JP2017500009A5 - - Google Patents
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- JP2017500009A5 JP2017500009A5 JP2016527261A JP2016527261A JP2017500009A5 JP 2017500009 A5 JP2017500009 A5 JP 2017500009A5 JP 2016527261 A JP2016527261 A JP 2016527261A JP 2016527261 A JP2016527261 A JP 2016527261A JP 2017500009 A5 JP2017500009 A5 JP 2017500009A5
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- 238000009472 formulation Methods 0.000 claims 26
- 239000000203 mixture Substances 0.000 claims 26
- 210000004027 cell Anatomy 0.000 claims 23
- 108020001756 ligand binding domains Proteins 0.000 claims 17
- 239000012636 effector Substances 0.000 claims 15
- 230000003834 intracellular effect Effects 0.000 claims 15
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 14
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 14
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 14
- 125000006850 spacer group Chemical group 0.000 claims 14
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 12
- 230000011664 signaling Effects 0.000 claims 11
- 210000000130 stem cell Anatomy 0.000 claims 11
- 230000004068 intracellular signaling Effects 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 6
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims 5
- 210000004698 lymphocyte Anatomy 0.000 claims 5
- 102100027207 CD27 antigen Human genes 0.000 claims 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 4
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 4
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 4
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 4
- 239000002771 cell marker Substances 0.000 claims 4
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 3
- 101150029707 ERBB2 gene Proteins 0.000 claims 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 3
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 3
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 3
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims 3
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 3
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims 3
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims 3
- 102000003735 Mesothelin Human genes 0.000 claims 3
- 108090000015 Mesothelin Proteins 0.000 claims 3
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims 3
- 102000040856 WT1 Human genes 0.000 claims 3
- 108700020467 WT1 Proteins 0.000 claims 3
- 101150084041 WT1 gene Proteins 0.000 claims 3
- 230000003394 haemopoietic effect Effects 0.000 claims 3
- 210000000987 immune system Anatomy 0.000 claims 3
- 210000003643 myeloid progenitor cell Anatomy 0.000 claims 3
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 101710145634 Antigen 1 Proteins 0.000 claims 2
- 102100027205 B-cell antigen receptor complex-associated protein alpha chain Human genes 0.000 claims 2
- 102100027203 B-cell antigen receptor complex-associated protein beta chain Human genes 0.000 claims 2
- -1 CD3ζ Proteins 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 101001039256 Caenorhabditis elegans Low-density lipoprotein receptor-related protein Proteins 0.000 claims 2
- 101100364669 Caenorhabditis elegans lin-18 gene Proteins 0.000 claims 2
- 102100024965 Caspase recruitment domain-containing protein 11 Human genes 0.000 claims 2
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000694288 Homo sapiens 40S ribosomal protein SA Proteins 0.000 claims 2
- 101000914489 Homo sapiens B-cell antigen receptor complex-associated protein alpha chain Proteins 0.000 claims 2
- 101000914491 Homo sapiens B-cell antigen receptor complex-associated protein beta chain Proteins 0.000 claims 2
- 101100166600 Homo sapiens CD28 gene Proteins 0.000 claims 2
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 claims 2
- 101000761179 Homo sapiens Caspase recruitment domain-containing protein 11 Proteins 0.000 claims 2
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 101001047640 Homo sapiens Linker for activation of T-cells family member 1 Proteins 0.000 claims 2
