JP2017165776A5 - - Google Patents
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- Publication number
- JP2017165776A5 JP2017165776A5 JP2017119963A JP2017119963A JP2017165776A5 JP 2017165776 A5 JP2017165776 A5 JP 2017165776A5 JP 2017119963 A JP2017119963 A JP 2017119963A JP 2017119963 A JP2017119963 A JP 2017119963A JP 2017165776 A5 JP2017165776 A5 JP 2017165776A5
- Authority
- JP
- Japan
- Prior art keywords
- agent according
- agent
- diosgenin
- food
- memory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003795 chemical substances by application Substances 0.000 claims 15
- 210000003050 axon Anatomy 0.000 claims 12
- 230000001537 neural effect Effects 0.000 claims 8
- WQLVFSAGQJTQCK-VKROHFNGSA-N diosgenin Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CC[C@H](O)CC4=CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CC[C@@H](C)CO1 WQLVFSAGQJTQCK-VKROHFNGSA-N 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 230000004064 dysfunction Effects 0.000 claims 4
- 235000013305 food Nutrition 0.000 claims 4
- DWCSNWXARWMZTG-UHFFFAOYSA-N Trigonegenin A Natural products CC1C(C2(CCC3C4(C)CCC(O)C=C4CCC3C2C2)C)C2OC11CCC(C)CO1 DWCSNWXARWMZTG-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 claims 3
- 239000003925 fat Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- -1 medium chain fatty acid triglycerides Chemical class 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 235000019198 oils Nutrition 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 239000004606 Fillers/Extenders Substances 0.000 claims 1
- 235000008753 Papaver somniferum Nutrition 0.000 claims 1
- 240000001090 Papaver somniferum Species 0.000 claims 1
- 239000010775 animal oil Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000007910 chewable tablet Substances 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000000994 depressogenic effect Effects 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 235000013376 functional food Nutrition 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 235000015110 jellies Nutrition 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 230000008897 memory decline Effects 0.000 claims 1
- 239000003695 memory enhancer Substances 0.000 claims 1
- 239000006191 orally-disintegrating tablet Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 239000007901 soft capsule Substances 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014091718 | 2014-04-25 | ||
| JP2014091718 | 2014-04-25 | ||
| JP2014147890 | 2014-07-18 | ||
| JP2014147890 | 2014-07-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514946A Division JP6165323B2 (ja) | 2014-04-25 | 2015-04-21 | アルツハイマー病の治療剤を含む、神経細胞の軸索の機能不全が関与する疾患の治療剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017165776A JP2017165776A (ja) | 2017-09-21 |
| JP2017165776A5 true JP2017165776A5 (enExample) | 2018-06-07 |
Family
ID=54332482
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514946A Active JP6165323B2 (ja) | 2014-04-25 | 2015-04-21 | アルツハイマー病の治療剤を含む、神経細胞の軸索の機能不全が関与する疾患の治療剤 |
| JP2017119963A Pending JP2017165776A (ja) | 2014-04-25 | 2017-06-19 | アルツハイマー病の治療剤を含む、神経細胞の軸索の機能不全が関与する疾患の治療剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514946A Active JP6165323B2 (ja) | 2014-04-25 | 2015-04-21 | アルツハイマー病の治療剤を含む、神経細胞の軸索の機能不全が関与する疾患の治療剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20170129915A1 (enExample) |
