JP2014176384A5 - - Google Patents
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- JP2014176384A5 JP2014176384A5 JP2014080591A JP2014080591A JP2014176384A5 JP 2014176384 A5 JP2014176384 A5 JP 2014176384A5 JP 2014080591 A JP2014080591 A JP 2014080591A JP 2014080591 A JP2014080591 A JP 2014080591A JP 2014176384 A5 JP2014176384 A5 JP 2014176384A5
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- JP
- Japan
- Prior art keywords
- compound according
- och
- compound
- treatment
- following formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 27
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010062016 Immunosuppression Diseases 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 230000001772 anti-angiogenic effect Effects 0.000 claims 1
- 230000003510 anti-fibrotic effect Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 230000007246 mechanism Effects 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 0 C[C@](C[C@](CC1)C[C@@](*)[C@@]1O)[C@](CC([C@](C)C=C(C)[C@]([C@@](*)C([C@](C)C[C@](C)C=CC=CC=C(C)[C@@](C[C@](CC[C@]1C)O[C@]1(C(C(N1[C@]2CCCC1)O)=O)O)O*)=O)O)=O)OC2=O Chemical compound C[C@](C[C@](CC1)C[C@@](*)[C@@]1O)[C@](CC([C@](C)C=C(C)[C@]([C@@](*)C([C@](C)C[C@](C)C=CC=CC=C(C)[C@@](C[C@](CC[C@]1C)O[C@]1(C(C(N1[C@]2CCCC1)O)=O)O)O*)=O)O)=O)OC2=O 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0216509.0 | 2002-07-16 | ||
| GB0216509A GB0216509D0 (en) | 2002-07-16 | 2002-07-16 | Production of polyketides and other natural products |
| GB0224922.5 | 2002-10-25 | ||
| GB0224922A GB0224922D0 (en) | 2002-10-25 | 2002-10-25 | Production of polyketides and other natural products |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009255660A Division JP2010075187A (ja) | 2002-07-16 | 2009-11-09 | ポリケチド、及び他の天然物の製造 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014176384A JP2014176384A (ja) | 2014-09-25 |
| JP2014176384A5 true JP2014176384A5 (enExample) | 2015-03-05 |
Family
ID=30117119
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004520912A Pending JP2005532809A (ja) | 2002-07-16 | 2003-07-16 | ポリケチド、及び他の天然物の製造 |
| JP2008028177A Expired - Fee Related JP4751899B2 (ja) | 2002-07-16 | 2008-02-07 | ポリケチド、及び他の天然物の製造 |
| JP2008028178A Ceased JP2008200039A (ja) | 2002-07-16 | 2008-02-07 | ポリケチド、及び他の天然物の製造 |
| JP2009255660A Withdrawn JP2010075187A (ja) | 2002-07-16 | 2009-11-09 | ポリケチド、及び他の天然物の製造 |
| JP2014080591A Pending JP2014176384A (ja) | 2002-07-16 | 2014-04-09 | ポリケチド、及び他の天然物の製造 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004520912A Pending JP2005532809A (ja) | 2002-07-16 | 2003-07-16 | ポリケチド、及び他の天然物の製造 |
| JP2008028177A Expired - Fee Related JP4751899B2 (ja) | 2002-07-16 | 2008-02-07 | ポリケチド、及び他の天然物の製造 |
| JP2008028178A Ceased JP2008200039A (ja) | 2002-07-16 | 2008-02-07 | ポリケチド、及び他の天然物の製造 |
| JP2009255660A Withdrawn JP2010075187A (ja) | 2002-07-16 | 2009-11-09 | ポリケチド、及び他の天然物の製造 |
Country Status (15)
| Country | Link |
|---|---|
| US (7) | US7300942B2 (enExample) |
| EP (5) | EP2277898A3 (enExample) |
| JP (5) | JP2005532809A (enExample) |
| CN (1) | CN100569944C (enExample) |
| AT (1) | ATE370161T1 (enExample) |
