JP2017504561A5 - - Google Patents
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- Publication number
- JP2017504561A5 JP2017504561A5 JP2016528880A JP2016528880A JP2017504561A5 JP 2017504561 A5 JP2017504561 A5 JP 2017504561A5 JP 2016528880 A JP2016528880 A JP 2016528880A JP 2016528880 A JP2016528880 A JP 2016528880A JP 2017504561 A5 JP2017504561 A5 JP 2017504561A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- compound
- nhr
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 16
- -1 2-phenylchromanyl Chemical group 0.000 claims 9
- 230000002438 mitochondrial effect Effects 0.000 claims 8
- 230000008685 targeting Effects 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000003107 substituted aryl group Chemical group 0.000 claims 5
- 125000002091 cationic group Chemical group 0.000 claims 4
- 125000004989 dicarbonyl group Chemical group 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000002993 cycloalkylene group Chemical group 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 101150009274 nhr-1 gene Proteins 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 1
- 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004471 alkyl aminosulfonyl group Chemical group 0.000 claims 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 229910052785 arsenic Inorganic materials 0.000 claims 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 claims 1
- 125000005125 aryl alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000005126 aryl alkyl carbonyl amino group Chemical group 0.000 claims 1
- 125000005100 aryl amino carbonyl group Chemical group 0.000 claims 1
- 125000004658 aryl carbonyl amino group Chemical group 0.000 claims 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 claims 1
- OTAFHZMPRISVEM-UHFFFAOYSA-N chromone Chemical compound C1=CC=C2C(=O)C=COC2=C1 OTAFHZMPRISVEM-UHFFFAOYSA-N 0.000 claims 1
- 125000000332 coumarinyl group Chemical group O1C(=O)C(=CC2=CC=CC=C12)* 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N flavone Chemical compound O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 230000003345 hyperglycaemic effect Effects 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1320636.2A GB201320636D0 (en) | 2013-11-22 | 2013-11-22 | Compounds |
| GB1320636.2 | 2013-11-22 | ||
| PCT/EP2014/075323 WO2015075200A1 (en) | 2013-11-22 | 2014-11-21 | Mitochondria-targeted dicarbonyl sequestering compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017504561A JP2017504561A (ja) | 2017-02-09 |
| JP2017504561A5 true JP2017504561A5 (https=) | 2017-12-28 |
| JP6661533B2 JP6661533B2 (ja) | 2020-03-11 |
Family
ID=49918047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016528880A Expired - Fee Related JP6661533B2 (ja) | 2013-11-22 | 2014-11-21 | ミトコンドリアを標的とするジカルボニル捕捉化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9963474B2 (https=) |
| EP (2) | EP3623375A1 (https=) |
| JP (1) | JP6661533B2 (https=) |
| CN (1) | CN105873936B (https=) |
| AU (1) | AU2014351802B2 (https=) |
| CA (1) | CA2931000A1 (https=) |
| ES (1) | ES2802123T3 (https=) |
| GB (1) | GB201320636D0 (https=) |
| HK (1) | HK1226079A1 (https=) |
| SG (2) | SG11201603485TA (https=) |
| WO (1) | WO2015075200A1 (https=) |
| ZA (1) | ZA201603129B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018122789A1 (en) * | 2016-12-29 | 2018-07-05 | Universidade Do Porto | Hydroxybenzoic acid derivatives, methods and uses thereof |
| JP6985730B2 (ja) * | 2017-11-17 | 2021-12-22 | 株式会社日立ハイテクサイエンス | 試料分析システム、表示方法及び試料分析方法 |
| KR101920902B1 (ko) * | 2017-12-27 | 2018-11-21 | 전남대학교 산학협력단 | 심혈관 질환 조기진단 pet 조영용 화합물 및 그의 용도 |
