JP2017504632A5 - - Google Patents
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- JP2017504632A5 JP2017504632A5 JP2016549045A JP2016549045A JP2017504632A5 JP 2017504632 A5 JP2017504632 A5 JP 2017504632A5 JP 2016549045 A JP2016549045 A JP 2016549045A JP 2016549045 A JP2016549045 A JP 2016549045A JP 2017504632 A5 JP2017504632 A5 JP 2017504632A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- effective amount
- crystalline form
- liver fibrosis
- jnk1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- 108700027648 Mitogen-Activated Protein Kinase 8 Proteins 0.000 claims 18
- 108700027653 Mitogen-Activated Protein Kinase 9 Proteins 0.000 claims 18
- 102100037808 Mitogen-activated protein kinase 8 Human genes 0.000 claims 18
- 208000019425 cirrhosis of liver Diseases 0.000 claims 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 18
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 9
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 9
- 102000001253 Protein Kinase Human genes 0.000 claims 9
- 206010039710 Scleroderma Diseases 0.000 claims 9
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 9
- 206010042953 Systemic sclerosis Diseases 0.000 claims 9
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 9
- 229940125904 compound 1 Drugs 0.000 claims 9
- 206010012601 diabetes mellitus Diseases 0.000 claims 9
- 230000002401 inhibitory effect Effects 0.000 claims 9
- 206010025135 lupus erythematosus Diseases 0.000 claims 9
- 238000000634 powder X-ray diffraction Methods 0.000 claims 9
- 230000001684 chronic effect Effects 0.000 claims 8
- 208000017169 kidney disease Diseases 0.000 claims 8
- 206010063209 Chronic allograft nephropathy Diseases 0.000 claims 1
- 201000001200 Crouzon syndrome-acanthosis nigricans syndrome Diseases 0.000 claims 1
- QBBRJRLJWXRSHQ-CKYFFXLPSA-N C[C@H](CC[C@H](C1)Nc2nc(NC(C)(C)C)ncc2C(N)=O)[C@@H]1O Chemical compound C[C@H](CC[C@H](C1)Nc2nc(NC(C)(C)C)ncc2C(N)=O)[C@@H]1O QBBRJRLJWXRSHQ-CKYFFXLPSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461933636P | 2014-01-30 | 2014-01-30 | |
| US61/933,636 | 2014-01-30 | ||
| US201462025161P | 2014-07-16 | 2014-07-16 | |
| US62/025,161 | 2014-07-16 | ||
| PCT/US2015/013412 WO2015116755A2 (en) | 2014-01-30 | 2015-01-29 | Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019071044A Division JP6742466B2 (ja) | 2014-01-30 | 2019-04-03 | ２−（ｔｅｒｔ−ブチルアミノ）−４−（（１Ｒ，３Ｒ，４Ｒ）−３−ヒドロキシ−４−メチルシクロヘキシルアミノ）−ピリミジン−５−カルボキサミドの固体形態、その組成物、及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017504632A JP2017504632A (ja) | 2017-02-09 |
| JP2017504632A5 true JP2017504632A5 (enExample) | 2018-04-19 |
Family
ID=53678405
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549045A Pending JP2017504632A (ja) | 2014-01-30 | 2015-01-29 | ２−（ｔｅｒｔ−ブチルアミノ）−４−（（１Ｒ，３Ｒ，４Ｒ）−３−ヒドロキシ−４−メチルシクロヘキシルアミノ）−ピリミジン−５−カルボキサミドの固体形態、その組成物、及びその使用方法 |
| JP2019071044A Active JP6742466B2 (ja) | 2014-01-30 | 2019-04-03 | ２−（ｔｅｒｔ−ブチルアミノ）−４−（（１Ｒ，３Ｒ，４Ｒ）−３−ヒドロキシ−４−メチルシクロヘキシルアミノ）−ピリミジン−５−カルボキサミドの固体形態、その組成物、及びその使用方法 |
