JP2017500885A5 - - Google Patents
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- Publication number
- JP2017500885A5 JP2017500885A5 JP2016552457A JP2016552457A JP2017500885A5 JP 2017500885 A5 JP2017500885 A5 JP 2017500885A5 JP 2016552457 A JP2016552457 A JP 2016552457A JP 2016552457 A JP2016552457 A JP 2016552457A JP 2017500885 A5 JP2017500885 A5 JP 2017500885A5
- Authority
- JP
- Japan
- Prior art keywords
- pancreatin
- solvent
- mpa
- organic solvent
- hildebrand solubility
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010019160 Pancreatin Proteins 0.000 claims 27
- 229940055695 pancreatin Drugs 0.000 claims 27
- 238000000034 method Methods 0.000 claims 24
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 19
- 239000003960 organic solvent Substances 0.000 claims 19
- 239000002904 solvent Substances 0.000 claims 18
- 239000003125 aqueous solvent Substances 0.000 claims 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 12
- 239000000243 solution Substances 0.000 claims 11
- 230000000694 effects Effects 0.000 claims 9
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical class N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims 8
- 239000007853 buffer solution Substances 0.000 claims 7
- 238000001035 drying Methods 0.000 claims 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 4
- 239000004367 Lipase Substances 0.000 claims 4
- 102000004882 Lipase Human genes 0.000 claims 4
- 108090001060 Lipase Proteins 0.000 claims 4
- 239000000872 buffer Substances 0.000 claims 4
- 235000019421 lipase Nutrition 0.000 claims 4
- 239000008188 pellet Substances 0.000 claims 4
- 230000001376 precipitating effect Effects 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 239000004382 Amylase Substances 0.000 claims 3
- 102000013142 Amylases Human genes 0.000 claims 3
- 108010065511 Amylases Proteins 0.000 claims 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims 3
- 235000011130 ammonium sulphate Nutrition 0.000 claims 3
- 235000019418 amylase Nutrition 0.000 claims 3
- 235000019626 lipase activity Nutrition 0.000 claims 3
- 239000006228 supernatant Substances 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical group CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 239000012062 aqueous buffer Substances 0.000 claims 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims 2
- 238000002523 gelfiltration Methods 0.000 claims 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 claims 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 229920005654 Sephadex Polymers 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229960003624 creatine Drugs 0.000 claims 1
- 239000006046 creatine Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 230000005865 ionizing radiation Effects 0.000 claims 1
- 239000006193 liquid solution Substances 0.000 claims 1
- 239000006194 liquid suspension Substances 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 230000004962 physiological condition Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- -1 sachets Substances 0.000 claims 1
- 230000003381 solubilizing effect Effects 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- UBOXGVDOUJQMTN-UHFFFAOYSA-N trichloroethylene Natural products ClCC(Cl)Cl UBOXGVDOUJQMTN-UHFFFAOYSA-N 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361900092P | 2013-11-05 | 2013-11-05 | |
| US61/900,092 | 2013-11-05 | ||
| PCT/US2014/063984 WO2015069677A1 (en) | 2013-11-05 | 2014-11-05 | High potency pancreatin pharmaceutical compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017500885A JP2017500885A (ja) | 2017-01-12 |
| JP2017500885A5 true JP2017500885A5 (https=) | 2017-11-09 |
Family
ID=53042009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552457A Pending JP2017500885A (ja) | 2013-11-05 | 2014-11-05 | 高力価パンクレアチン医薬組成物 |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP3613429A1 (https=) |
| JP (1) | JP2017500885A (https=) |
| KR (1) | KR20170052520A (https=) |
| CN (1) | CN106659773A (https=) |
| AU (1) | AU2014346930A1 (https=) |
| BR (1) | BR112016000658A2 (https=) |
| CA (1) | CA2915671A1 (https=) |
| ES (1) | ES2834483T3 (https=) |
| HK (1) | HK1222325A1 (https=) |
| IL (3) | IL243435B (https=) |
| MX (1) | MX2016000480A (https=) |
| RU (1) | RU2015155470A (https=) |
| WO (1) | WO2015069677A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
| US8246950B2 (en) | 2007-02-20 | 2012-08-21 | Aptalis Pharma Limited | Stable digestive enzyme compositions |
| WO2009109856A2 (en) | 2008-03-07 | 2009-09-11 | Axcan Pharma Inc. | Method for detecting infectious parvovirus in pharmaceutical preparations |
| UA111726C2 (uk) | 2010-10-01 | 2016-06-10 | Апталіс Фарма Лімітед | Препарат панкреліпази низької сили з кишковорозчинним покриттям |
