JP2017215338A5 - - Google Patents
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- Publication number
- JP2017215338A5 JP2017215338A5 JP2017149809A JP2017149809A JP2017215338A5 JP 2017215338 A5 JP2017215338 A5 JP 2017215338A5 JP 2017149809 A JP2017149809 A JP 2017149809A JP 2017149809 A JP2017149809 A JP 2017149809A JP 2017215338 A5 JP2017215338 A5 JP 2017215338A5
- Authority
- JP
- Japan
- Prior art keywords
- histone
- body fluid
- isoform
- fluid sample
- nucleosome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108010033040 Histones Proteins 0.000 claims 50
- 108010047956 Nucleosomes Proteins 0.000 claims 26
- 210000001623 nucleosome Anatomy 0.000 claims 26
- 102000001708 Protein Isoforms Human genes 0.000 claims 25
- 108010029485 Protein Isoforms Proteins 0.000 claims 25
- 210000001124 body fluid Anatomy 0.000 claims 20
- 238000000034 method Methods 0.000 claims 18
- 239000010839 body fluid Substances 0.000 claims 16
- 239000011230 binding agent Substances 0.000 claims 10
- 239000000090 biomarker Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 210000000214 mouth Anatomy 0.000 claims 2
- 201000005443 oral cavity cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 210000002429 large intestine Anatomy 0.000 claims 1
- 201000011061 large intestine cancer Diseases 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161530304P | 2011-09-01 | 2011-09-01 | |
| GB1115098.4 | 2011-09-01 | ||
| GBGB1115098.4A GB201115098D0 (en) | 2011-09-01 | 2011-09-01 | Method for detecting nucleosomes containing histone variants |
| US61/530,304 | 2011-09-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014527738A Division JP2014529405A (ja) | 2011-09-01 | 2012-08-31 | ヒストン変種含有ヌクレオソーム検出法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017215338A JP2017215338A (ja) | 2017-12-07 |
| JP2017215338A5 true JP2017215338A5 (enExample) | 2018-02-22 |
| JP6494703B2 JP6494703B2 (ja) | 2019-04-03 |
Family
ID=44882049
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014527738A Withdrawn JP2014529405A (ja) | 2011-09-01 | 2012-08-31 | ヒストン変種含有ヌクレオソーム検出法 |
| JP2017149809A Active JP6494703B2 (ja) | 2011-09-01 | 2017-08-02 | ヒストン変種含有ヌクレオソーム検出法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014527738A Withdrawn JP2014529405A (ja) | 2011-09-01 | 2012-08-31 | ヒストン変種含有ヌクレオソーム検出法 |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US9400276B2 (enExample) |
| EP (2) | EP2751569B1 (enExample) |
| JP (2) | JP2014529405A (enExample) |
| KR (1) | KR102130855B1 (enExample) |
| CN (2) | CN104053993A (enExample) |
| AU (1) | AU2012300643B2 (enExample) |
| BR (1) | BR112014004584B1 (enExample) |
| CA (1) | CA2845994C (enExample) |
| DK (1) | DK2751569T3 (enExample) |
| ES (2) | ES2662380T3 (enExample) |
| GB (1) | GB201115098D0 (enExample) |
| HR (1) | HRP20180362T1 (enExample) |
| HU (1) | HUE038517T2 (enExample) |
| MX (1) | MX349561B (enExample) |
| PL (1) | PL2751569T3 (enExample) |
| PT (1) | PT2751569T (enExample) |
| RU (2) | RU2014112348A (enExample) |
| SG (2) | SG11201400202SA (enExample) |
| WO (1) | WO2013030579A1 (enExample) |
| ZA (1) | ZA201401296B (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201115098D0 (en) | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes containing histone variants |
| GB201115095D0 (en) * | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| US9605313B2 (en) | 2012-03-02 | 2017-03-28 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| JP6293742B2 (ja) * | 2012-06-06 | 2018-03-14 | ザ、トラスティーズ オブ プリンストン ユニバーシティ | デザイナーモノヌクレオソーム（ｄｅｓｉｇｎｅｒｍｏｎｏｎｕｃｌｅｏｓｏｍｅ）のＤＮＡバーコード化ならびにクロマチンリーダー、ライター、イレーサーおよびそのモジュレーターをプロファイリングするためのクロマチンアレイライブラリー |
