WO2013121439A3 - Garenoxacin mesylate, process for preparation thereof, and crystalline form thereof. - Google Patents

Garenoxacin mesylate, process for preparation thereof, and crystalline form thereof. Download PDF

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Publication number
WO2013121439A3
WO2013121439A3 PCT/IN2013/000090 IN2013000090W WO2013121439A3 WO 2013121439 A3 WO2013121439 A3 WO 2013121439A3 IN 2013000090 W IN2013000090 W IN 2013000090W WO 2013121439 A3 WO2013121439 A3 WO 2013121439A3
Authority
WO
WIPO (PCT)
Prior art keywords
garenoxacin
mesylate
crystalline form
preparation
peaks
Prior art date
Application number
PCT/IN2013/000090
Other languages
French (fr)
Other versions
WO2013121439A2 (en
Inventor
Changdev Namdev Raut
Pramod A DHEBADE
Shekhar Ashok DESHMUKH
Original Assignee
Glenmark Generics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Generics Limited filed Critical Glenmark Generics Limited
Publication of WO2013121439A2 publication Critical patent/WO2013121439A2/en
Publication of WO2013121439A3 publication Critical patent/WO2013121439A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Provided are garenoxacin mesylate, process for preparation thereof, and crystalline form thereof. The garenoxacin mesylate crystalline form is characterized by an X-ray powder diffraction pattern with peaks at about 13.77, 20.54, 21.50, 21.77, 22.12 and 23.90±0.20. A pharmaceutical composition of the garenoxacin mesylate crystalline form is also provided.
PCT/IN2013/000090 2012-02-15 2013-02-11 Process for garenoxacin mesylate WO2013121439A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN419/MUM/2012 2012-02-15
IN419MU2012 2012-02-15

Publications (2)

Publication Number Publication Date
WO2013121439A2 WO2013121439A2 (en) 2013-08-22
WO2013121439A3 true WO2013121439A3 (en) 2013-10-24

Family

ID=48984863

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2013/000090 WO2013121439A2 (en) 2012-02-15 2013-02-11 Process for garenoxacin mesylate

Country Status (1)

Country Link
WO (1) WO2013121439A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105801482B (en) * 2016-04-18 2018-06-22 浙江中欣氟材股份有限公司 A kind of preparation method of the bromo- 8- difluoro-methoxies -1,4- dihydroquinoline -3- carboxylic acid, ethyl esters of 1- cyclopropyl -4- oxos -7-
CN105777631B (en) * 2016-04-18 2018-06-29 浙江中欣氟材股份有限公司 A kind of synthetic method of the bromo- 8- difluoro-methoxies -1,4- dihydroquinoline -3- carboxylic acid, ethyl esters of 1- cyclopropyl -4- oxos -7-
CN105801390A (en) * 2016-04-18 2016-07-27 浙江中欣氟材股份有限公司 Method for synthesizing 2,4-dibromo-3-difluoromethoxy acetophenone

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025370A (en) * 1996-02-09 2000-02-15 Toyama Chemical Co., Ltd. Quinolonecarboxylic acid derivatives or salts thereof
JP2000229946A (en) * 1998-12-10 2000-08-22 Toyama Chem Co Ltd Production of quinolonecarboxylic acid and its intermediate
US6337399B1 (en) * 1997-10-27 2002-01-08 Toyama Chemical Co., Ltd. Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient
JP2003206290A (en) * 2001-11-06 2003-07-22 Toyama Chem Co Ltd Non-solvate of 2-[(1r)-1-methyl-2-trityl-2,3-dihydro-1h-5 isoindolyl]-1,3,6,2-dioxaazaborocane and method for producing the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025370A (en) * 1996-02-09 2000-02-15 Toyama Chemical Co., Ltd. Quinolonecarboxylic acid derivatives or salts thereof
US6337399B1 (en) * 1997-10-27 2002-01-08 Toyama Chemical Co., Ltd. Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient
JP2000229946A (en) * 1998-12-10 2000-08-22 Toyama Chem Co Ltd Production of quinolonecarboxylic acid and its intermediate
JP2003206290A (en) * 2001-11-06 2003-07-22 Toyama Chem Co Ltd Non-solvate of 2-[(1r)-1-methyl-2-trityl-2,3-dihydro-1h-5 isoindolyl]-1,3,6,2-dioxaazaborocane and method for producing the same

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DANESHTALAB, MOHSEN: "Novel synthetic antibacterial agents", TOPICS IN HETEROCYCLIC CHEMISTRY, vol. 2, 2006, pages 153 - 206 *
GRAUL, A. ET AL.: "T-3811ME: quinolone antibacterial", DRUGS OF THE FUTURE, vol. 12, no. 24, 1999, pages 1324 - 1331 *
HAYASHI, KAZUYA ET AL.: "Synthesis, antibacterial activity, and toxicity of 7-(isoindolin-5-yl)-4-oxoquinoline-3-carboxylic acids: Discovery of the novel Des-F (6)-quinolone antibacterial agent garenoxacin (T-3811 or BMS-284756)", ARZNEIMITTEL-FORSCHUNG, vol. 12, no. 52, 2002, pages 903 - 913 *
WANG, XIUYUN ET AL.: "Synthesis and antibacterial activities of Garenoxacin", WORLD NOTES ON ANTIBIOTICS, vol. 3, no. 27, 2006, pages 100 - 104 *
WU, XIAOGUO ET AL.: "The synthesis of Garenoxacin", CHINESE JOURNAL OF MODEM APPLIED PHARMACY, vol. 3, no. 26, 2009, pages 218 - 220 *

Also Published As

Publication number Publication date
WO2013121439A2 (en) 2013-08-22

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