| CA2843556A1 (en) | 2011-08-08 | 2013-02-14 | Aptalis Pharma Ltd. | Method for dissolution testing of solid compositions containing digestive enzymes |
| WO2015019198A2 (en) | 2013-07-22 | 2015-02-12 | Aptalis Pharma S.R.L. | High potency pancreatin pharmaceutical compositions |
| MX2016001593A (es) | 2013-08-09 | 2016-09-29 | Allergan Pharmaceuticals Int Ltd | Composicion de enzima digestiva adecuada para administracion enterica. |
| JP2017519490A (ja) * | 2014-06-19 | 2017-07-20 | アプタリス ファルマ リミテッド | 膵臓抽出物からのウイルス汚染の除去方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2751330A (en) * | 1952-08-27 | 1956-06-19 | Armour & Co | Use of a salt in the extraction slurry in recovering proteolytic enzymes from pancreas gland material |
| GB928654A (en) | 1960-10-25 | 1963-06-12 | Philips Nv | Improvements in or relating to the production of pancreatin |
| US3168448A (en) | 1963-01-07 | 1965-02-02 | Wilson & Co Inc | Process of preparing a lipolytic enzyme composition |
| DE2460334C3 (de) * | 1974-12-20 | 1979-09-06 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Gewinnung von Insulin und Pankreatin aus Schweinepankreas |
| EP0115023B1 (de) * | 1982-12-30 | 1988-07-27 | Nordmark Arzneimittel GmbH | Verfahren zur Gewinnung von Pankreatin |
| FR2603804B1 (fr) * | 1986-09-17 | 1989-10-27 | Jouveinal Sa | Lipases et extraits lipasiques, leur procede de preparation et leur application en therapeutique |
| DE3927286C2 (de) * | 1989-08-18 | 1997-07-24 | Roehm Gmbh | Wäßrige Enzym-Flüssigformulierungen |
| US6051220A (en) | 1995-05-31 | 2000-04-18 | Medzyme N.V. And Simon Lodewijk Scharpe | Composition to improve digestibility and utilization of nutrients |
| US5750104A (en) * | 1996-05-29 | 1998-05-12 | Digestive Care Inc. | High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith |
| DE19724845A1 (de) * | 1996-08-28 | 1998-03-05 | Solvay Pharm Gmbh | Verwendung von komplexen Lipiden als stabilisierende Zusätze zu pharmazeutischen Zubereitungen von Verdauungsenzymgemischen |
| US20010046493A1 (en) | 2000-02-24 | 2001-11-29 | Alex Margolin | Lipase-containing composition and methods of use thereof |
| AR032392A1 (es) * | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
| CA2419572A1 (en) * | 2003-02-18 | 2004-08-18 | Axcan Pharma Inc. | High dosage protease formulation |
| US20060198838A1 (en) * | 2004-09-28 | 2006-09-07 | Fallon Joan M | Combination enzyme for cystic fibrosis |
| PT1809320E (pt) * | 2004-10-14 | 2010-10-25 | Altus Pharmaceuticals Inc | Composições contendo lipase, protease e amilase para o tratamento de insuficiência pancreática |
| HUE031042T2 (en) | 2005-07-29 | 2017-06-28 | Abbott Laboratories Gmbh | Methods for producing pancreatin powder with low viral content |
| US8246950B2 (en) * | 2007-02-20 | 2012-08-21 | Aptalis Pharma Limited | Stable digestive enzyme compositions |
| RU2012142134A (ru) * | 2010-03-19 | 2014-04-27 | Апталис Фарма Кэнэда Инк. | Желудочно-резистентные ферментные фармацевтические композиции |
| AU2011248293A1 (en) * | 2010-05-03 | 2012-11-15 | Eurand Pharmaceuticals Limited | Micropellet compositions comprising pancreatin containing digestive enzyme mixtures |
| UA111726C2 (uk) * | 2010-10-01 | 2016-06-10 | Апталіс Фарма Лімітед | Препарат панкреліпази низької сили з кишковорозчинним покриттям |
| CN103060297B (zh) * | 2012-12-28 | 2014-06-25 | 青岛九龙生物医药有限公司 | 一种分离纯化胰蛋白酶的方法 |
| CN103060296B (zh) * | 2012-12-30 | 2014-05-21 | 青岛九龙生物医药有限公司 | 从动物胰脏中提取胰蛋白酶的方法 |
| WO2015019198A2 (en) | 2013-07-22 | 2015-02-12 | Aptalis Pharma S.R.L. | High potency pancreatin pharmaceutical compositions |
-
2014
- 2014-11-05 MX MX2016000480A patent/MX2016000480A/es unknown
- 2014-11-05 ES ES14859866T patent/ES2834483T3/es active Active
- 2014-11-05 CA CA2915671A patent/CA2915671A1/en active Pending
- 2014-11-05 JP JP2016552457A patent/JP2017500885A/ja active Pending
- 2014-11-05 CN CN201480040273.7A patent/CN106659773A/zh active Pending
- 2014-11-05 AU AU2014346930A patent/AU2014346930A1/en not_active Abandoned
- 2014-11-05 EP EP19201877.8A patent/EP3613429A1/en not_active Withdrawn
- 2014-11-05 KR KR1020167001052A patent/KR20170052520A/ko not_active Withdrawn
- 2014-11-05 HK HK16110490.6A patent/HK1222325A1/zh unknown
- 2014-11-05 WO PCT/US2014/063984 patent/WO2015069677A1/en not_active Ceased
- 2014-11-05 RU RU2015155470A patent/RU2015155470A/ru not_active Application Discontinuation
- 2014-11-05 EP EP14859866.7A patent/EP3003360B1/en not_active Revoked
- 2014-11-05 BR BR112016000658A patent/BR112016000658A2/pt not_active Application Discontinuation
-
2015
- 2015-12-31 IL IL243435A patent/IL243435B/en active IP Right Grant
-
2020
- 2020-05-11 IL IL274583A patent/IL274583B/en unknown
-
2021
- 2021-06-27 IL IL284419A patent/IL284419A/en unknown
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