HK1226079A1 - 線粒體靶向的二羰基螯合化合物 - Google Patents

線粒體靶向的二羰基螯合化合物

Info

Publication number
HK1226079A1
HK1226079A1 HK16114224A HK16114224A HK1226079A1 HK 1226079 A1 HK1226079 A1 HK 1226079A1 HK 16114224 A HK16114224 A HK 16114224A HK 16114224 A HK16114224 A HK 16114224A HK 1226079 A1 HK1226079 A1 HK 1226079A1
Authority
HK
Hong Kong
Prior art keywords
mitochondria
targeted
sequestering compounds
dicarbonyl sequestering
dicarbonyl
Prior art date
Application number
HK16114224A
Other languages
English (en)
Inventor
Michael Patrick Murphy
Robin Andrew James Smith
Richard Charles Hartley
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Res Council filed Critical Medical Res Council
Publication of HK1226079A1 publication Critical patent/HK1226079A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • C07F9/5442Aromatic phosphonium compounds (P-C aromatic linkage)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02Preservation of living parts
    • A01N1/0205Chemical aspects
    • A01N1/021Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physiology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK16114224A 2013-11-22 2016-12-14 線粒體靶向的二羰基螯合化合物 HK1226079A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1320636.2A GB201320636D0 (en) 2013-11-22 2013-11-22 Compounds

Publications (1)

Publication Number Publication Date
HK1226079A1 true HK1226079A1 (zh) 2017-09-22

Family

ID=49918047

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16114224A HK1226079A1 (zh) 2013-11-22 2016-12-14 線粒體靶向的二羰基螯合化合物

Country Status (12)

Country Link
US (1) US9963474B2 (zh)
EP (2) EP3623375A1 (zh)
JP (1) JP6661533B2 (zh)
CN (1) CN105873936B (zh)
AU (1) AU2014351802B2 (zh)
CA (1) CA2931000A1 (zh)
ES (1) ES2802123T3 (zh)
GB (1) GB201320636D0 (zh)
HK (1) HK1226079A1 (zh)
SG (2) SG10201807904RA (zh)
WO (1) WO2015075200A1 (zh)
ZA (1) ZA201603129B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019011303B1 (pt) * 2016-12-29 2023-03-14 Centro De Neurociências E Biologia Celular Derivados de ácido hidroxibenzoico, métodos e usos dos mesmos
JP6985730B2 (ja) * 2017-11-17 2021-12-22 株式会社日立ハイテクサイエンス 試料分析システム、表示方法及び試料分析方法
KR101920902B1 (ko) * 2017-12-27 2018-11-21 전남대학교 산학협력단 심혈관 질환 조기진단 pet 조영용 화합물 및 그의 용도
WO2020036329A1 (ko) * 2018-08-16 2020-02-20 숙명여자대학교산학협력단 미토콘드리아 내 nad(p)h 검출을 위한 형광 프로브 및 이를 이용한 검출방법
EP3914077A4 (en) 2019-01-25 2022-11-30 Vanderbilt University ISOCETAL/ISOLEVUGLANDINE SENSORS TARGETING MITOCHONDRIA
US20220112152A1 (en) * 2019-01-25 2022-04-14 Mti Biotech, Inc. Triphenylphosphonium-tethered salicylamine derivatives
EP3925961A4 (en) * 2019-10-30 2022-05-11 Fusion Biotechnology Co., Ltd. MITOCHONDRIAL TARGETED COMPOUND AND COMPOSITION THEREOF FOR THE TREATMENT OR PREVENTION OF AGE-RELATED DISEASES
BR112022014876A2 (pt) * 2020-01-27 2022-12-13 Univ Vanderbilt Sequestradores de isolevuglandinas/isocetais que têm mitocôndria como alvo e usos dos mesmos

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB926998A (en) * 1960-04-25 1963-05-22 Ici Ltd New water-soluble azo dyestuffs containing phosphonium groups
JPS52806A (en) 1975-02-20 1977-01-06 Dai Ichi Kogyo Seiyaku Co Ltd Preparation of ester
JPS6029391B2 (ja) 1976-02-04 1985-07-10 富士写真フイルム株式会社 ベンゾトリアゾ−ル化合物
FR2776290B1 (fr) * 1998-03-20 2001-08-10 Oreal Nouveaux composes cationiques, leur utilisation comme coupleurs pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture
FR2776289B1 (fr) 1998-03-20 2001-02-02 Oreal Composition de teinture d'oxydation contenant un coupleur cationique, procedes de teinture, nouveaux coupleurs cationiques
FR2788520B1 (fr) * 1999-01-19 2003-02-28 Oreal Nouveaux colorants mono-benzeniques cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture
JP2004517913A (ja) * 2001-01-23 2004-06-17 ピーアンドジー−クレイロール・インコーポレイテッド 毛髪の酸化的着色用カップラー
KR20050058415A (ko) * 2002-09-02 2005-06-16 시바 스폐셜티 케미칼스 홀딩 인코포레이티드 다공성 물질의 착색방법
WO2006059423A1 (ja) * 2004-12-02 2006-06-08 Japan Science And Technology Agency 過興奮性の細胞傷害によって生じる疾患を治療するための薬剤および方法
US7956193B2 (en) * 2007-05-04 2011-06-07 University Of South Florida Intramolecular C-H amination with sulfonyl azides
CA2699794C (en) 2007-09-10 2016-07-19 University Of Massachusetts Mitochondria-targeted anti-tumor agents
FR2984321A1 (fr) * 2011-12-16 2013-06-21 Oreal Paraphenylenediamines cationiques, composition comprenant au moins de tels composes, procede de mise en oeuvre et utilisation
CN102617467A (zh) 2012-02-21 2012-08-01 大连理工大学 一种检测一氧化氮的超高灵敏荧光探针
FR2996552B1 (fr) * 2012-08-17 2016-10-14 Oreal Composition tinctoriale comprenant un derive o-alkyle substitue de meta-phenylenediamine cationique

Also Published As

Publication number Publication date
SG10201807904RA (en) 2018-10-30
GB201320636D0 (en) 2014-01-08
JP2017504561A (ja) 2017-02-09
SG11201603485TA (en) 2016-05-30
EP3071582B1 (en) 2020-04-29
US9963474B2 (en) 2018-05-08
EP3623375A1 (en) 2020-03-18
EP3071582A1 (en) 2016-09-28
WO2015075200A1 (en) 2015-05-28
CA2931000A1 (en) 2015-05-28
CN105873936B (zh) 2018-09-14
ZA201603129B (en) 2018-12-19
AU2014351802A1 (en) 2016-05-26
NZ719705A (en) 2021-09-24
ES2802123T3 (es) 2021-01-15
AU2014351802B2 (en) 2019-10-03
CN105873936A (zh) 2016-08-17
US20160289252A1 (en) 2016-10-06
JP6661533B2 (ja) 2020-03-11

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