JP2017504561A5 - - Google Patents
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- Publication number
- JP2017504561A5 JP2017504561A5 JP2016528880A JP2016528880A JP2017504561A5 JP 2017504561 A5 JP2017504561 A5 JP 2017504561A5 JP 2016528880 A JP2016528880 A JP 2016528880A JP 2016528880 A JP2016528880 A JP 2016528880A JP 2017504561 A5 JP2017504561 A5 JP 2017504561A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- compound
- nhr
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 16
- -1 2-phenylchromanyl Chemical group 0.000 claims 9
- 230000002438 mitochondrial effect Effects 0.000 claims 8
- 230000008685 targeting Effects 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000003107 substituted aryl group Chemical group 0.000 claims 5
- 125000002091 cationic group Chemical group 0.000 claims 4
- 125000004989 dicarbonyl group Chemical group 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000002993 cycloalkylene group Chemical group 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 101150009274 nhr-1 gene Proteins 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 1
- 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004471 alkyl aminosulfonyl group Chemical group 0.000 claims 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 229910052785 arsenic Inorganic materials 0.000 claims 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 claims 1
- 125000005125 aryl alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000005126 aryl alkyl carbonyl amino group Chemical group 0.000 claims 1
- 125000005100 aryl amino carbonyl group Chemical group 0.000 claims 1
- 125000004658 aryl carbonyl amino group Chemical group 0.000 claims 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 claims 1
- OTAFHZMPRISVEM-UHFFFAOYSA-N chromone Chemical compound C1=CC=C2C(=O)C=COC2=C1 OTAFHZMPRISVEM-UHFFFAOYSA-N 0.000 claims 1
- 125000000332 coumarinyl group Chemical group O1C(=O)C(=CC2=CC=CC=C12)* 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N flavone Chemical compound O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 230000003345 hyperglycaemic effect Effects 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1320636.2A GB201320636D0 (en) | 2013-11-22 | 2013-11-22 | Compounds |
| GB1320636.2 | 2013-11-22 | ||
| PCT/EP2014/075323 WO2015075200A1 (en) | 2013-11-22 | 2014-11-21 | Mitochondria-targeted dicarbonyl sequestering compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017504561A JP2017504561A (ja) | 2017-02-09 |
| JP2017504561A5 true JP2017504561A5 (enExample) | 2017-12-28 |
| JP6661533B2 JP6661533B2 (ja) | 2020-03-11 |
Family
ID=49918047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016528880A Expired - Fee Related JP6661533B2 (ja) | 2013-11-22 | 2014-11-21 | ミトコンドリアを標的とするジカルボニル捕捉化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9963474B2 (enExample) |
| EP (2) | EP3071582B1 (enExample) |
| JP (1) | JP6661533B2 (enExample) |
| CN (1) | CN105873936B (enExample) |
| AU (1) | AU2014351802B2 (enExample) |
| CA (1) | CA2931000A1 (enExample) |
| ES (1) | ES2802123T3 (enExample) |
| GB (1) | GB201320636D0 (enExample) |
| HK (1) | HK1226079A1 (enExample) |
| SG (2) | SG10201807904RA (enExample) |
| WO (1) | WO2015075200A1 (enExample) |
| ZA (1) | ZA201603129B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3048966A1 (en) * | 2016-12-29 | 2018-07-05 | Universidade Do Porto | Hydroxybenzoic acid derivatives, methods and uses thereof |
| JP6985730B2 (ja) * | 2017-11-17 | 2021-12-22 | 株式会社日立ハイテクサイエンス | 試料分析システム、表示方法及び試料分析方法 |
| KR101920902B1 (ko) * | 2017-12-27 | 2018-11-21 | 전남대학교 산학협력단 | 심혈관 질환 조기진단 pet 조영용 화합물 및 그의 용도 |
