CN106659773A - 高效的胰酶药物组合物 - Google Patents

高效的胰酶药物组合物 Download PDF

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Publication number
CN106659773A
CN106659773A CN201480040273.7A CN201480040273A CN106659773A CN 106659773 A CN106659773 A CN 106659773A CN 201480040273 A CN201480040273 A CN 201480040273A CN 106659773 A CN106659773 A CN 106659773A
Authority
CN
China
Prior art keywords
solvent
pancreatin
trypsin
lipase
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480040273.7A
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English (en)
Chinese (zh)
Inventor
斯蒂芬·佩雷特
罗伯特·贝克尔
路易吉·波尔特里
路易吉·吉多斯
保拉·阿尔祖菲
温琴扎·皮隆蒂
迈克尔·托塔
威廉·沃德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Pharmaceuticals International Ltd
Original Assignee
Allergan Pharmaceuticals International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53042009&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN106659773(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Pharmaceuticals International Ltd filed Critical Allergan Pharmaceuticals International Ltd
Publication of CN106659773A publication Critical patent/CN106659773A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/94—Pancreatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201480040273.7A 2013-11-05 2014-11-05 高效的胰酶药物组合物 Pending CN106659773A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361900092P 2013-11-05 2013-11-05
US61/900,092 2013-11-05
PCT/US2014/063984 WO2015069677A1 (en) 2013-11-05 2014-11-05 High potency pancreatin pharmaceutical compositions

Publications (1)

Publication Number Publication Date
CN106659773A true CN106659773A (zh) 2017-05-10

Family

ID=53042009

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480040273.7A Pending CN106659773A (zh) 2013-11-05 2014-11-05 高效的胰酶药物组合物

Country Status (13)

Country Link
EP (2) EP3613429A1 (https=)
JP (1) JP2017500885A (https=)
KR (1) KR20170052520A (https=)
CN (1) CN106659773A (https=)
AU (1) AU2014346930A1 (https=)
BR (1) BR112016000658A2 (https=)
CA (1) CA2915671A1 (https=)
ES (1) ES2834483T3 (https=)
HK (1) HK1222325A1 (https=)
IL (3) IL243435B (https=)
MX (1) MX2016000480A (https=)
RU (1) RU2015155470A (https=)
WO (1) WO2015069677A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
US8246950B2 (en) 2007-02-20 2012-08-21 Aptalis Pharma Limited Stable digestive enzyme compositions
WO2009109856A2 (en) 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations
UA111726C2 (uk) 2010-10-01 2016-06-10 Апталіс Фарма Лімітед Препарат панкреліпази низької сили з кишковорозчинним покриттям
CA2843556A1 (en) 2011-08-08 2013-02-14 Aptalis Pharma Ltd. Method for dissolution testing of solid compositions containing digestive enzymes
WO2015019198A2 (en) 2013-07-22 2015-02-12 Aptalis Pharma S.R.L. High potency pancreatin pharmaceutical compositions
MX2016001593A (es) 2013-08-09 2016-09-29 Allergan Pharmaceuticals Int Ltd Composicion de enzima digestiva adecuada para administracion enterica.
JP2017519490A (ja) * 2014-06-19 2017-07-20 アプタリス ファルマ リミテッド 膵臓抽出物からのウイルス汚染の除去方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1487837A (zh) * 2001-01-19 2004-04-07 ������ҩ�����޹�˾ 新的微生物酶混合物
CN102883712A (zh) * 2010-03-19 2013-01-16 加拿大阿普塔利斯制药公司 耐胃液酶药物组合物
CN102946872A (zh) * 2010-05-03 2013-02-27 阿普塔利斯制药有限公司 包含含有胰酶的消化酶混合物的微丸组合物
CN103060297A (zh) * 2012-12-28 2013-04-24 青岛九龙生物医药有限公司 一种分离纯化胰蛋白酶的方法
CN103060296A (zh) * 2012-12-30 2013-04-24 青岛九龙生物医药有限公司 从动物胰脏中提取胰蛋白酶的方法
CN105392496A (zh) * 2013-07-22 2016-03-09 阿普塔利斯制药有限公司 高效的胰酶药物组合物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2751330A (en) * 1952-08-27 1956-06-19 Armour & Co Use of a salt in the extraction slurry in recovering proteolytic enzymes from pancreas gland material
GB928654A (en) 1960-10-25 1963-06-12 Philips Nv Improvements in or relating to the production of pancreatin
US3168448A (en) 1963-01-07 1965-02-02 Wilson & Co Inc Process of preparing a lipolytic enzyme composition
DE2460334C3 (de) * 1974-12-20 1979-09-06 Hoechst Ag, 6000 Frankfurt Verfahren zur Gewinnung von Insulin und Pankreatin aus Schweinepankreas
EP0115023B1 (de) * 1982-12-30 1988-07-27 Nordmark Arzneimittel GmbH Verfahren zur Gewinnung von Pankreatin
FR2603804B1 (fr) * 1986-09-17 1989-10-27 Jouveinal Sa Lipases et extraits lipasiques, leur procede de preparation et leur application en therapeutique
DE3927286C2 (de) * 1989-08-18 1997-07-24 Roehm Gmbh Wäßrige Enzym-Flüssigformulierungen
US6051220A (en) 1995-05-31 2000-04-18 Medzyme N.V. And Simon Lodewijk Scharpe Composition to improve digestibility and utilization of nutrients
US5750104A (en) * 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
DE19724845A1 (de) * 1996-08-28 1998-03-05 Solvay Pharm Gmbh Verwendung von komplexen Lipiden als stabilisierende Zusätze zu pharmazeutischen Zubereitungen von Verdauungsenzymgemischen
US20010046493A1 (en) 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
CA2419572A1 (en) * 2003-02-18 2004-08-18 Axcan Pharma Inc. High dosage protease formulation
US20060198838A1 (en) * 2004-09-28 2006-09-07 Fallon Joan M Combination enzyme for cystic fibrosis
PT1809320E (pt) * 2004-10-14 2010-10-25 Altus Pharmaceuticals Inc Composições contendo lipase, protease e amilase para o tratamento de insuficiência pancreática
HUE031042T2 (en) 2005-07-29 2017-06-28 Abbott Laboratories Gmbh Methods for producing pancreatin powder with low viral content
US8246950B2 (en) * 2007-02-20 2012-08-21 Aptalis Pharma Limited Stable digestive enzyme compositions
UA111726C2 (uk) * 2010-10-01 2016-06-10 Апталіс Фарма Лімітед Препарат панкреліпази низької сили з кишковорозчинним покриттям