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 2
- 101001030069 Homo sapiens Major vault protein Proteins 0.000 claims 2
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 2
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 2
- 101001043564 Homo sapiens Prolow-density lipoprotein receptor-related protein 1 Proteins 0.000 claims 2
- 101000702132 Homo sapiens Protein spinster homolog 1 Proteins 0.000 claims 2
- 101000738769 Homo sapiens Receptor-type tyrosine-protein phosphatase alpha Proteins 0.000 claims 2
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 2
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 2
- 101001103033 Homo sapiens Tyrosine-protein kinase transmembrane receptor ROR2 Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 102000017578 LAG3 Human genes 0.000 claims 2
- 101150028321 Lck gene Proteins 0.000 claims 2
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 2
- 101100364671 Mus musculus Ryk gene Proteins 0.000 claims 2
- 101100268066 Mus musculus Zap70 gene Proteins 0.000 claims 2
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 2
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 2
- 108010029755 Notch1 Receptor Proteins 0.000 claims 2
- 108010071083 Patched-2 Receptor Proteins 0.000 claims 2
- 102000007497 Patched-2 Receptor Human genes 0.000 claims 2
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims 2
- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 claims 2
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 2
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 2
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 2
- 102100039616 Tyrosine-protein kinase transmembrane receptor ROR2 Human genes 0.000 claims 2
- 101001038499 Yarrowia lipolytica (strain CLIB 122 / E 150) Lysine acetyltransferase Proteins 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical group FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 206010065553 Bone marrow failure Diseases 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010033661 Pancytopenia Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 208000018805 childhood acute lymphoblastic leukemia Diseases 0.000 claims 1
- 201000011633 childhood acute lymphocytic leukemia Diseases 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 230000007813 immunodeficiency Effects 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 201000002364 leukopenia Diseases 0.000 claims 1
- 208000004235 neutropenia Diseases 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361898387P | 2013-10-31 | 2013-10-31 | |
| US61/898,387 | 2013-10-31 | ||
| PCT/US2014/063576 WO2015066551A2 (en) | 2013-10-31 | 2014-10-31 | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020062173A Division JP7046112B2 (ja) | 2013-10-31 | 2020-03-31 | 改変された造血幹／前駆細胞及び非エフェクターｔ細胞、そしてそれらの用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017500009A JP2017500009A (ja) | 2017-01-05 |
| JP2017500009A5 true JP2017500009A5 (Direct) | 2017-12-14 |
| JP6685900B2 JP6685900B2 (ja) | 2020-04-22 |
Family
ID=53005396
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016527261A Active JP6685900B2 (ja) | 2013-10-31 | 2014-10-31 | 改変された造血幹／前駆細胞及び非エフェクターｔ細胞、そしてそれらの用途 |
| JP2020062173A Active JP7046112B2 (ja) | 2013-10-31 | 2020-03-31 | 改変された造血幹／前駆細胞及び非エフェクターｔ細胞、そしてそれらの用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020062173A Active JP7046112B2 (ja) | 2013-10-31 | 2020-03-31 | 改変された造血幹／前駆細胞及び非エフェクターｔ細胞、そしてそれらの用途 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20160250258A1 (Direct) |
| EP (2) | EP4083062A1 (Direct) |
| JP (2) | JP6685900B2 (Direct) |
| KR (1) | KR20160079854A (Direct) |
| CN (1) | CN105873952A (Direct) |
| AU (2) | AU2014342020C1 (Direct) |
| BR (1) | BR112016009898A2 (Direct) |
| CA (1) | CA2929087A1 (Direct) |
| IL (2) | IL245360B (Direct) |
| MX (1) | MX389160B (Direct) |
| NZ (2) | NZ719840A (Direct) |
