1 (en) 2013-12-13 2014-12-15 Modified serpins for the treatment of bleeding disorders

Publications (1)

Publication Number Publication Date
SI3080157T1 true SI3080157T1 (sl) 2018-12-31

Family

ID=50030900

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201430967T SI3080157T1 (sl) 2013-12-13 2014-12-15 Modificirani serpini za zdravljenje krvavitvenih motenj

Country Status (24)

Country Link
US (2) US9982035B2 (sl)
EP (2) EP3434689A1 (sl)
JP (2) JP6431541B2 (sl)
KR (2) KR102186924B1 (sl)
CN (2) CN105992771B (sl)
AU (2) AU2014363359B2 (sl)
CA (1) CA2933508C (sl)
CY (1) CY1121267T1 (sl)
DK (1) DK3080157T3 (sl)
EA (1) EA034050B1 (sl)
ES (1) ES2704058T3 (sl)
GB (1) GB201322091D0 (sl)
HR (1) HRP20182138T1 (sl)
HU (1) HUE042763T2 (sl)
IL (2) IL246180B (sl)
LT (1) LT3080157T (sl)
MX (1) MX357941B (sl)
NZ (1) NZ721918A (sl)
PL (1) PL3080157T3 (sl)
PT (1) PT3080157T (sl)
RS (1) RS58191B1 (sl)
SI (1) SI3080157T1 (sl)
TR (1) TR201819781T4 (sl)
WO (1) WO2015086854A1 (sl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010045659A1 (en) 2008-10-17 2010-04-22 American Gene Technologies International Inc. Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
WO2017156311A2 (en) 2016-03-09 2017-09-14 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
EP3468617A4 (en) 2016-06-08 2020-01-22 American Gene Technologies International Inc. INTEGRATED VIRAL ADMINISTRATION SYSTEM AND RELATED METHODS
IL300730A (en) 2016-07-08 2023-04-01 American Gene Tech Int Inc Pre-HIV vaccine and immunotherapy
EP3585808B1 (en) * 2017-02-23 2021-11-10 Preclinics Gesellschaft für präklinische Forschung mbH Modified serpins for the treatment of bradykinin-mediated disease
EP3607072A4 (en) 2017-04-03 2021-01-06 American Gene Technologies International Inc. COMPOSITIONS AND METHODS OF TREATMENT OF PHENYLCETONURISM
RU2663464C1 (ru) * 2018-02-26 2018-08-06 Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" Комбинаторная терапия для лечения геморрагического шока
CN110051830A (zh) * 2019-03-14 2019-07-26 苏州新凝生物医药科技有限公司 一种protease nexin II\KPI蛋白突变体的应用
US20240051991A1 (en) * 2021-04-20 2024-02-15 University Of Louisville Recombinant Miropin
WO2023118150A1 (en) 2021-12-22 2023-06-29 Royal College Of Surgeons In Ireland A conjugate for use in localising a molecule to the vascular endothelium.