| JP2020127493A Active JP7317768B2 (ja) | 2014-01-30 | 2020-07-28 | ２－（ｔｅｒｔ－ブチルアミノ）－４－（（１Ｒ，３Ｒ，４Ｒ）－３－ヒドロキシ－４－メチルシクロヘキシルアミノ）－ピリミジン－５－カルボキサミドの固体形態、その組成物、及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019071044A Active JP6742466B2 (ja) | 2014-01-30 | 2019-04-03 | ２−（ｔｅｒｔ−ブチルアミノ）−４−（（１Ｒ，３Ｒ，４Ｒ）−３−ヒドロキシ−４−メチルシクロヘキシルアミノ）−ピリミジン−５−カルボキサミドの固体形態、その組成物、及びその使用方法 |
| JP2020127493A Active JP7317768B2 (ja) | 2014-01-30 | 2020-07-28 | ２－（ｔｅｒｔ－ブチルアミノ）－４－（（１Ｒ，３Ｒ，４Ｒ）－３－ヒドロキシ－４－メチルシクロヘキシルアミノ）－ピリミジン－５－カルボキサミドの固体形態、その組成物、及びその使用方法 |
Country Status (32)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106946795B (zh) | 2011-04-22 | 2020-06-02 | 西格诺药品有限公司 | 取代的二氨基甲酰胺和二氨基甲腈嘧啶，其组合物，和用其治疗的方法 |
| NZ715903A (en) | 2014-01-30 | 2017-06-30 | Signal Pharm Llc | Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use |
| WO2016100308A1 (en) * | 2014-12-16 | 2016-06-23 | Signal Pharmaceuticals, Llc | Methods for measurement of inhibition of c-jun n-terminal kinase in skin |
| BR112017012795A2 (pt) * | 2014-12-16 | 2018-01-02 | Signal Pharmaceuticals, Llc | Formulações de 2-(terc-butilamino)-4-((1r,3r,4r)-3- hidroxi-4-metilciclo-hexilamino)-pirimidina-5- carboxamida |
| WO2016123291A1 (en) | 2015-01-29 | 2016-08-04 | Signal Pharmaceuticals, Llc | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| WO2017019487A1 (en) | 2015-07-24 | 2017-02-02 | Celgene Corporation | Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein |
| CN111934089B (zh) | 2019-05-13 | 2021-10-26 | 华为技术有限公司 | 天线装置及移动终端 |
| CN113698408B (zh) * | 2020-05-22 | 2025-07-25 | 武汉朗来科技发展有限公司 | Jnk抑制剂、其药物组合物和用途 |
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| BR112017012795A2 (pt) * | 2014-12-16 | 2018-01-02 | Signal Pharmaceuticals, Llc | Formulações de 2-(terc-butilamino)-4-((1r,3r,4r)-3- hidroxi-4-metilciclo-hexilamino)-pirimidina-5- carboxamida |
| WO2016123291A1 (en) * | 2015-01-29 | 2016-08-04 | Signal Pharmaceuticals, Llc | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
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2014
- 2014-09-03 NZ NZ715903A patent/NZ715903A/en unknown
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2015
- 2015-01-29 RS RS20200970A patent/RS60715B1/sr unknown
- 2015-01-29 PT PT157435033T patent/PT3099302T/pt unknown
- 2015-01-29 ES ES15743503T patent/ES2811834T3/es active Active
- 2015-01-29 EA EA201792281A patent/EA036964B1/ru not_active IP Right Cessation
- 2015-01-29 MX MX2020003173A patent/MX391127B/es unknown
- 2015-01-29 KR KR1020167023497A patent/KR102505677B1/ko active Active
- 2015-01-29 EP EP20178344.6A patent/EP3738954A1/en active Pending
- 2015-01-29 CA CA2938187A patent/CA2938187C/en active Active
- 2015-01-29 DK DK15743503.3T patent/DK3099302T3/da active
- 2015-01-29 AU AU2015211036A patent/AU2015211036B2/en active Active
- 2015-01-29 NZ NZ722412A patent/NZ722412A/en unknown
- 2015-01-29 HR HRP20201244TT patent/HRP20201244T1/hr unknown
- 2015-01-29 CR CR20160346A patent/CR20160346A/es unknown
