JP2017171595A - Bdnf産生促進剤 - Google Patents
Bdnf産生促進剤 Download PDFInfo
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Abstract
Description
末梢組織での糖利用を促進して糖代謝改善に関与すること(非特許文献6)、加齢に伴って低下する勃起能を維持させること(非特許文献7)、卵子を成熟させること(非特許文献8)などといった様々な報告がなされている。
(1)
リン脂質を有効成分とするBDNF産生促進剤。
(2)
乳由来リン脂質を有効成分とするBDNF産生促進剤。
(3)
乳又は乳素材から得られる組成物であって、全固形中10重量%以上のリン脂質を含有する組成物(乳由来リン脂質含有組成物)を乳由来リン脂質として使用する(2)記載のBDNF産生促進剤。
(4)
乳又は乳素材から得られる組成物であって、全固形中30重量%以上のリン脂質を含有する組成物(乳由来リン脂質含有組成物)を乳由来リン脂質として使用する(2)記載のBDNF産生促進剤。
(5)
乳由来リン脂質含有組成物が、乳又は乳素材を孔径0.1〜2.0μmの精密濾過(MF)膜処理又は分画分子量5〜500kDaの限外濾過(UF)膜処理することにより得られる組成物である(2)記載のBDNF産生促進剤。
(6)
乳由来リン脂質含有組成物が、乳又は乳素材に酸を加えてpHを4.0〜5.0に調整し、カゼインタンパク質を沈殿として除去した後、孔径0.1〜2.0μmのMF膜処理又は分画分子量5〜500kDaのUF膜処理することにより得られる組成物である(2)記載のBDNF産生促進剤。
(7)
乳又は乳素材が、バターセーラム又はバターミルクである(3)乃至(6)のいずれか1つ以上に記載のBDNF産生促進剤。
(8)
(1)乃至(7)のいずれか1つ以上に記載のBDNF産生促進剤を配合したBDNF産生促進栄養組成物、飲食品又は飼料、治療薬。
(動物実験によるBDNF産生促進効果の確認)
2年齢のWistar系雄性ラットを平均体重が均等になるように3群(n=10)に分け、コントロール群、大豆レシチン群、ミルクリン脂質群とした。それぞれの群には、表1に示す配合の食餌を2週間自由摂食させた。なお、各食餌中に含まれるタンパク質含量、脂質含量および必須脂肪酸含量は同一になるように調整(リノール酸、リノレン酸の総量として3.1%)し、大豆レシチン群およびミルクリン脂質群についてはコリンを含むリン脂質であるホスファチジルコリンおよびスフィンゴミエリンの総量が同一になるように調整した(0.8%)。2週間の試験食摂取後に脳組織を摘出し神経栄養因子であるBDNFの含有量をELISAキット(BDNF Emax ImmunoAssay System: Promega社製, Madison, WI, USA)を使用し測定した。その結果を表2に示す。
実施例1の乳由来リン脂質含有組成物50gを4950gの脱イオン水に溶解し、50℃まで加熱後、TKホモミクサー(TK ROBO MICS;特殊機化工業社製)にて、6000rpmで30分間撹拌混合して乳由来リン脂質310mg/100gの乳由来リン脂質溶液を得た。この乳由来リン脂質含有組成物溶液4.0kgに、カゼイン5.0kg、大豆タンパク質5.0kg、魚油1.0kg、シソ油3.0kg、デキストリン18.0kg、ミネラル混合物6.0kg、ビタミン混合物1.95kg、乳化剤2.0kg、安定剤4.0kg、香料0.05kgを配合し、200mlのレトルトパウチに充填し、レトルト殺菌機(第1種圧力容器、TYPE:RCS−4CRTGN、日阪製作所社製)で121℃、20分間殺菌して、本発明のBDNF産生促進用液状栄養組成物50kgを製造した。なお、このBDNF産生促進用液状栄養組成物には、100gあたり、乳由来リン脂質が24.8mg含まれていた。