| WO2014168711A1 (en) | 2013-03-13 | 2014-10-16 | Sequenom, Inc. | Primers for dna methylation analysis |
| US11365447B2 (en) | 2014-03-13 | 2022-06-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| CA2965752C (en) * | 2014-10-29 | 2024-04-02 | Belgian Volition Sprl | Method for the enrichment of circulating tumor dna |
| JP6813503B2 (ja) * | 2015-02-10 | 2021-01-13 | ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | バイオマーカーとしての遊離ヒストンタンパク質 |
| GB201511512D0 (en) * | 2015-07-01 | 2015-08-12 | Singapore Volition Pte Ltd | Use of cell-free nucleosomes as biomarkers |
| GB201511542D0 (en) * | 2015-07-01 | 2015-08-12 | Singapore Volition Pte Ltd | Use of cell free nucleosomes as biomarkers |
| GB201518665D0 (en) * | 2015-10-21 | 2015-12-02 | Singapore Volition Pte Ltd | Method for enrichment of cell free nucleosomes |
| GB201518674D0 (en) | 2015-10-21 | 2015-12-02 | Singapore Volition Pte Ltd | Method for detecting nuleosomes containing histone modifications and variants |
| GB201604806D0 (en) * | 2016-03-22 | 2016-05-04 | Singapore Volition Pte Ltd | Method of identifying a cancer of unknown origin |
| GB201612815D0 (en) * | 2016-07-25 | 2016-09-07 | Belgian Volition Sa | Novel combination test |
| TWI726009B (zh) * | 2016-11-28 | 2021-05-01 | 比利時商比利時意志有限公司 | 用親和純化法分析生物樣品中源自腫瘤之無細胞核小體、分離生物樣品中純化之腫瘤dna、檢測生物樣品中源自腫瘤之核小體表觀遺傳表位或在動物或人類受試者中檢測癌症之方法或包括組蛋白h1結合劑之套組之用途 |
| BR112018015871B1 (pt) | 2016-12-09 | 2021-12-07 | The Broad Institute, Inc. | Sistema, método e dispositivo para detectar a presença de uma sequência alvo de ácido nucleico em uma amostra |
| JP2020513815A (ja) | 2017-03-15 | 2020-05-21 | ザ・ブロード・インスティテュート・インコーポレイテッド | クラスター化短鎖反復回文配列エフェクター系に基づくウイルス検出用診断法 |
| GB201721569D0 (en) | 2017-12-21 | 2018-02-07 | Belgian Volition Sprl | Method for the detection and treatment of colorectal adenomas |
| US20210371926A1 (en) | 2018-01-29 | 2021-12-02 | The Broad Institute, Inc. | Crispr effector system based diagnostics |
| EP4215621B1 (en) | 2018-03-01 | 2025-05-28 | Epicypher, Inc. | Quantification of nucleosome modifications using chemically-defined recombinant nucleosomes |
| AU2019249422B2 (en) | 2018-04-02 | 2025-09-25 | Grail, Inc. | Methylation markers and targeted methylation probe panels |
| IL281741B2 (en) | 2018-09-27 | 2026-04-01 | Grail Inc | Methylation markers and a targeted methylation detection panel |
| GB201818963D0 (en) | 2018-11-21 | 2019-01-09 | Belgian Volition Sprl | Methof for the detection of prostate cancer |
| GB201818965D0 (en) | 2018-11-21 | 2019-01-09 | Belgian Volition Sprl | Method for the detection of colorectal cancer |
| GB201906199D0 (en) | 2019-05-02 | 2019-06-19 | Belgian Volition Sprl | Method for the detection of cancer |
| GB201906201D0 (en) | 2019-05-02 | 2019-06-19 | Belgian Voltion Sprl | Method for the detection of protate cancer |
| GB201912251D0 (en) | 2019-08-27 | 2019-10-09 | Belgian Volition Sprl | Method of isolating circulating nucleosomes |
| KR20220111246A (ko) | 2019-08-27 | 2022-08-09 | 벨지언 볼리션 에스알엘 | 순환 뉴클레오솜을 단리하는 방법 |
| CN114829939B (zh) | 2019-12-02 | 2025-10-21 | 比利时意志有限责任公司 | 无细胞核小体作为生物标志物的用途 |
| AU2021238782A1 (en) | 2020-03-20 | 2022-09-22 | Belgian Volition Srl | Triaging method using cell free nucleosome levels |
| JP7839784B2 (ja) | 2020-09-21 | 2026-04-02 | ベルジアン ボリション エスアールエル | 血液中の遊離ヌクレオソームのインラインモニタリングのための装置 |
