JP2017503024A5 - - Google Patents
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- Publication number
- JP2017503024A5 JP2017503024A5 JP2016562455A JP2016562455A JP2017503024A5 JP 2017503024 A5 JP2017503024 A5 JP 2017503024A5 JP 2016562455 A JP2016562455 A JP 2016562455A JP 2016562455 A JP2016562455 A JP 2016562455A JP 2017503024 A5 JP2017503024 A5 JP 2017503024A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- formula
- member selected
- cyano
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C[C@](CCC1CC1)CCC=C(C1)[C@]1C(C1)C1[C@@](C1)[C@@]1(C)C1=CC[C@@](*)C1 Chemical compound C[C@](CCC1CC1)CCC=C(C1)[C@]1C(C1)C1[C@@](C1)[C@@]1(C)C1=CC[C@@](*)C1 0.000 description 9
- KYUDTBPIZLFHNU-UHFFFAOYSA-N CC(C)c(cc1)cnc1F Chemical compound CC(C)c(cc1)cnc1F KYUDTBPIZLFHNU-UHFFFAOYSA-N 0.000 description 1
- NWEJXSNMXOLSTN-UHFFFAOYSA-N CC1=CCC(C(F)(F)F)C(F)=C1 Chemical compound CC1=CCC(C(F)(F)F)C(F)=C1 NWEJXSNMXOLSTN-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461924119P | 2014-01-06 | 2014-01-06 | |
| US61/924,119 | 2014-01-06 | ||
| PCT/US2014/072291 WO2015103060A1 (en) | 2014-01-06 | 2014-12-23 | Trpa1 modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017503024A JP2017503024A (ja) | 2017-01-26 |
| JP2017503024A5 true JP2017503024A5 (enExample) | 2018-02-08 |
| JP6626454B2 JP6626454B2 (ja) | 2019-12-25 |
Family
ID=53493929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562455A Active JP6626454B2 (ja) | 2014-01-06 | 2014-12-23 | Ｔｒｐａ１モジュレーター |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9951046B2 (enExample) |
| EP (1) | EP3092228A4 (enExample) |
| JP (1) | JP6626454B2 (enExample) |
| CN (1) | CN106061969B (enExample) |
| AU (1) | AU2014374043B2 (enExample) |
| CA (1) | CA2936111C (enExample) |
| IL (1) | IL246625B (enExample) |
| SG (1) | SG11201605559VA (enExample) |
| WO (1) | WO2015103060A1 (enExample) |
| ZA (1) | ZA201605332B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106061969B (zh) | 2014-01-06 | 2019-10-29 | 阿尔戈么迪克斯有限公司 | Trpa1调节剂 |
| FI3381896T3 (fi) * | 2015-11-27 | 2023-04-21 | Taiho Pharmaceutical Co Ltd | Bifenyyliyhdiste tai sen suola |
| CA3029901A1 (en) * | 2016-07-06 | 2018-01-11 | Algomedix, Inc. | Trpa1 antagonists for treatment of dry eye, ocular pain and inflammation |
| CN106580984A (zh) * | 2016-12-12 | 2017-04-26 | 高群 | 一种治疗高血脂症的药物组合物 |
| JP7178357B2 (ja) * | 2017-03-07 | 2022-11-25 | エフ．ホフマン－ラ ロシュ アーゲー | オキサジアゾール一過性受容器電位チャネル阻害剤 |
| RU2765152C2 (ru) | 2017-05-26 | 2022-01-26 | Тайхо Фармасьютикал Ко., Лтд. | Новое соединение бифенила или его соль |
| WO2018216795A1 (ja) * | 2017-05-26 | 2018-11-29 | 大鵬薬品工業株式会社 | 新規なビフェニル化合物を用いた抗腫瘍効果増強剤 |
| AU2018276611B2 (en) | 2017-05-31 | 2022-01-06 | Taiho Pharmaceutical Co., Ltd. | Method for predicting therapeutic effect of LSD1 inhibitor based on expression of INSM1 |
| CN109596818B (zh) * | 2018-12-13 | 2024-03-19 | 丁蓉 | 一种基于电生理学分析当归四逆汤预防奥沙利铂神经毒性机制的研究方法 |
| MX2022005811A (es) | 2019-11-13 | 2022-06-08 | Taiho Pharmaceutical Co Ltd | Sal novedosa de compuesto de terfenilo. |
| JP7688339B2 (ja) * | 2020-01-22 | 2025-06-04 | 国立研究開発法人理化学研究所 | 新規化合物、およびその利用 |
| FR3114235A1 (fr) | 2020-09-18 | 2022-03-25 | Université Grenoble Alpes | Inhibition du canal trpa1 astrocytaire comme nouvelle cible therapeutique neuroprotectrice dans les phases prodromales de la maladie d’alzheimer |
| CN112694436B (zh) * | 2020-12-30 | 2022-07-08 | 济南周行医药科技有限公司 | 一种槟榔碱的合成方法 |
| IT202100015098A1 (it) | 2021-06-09 | 2022-12-09 | Flonext S R L | Composto antagonista del canale trpa1 per uso in patologie degenerative della retina |
| WO2024099404A1 (zh) * | 2022-11-10 | 2024-05-16 | 北京普祺医药科技股份有限公司 | 一种含氮螺环类化合物、药物组合物以及其用途 |
| CN121735827A (zh) * | 2026-02-27 | 2026-03-27 | 泰励生物科技（上海）有限公司 | 哌啶酮类化合物的制备方法 |