実施例1の乳由来リン脂質含有組成物10gを700gの脱イオン水に溶解し、50℃まで加熱後、ウルトラディスパーサー(ULTRA−TURRAX T−25;IKAジャパン社製)にて、9500rpmで30分間撹拌混合した。この溶液に、ソルビトール40g、酸味料2g、香料2g、ペクチン5g、乳清タンパク質濃縮物5g、乳酸カルシウム1g、脱イオン水235gを添加して、撹拌混合した後、200mlのチアパックに充填し、85℃、20分間殺菌後、密栓し、本発明のBDNF産生促進用ゲル状食品5袋(200g入り)を調製した。このようにして得られたBDNF産生促進用ゲル状食品は、すべて沈殿等は認められず、風味に異常は感じられなかった。なお、このBDNF産生促進用ゲル状食品には、100gあたり、乳由来リン脂質が310mg含まれていた。
酸味料2gを700gの脱イオン水に溶解した後、実施例2の乳由来リン脂質含有組成物10gを溶解し、50℃まで加熱後、ウルトラディスパーサー(ULTRA−TURRAX T−25;IKAジャパン社製)にて、9500rpmで30分間撹拌混合した。マルチトール100g、還元水飴20g、香料2g、脱イオン水166gを添加した後、100mlのガラス瓶に充填し、90℃、15分間殺菌後、密栓し、BDNF産生促進用飲料10本(100ml入り)を調製した。このようにして得られたBDNF産生促進用飲料は、すべて沈殿は認められず、風味に異常は感じられなかった。なお、このBDNF産生促進用飲料には、100gあたり、乳由来リン脂質が380mg含まれていた。
実施例2の乳由来リン脂質含有組成物2kgを98kgの脱イオン水に溶解し、50℃まで加熱後、TKホモミクサー(MARKII 160型;特殊機化工業社製)にて、3600rpmで40分間撹拌混合して乳由来リン脂質760mg/100gの乳由来リン脂質溶液を得た。この乳由来リン脂質溶液10kgに大豆粕12kg、脱脂粉乳14kg、大豆油4kg、コーン油2kg、パーム油23.2kg、トウモロコシ澱粉14kg、小麦粉9kg、ふすま2kg、ビタミン混合物5kg、セルロース2.8kg、ミネラル混合物2kgを配合し、120℃、4分間殺菌して、本発明のBDNF産生促進用イヌ飼育飼料100kgを製造した。なお、このBDNF産生促進用イヌ飼育飼料には、100gあたり、乳由来リン脂質が76mg含まれていた。
表3に示す配合で原料を混合後、常法1gに成型、打錠して本発明のBDNF産生促進剤を製造した。なお、この感覚改善剤1g中には、乳由来リン脂質が31mg含まれていた。
Claims (8)
- リン脂質を有効成分とするBDNF産生促進剤。
- 乳由来リン脂質を有効成分とするBDNF産生促進剤。
- 乳又は乳素材から得られる組成物であって、全固形中10重量%以上のリン脂質を含有する組成物(乳由来リン脂質含有組成物)を乳由来リン脂質として使用する請求項2記載のBDNF産生促進剤。
- 乳又は乳素材から得られる組成物であって、全固形中30重量%以上のリン脂質を含有する組成物(乳由来リン脂質含有組成物)を乳由来リン脂質として使用する請求項2記載のBDNF産生促進剤。
- 乳由来リン脂質含有組成物が、乳又は乳素材を孔径0.1〜2.0μmの精密濾過(MF)膜処理又は分画分子量5〜500kDaの限外濾過(UF)膜処理することにより得られる組成物である請求項2記載のBDNF産生促進剤。
- 乳由来リン脂質含有組成物が、乳又は乳素材に酸を加えてpHを4.0〜5.0に調整し、カゼインタンパク質を沈殿として除去した後、孔径0.1〜2.0μmのMF膜処理又は分画分子量5〜500kDaのUF膜処理することにより得られる組成物である請求項2記載のBDNF産生促進剤。
- 乳又は乳素材が、バターセーラム又はバターミルクである請求項3乃至6のいずれか1つ以上に記載のBDNF産生促進剤。
- 請求項1乃至7に記載のいずれか1つ以上に記載のBDNF産生促進剤を配合したBDNF産生促進栄養組成物、飲食品又は飼料、治療薬。
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