| AU (1) | AU2003246965B2 (enExample) |
| BR (1) | BR0312691A (enExample) |
| CA (1) | CA2492153C (enExample) |
| CY (1) | CY1107764T1 (enExample) |
| DE (1) | DE60315723T2 (enExample) |
| DK (1) | DK1589031T3 (enExample) |
| ES (2) | ES2296063T3 (enExample) |
| MX (1) | MXPA05000139A (enExample) |
| PT (1) | PT1589031E (enExample) |
| WO (1) | WO2004007709A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0312691A (pt) * | 2002-07-16 | 2005-05-10 | Biotica Tech Ltd | Métodos para converter uma cepa hospedeira em uma cepa recombinante, para gerar uma cepa recombinante contendo agrupamento biossintéticos, para produzir um análogo de um ligando de fbkp, para construir uma coleção de colÈnias de cepas recombinantes e para preparar uma coleção combinatorial de ligando de fkbp, coleção de análogos de ligando fbkp, cepa recombinante, método para gerar análogos de ligandos de fbkp, composto, e, uso do mesmo |
| WO2005027906A1 (en) | 2003-09-18 | 2005-03-31 | Macusight, Inc. | Transscleral delivery |
| US20050239178A1 (en) * | 2004-04-27 | 2005-10-27 | Wyeth | Labeling of rapamycin using rapamycin-specific methylases |
| BRPI0511777A (pt) | 2004-06-03 | 2008-01-15 | Wyeth Corp | complexo de meridamicina sintase, célula hospedeira, policetìdeo sintase sintética, seqüência de ácido nucleico, vetor recombinante, ácido nucleico isolado, construção de ácido nucleico quimérico, métodos para produzir um composto de policetìdeo e para determinar o requerimento estrutural da atividade de policetìdio, análogo de meridamicina, cepa de streptomyces mutante, ceto meridamicina c36 ou um sal farmaceuticamente aceitável da mesma, composto de desoximeridamicina, sais ou misturas farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, cepa de actinomiceto m507, e, métodos para produzir um macrolìdeo e para produzir um composto |
| GB0417852D0 (en) * | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
| RU2007119585A (ru) | 2004-12-20 | 2009-01-27 | Вайет (Us) | Производные рапамицина и их применение при лечении неврологических заболеваний |
| AR052269A1 (es) | 2004-12-20 | 2007-03-07 | Wyeth Corp | Analogos de rapamicina, un proceso para su elaboracion y los usos de los mismos en la preparacion de un medicamento para el tratamiento de trastornos neurologicos, proliferativos e inflamatorios. |
| US20060182771A1 (en) | 2005-02-09 | 2006-08-17 | Dor Philippe J | Formulations for ocular treatment |
| US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
| GB0504995D0 (en) * | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Use of a compound |
| CA2599547A1 (en) * | 2005-03-11 | 2006-09-14 | Biotica Technology Limited | Medical uses of 39-desmethoxyrapamycin and analogues thereof |
| GB0504994D0 (en) | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Novel compounds |
| CN101836980A (zh) * | 2005-03-11 | 2010-09-22 | 比奥蒂卡科技有限公司 | 39-去甲氧基雷帕霉素及其类似物的医药用途 |
| EP2001438A2 (en) | 2006-02-09 | 2008-12-17 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
| DK2001466T3 (en) | 2006-03-23 | 2016-02-29 | Santen Pharmaceutical Co Ltd | LOW-DOSAGE RAPAMYCINE FOR TREATMENT OF VASCULAR PERMEABILITY-RELATED DISEASES |