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1487837A (zh) * 2001-01-19 2004-04-07 ������ҩ�����޹�˾ 新的微生物酶混合物
CN102883712A (zh) * 2010-03-19 2013-01-16 加拿大阿普塔利斯制药公司 耐胃液酶药物组合物
CN102946872A (zh) * 2010-05-03 2013-02-27 阿普塔利斯制药有限公司 包含含有胰酶的消化酶混合物的微丸组合物
CN103060297A (zh) * 2012-12-28 2013-04-24 青岛九龙生物医药有限公司 一种分离纯化胰蛋白酶的方法
CN103060296A (zh) * 2012-12-30 2013-04-24 青岛九龙生物医药有限公司 从动物胰脏中提取胰蛋白酶的方法
CN105392496A (zh) * 2013-07-22 2016-03-09 阿普塔利斯制药有限公司 高效的胰酶药物组合物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
J-H HWANG等: "Selective Precipitation of Proteins from Pancreatin Using Designed Antisolvents", 《INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH》 *
万峰等: "猪胰脂肪酶制备工艺研究", 《畜牧兽医科技信息》 *
李从军等: "《生物产品分离纯化技术》", 31 August 2009, 华中师范大学出版社 *
黄宇烽等: "《男科诊断学》", 31 October 1999, 第二军医大学出版社 *

Also Published As

Publication number Publication date
IL243435A0 (en) 2016-03-31
AU2014346930A1 (en) 2016-01-07
EP3613429A1 (en) 2020-02-26
MX2016000480A (es) 2016-10-21
HK1222325A1 (zh) 2017-06-30
EP3003360A4 (en) 2017-04-26
IL274583A (en) 2020-06-30
CA2915671A1 (en) 2015-05-14
IL243435B (en) 2020-06-30
WO2015069677A1 (en) 2015-05-14
JP2017500885A (ja) 2017-01-12
IL284419A (en) 2021-07-29
IL274583B (en) 2022-06-01
RU2015155470A3 (https=) 2018-09-10
RU2015155470A (ru) 2017-08-21
KR20170052520A (ko) 2017-05-12
BR112016000658A2 (pt) 2018-03-20
EP3003360A1 (en) 2016-04-13
EP3003360B1 (en) 2020-10-07
ES2834483T3 (es) 2021-06-17

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SE01 Entry into force of request for substantive examination
CB03 Change of inventor or designer information

Inventor after: Perrett Stephen

Inventor after: Robert Bacal

Inventor after: Luigi Boltry

Inventor after: GHIDORSI LUIGI

Inventor after: Paula Arzufi

Inventor after: Vincenza Pironti

Inventor before: Perrett Stephen

Inventor before: Robert Bacal

Inventor before: Luigi Boltry

Inventor before: GHIDORSI LUIGI

Inventor before: Paula Arzufi

Inventor before: Vincenza Pironti

Inventor before: Michael Throtha

Inventor before: William Ward

CB03 Change of inventor or designer information
CB02 Change of applicant information

Address after: Irish Dublin

Applicant after: APTALIS PHARMA LTD.

Address before: Vic County, Ireland

Applicant before: APTALIS PHARMA LTD.

CB02 Change of applicant information