| JP (2) | JP6165323B2 (enExample) |
| TW (1) | TW201625268A (enExample) |
| WO (1) | WO2015163318A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108264535A (zh) * | 2016-12-30 | 2018-07-10 | 中国科学院上海药物研究所 | 一种抗抑郁化合物及其制备方法和应用 |
| US11660287B2 (en) | 2017-06-02 | 2023-05-30 | Fujifilm Toyama Chemical Co., Ltd. | Agent for preventing or treating spinocerebellar ataxia |
| BR112019024983A2 (pt) | 2017-06-02 | 2020-06-23 | Fujifilm Toyama Chemical Co., Ltd. | Agente para reduzir a quantidade de proteína b amiloide |
| EP3636262A4 (en) | 2017-06-02 | 2020-06-10 | FUJIFILM Toyama Chemical Co., Ltd. | AGENT FOR PREVENTING OR TREATING ALZHEIMER-LIKE DEMENTIA |
| MX393052B (es) | 2017-06-02 | 2025-03-24 | Fujifilm Toyama Chemical Co Ltd | Agente para prevenir o tratar atrofia cerebral. |
| EP3705121B1 (en) | 2017-10-30 | 2023-08-30 | FUJIFILM Toyama Chemical Co., Ltd. | Emopamil binding protein binding agent and use thereof |
| WO2019129176A1 (zh) * | 2017-12-29 | 2019-07-04 | 中国科学院上海药物研究所 | 一种菝葜皂苷元衍生物及其制备方法和应用 |
| CN109988218B (zh) * | 2017-12-29 | 2022-11-25 | 中国科学院上海药物研究所 | 一种菝葜皂苷元衍生物及其制备方法和应用 |
| EP3572085A1 (en) | 2018-05-25 | 2019-11-27 | Neuro-Sys | Synergestic combination composition comprising a steroidal saponin, a first polyphenolic compound and optionnaly a second polyphenolic compound |
| CN109206472A (zh) * | 2018-09-27 | 2019-01-15 | 华东理工大学 | 薯蓣皂苷元衍生物、其药物组合物及其应用 |
| CN112142817B (zh) * | 2019-06-26 | 2021-10-22 | 中国科学院上海药物研究所 | 一种抗抑郁甾体化合物 |
| US20250213593A1 (en) * | 2022-02-18 | 2025-07-03 | Beijing Phytovent Pharmaceutical Technology Co., Ltd. | Use of Derivatives based on Sarsasapogenin Structure and Pharmaceutical Compositions thereof |
| CN116621912A (zh) * | 2022-02-18 | 2023-08-22 | 北京清博汇能医药科技有限公司 | 基于菝契皂苷元结构的衍生物及其药物组合物的用途 |
| CN114805286B (zh) * | 2022-05-06 | 2023-06-16 | 深圳职业技术学院 | 一种萘并氧硫杂卓类衍生物的制备方法 |
| JPWO2024024395A1 (enExample) * | 2022-07-29 | 2024-02-01 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU746930B2 (en) * | 1998-04-24 | 2002-05-09 | New Chapter IP Pty Ltd | Therapeutic compositions |
| CN100430062C (zh) * | 2002-03-15 | 2008-11-05 | 萨马里坦药品公司 | 神经保护性螺甾烯醇药用组合物 |
| AU2005295617A1 (en) * | 2004-10-14 | 2006-04-27 | Georgetown University | Neuroprotective spirostenol pharmaceutical compositions |
| JP2007016013A (ja) * | 2005-06-10 | 2007-01-25 | Kanebo Cosmetics Inc | 更年期の皮膚改善用経口組成物 |
| US20090123575A1 (en) * | 2007-11-12 | 2009-05-14 | Thomas Lake | Blended Compositions for Treatment of Alzheimer's Disease and Other Amyloidoses |
| JP2012031153A (ja) * | 2010-06-29 | 2012-02-16 | Takara Bio Inc | 脂肪燃焼促進剤 |
| WO2013149580A1 (en) * | 2012-04-03 | 2013-10-10 | Chiming Che | Timosaponin compounds |
-
2015
- 2015-04-21 JP JP2016514946A patent/JP6165323B2/ja active Active
- 2015-04-21 US US15/306,576 patent/US20170129915A1/en not_active Abandoned
- 2015-04-21 WO PCT/JP2015/062094 patent/WO2015163318A1/ja not_active Ceased
- 2015-04-24 TW TW104113201A patent/TW201625268A/zh unknown
-
2017
- 2017-06-19 JP JP2017119963A patent/JP2017165776A/ja active Pending
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