| GB0609962D0 (en) * | 2006-05-19 | 2006-06-28 | Biotica Tech Ltd | Novel compounds |
| GB0609963D0 (en) | 2006-05-19 | 2006-06-28 | Biotica Tech Ltd | Novel compounds |
| KR100750810B1 (ko) | 2006-08-07 | 2007-08-22 | 동국제약 주식회사 | 스트렙토마이세스 히그로스코피쿠스 ａｔｃｃ １４８９１변이주 및 이를 이용한 타크로리무스 생산 방법 |
| DK2142638T3 (en) * | 2007-04-02 | 2016-12-12 | Newsouth Innovations Pty Ltd | Process for the production of secondary metabolites |
| TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
| US20080287675A1 (en) * | 2007-05-18 | 2008-11-20 | Abbott Laboratories | Cascade system |
| US8921642B2 (en) * | 2008-01-11 | 2014-12-30 | Massachusetts Eye And Ear Infirmary | Conditional-stop dimerizable caspase transgenic animals |
| EP2342335B1 (en) | 2008-09-24 | 2015-09-16 | Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences | Novel gene cluster |
| GB0904540D0 (en) | 2009-03-17 | 2009-04-29 | Biotica Tech Ltd | Novel compounds and methods for their production |
| GB0914589D0 (en) | 2009-08-20 | 2009-09-30 | Biotica Tech Ltd | Novel compounds and methods for their production |
| GB0917817D0 (en) | 2009-10-12 | 2009-11-25 | Biotica Tech Ltd | Novel compounds and methods for their production |
| GB0917816D0 (en) | 2009-10-12 | 2009-11-25 | Biotica Tech Ltd | Novel compounds and methods for their production |
| WO2012076898A1 (en) | 2010-12-08 | 2012-06-14 | Oslo University Hospital Hf | Triazole derivatives as wnt signaling pathway inhibitors |
| EP2589383A1 (en) | 2011-11-06 | 2013-05-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin | FKBP subtype-specific rapamycin analogue for use in treatment of diseases |
| GB201122305D0 (en) | 2011-12-23 | 2012-02-01 | Biotica Tech Ltd | Novel compound |
| WO2013107413A1 (zh) * | 2012-01-19 | 2013-07-25 | 中国科学院上海巴斯德研究所 | 磷酸化途径相关因子在调控调节性t细胞功能中的应用 |
| KR101331491B1 (ko) | 2012-03-21 | 2013-11-20 | 이화여자대학교 산학협력단 | 증가된 라파마이신 생성능을 갖는 신규 미생물 균주 |
| GB201312318D0 (en) | 2013-07-09 | 2013-08-21 | Isomerase Therapeutics Ltd | Novel methods and compounds |
| WO2017040341A1 (en) * | 2015-08-28 | 2017-03-09 | Buck Institute For Research On Aging | RAPAMYCIN ANALOGS SHOWING IMPROVED mTORC1 SPECIFICITY |
| AU2018219317A1 (en) | 2017-02-10 | 2019-09-26 | Mount Tam Therapeutics, Inc. | Rapamycin analog |
| WO2019157363A2 (en) * | 2018-02-09 | 2019-08-15 | Mount Tam Therapeutics, Inc. | Rapamycin analog for prevention and/or treatment of cancer |
| WO2019157374A1 (en) * | 2018-02-09 | 2019-08-15 | Mount Tam Therapeutics, Inc. | Rapamycin analog for prevention and/or treatment of neurodegenerative conditions |
| IL315399A (en) | 2019-01-22 | 2024-11-01 | Aeovian Pharmaceuticals Inc | Mtorc modulators and uses thereof |
| CN115125179B (zh) * | 2021-03-26 | 2023-10-27 | 上海医药工业研究院 | 产雷帕霉素的基因工程菌及其应用 |
| US20240376122A1 (en) * | 2021-06-25 | 2024-11-14 | Apertor Pharmaceuticals, Inc. | Small molecule compounds |
| US20240350463A1 (en) * | 2021-06-25 | 2024-10-24 | Apertor Pharmaceuticals, Inc. | Small molecule compounds |
