WO2017191619A3 - A process for the preparation of a salt of sacubitril and valsartan - Google Patents

A process for the preparation of a salt of sacubitril and valsartan Download PDF

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Publication number
WO2017191619A3
WO2017191619A3 PCT/IB2017/052672 IB2017052672W WO2017191619A3 WO 2017191619 A3 WO2017191619 A3 WO 2017191619A3 IB 2017052672 W IB2017052672 W IB 2017052672W WO 2017191619 A3 WO2017191619 A3 WO 2017191619A3
Authority
WO
WIPO (PCT)
Prior art keywords
sacubitril
valsartan
preparation
salt
provides
Prior art date
Application number
PCT/IB2017/052672
Other languages
French (fr)
Other versions
WO2017191619A2 (en
Inventor
Siddamal Reddy PUTAPATRI
Bhushan Balasaheb KHAIRNAR
Ashok Kumar
Gyanendra Pandey
Kaptan Singh
Mohan Prasad
Original Assignee
Sun Pharmaceutical Industries Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Industries Limited filed Critical Sun Pharmaceutical Industries Limited
Publication of WO2017191619A2 publication Critical patent/WO2017191619A2/en
Publication of WO2017191619A3 publication Critical patent/WO2017191619A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/31—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a process for the preparation of a salt of sacubitril and valsartan. Specifically, the present invention provides a process for the preparation of a sodium salt of sacubitril and valsartan.
PCT/IB2017/052672 2016-05-06 2017-05-08 A process for the preparation of a salt of sacubitril and valsartan WO2017191619A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201611015864 2016-05-06
IN201611015864 2016-05-06

Publications (2)

Publication Number Publication Date
WO2017191619A2 WO2017191619A2 (en) 2017-11-09
WO2017191619A3 true WO2017191619A3 (en) 2017-12-14

Family

ID=60202847

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2017/052672 WO2017191619A2 (en) 2016-05-06 2017-05-08 A process for the preparation of a salt of sacubitril and valsartan

Country Status (1)

Country Link
WO (1) WO2017191619A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3110152A1 (en) 2018-08-23 2020-02-27 Novartis Ag New pharmaceutical use for the treatment of heart failure
WO2020039394A1 (en) 2018-08-24 2020-02-27 Novartis Ag New drug combinations

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007056546A1 (en) * 2005-11-09 2007-05-18 Novartis Ag Pharmaceutical combinations of an angiotensin receptor antagonist and an nep inhibitor
US20130109729A1 (en) * 2007-11-12 2013-05-02 Novartis Ag Pharmaceutical composition
WO2017042700A1 (en) * 2015-09-07 2017-03-16 Sun Pharmaceutical Industries Limited Solid forms of valsartan and sacubitril

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007056546A1 (en) * 2005-11-09 2007-05-18 Novartis Ag Pharmaceutical combinations of an angiotensin receptor antagonist and an nep inhibitor
US20130109729A1 (en) * 2007-11-12 2013-05-02 Novartis Ag Pharmaceutical composition
WO2017042700A1 (en) * 2015-09-07 2017-03-16 Sun Pharmaceutical Industries Limited Solid forms of valsartan and sacubitril

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FENG, L ET AL.: "LCZ696: a dual-acting sodium supramolecular complex", TETRAHEDRON LETTERS, vol. 53, no. 33, 18 January 2012 (2012-01-18), pages 275 - 276, XP028393477 *

Also Published As

Publication number Publication date
WO2017191619A2 (en) 2017-11-09

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