CN105873936B - 线粒体靶向的二羰基螯合化合物 - Google Patents

线粒体靶向的二羰基螯合化合物 Download PDF

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Publication number
CN105873936B
CN105873936B CN201480063625.0A CN201480063625A CN105873936B CN 105873936 B CN105873936 B CN 105873936B CN 201480063625 A CN201480063625 A CN 201480063625A CN 105873936 B CN105873936 B CN 105873936B
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China
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formula
alkyl
mitog
compound
alkylidene
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Expired - Fee Related
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CN201480063625.0A
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Chinese (zh)
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CN105873936A (zh
Inventor
迈克尔·帕特里克·墨菲
罗宾·安德鲁·詹姆斯·史密斯
理查德·查理·哈特利
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United Kingdom Research and Innovation
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Medical Research Council
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Dentistry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CN201480063625.0A 2013-11-22 2014-11-21 线粒体靶向的二羰基螯合化合物 Expired - Fee Related CN105873936B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1320636.2A GB201320636D0 (en) 2013-11-22 2013-11-22 Compounds
GB1320636.2 2013-11-22
PCT/EP2014/075323 WO2015075200A1 (en) 2013-11-22 2014-11-21 Mitochondria-targeted dicarbonyl sequestering compounds

Publications (2)

Publication Number Publication Date
CN105873936A CN105873936A (zh) 2016-08-17
CN105873936B true CN105873936B (zh) 2018-09-14

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CN201480063625.0A Expired - Fee Related CN105873936B (zh) 2013-11-22 2014-11-21 线粒体靶向的二羰基螯合化合物

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Country Link
US (1) US9963474B2 (https=)
EP (2) EP3623375A1 (https=)
JP (1) JP6661533B2 (https=)
CN (1) CN105873936B (https=)
AU (1) AU2014351802B2 (https=)
CA (1) CA2931000A1 (https=)
ES (1) ES2802123T3 (https=)
GB (1) GB201320636D0 (https=)
HK (1) HK1226079A1 (https=)
SG (2) SG11201603485TA (https=)
WO (1) WO2015075200A1 (https=)
ZA (1) ZA201603129B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018122789A1 (en) * 2016-12-29 2018-07-05 Universidade Do Porto Hydroxybenzoic acid derivatives, methods and uses thereof
JP6985730B2 (ja) * 2017-11-17 2021-12-22 株式会社日立ハイテクサイエンス 試料分析システム、表示方法及び試料分析方法
KR101920902B1 (ko) * 2017-12-27 2018-11-21 전남대학교 산학협력단 심혈관 질환 조기진단 pet 조영용 화합물 및 그의 용도
WO2020036329A1 (ko) * 2018-08-16 2020-02-20 숙명여자대학교산학협력단 미토콘드리아 내 nad(p)h 검출을 위한 형광 프로브 및 이를 이용한 검출방법
PL3914359T3 (pl) * 2019-01-25 2025-07-28 Mti Biotech, Inc. Pochodne salicyloaminy przyłączone do trifenylofosfonium
EP3914077A4 (en) * 2019-01-25 2022-11-30 Vanderbilt University MITOCHONDRIAL TARGETING ISOKETAL/ISOLEVUGLANDIN SCAVENGERS
WO2021085906A1 (ko) * 2019-10-30 2021-05-06 주식회사 퓨전바이오텍 미토콘드리아 표적 화합물 및 이를 포함하는 노화 관련 질환의 치료 또는 예방을 위한 조성물
MX2022009256A (es) 2020-01-27 2022-10-07 Univ Vanderbilt Depuradores de isocetal/isolevuglandina dirigidos a la mitocondria y usos de los mismos.