| RU (1) | RU2733652C2 (Direct) |
| SG (2) | SG11201603228TA (Direct) |
| WO (1) | WO2015066551A2 (Direct) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2776698T3 (es) | 2012-12-20 | 2020-07-31 | Purdue Research Foundation | Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer |
| US9511092B2 (en) | 2013-01-28 | 2016-12-06 | St. Jude Children's Research Hospital, Inc. | Chimeric receptor with NKG2D specificity for use in cell therapy against cancer and infectious disease |
| JP6942467B2 (ja) | 2013-12-20 | 2021-10-06 | フレッド ハッチンソン キャンサー リサーチ センター | タグ化キメラエフェクター分子およびそのレセプター |
| CN106661570B (zh) | 2014-04-10 | 2020-02-07 | 西雅图儿童医院（Dba西雅图儿童研究所） | 通过与氨甲蝶呤选择偶联的睡美人转座子制备工程化t细胞 |
| EP3134437A1 (en) * | 2014-04-23 | 2017-03-01 | Board of Regents, The University of Texas System | Chimeric antigen receptors (car) for use in therapy and methods for making the same |
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| TWI805109B (zh) | 2014-08-28 | 2023-06-11 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
| EP3757206B1 (en) | 2014-11-05 | 2024-04-10 | Juno Therapeutics, Inc. | Methods for transduction and cell processing |
| CA2973964A1 (en) | 2015-01-16 | 2016-07-21 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for ror1 |
| US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
| JP6784687B2 (ja) | 2015-02-24 | 2020-11-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 結合誘発型転写スイッチ及びその使用方法 |
| WO2016176651A2 (en) * | 2015-04-29 | 2016-11-03 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| US11827904B2 (en) | 2015-04-29 | 2023-11-28 | Fred Hutchinson Cancer Center | Modified stem cells and uses thereof |
| EP3303586A1 (en) * | 2015-05-29 | 2018-04-11 | Juno Therapeutics, Inc. | Composition and methods for regulating inhibitory interactions in genetically engineered cells |
| US11173179B2 (en) | 2015-06-25 | 2021-11-16 | Icell Gene Therapeutics Llc | Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof |
| TW202444897A (zh) | 2015-06-25 | 2024-11-16 | 美商生物細胞基因治療有限公司 | 嵌合抗原受體(car)、組合物及其使用方法 |
| GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
| EP3331920A4 (en) | 2015-08-07 | 2019-04-03 | Seattle Children's Hospital, dba Seattle Children's Research Institute | BIS SPECIFIC CAR T CELLS FOR TARGETING OF SOLID TUMORS |
| EP3359574B1 (en) * | 2015-10-06 | 2020-04-22 | City of Hope | Chimeric antigen receptors targeted to psca |
| WO2017062820A1 (en) | 2015-10-09 | 2017-04-13 | Miltenyi Biotec Technology, Inc. | Chimeric antigen receptors and methods of use |
| IL296410A (en) * | 2015-11-27 | 2022-11-01 | Cartherics Pty Ltd | Genetically modified stem cells and uses thereof |
| WO2017096327A2 (en) * | 2015-12-03 | 2017-06-08 | Juno Therapeutics, Inc. | Compositions and methods for reducing immune responses against cell therapies |
| US12144850B2 (en) | 2016-04-08 | 2024-11-19 | Purdue Research Foundation | Methods and compositions for car T cell therapy |
| US10188749B2 (en) | 2016-04-14 | 2019-01-29 | Fred Hutchinson Cancer Research Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
| US11400116B2 (en) | 2016-05-06 | 2022-08-02 | The Regents Of The University Of California | Systems and methods for targeting cancer cells |
| CA3029197A1 (en) * | 2016-06-24 | 2017-12-28 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars), compositions and methods thereof |
| CN106222145A (zh) * | 2016-08-22 | 2016-12-14 | 侯昌禾 | 一种用于治疗肿瘤的基因重组造血干细胞及其制备方法 |
| US11401332B2 (en) | 2016-08-23 | 2022-08-02 | The Regents Of The University Of California | Proteolytically cleavable chimeric polypeptides and methods of use thereof |
| EP3519433A1 (en) | 2016-10-03 | 2019-08-07 | Juno Therapeutics, Inc. | Hpv-specific binding molecules |
| US11540507B2 (en) | 2016-11-04 | 2023-01-03 | The University Of Tokyo | Solution for cryopreservation of animal cells or animal tissues, cryopreserved product, and cryopreservation method |