- 2015-01-29 EA EA201691544A patent/EA031671B1/ru not_active IP Right Cessation
- 2015-01-29 PE PE2016001300A patent/PE20161437A1/es not_active Application Discontinuation
- 2015-01-29 SI SI201531322T patent/SI3099302T1/sl unknown
- 2015-01-29 KR KR1020227013115A patent/KR102760889B1/ko active Active
- 2015-01-29 BR BR122020003206-5A patent/BR122020003206B1/pt active IP Right Grant
- 2015-01-29 LT LTEP15743503.3T patent/LT3099302T/lt unknown
- 2015-01-29 MX MX2016009989A patent/MX373804B/es active IP Right Grant
- 2015-01-29 MY MYPI2016702761A patent/MY180020A/en unknown
- 2015-01-29 CN CN201580016658.4A patent/CN106163523A/zh active Pending
- 2015-01-29 EP EP15743503.3A patent/EP3099302B1/en active Active
- 2015-01-29 TW TW104103137A patent/TWI631108B/zh active
- 2015-01-29 JP JP2016549045A patent/JP2017504632A/ja active Pending
- 2015-01-29 PL PL15743503T patent/PL3099302T3/pl unknown
- 2015-01-29 HU HUE15743503A patent/HUE051266T2/hu unknown
- 2015-01-29 CN CN202110386057.XA patent/CN113717109A/zh active Pending
- 2015-01-29 SG SG11201606054SA patent/SG11201606054SA/en unknown
- 2015-01-29 WO PCT/US2015/013412 patent/WO2015116755A2/en not_active Ceased
- 2015-01-29 US US14/608,314 patent/US9365524B2/en active Active
- 2015-01-29 NZ NZ761068A patent/NZ761068A/en unknown
- 2015-01-29 CN CN202110386098.9A patent/CN113717110A/zh active Pending
- 2015-01-29 BR BR112016017776A patent/BR112016017776A8/pt not_active Application Discontinuation
- 2015-01-29 SM SM20200430T patent/SMT202000430T1/it unknown
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2016
- 2016-05-12 US US15/152,653 patent/US9814713B2/en active Active
- 2016-07-25 IL IL246931A patent/IL246931B/en active IP Right Grant
- 2016-07-26 PH PH12016501472A patent/PH12016501472B1/en unknown
- 2016-07-28 SA SA516371578A patent/SA516371578B1/ar unknown
- 2016-07-29 CL CL2016001927A patent/CL2016001927A1/es unknown
- 2016-07-29 MX MX2019005715A patent/MX2019005715A/es unknown
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2017
- 2017-10-09 US US15/727,659 patent/US10226461B2/en active Active
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2019
- 2019-02-04 US US16/266,793 patent/US10517873B2/en active Active
- 2019-04-03 JP JP2019071044A patent/JP6742466B2/ja active Active
- 2019-11-11 US US16/679,592 patent/US11241430B2/en active Active
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2020
- 2020-03-26 AU AU2020202146A patent/AU2020202146B2/en active Active
- 2020-06-11 IL IL275305A patent/IL275305B/en unknown
- 2020-07-28 JP JP2020127493A patent/JP7317768B2/ja active Active
- 2020-08-12 CY CY20201100757T patent/CY1123267T1/el unknown
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2021
- 2021-12-27 US US17/562,933 patent/US20220378785A1/en not_active Abandoned
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2024
- 2024-06-26 US US18/754,494 patent/US20250000860A1/en active Pending
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