| TW202238131A (zh) | 2020-11-25 | 2022-10-01 | 比利時商比利時意志有限公司 | 測量無細胞核蛋白染色質片段之方法 |
| TW202238132A (zh) | 2020-12-08 | 2022-10-01 | 比利時商比利時意志有限公司 | 多發性硬化症之診斷方法 |
| TW202242145A (zh) | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析 |
| TW202242130A (zh) | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 循環轉錄因子分析 |
| TW202242146A (zh) | 2021-01-13 | 2022-11-01 | 比利時商比利時意志有限公司 | 肺癌的檢測方法 |
| GB202108185D0 (en) | 2021-06-08 | 2021-07-21 | Belgian Volition Sprl | Standardisation of nucleosome assays using biologically derived calibrants |
| GB202108452D0 (en) | 2021-06-14 | 2021-07-28 | Belgian Volition Sprl | Triaging method using cell free nucleosome levels |
| EP4423501A1 (en) | 2021-10-29 | 2024-09-04 | Belgian Volition SRL | Homogeneous immunoassay method |
| GB202117799D0 (en) | 2021-12-09 | 2022-01-26 | Belgian Volition Srl | Method for the detection of blood cancer |
| WO2023170298A1 (en) | 2022-03-11 | 2023-09-14 | Belgian Volition Srl | Differential diagnosis method |
| GB202205212D0 (en) | 2022-04-08 | 2022-05-25 | Belgian Volition Sprl | Method for transplant organ health assessment |
| EP4577835A1 (en) | 2022-08-25 | 2025-07-02 | Belgian Volition SRL | Method for the detection of dementia |
| EP4577833A1 (en) | 2022-08-25 | 2025-07-02 | Belgian Volition SRL | Method for measuring cell free chromatin |
| EP4639173A1 (en) | 2022-12-19 | 2025-10-29 | Belgian Volition SRL | Calibration |
| WO2024133222A1 (en) | 2022-12-19 | 2024-06-27 | Belgian Volition Srl | Assessment of biological samples for nucleic acid analysis |
| GB202300607D0 (en) | 2023-01-16 | 2023-03-01 | Belgian Volition Srl | Proteins and methods for isolating circulating nucleosomes |
| GB202303562D0 (en) | 2023-03-10 | 2023-04-26 | Belgian Volition Sprl | Sample collection for liquid biopsy |
| CN121713065A (zh) | 2023-04-14 | 2026-03-20 | 比利时意志有限责任公司 | 使用无细胞核小体水平的诊断方法 |
| WO2024223947A1 (en) | 2023-04-28 | 2024-10-31 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers of carcinomas |
| GB202307768D0 (en) | 2023-05-24 | 2023-07-05 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers |
| GB202310137D0 (en) | 2023-07-03 | 2023-08-16 | Belgian Volition Srl | Method for the detection of cancer |
| EP4743782A1 (en) | 2023-07-13 | 2026-05-20 | Belgian Volition Srl | METHOD FOR DETECTING THE POTENTIAL OF A BODY FLUID SAMPLE FOR PRODUCING EXTRACELLULAR TRAPS |
| WO2025061853A1 (en) | 2023-09-19 | 2025-03-27 | Belgian Volition Srl | Lateral flow test device |
| WO2025093747A1 (en) | 2023-11-02 | 2025-05-08 | Belgian Volition Srl | Novel rapid high-throughput method of netosis induction and inhibition with physiologically relevant molecules |
| WO2025181348A1 (en) | 2024-03-01 | 2025-09-04 | Belgian Volition Srl | Method for determining the origin of circulating dna |
| WO2025253002A1 (en) | 2024-06-07 | 2025-12-11 | Belgian Volition Srl | Sample collection for liquid biopsy |
| WO2026052765A1 (en) | 2024-09-05 | 2026-03-12 | Belgian Volition Srl | Method using nucleosome levels |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4276843B2 (ja) * | 2001-03-23 | 2009-06-10 | 芳之 金井 | モノヌクレオソーム及びその製造方法、ヌクレオソームに特異的な抗体の測定方法、自己免疫病診断方法、ヌクレオソームｄｎａ製造方法、ｄｎａプレート、ｄｎａプレート製造方法、並びに抗ｄｎａ抗体測定法 |
| WO2003004050A1 (en) | 2001-07-03 | 2003-01-16 | University Of Virginia Patent Foundation | Methylation of histone h4 at arginine 3 |