| CN106755107B (zh) * | 2016-11-22 | 2019-10-01 | 上海健信生物医药科技有限公司 | 一种car新分子及其在肿瘤治疗中的应用 |
| US11286306B2 (en) | 2016-12-09 | 2022-03-29 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | TLR9-binding chimeric antigen receptors |
| CN106755397A (zh) * | 2016-12-20 | 2017-05-31 | 江苏省肿瘤医院 | 基因多态性位点的用途和试剂盒 |
| US20180100016A1 (en) * | 2016-12-22 | 2018-04-12 | Xiaotong Song | Use of car-modified human natural killer cells to treat cancer |
| CA3049244A1 (en) | 2017-01-05 | 2018-07-12 | Fred Hutchinson Cancer Research Center | Systems and methods to improve vaccine efficacy |
| ES3010559T3 (en) | 2017-02-28 | 2025-04-03 | Endocyte Inc | Compositions and methods for car t cell therapy |
| BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| RU2019128544A (ru) | 2017-03-27 | 2021-04-28 | Нэшнл Юниверсити Оф Сингапур | Линии стимулирующих клеток для ex vivo размножения и активации клеток-натуральных киллеров |
| US12129487B2 (en) * | 2017-03-27 | 2024-10-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to obtain lymphoid progenitors |
| WO2018197675A1 (en) * | 2017-04-28 | 2018-11-01 | Julius-Maximilians-Universität Würzburg | Ror1-specific chimeric antigen receptors (car) with humanized targeting domains |
| CN111247242B (zh) | 2017-06-21 | 2024-07-19 | 美商生物细胞基因治疗有限公司 | 嵌合抗原受体(CARs)、组合物及其使用方法 |
| CN107541499B (zh) * | 2017-07-27 | 2020-04-14 | 山东兴瑞生物科技有限公司 | 一种靶向免疫检测点tnfr2的cik的制备及其应用 |
| EP3692063A1 (en) | 2017-10-03 | 2020-08-12 | Juno Therapeutics, Inc. | Hpv-specific binding molecules |
| US10561686B2 (en) | 2018-01-12 | 2020-02-18 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| CA3089051A1 (en) | 2018-01-22 | 2019-07-25 | Endocyte, Inc. | Methods of use for car t cells |
| DK3749334T3 (da) * | 2018-02-08 | 2025-02-17 | Univ Leland Stanford Junior | Allogen hæmatopoietisk stamcelletransplantation |
| AU2019219454A1 (en) | 2018-02-09 | 2020-08-27 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| US12240870B2 (en) | 2018-02-23 | 2025-03-04 | Purdue Research Foundation | Sequencing method for CAR T cell therapy |
| US12441787B2 (en) | 2018-04-02 | 2025-10-14 | National University Of Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| KR102764123B1 (ko) | 2018-04-05 | 2025-02-05 | 주노 쎄러퓨티크스 인코퍼레이티드 | Τ 세포 수용체 및 이를 발현하는 조작된 세포 |
| US10869888B2 (en) | 2018-04-17 | 2020-12-22 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| JP2021525066A (ja) * | 2018-05-30 | 2021-09-24 | グリコステム セラピューティクス ベスローテン フェンノートシャップ | Ｃａｒ ｎｋ細胞 |
| WO2020044239A1 (en) | 2018-08-29 | 2020-03-05 | National University Of Singapore | A method to specifically stimulate survival and expansion of genetically-modified immune cells |
| US12240915B2 (en) | 2018-08-30 | 2025-03-04 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
| EP3844191A4 (en) * | 2018-08-31 | 2022-06-15 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | Methods and compositions comprising b7h3 chimeric antigen receptors |
| ES2965229T3 (es) | 2018-09-06 | 2024-04-11 | Chr Hansen Hmo Gmbh | Producción fermentativa de oligosacáridos mediante fermentación total usando una materia prima mixta |
| WO2020097193A1 (en) | 2018-11-06 | 2020-05-14 | The Regents Of The University Of California | Chimeric antigen receptors for phagocytosis |
| US10918667B2 (en) | 2018-11-20 | 2021-02-16 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expressing therapeutic agent and uses thereof |
| WO2020180882A1 (en) | 2019-03-05 | 2020-09-10 | Nkarta, Inc. | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| JP7352307B2 (ja) * | 2019-03-15 | 2023-09-28 | 阿思科力（蘇州）生物科技有限公司 | 自殺遺伝子を持つｒｏｂｏ１ ｃａｒ－ｎｋ細胞、その製造方法及び使用 |
| WO2020191358A1 (en) * | 2019-03-20 | 2020-09-24 | Bluebird Bio, Inc. | Adoptive cell therapy |
| US11013764B2 (en) | 2019-04-30 | 2021-05-25 | Myeloid Therapeutics, Inc. | Engineered phagocytic receptor compositions and methods of use thereof |
| CA3139319A1 (en) * | 2019-05-07 | 2020-11-12 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of polypeptides and chimeric antigen receptors via hinge domains |