| WO2020036329A1 (ko) * | 2018-08-16 | 2020-02-20 | 숙명여자대학교산학협력단 | 미토콘드리아 내 nad(p)h 검출을 위한 형광 프로브 및 이를 이용한 검출방법 |
| HUE072226T2 (hu) * | 2019-01-25 | 2025-11-28 | Mti Biotech Inc | Trifenilfoszfóniumhoz kötött szalicilamin származékok |
| AU2020210888A1 (en) | 2019-01-25 | 2021-08-19 | Vanderbilt University | Mitochondria-targeted isoketal/isolevuglandin scavengers |
| KR102596981B1 (ko) * | 2019-10-30 | 2023-10-31 | 주식회사 퓨전바이오텍 | 미토콘드리아 표적 화합물 및 이를 포함하는 노화 관련 질환의 치료 또는 예방을 위한 조성물 |
| JP2023512225A (ja) * | 2020-01-27 | 2023-03-24 | ヴァンダービルト ユニバーシティー | ミトコンドリア標的イソケタール／イソレブグランジンスカベンジャー及びその使用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB926998A (en) * | 1960-04-25 | 1963-05-22 | Ici Ltd | New water-soluble azo dyestuffs containing phosphonium groups |
| JPS52806A (en) | 1975-02-20 | 1977-01-06 | Dai Ichi Kogyo Seiyaku Co Ltd | Preparation of ester |
| JPS6029391B2 (ja) | 1976-02-04 | 1985-07-10 | 富士写真フイルム株式会社 | ベンゾトリアゾ−ル化合物 |
| FR2776290B1 (fr) * | 1998-03-20 | 2001-08-10 | Oreal | Nouveaux composes cationiques, leur utilisation comme coupleurs pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture |
| FR2776289B1 (fr) * | 1998-03-20 | 2001-02-02 | Oreal | Composition de teinture d'oxydation contenant un coupleur cationique, procedes de teinture, nouveaux coupleurs cationiques |
| FR2788520B1 (fr) * | 1999-01-19 | 2003-02-28 | Oreal | Nouveaux colorants mono-benzeniques cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture |
| EP1359888A1 (en) * | 2001-01-23 | 2003-11-12 | P&G-Clairol, Inc. | Couplers for oxidative coloration of hair |
| KR20050058415A (ko) * | 2002-09-02 | 2005-06-16 | 시바 스폐셜티 케미칼스 홀딩 인코포레이티드 | 다공성 물질의 착색방법 |
| EP1818063A1 (en) * | 2004-12-02 | 2007-08-15 | Japan Science and Technology Agency | Medicine for treatment of disease caused by hyperstimulatory cytotoxicity and therapeutic method |
| US7956193B2 (en) | 2007-05-04 | 2011-06-07 | University Of South Florida | Intramolecular C-H amination with sulfonyl azides |
| EP2200653A2 (en) | 2007-09-10 | 2010-06-30 | University of Massachusetts | Mitochondria-targeted anti-tumour agents |
| FR2984321A1 (fr) * | 2011-12-16 | 2013-06-21 | Oreal | Paraphenylenediamines cationiques, composition comprenant au moins de tels composes, procede de mise en oeuvre et utilisation |
| CN102617467A (zh) * | 2012-02-21 | 2012-08-01 | 大连理工大学 | 一种检测一氧化氮的超高灵敏荧光探针 |
| FR2996552B1 (fr) * | 2012-08-17 | 2016-10-14 | Oreal | Composition tinctoriale comprenant un derive o-alkyle substitue de meta-phenylenediamine cationique |
-
2013
- 2013-11-22 GB GBGB1320636.2A patent/GB201320636D0/en not_active Ceased
-
2014
- 2014-11-21 CA CA2931000A patent/CA2931000A1/en not_active Abandoned
- 2014-11-21 AU AU2014351802A patent/AU2014351802B2/en not_active Ceased
- 2014-11-21 ES ES14818889T patent/ES2802123T3/es active Active
- 2014-11-21 WO PCT/EP2014/075323 patent/WO2015075200A1/en not_active Ceased
- 2014-11-21 EP EP14818889.9A patent/EP3071582B1/en active Active
- 2014-11-21 HK HK16114224.1A patent/HK1226079A1/zh unknown
- 2014-11-21 SG SG10201807904RA patent/SG10201807904RA/en unknown
- 2014-11-21 JP JP2016528880A patent/JP6661533B2/ja not_active Expired - Fee Related
- 2014-11-21 EP EP19204357.8A patent/EP3623375A1/en not_active Withdrawn
- 2014-11-21 SG SG11201603485TA patent/SG11201603485TA/en unknown
- 2014-11-21 CN CN201480063625.0A patent/CN105873936B/zh not_active Expired - Fee Related
- 2014-11-21 US US15/037,941 patent/US9963474B2/en active Active
-
2016
- 2016-05-10 ZA ZA2016/03129A patent/ZA201603129B/en unknown
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