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| BR0312691A (pt) | 2002-07-16 | 2005-05-10 | Biotica Tech Ltd | Métodos para converter uma cepa hospedeira em uma cepa recombinante, para gerar uma cepa recombinante contendo agrupamento biossintéticos, para produzir um análogo de um ligando de fbkp, para construir uma coleção de colÈnias de cepas recombinantes e para preparar uma coleção combinatorial de ligando de fkbp, coleção de análogos de ligando fbkp, cepa recombinante, método para gerar análogos de ligandos de fbkp, composto, e, uso do mesmo |
| CA2621093A1 (en) | 2002-07-16 | 2004-01-22 | Biotica Technology Limited | Production of polyketides and other natural products |
| AU2007237187B2 (en) | 2002-07-16 | 2010-08-05 | Biotica Technology Limited | Production of polyketides |
| GB0216509D0 (en) | 2002-07-16 | 2002-08-28 | Biotica Tech Ltd | Production of polyketides and other natural products |
-
2003
- 2003-07-16 BR BR0312691-9A patent/BR0312691A/pt not_active IP Right Cessation
- 2003-07-16 JP JP2004520912A patent/JP2005532809A/ja active Pending
- 2003-07-16 CN CNB038169169A patent/CN100569944C/zh not_active Expired - Fee Related
- 2003-07-16 ES ES05075774T patent/ES2296063T3/es not_active Expired - Lifetime
- 2003-07-16 EP EP10179385A patent/EP2277898A3/en not_active Withdrawn
- 2003-07-16 DE DE60315723T patent/DE60315723T2/de not_active Expired - Lifetime
- 2003-07-16 AT AT05075774T patent/ATE370161T1/de active
- 2003-07-16 AU AU2003246965A patent/AU2003246965B2/en not_active Ceased
- 2003-07-16 EP EP05077470A patent/EP1655372A3/en not_active Withdrawn
- 2003-07-16 EP EP03764029.9A patent/EP1521828B1/en not_active Expired - Lifetime
- 2003-07-16 WO PCT/GB2003/003230 patent/WO2004007709A2/en not_active Ceased
- 2003-07-16 PT PT05075774T patent/PT1589031E/pt unknown
- 2003-07-16 US US10/497,135 patent/US7300942B2/en not_active Expired - Lifetime
- 2003-07-16 EP EP05075774A patent/EP1589031B1/en not_active Expired - Lifetime
- 2003-07-16 DK DK05075774T patent/DK1589031T3/da active
- 2003-07-16 MX MXPA05000139A patent/MXPA05000139A/es active IP Right Grant
- 2003-07-16 CA CA2492153A patent/CA2492153C/en not_active Expired - Fee Related
- 2003-07-16 EP EP08075113A patent/EP1967520A2/en not_active Withdrawn
- 2003-07-16 ES ES03764029.9T patent/ES2544624T3/es not_active Expired - Lifetime
-
2005
- 2005-11-08 US US11/269,215 patent/US20060078980A1/en not_active Abandoned
-
2007
- 2007-07-16 US US11/778,319 patent/US7645768B2/en not_active Expired - Fee Related
- 2007-07-16 US US11/778,264 patent/US7390895B2/en not_active Expired - Lifetime
- 2007-10-15 CY CY20071101328T patent/CY1107764T1/el unknown
- 2007-10-31 US US11/931,474 patent/US20080287482A1/en not_active Abandoned
-
2008
- 2008-02-07 JP JP2008028177A patent/JP4751899B2/ja not_active Expired - Fee Related
- 2008-02-07 JP JP2008028178A patent/JP2008200039A/ja not_active Ceased
-
2009
- 2009-11-09 JP JP2009255660A patent/JP2010075187A/ja not_active Withdrawn
-
2011
- 2011-03-11 US US13/046,304 patent/US9040259B2/en not_active Expired - Lifetime
-
2014
- 2014-04-09 JP JP2014080591A patent/JP2014176384A/ja active Pending
-
2015
- 2015-03-02 US US14/635,979 patent/US9605001B2/en not_active Expired - Fee Related
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