| CA3138292A1 (en) * | 2019-05-17 | 2020-11-26 | Deverra Therapeutics Inc. | Compositions and methods for improving treatment outcomes for patients having hematological malignancies using an expanded stem cell product |
| CA3143108A1 (en) * | 2019-06-19 | 2020-12-24 | Julius-Maximilians-Universitat Wurzburg | Ultramodular igg3-based spacer domain and multi-function site for implementation in chimeric antigen receptor design |
| WO2021046243A2 (en) | 2019-09-03 | 2021-03-11 | Myeloid Therapeutics, Inc. | Methods and compositions for genomic integration |
| US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
| US12076343B2 (en) | 2020-02-19 | 2024-09-03 | Innovative Cellular Therapeutics Holdings, Ltd. | Engineered safety in cell therapy |
| US12043654B2 (en) | 2020-06-02 | 2024-07-23 | Innovative Cellular Therapeutics Holdings, Ltd. | Anti-GCC antibody and CAR thereof for treating digestive system cancer |
| CN112094817B (zh) * | 2020-09-23 | 2021-06-04 | 绿城农科检测技术有限公司 | 分泌丙硫氧嘧啶单克隆抗体的杂交瘤细胞株、单克隆抗体及应用 |
| JP2023549140A (ja) | 2020-11-04 | 2023-11-22 | マイエロイド・セラピューティクス，インコーポレーテッド | 操作されたキメラ融合タンパク質組成物およびその使用方法 |
| WO2022133169A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| IL305950A (en) | 2021-03-17 | 2023-11-01 | Myeloid Therapeutics Inc | Engineered chimeric fusion protein compositions and methods of using them |
| KR20240037192A (ko) | 2021-05-11 | 2024-03-21 | 마이얼로이드 테라퓨틱스, 인크. | 게놈 통합을 위한 방법 및 조성물 |
| KR20240109617A (ko) * | 2021-10-28 | 2024-07-11 | 라이엘 이뮤노파마, 인크. | Ror1-결합 단백질을 발현하는 세포를 배양하는 방법 |
| JP2025508371A (ja) * | 2022-02-11 | 2025-03-26 | フレッド ハッチンソン キャンサー センター | Ｓｔｅａｐ１に結合するキメラ抗原受容体 |
| CN115433774A (zh) * | 2022-08-18 | 2022-12-06 | 浙江丰能医药科技有限公司 | 一种用于原发免疫性血小板减少症检测的生物标志物及其试剂盒 |
| WO2025059062A1 (en) * | 2023-09-11 | 2025-03-20 | The Trustees Of The University Of Pennsylvania | Genetic engineering of human hematopoietic stem/progenitor cells (hspcs) for locus-specific expression of therapeutic proteins |
| WO2025064828A1 (en) * | 2023-09-20 | 2025-03-27 | Kure.Ai, Inc. | Methods and reagents to improve cell therapy with the creation of novel car-targeting mr1 protein |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4199022A (en) | 1978-12-08 | 1980-04-22 | The United States Of America As Represented By The Department Of Energy | Method of freezing living cells and tissues with improved subsequent survival |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| US6291161B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertiore |
| WO1992008796A1 (en) | 1990-11-13 | 1992-05-29 | Immunex Corporation | Bifunctional selectable fusion genes |
| IL101728A (en) | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| US5856441A (en) | 1991-05-03 | 1999-01-05 | Yale University | Serrate fragments and derivatives |
| WO1993012141A1 (en) | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US5869282A (en) | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| EP0804590A1 (en) | 1993-05-21 | 1997-11-05 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| EP0737207B1 (en) | 1994-01-11 | 2004-09-22 | Dyax Corporation | Inhibitors of human plasmin derived from the kunitz domains |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US5877299A (en) | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| AU723939B2 (en) | 1995-06-28 | 2000-09-07 | Imperial Cancer Research Technology Ltd | Nucleotide and protein sequences of vertebrate delta genes and methods based thereon |
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
| WO2000009560A2 (en) * | 1998-08-17 | 2000-02-24 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
| US7399633B2 (en) | 2000-10-27 | 2008-07-15 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