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711848A (en) 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
FR2599752B1 (fr) 1986-06-10 1989-11-03 Transgene Sa Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine
DE3705745A1 (de) 1987-02-23 1988-09-01 Behringwerke Ag Protein c-inhibitor (pci) als pharmazeutikum und in vitro-diagnostikum, verfahren zur herstellung eines solchen pharmazeutikums oder diagnostikums sowie ein mittel enthaltend pci
US5612194A (en) 1989-06-23 1997-03-18 Trustees Of The University Of Pennsylvania Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors
IE902276A1 (en) 1989-06-26 1991-01-16 Akzo Nv Serpin variants
WO1998022125A1 (en) 1996-11-19 1998-05-28 Saulius Butenas Peptidomimetics containing 6-peptidylamino-1-naphthalenesulfonamide moieties
WO2001055390A1 (en) 2000-01-28 2001-08-02 Human Genome Sciences, Inc. Human serpin polynucleotides, polypeptides, and antibodies
JP2002010783A (ja) 2000-06-29 2002-01-15 Jcr Pharmaceuticals Co Ltd 改変型ヒトプロテインｃインヒビター
US6924267B2 (en) 2001-09-18 2005-08-02 Suomen Punainen Risti Veripalvelu Methods and active substances for protecting organs
JP2003093063A (ja) 2001-09-20 2003-04-02 Jcr Pharmaceuticals Co Ltd 改変型ヒトプロテインｃインヒビター
EP1446150A1 (en) 2001-11-09 2004-08-18 Novo Nordisk Health Care AG Pharmaceutical composition comprising factor vii polypeptides and protein c inhibitors
FR2836143B1 (fr) 2002-02-21 2004-04-16 Servier Lab Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2004056309A2 (en) 2002-12-05 2004-07-08 Socratech L.L.C. Neuroprotective activity of activated protein c is independent of its anticoagulant activity
EP1567199B1 (en) 2002-12-05 2014-07-23 Zz Biotech L.L.C. Neuroprotective activity of activated protein c is independent of its anticoagulant activity
WO2006090282A2 (en) * 2005-02-28 2006-08-31 Universite De Lausanne Recombinant inhibitor proteins of an hk14 protease and use thereof
US8106002B2 (en) 2005-04-18 2012-01-31 Chugai Seiyaku Kabushiki Kaisha Anti-cancer agent comprising protein C inhibitor
EP1960266B1 (en) * 2005-12-15 2019-02-20 Gulfstream Aerospace Corporation Isentropic compression inlet for supersonic aircraft
NZ574140A (en) * 2006-07-05 2012-02-24 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby
WO2008059043A2 (en) 2006-11-16 2008-05-22 Crucell Holland B.V. Combination of coagulation factor viii with apc-resistant factor v
EP2081589B1 (en) 2006-11-16 2010-10-06 Crucell Holland B.V. Complementation of factor xi deficiency by factor v mutants
WO2008059009A2 (en) 2006-11-16 2008-05-22 Crucell Holland B.V. Factor v mutants for hemostasis in hemophilia
US8741844B2 (en) 2007-07-20 2014-06-03 Universite Paris-Sud Xi Use of mutated antithrombins for treating or preventing coagulation disorders
GB0714649D0 (en) 2007-07-27 2007-09-05 Univ Leuven Kath Novel viral replication inhibitors
CN105153308A (zh) 2007-10-26 2015-12-16 俄克拉荷马医学研究基金会 针对活化蛋白c的单克隆抗体
EP2055783A1 (en) * 2007-10-30 2009-05-06 VIB vzw Insect inhibiting plant serpin mutants
US8183345B2 (en) 2007-11-01 2012-05-22 University Of Rochester Recombinant factor VIII having reduced inactivation by activated protein C
JP5615184B2 (ja) * 2008-01-21 2014-10-29 ドゥルマディス エスアーＤｅｒｍａｄｉｓ Ｓａ 皮膚病の治療におけるセリンプロテアーゼ阻害剤の使用
WO2010081878A1 (en) 2009-01-16 2010-07-22 Universite Paris-Sud Xi Mutated antithrombins, a process for preparing the same and their use as drugs
CA2758445C (en) * 2009-04-22 2016-02-16 Alteogen, Inc. In vivo half life increased fusion protein or peptide maintained by sustained in vivo release, and method for increasing in vivo half-life using same
US8557961B2 (en) * 2010-04-02 2013-10-15 Amunix Operating Inc. Alpha 1-antitrypsin compositions and methods of making and using same
US9127274B2 (en) 2012-04-26 2015-09-08 Alnylam Pharmaceuticals, Inc. Serpinc1 iRNA compositions and methods of use thereof
CN105431165A (zh) 2013-05-15 2016-03-23 莫尔研究应用有限公司 用于治疗心肺手术后的术后并发症的组合物和方法
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
EP3585808B1 (en) * 2017-02-23 2021-11-10 Preclinics Gesellschaft für präklinische Forschung mbH Modified serpins for the treatment of bradykinin-mediated disease

