WO2016189443A3 - Solid forms of nucleoside phosphoramidate - Google Patents

Solid forms of nucleoside phosphoramidate Download PDF

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Publication number
WO2016189443A3
WO2016189443A3 PCT/IB2016/052995 IB2016052995W WO2016189443A3 WO 2016189443 A3 WO2016189443 A3 WO 2016189443A3 IB 2016052995 W IB2016052995 W IB 2016052995W WO 2016189443 A3 WO2016189443 A3 WO 2016189443A3
Authority
WO
WIPO (PCT)
Prior art keywords
solid forms
nucleoside phosphoramidate
present
phosphoramidate
nucleoside
Prior art date
Application number
PCT/IB2016/052995
Other languages
French (fr)
Other versions
WO2016189443A2 (en
Inventor
Chandramouliswar Reddy GANGAVARAM
Bala Subba Reddy MAMILLA
Vamsee Krishna Muppidi
Sivakumar SANGARAPPAN
Original Assignee
Virupaksha Organics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virupaksha Organics Limited filed Critical Virupaksha Organics Limited
Publication of WO2016189443A2 publication Critical patent/WO2016189443A2/en
Publication of WO2016189443A3 publication Critical patent/WO2016189443A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention provides new crystalline compounds containing nucleoside phosphoramidate and a cocrystal former. Particularly, the present invention relates to Sofosbuvir Piperazine cocrystals.
PCT/IB2016/052995 2015-05-23 2016-05-21 Solid forms of nucleoside phosphoramidate WO2016189443A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2588/CHE/2015 2015-05-23
IN2588CH2015 2015-05-23

Publications (2)

Publication Number Publication Date
WO2016189443A2 WO2016189443A2 (en) 2016-12-01
WO2016189443A3 true WO2016189443A3 (en) 2017-01-12

Family

ID=57392206

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2016/052995 WO2016189443A2 (en) 2015-05-23 2016-05-21 Solid forms of nucleoside phosphoramidate

Country Status (1)

Country Link
WO (1) WO2016189443A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2988393C (en) 2014-06-13 2023-08-22 Ratiopharm Gmbh Solid state forms of sofosbuvir
EP3430023A1 (en) 2016-03-17 2019-01-23 Mylan Laboratories, Limited Polymorphic forms of sofosbuvir
RU2656228C9 (en) * 2017-06-13 2019-04-16 Олег Ростиславович Михайлов WEAKLY CRYSTALLISED β-MODIFICATION OF (S)-ISOPROPYL 2-((S)-(((2R,3R,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-(2H)-YL)-4-FLUORO-3-HYDROXY-4-METHYLTETRAHYDROFURAN-2-YL)METHOXY)-(PHENOXY)PHOSPHORYLAMINO)PROPANOATE, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION BASED THEREON

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008121634A2 (en) * 2007-03-30 2008-10-09 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
WO2015126995A1 (en) * 2014-02-20 2015-08-27 Ratiopharm Gmbh Solid state forms of sofosbuvir

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008121634A2 (en) * 2007-03-30 2008-10-09 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
WO2015126995A1 (en) * 2014-02-20 2015-08-27 Ratiopharm Gmbh Solid state forms of sofosbuvir

Also Published As

Publication number Publication date
WO2016189443A2 (en) 2016-12-01

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