| US20130266551A1 (en) * | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| ATE475669T1 (de) | 2004-06-29 | 2010-08-15 | Immunocore Ltd | Einen modifizierten t-zellen-rezeptor exprimierende zellen |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| US8252587B2 (en) | 2004-10-25 | 2012-08-28 | Celerant Therapeutics, Inc. | Methods of expanding myeloid cell populations and uses thereof |
| ES2320374T3 (es) | 2005-01-05 | 2009-05-21 | F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H. | Dominios de inmunoglobulina sintetica con propiedades de enlace modificadas en regiones de la molecula diferentes de las regiones de determinacion de complementariedad. |
| GB0504767D0 (en) | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
| US8383095B2 (en) | 2006-02-14 | 2013-02-26 | Cellerant Therapeutics, Inc. | Methods and compositions for enhancing engraftment of hematopoietic stem cells |
| EP1829895A1 (en) | 2006-03-03 | 2007-09-05 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies |
| KR20090021217A (ko) | 2006-06-14 | 2009-02-27 | 추가이 세이야쿠 가부시키가이샤 | 조혈 줄기세포 증가 촉진제 |
| US8003761B2 (en) * | 2007-01-23 | 2011-08-23 | Hoffmann-La Roche Inc. | Cancerous disease modifying antibodies |
| CA2700391A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Designed armadillo repeat proteins |
| WO2009091826A2 (en) * | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
| WO2009097140A1 (en) * | 2008-01-30 | 2009-08-06 | Memorial Sloan-Kettering Cancer Center | Methods for off -the -shelf tumor immunotherapy using allogeneic t-cell precursors |
| PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
| EA201190132A1 (ru) * | 2009-02-23 | 2013-01-30 | Гленмарк Фармасьютикалс С.А. | Гуманизированные антитела, связывающиеся с cd19, и их применение |
| WO2011079902A2 (en) * | 2009-12-18 | 2011-07-07 | Biolnvent International Ab | Biological materials and uses thereof |
| CA2795627C (en) | 2010-04-09 | 2023-03-14 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function without hla matching |
| US20130095080A1 (en) | 2010-04-09 | 2013-04-18 | Fred Hutchinson Cancer Reserach Center | Compositions and methods for providing hematopoietic function |
| US9758586B2 (en) * | 2010-12-01 | 2017-09-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric rabbit/human ROR1 antibodies |
| AU2012347534B2 (en) | 2011-12-08 | 2018-01-25 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| EP2814846B1 (en) * | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
-
2014
- 2014-10-31 US US15/033,518 patent/US20160250258A1/en not_active Abandoned
- 2014-10-31 EP EP22166188.7A patent/EP4083062A1/en not_active Withdrawn
- 2014-10-31 SG SG11201603228TA patent/SG11201603228TA/en unknown
- 2014-10-31 MX MX2016005689A patent/MX389160B/es unknown
- 2014-10-31 EP EP14859129.0A patent/EP3063175A4/en not_active Withdrawn
- 2014-10-31 CN CN201480071639.7A patent/CN105873952A/zh active Pending
- 2014-10-31 BR BR112016009898A patent/BR112016009898A2/pt not_active Application Discontinuation
- 2014-10-31 RU RU2016121174A patent/RU2733652C2/ru active
- 2014-10-31 SG SG10201803533YA patent/SG10201803533YA/en unknown
- 2014-10-31 WO PCT/US2014/063576 patent/WO2015066551A2/en not_active Ceased
- 2014-10-31 KR KR1020167014445A patent/KR20160079854A/ko not_active Ceased
- 2014-10-31 CA CA2929087A patent/CA2929087A1/en active Pending
- 2014-10-31 NZ NZ719840A patent/NZ719840A/en not_active IP Right Cessation
- 2014-10-31 JP JP2016527261A patent/JP6685900B2/ja active Active
- 2014-10-31 NZ NZ758715A patent/NZ758715A/en not_active IP Right Cessation
- 2014-10-31 AU AU2014342020A patent/AU2014342020C1/en active Active
-
2016
- 2016-05-01 IL IL245360A patent/IL245360B/en active IP Right Grant
-
2019
- 2019-06-18 US US16/445,053 patent/US20190381104A1/en not_active Abandoned
- 2019-06-24 AU AU2019204429A patent/AU2019204429B2/en active Active
-
2020
- 2020-01-28 IL IL272325A patent/IL272325B/en unknown
- 2020-03-31 JP JP2020062173A patent/JP7046112B2/ja active Active
-
2022
- 2022-11-28 US US18/059,369 patent/US20240041933A1/en active Pending
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