| CN121717751A (zh) * | 2026-02-27 | 2026-03-24 | 泰励生物科技（上海）有限公司 | 手性哌啶酮类化合物的制备方法 |
| CN121735881A (zh) * | 2026-02-27 | 2026-03-27 | 泰励生物科技（上海）有限公司 | 砜类化合物的制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3575130D1 (de) * | 1984-05-12 | 1990-02-08 | Fisons Plc | Antiinflammatorische 1,n-diarylpyrazol-3-amine, deren zusammensetzungen und verfahren zu deren herstellung. |
| GB8429128D0 (en) * | 1984-11-17 | 1984-12-27 | Fisons Plc | Heterocyclic compounds |
| US6087381A (en) * | 1997-05-22 | 2000-07-11 | G. D. Searle & Company | Pyrazole derivatives as p38 kinase inhibitors |
| WO1999058523A1 (en) * | 1998-05-14 | 1999-11-18 | G.D. Searle & Co. | 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
| AU2004200420A1 (en) * | 2003-03-11 | 2004-09-30 | Astellas Pharma Inc. | Inhibitor of cyclooxygenase |
| AU2004233827B2 (en) * | 2003-04-24 | 2009-05-28 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
| RU2006117368A (ru) | 2003-10-23 | 2007-12-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные триазаспиропипередина, предназначенные для применения в качестве ингибиторов glyt-1 при лечении неврологических и психоневрологических нарушений |
| CN1902191A (zh) * | 2003-12-26 | 2007-01-24 | 第一制药株式会社 | 酰胺基吡唑衍生物 |
| TW200526641A (en) * | 2003-12-26 | 2005-08-16 | Daiichi Seiyaku Co | Amidopyrazole derivatives |
| GB0417910D0 (en) * | 2004-08-11 | 2004-09-15 | Novartis Ag | Organic compounds |
| KR101363278B1 (ko) | 2005-06-27 | 2014-02-21 | 엑셀리시스 페이턴트 컴퍼니 엘엘씨 | 이미다졸계 ｌｘｒ 변조제 |
| EP1962855B1 (en) | 2005-12-22 | 2013-08-21 | Hydra Biosciences, Inc. | Trpa1 inhibitors for treating pain |
| US7977358B2 (en) | 2007-07-26 | 2011-07-12 | Hoffmann-La Roche Inc. | Pyrazol derivatives |
| US8877784B2 (en) | 2008-01-04 | 2014-11-04 | Abbvie Inc. | TRPA1 antagonists |
| JP5559156B2 (ja) | 2008-06-02 | 2014-07-23 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ３，４−ジヒドロピリミジンｔｒｐａ１アンタゴニスト |
| WO2010125469A1 (en) * | 2009-04-29 | 2010-11-04 | Glenmark Pharmaceuticals, S.A. | Pyrimidinedione-fused heterocyclic compounds as trpa1 modulators |
| CA2773713A1 (en) | 2009-10-07 | 2011-04-14 | Merck Sharp & Dohme Corp. | Novel trpa1 antagonists |
| US9133128B2 (en) | 2011-06-17 | 2015-09-15 | Research Triangle Institute | Pyrazole derivatives as cannabinoid receptor 1 antagonists |
| DE102011055815A1 (de) | 2011-11-29 | 2013-05-29 | Aicuris Gmbh & Co. Kg | Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung |
| PE20150598A1 (es) | 2012-10-01 | 2015-05-20 | Orion Corp | Derivados de n-prop-2-inil carboxamida y su uso como antagonistas del receptor transitorio potencial de la subfamilia a, miembro 1 |
| CN106061969B (zh) | 2014-01-06 | 2019-10-29 | 阿尔戈么迪克斯有限公司 | Trpa1调节剂 |
| CA3029901A1 (en) | 2016-07-06 | 2018-01-11 | Algomedix, Inc. | Trpa1 antagonists for treatment of dry eye, ocular pain and inflammation |
-
2014
- 2014-12-23 CN CN201480076547.8A patent/CN106061969B/zh not_active Expired - Fee Related
- 2014-12-23 EP EP14876732.0A patent/EP3092228A4/en not_active Withdrawn
- 2014-12-23 WO PCT/US2014/072291 patent/WO2015103060A1/en not_active Ceased
- 2014-12-23 CA CA2936111A patent/CA2936111C/en active Active
- 2014-12-23 JP JP2016562455A patent/JP6626454B2/ja active Active
- 2014-12-23 AU AU2014374043A patent/AU2014374043B2/en not_active Ceased
- 2014-12-23 SG SG11201605559VA patent/SG11201605559VA/en unknown
-
2016
- 2016-07-06 IL IL246625A patent/IL246625B/en active IP Right Grant
- 2016-07-06 US US15/203,774 patent/US9951046B2/en not_active Expired - Fee Related
- 2016-08-02 ZA ZA2016/05332A patent/ZA201605332B/en unknown
-
2018
- 2018-03-01 US US15/909,652 patent/US10428049B2/en not_active Expired - Fee Related
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