| DE10207735A1 (de) * | 2002-02-15 | 2003-08-28 | Euroimmun Gmbh | Verfahren zur Herstellung einer Nukleosomen-Präparation und deren Verwendung zur in vitro-Diagnose von Lupus erythematodes disseminatus (LED) |
| WO2003070894A2 (en) | 2002-02-20 | 2003-08-28 | University Of Virginia Patent Foundation | A non-invasive diagnostic test utilizing histone modification markers |
| GB0319376D0 (en) | 2003-08-18 | 2003-09-17 | Chroma Therapeutics Ltd | Histone modification detection |
| WO2005040814A1 (en) * | 2003-10-14 | 2005-05-06 | Cancer Research Technology Limited | Methods and means of cancer detection by histone modification |
| EP1907856A2 (en) * | 2005-07-27 | 2008-04-09 | Oncomethylome Sciences SA | Angiogenesis inhibition based upon icam 1 or junb expression levels |
| EP1937706A4 (en) * | 2005-09-09 | 2008-10-22 | Univ Iowa Res Found | ORGANIC MARKERS RELATED TO AGE DEPENDENT MAKULAR GENERATION |
| US20110312897A1 (en) * | 2008-09-17 | 2011-12-22 | The Rockefeller University | Cathepsin l proteolytically processes histone h3 during mouse embryonic stem cell differentiation |
| EP2270510A1 (en) | 2009-07-02 | 2011-01-05 | EMBL (European Molecular Biology Laboratory) | Diagnostic method for predicting the risk of cancer recurrence based on Histone macroH2A isoforms |
| GB201115098D0 (en) | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes containing histone variants |
-
2011
- 2011-09-01 GB GBGB1115098.4A patent/GB201115098D0/en not_active Ceased
-
2012
- 2012-08-31 SG SG11201400202SA patent/SG11201400202SA/en unknown
- 2012-08-31 EP EP12762367.6A patent/EP2751569B1/en active Active
- 2012-08-31 EP EP17201723.8A patent/EP3301449B1/en active Active
- 2012-08-31 HU HUE12762367A patent/HUE038517T2/hu unknown
- 2012-08-31 KR KR1020147008116A patent/KR102130855B1/ko active Active
- 2012-08-31 JP JP2014527738A patent/JP2014529405A/ja not_active Withdrawn
- 2012-08-31 BR BR112014004584-4A patent/BR112014004584B1/pt active IP Right Grant
- 2012-08-31 RU RU2014112348/15A patent/RU2014112348A/ru unknown
- 2012-08-31 CA CA2845994A patent/CA2845994C/en active Active
- 2012-08-31 CN CN201280053594.1A patent/CN104053993A/zh active Pending
- 2012-08-31 ES ES12762367.6T patent/ES2662380T3/es active Active
- 2012-08-31 HR HRP20180362TT patent/HRP20180362T1/hr unknown
- 2012-08-31 US US14/239,779 patent/US9400276B2/en active Active
- 2012-08-31 DK DK12762367.6T patent/DK2751569T3/en active
- 2012-08-31 CN CN201711384538.7A patent/CN108107215A/zh active Pending
- 2012-08-31 WO PCT/GB2012/052131 patent/WO2013030579A1/en not_active Ceased
- 2012-08-31 AU AU2012300643A patent/AU2012300643B2/en active Active
- 2012-08-31 ES ES17201723T patent/ES2955475T3/es active Active
- 2012-08-31 RU RU2018101257A patent/RU2716494C2/ru active
- 2012-08-31 PL PL12762367T patent/PL2751569T3/pl unknown
- 2012-08-31 PT PT127623676T patent/PT2751569T/pt unknown
- 2012-08-31 MX MX2014002444A patent/MX349561B/es active IP Right Grant
- 2012-08-31 SG SG10201601168QA patent/SG10201601168QA/en unknown
-
2014
- 2014-02-20 ZA ZA2014/01296A patent/ZA201401296B/en unknown
-
2016
- 2016-06-22 US US15/189,977 patent/US10184945B2/en active Active
-
2017
- 2017-08-02 JP JP2017149809A patent/JP6494703B2/ja active Active
-
2018
- 2018-12-14 US US16/221,411 patent/US20190120853A1/en not_active Abandoned
-
2020
- 2020-07-09 US US16/925,125 patent/US20200341006A1/en not_active Abandoned
-
2022
- 2022-12-06 US US18/076,005 patent/US20230116530A1/en not_active Abandoned
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