| WO2020036329A1 (ko) * | 2018-08-16 | 2020-02-20 | 숙명여자대학교산학협력단 | 미토콘드리아 내 nad(p)h 검출을 위한 형광 프로브 및 이를 이용한 검출방법 |
| PL3914359T3 (pl) * | 2019-01-25 | 2025-07-28 | Mti Biotech, Inc. | Pochodne salicyloaminy przyłączone do trifenylofosfonium |
| EP3914077A4 (en) * | 2019-01-25 | 2022-11-30 | Vanderbilt University | MITOCHONDRIAL TARGETING ISOKETAL/ISOLEVUGLANDIN SCAVENGERS |
| WO2021085906A1 (ko) * | 2019-10-30 | 2021-05-06 | 주식회사 퓨전바이오텍 | 미토콘드리아 표적 화합물 및 이를 포함하는 노화 관련 질환의 치료 또는 예방을 위한 조성물 |
| MX2022009256A (es) | 2020-01-27 | 2022-10-07 | Univ Vanderbilt | Depuradores de isocetal/isolevuglandina dirigidos a la mitocondria y usos de los mismos. |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB926998A (en) * | 1960-04-25 | 1963-05-22 | Ici Ltd | New water-soluble azo dyestuffs containing phosphonium groups |
| JPS52806A (en) | 1975-02-20 | 1977-01-06 | Dai Ichi Kogyo Seiyaku Co Ltd | Preparation of ester |
| JPS6029391B2 (ja) | 1976-02-04 | 1985-07-10 | 富士写真フイルム株式会社 | ベンゾトリアゾ−ル化合物 |
| FR2776289B1 (fr) * | 1998-03-20 | 2001-02-02 | Oreal | Composition de teinture d'oxydation contenant un coupleur cationique, procedes de teinture, nouveaux coupleurs cationiques |
| FR2776290B1 (fr) * | 1998-03-20 | 2001-08-10 | Oreal | Nouveaux composes cationiques, leur utilisation comme coupleurs pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture |
| FR2788520B1 (fr) * | 1999-01-19 | 2003-02-28 | Oreal | Nouveaux colorants mono-benzeniques cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture |
| US20020144700A1 (en) * | 2001-01-23 | 2002-10-10 | Lim Mu-Lll | Couplers for oxidative coloration of hair |
| JP2006501248A (ja) * | 2002-09-02 | 2006-01-12 | チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド | 多孔質材料の着色方法 |
| WO2006059423A1 (ja) * | 2004-12-02 | 2006-06-08 | Japan Science And Technology Agency | 過興奮性の細胞傷害によって生じる疾患を治療するための薬剤および方法 |
| US7956193B2 (en) * | 2007-05-04 | 2011-06-07 | University Of South Florida | Intramolecular C-H amination with sulfonyl azides |
| US8466140B2 (en) | 2007-09-10 | 2013-06-18 | University Of Massachusetts | Mitochondria-targeted anti-tumor agents |
| FR2984321A1 (fr) * | 2011-12-16 | 2013-06-21 | Oreal | Paraphenylenediamines cationiques, composition comprenant au moins de tels composes, procede de mise en oeuvre et utilisation |
| CN102617467A (zh) * | 2012-02-21 | 2012-08-01 | 大连理工大学 | 一种检测一氧化氮的超高灵敏荧光探针 |
| FR2996552B1 (fr) * | 2012-08-17 | 2016-10-14 | Oreal | Composition tinctoriale comprenant un derive o-alkyle substitue de meta-phenylenediamine cationique |
-
2013
- 2013-11-22 GB GBGB1320636.2A patent/GB201320636D0/en not_active Ceased
-
2014
- 2014-11-21 SG SG11201603485TA patent/SG11201603485TA/en unknown
- 2014-11-21 ES ES14818889T patent/ES2802123T3/es active Active
- 2014-11-21 CN CN201480063625.0A patent/CN105873936B/zh not_active Expired - Fee Related
- 2014-11-21 HK HK16114224.1A patent/HK1226079A1/zh unknown
- 2014-11-21 JP JP2016528880A patent/JP6661533B2/ja not_active Expired - Fee Related
- 2014-11-21 EP EP19204357.8A patent/EP3623375A1/en not_active Withdrawn
- 2014-11-21 SG SG10201807904RA patent/SG10201807904RA/en unknown
- 2014-11-21 AU AU2014351802A patent/AU2014351802B2/en not_active Ceased
- 2014-11-21 EP EP14818889.9A patent/EP3071582B1/en active Active
- 2014-11-21 WO PCT/EP2014/075323 patent/WO2015075200A1/en not_active Ceased
- 2014-11-21 CA CA2931000A patent/CA2931000A1/en not_active Abandoned
- 2014-11-21 US US15/037,941 patent/US9963474B2/en active Active
-
2016
- 2016-05-10 ZA ZA2016/03129A patent/ZA201603129B/en unknown
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