Citations (3)

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Publication number Priority date Publication date Assignee Title
GB926998A (en) * 1960-04-25 1963-05-22 Ici Ltd New water-soluble azo dyestuffs containing phosphonium groups
US6419711B1 (en) * 1998-03-20 2002-07-16 L'oreal Oxidation dyeing compositions containing a cationic coupling agent, novel cationic coupling agents
CN102617467A (zh) * 2012-02-21 2012-08-01 大连理工大学 一种检测一氧化氮的超高灵敏荧光探针

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JPS52806A (en) 1975-02-20 1977-01-06 Dai Ichi Kogyo Seiyaku Co Ltd Preparation of ester
JPS6029391B2 (ja) 1976-02-04 1985-07-10 富士写真フイルム株式会社 ベンゾトリアゾ−ル化合物
FR2776290B1 (fr) * 1998-03-20 2001-08-10 Oreal Nouveaux composes cationiques, leur utilisation comme coupleurs pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture
FR2788520B1 (fr) * 1999-01-19 2003-02-28 Oreal Nouveaux colorants mono-benzeniques cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture
US20020144700A1 (en) * 2001-01-23 2002-10-10 Lim Mu-Lll Couplers for oxidative coloration of hair
JP2006501248A (ja) * 2002-09-02 2006-01-12 チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド 多孔質材料の着色方法
WO2006059423A1 (ja) * 2004-12-02 2006-06-08 Japan Science And Technology Agency 過興奮性の細胞傷害によって生じる疾患を治療するための薬剤および方法
US7956193B2 (en) * 2007-05-04 2011-06-07 University Of South Florida Intramolecular C-H amination with sulfonyl azides
US8466140B2 (en) 2007-09-10 2013-06-18 University Of Massachusetts Mitochondria-targeted anti-tumor agents
FR2984321A1 (fr) * 2011-12-16 2013-06-21 Oreal Paraphenylenediamines cationiques, composition comprenant au moins de tels composes, procede de mise en oeuvre et utilisation
FR2996552B1 (fr) * 2012-08-17 2016-10-14 Oreal Composition tinctoriale comprenant un derive o-alkyle substitue de meta-phenylenediamine cationique

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB926998A (en) * 1960-04-25 1963-05-22 Ici Ltd New water-soluble azo dyestuffs containing phosphonium groups
US6419711B1 (en) * 1998-03-20 2002-07-16 L'oreal Oxidation dyeing compositions containing a cationic coupling agent, novel cationic coupling agents
CN102617467A (zh) * 2012-02-21 2012-08-01 大连理工大学 一种检测一氧化氮的超高灵敏荧光探针

Non-Patent Citations (5)

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Title
A mitochondria-targeted mass spectrometry probe to detect glyoxals:implications for diabetes;Pamela Boon Li Pun et al.;《Free Radical Biology&Medicine》;20131204;第437-450页 *
Novel aromatic polyimides with pendent triphenylamine units: Synthesis,photophysical, electrochromic properties;Kun Zhang et al.;《Journal of Electroanalytical Chemistry》;20120716;第101-109页 *
Pathological Significance ofMitochondrial Glycation;Pamela Boon Li Pun et al.;《International Journal of Cell Biology》;20120101;第231-13页 *
Pathological Significance ofMitochondrial Glycation;Robin A.J. Smith et al.;《Trends in Pharmacological Sciences》;20120630;第341-352页 *
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes;Kristine M. Robinson et al.;《Proceedings of Hte National Academy of Sciences》;20061010;第15038-15043页 *

Also Published As

Publication number Publication date
US20160289252A1 (en) 2016-10-06
GB201320636D0 (en) 2014-01-08
ES2802123T3 (es) 2021-01-15
EP3623375A1 (en) 2020-03-18
SG10201807904RA (en) 2018-10-30
AU2014351802B2 (en) 2019-10-03
NZ719705A (en) 2021-09-24
CA2931000A1 (en) 2015-05-28
AU2014351802A1 (en) 2016-05-26
US9963474B2 (en) 2018-05-08
CN105873936A (zh) 2016-08-17
JP6661533B2 (ja) 2020-03-11
WO2015075200A1 (en) 2015-05-28
JP2017504561A (ja) 2017-02-09
EP3071582A1 (en) 2016-09-28
EP3071582B1 (en) 2020-04-29
SG11201603485TA (en) 2016-05-30
ZA201603129B (en) 2018-12-19
HK1226079A1 (zh) 2017-09-22

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