WO2016016774A8 - Crystalline forms of canagliflozin - Google Patents

Crystalline forms of canagliflozin Download PDF

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Publication number
WO2016016774A8
WO2016016774A8 PCT/IB2015/055559 IB2015055559W WO2016016774A8 WO 2016016774 A8 WO2016016774 A8 WO 2016016774A8 IB 2015055559 W IB2015055559 W IB 2015055559W WO 2016016774 A8 WO2016016774 A8 WO 2016016774A8
Authority
WO
WIPO (PCT)
Prior art keywords
canagliflozin
crystalline forms
crystalline form
crystalline
hyrate
Prior art date
Application number
PCT/IB2015/055559
Other languages
French (fr)
Other versions
WO2016016774A1 (en
Inventor
Ramkinkar SANTRA
Devendra Prakash NAGDA
Ram Thaimattam
Satish Kumar Aryan
Tarun Kumar SINGH
Mohan Prasad
Somenath Ganguly
Deepika WADHWA
Original Assignee
Sun Pharmaceutical Industries Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Industries Limited filed Critical Sun Pharmaceutical Industries Limited
Publication of WO2016016774A1 publication Critical patent/WO2016016774A1/en
Publication of WO2016016774A8 publication Critical patent/WO2016016774A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to crystalline forms of canagliflozin, processes for their preparation, and their use for the treatment of type 2 diabetes mellitus. A crystalline Form R3 pf canagliflozin hyrate. The crystalline Form R-3 canagliflozin hydrate, characterized by an X-ray powder diffraction peaks having d-spacing values at about 9.2,4.1,4.5, and 7.2 Å.
PCT/IB2015/055559 2014-07-31 2015-07-22 Crystalline forms of canagliflozin WO2016016774A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2156DE2014 2014-07-31
IN2156/DEL/2014 2014-07-31

Publications (2)

Publication Number Publication Date
WO2016016774A1 WO2016016774A1 (en) 2016-02-04
WO2016016774A8 true WO2016016774A8 (en) 2016-03-24

Family

ID=55216825

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2015/055559 WO2016016774A1 (en) 2014-07-31 2015-07-22 Crystalline forms of canagliflozin

Country Status (1)

Country Link
WO (1) WO2016016774A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3068779A4 (en) * 2013-11-11 2017-06-28 Crystal Pharmatech Co. Ltd. Crystalline forms b, c, and d of canagliflozin
EP2990029A1 (en) * 2014-08-29 2016-03-02 Sandoz Ag Pharmaceutical compositions comprising Canagliflozin
JP2018087140A (en) * 2015-02-27 2018-06-07 田辺三菱製薬株式会社 NOVEL CRYSTAL OF 1-(β-D-GLUCOPYRANOSYL)-4-METHYL-3-[5-(4-FLUOROPHENYL)-2-THIENYLMETHYL]BENZENE
CN108017626A (en) * 2016-11-04 2018-05-11 上海奥博生物医药技术有限公司 A kind of canagliflozin semihydrate novel crystal forms
CN111487266B (en) * 2020-04-30 2023-10-13 江苏德源药业股份有限公司 Quantitative determination method for monohydrate crystal form in canagliflozin hemihydrate medicinal crystal form

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30730A1 (en) * 2006-12-04 2008-07-03 Mitsubishi Tanabe Pharma Corp CRYSTAL FORM OF HEMIHYDRATE 1- (B (BETA) -D-GLUCOPYRANOSIL) -4-METHYL-3- [5- (4-FLUOROPHENYL) -2-TIENYLMETHYL] BENZENE
WO2014180872A1 (en) * 2013-05-08 2014-11-13 Lek Pharmaceuticals D.D. NOVEL CRYSTALLINE HYDRATES OF 1-(ß-D-GLUCOPYRANOSYL)-4-METHYL-3-[5-(4-FLUOROPHENYL)-2-THIENYLMETHYL]BENZENE
EP3068779A4 (en) * 2013-11-11 2017-06-28 Crystal Pharmatech Co. Ltd. Crystalline forms b, c, and d of canagliflozin
CN103936725B (en) * 2014-04-01 2016-07-27 天津大学 The C crystal form of canagliflozin and crystallization preparation method thereof
CN103980262B (en) * 2014-04-01 2016-06-22 天津大学 The B crystal form of canagliflozin and crystallization preparation method thereof
CN104130246A (en) * 2014-05-28 2014-11-05 华润赛科药业有限责任公司 New crystal form of 1-(beta-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene and preparation method thereof

Also Published As

Publication number Publication date
WO2016016774A1 (en) 2016-02-04

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