Also Published As

Publication number Publication date
RS58191B1 (sr) 2019-03-29
US10351619B2 (en) 2019-07-16
IL246180B (en) 2018-11-29
CA2933508C (en) 2021-04-06
US20180273610A1 (en) 2018-09-27
KR20160092025A (ko) 2016-08-03
MX357941B (es) 2018-07-31
EA034050B1 (ru) 2019-12-23
JP6723319B2 (ja) 2020-07-15
DK3080157T3 (en) 2018-12-17
HRP20182138T1 (hr) 2019-02-08
GB201322091D0 (en) 2014-01-29
ES2704058T3 (es) 2019-03-14
CN110330563A (zh) 2019-10-15
JP6431541B2 (ja) 2018-11-28
BR112016013591A2 (pt) 2017-10-03
JP2017505114A (ja) 2017-02-16
HUE042763T2 (hu) 2019-07-29
KR101954945B1 (ko) 2019-03-07
IL262879A (en) 2018-12-31
EP3080157A1 (en) 2016-10-19
TR201819781T4 (tr) 2019-01-21
CY1121267T1 (el) 2020-05-29
KR102186924B1 (ko) 2020-12-04
PT3080157T (pt) 2019-01-11
CN105992771A (zh) 2016-10-05
PL3080157T3 (pl) 2019-03-29
CN110330563B (zh) 2024-03-29
NZ721918A (en) 2019-12-20
CA2933508A1 (en) 2015-06-18
AU2014363359B2 (en) 2019-01-03
WO2015086854A1 (en) 2015-06-18
MX2016007711A (es) 2016-12-09
AU2014363359A1 (en) 2016-07-21
AU2018279054A1 (en) 2019-01-17
KR20190022945A (ko) 2019-03-06
IL246180A0 (en) 2016-07-31
US20160311887A1 (en) 2016-10-27
LT3080157T (lt) 2018-12-10
US9982035B2 (en) 2018-05-29
EP3080157B1 (en) 2018-10-03
EA201691235A1 (ru) 2016-12-30
EP3434689A1 (en) 2019-01-30
JP2019037242A (ja) 2019-03-14
CN105992771B (zh) 2019-08-23

Similar Documents

Publication Publication Date Title
HRP20182138T1 (hr) Modificirani serpini za liječenje poremećaja s krvarenjem
IL243976B (en) kdm1a inhibitors for disease treatment
HK1222552A1 (zh) 索布替羅用於治療髓鞘形成疾病
EP3019491A4 (en) KINASE INHIBITORS FOR THE TREATMENT OF DISEASE
HK1213886A1 (zh) 用於治療心血管疾病的 -哌啶- -基苯甲酰胺衍生物
HK1220324A1 (zh) 用於治療血管緊張素相關疾病的方法、化合物和組合物
HUE061618T2 (hu) Vegyület szemrendellenességek kezelésére
IL283432A (en) Preparations, methods and systems for the treatment of skin disorders
HK1220611A1 (zh) 用於治療胃腸道病症的組成物
HK1219653A1 (zh) 治療線粒體疾病的方法
EP2989123A4 (en) METHODS AND COMPOSITIONS FOR TREATING COAGULATION DISORDERS
HK1221166A1 (zh) 炎症性病症的治療
IL277377B (en) Prohemostatic proteins for the treatment of bleeding
IL241934A (en) Inhibitory peptides for the treatment of inflammatory diseases
EP2958570A4 (en) THERAPEUTIC COMPOSITION FOR THE TREATMENT OF PERIANAL DISORDERS
EP2968550A4 (en) COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANGIOGENESIS RELATED DISORDERS
PL3016948T3 (pl) 2-acyloaminotiazole do leczenia nowotworów
GB201303721D0 (en) Compositions for treatment of sleep disorders
GB201318433D0 (en) Candidate for the treatment of epilepsy
TH1501001181A (th) องค์ประกอบสำหรับรักษาโรคสะเก็ดเงิน