JP2017165776A5 - - Google Patents
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- Publication number
- JP2017165776A5 JP2017165776A5 JP2017119963A JP2017119963A JP2017165776A5 JP 2017165776 A5 JP2017165776 A5 JP 2017165776A5 JP 2017119963 A JP2017119963 A JP 2017119963A JP 2017119963 A JP2017119963 A JP 2017119963A JP 2017165776 A5 JP2017165776 A5 JP 2017165776A5
- Authority
- JP
- Japan
- Prior art keywords
- agent according
- agent
- diosgenin
- food
- memory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003795 chemical substances by application Substances 0.000 claims 15
- 210000003050 axon Anatomy 0.000 claims 12
- 230000001537 neural effect Effects 0.000 claims 8
- WQLVFSAGQJTQCK-VKROHFNGSA-N diosgenin Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CC[C@H](O)CC4=CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CC[C@@H](C)CO1 WQLVFSAGQJTQCK-VKROHFNGSA-N 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 230000004064 dysfunction Effects 0.000 claims 4
- 235000013305 food Nutrition 0.000 claims 4
- DWCSNWXARWMZTG-UHFFFAOYSA-N Trigonegenin A Natural products CC1C(C2(CCC3C4(C)CCC(O)C=C4CCC3C2C2)C)C2OC11CCC(C)CO1 DWCSNWXARWMZTG-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 claims 3
- 239000003925 fat Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- -1 medium chain fatty acid triglycerides Chemical class 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 235000019198 oils Nutrition 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 239000004606 Fillers/Extenders Substances 0.000 claims 1
- 235000008753 Papaver somniferum Nutrition 0.000 claims 1
- 240000001090 Papaver somniferum Species 0.000 claims 1
- 239000010775 animal oil Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000007910 chewable tablet Substances 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000000994 depressogenic effect Effects 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 235000013376 functional food Nutrition 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 235000015110 jellies Nutrition 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 230000008897 memory decline Effects 0.000 claims 1
- 239000003695 memory enhancer Substances 0.000 claims 1
- 239000006191 orally-disintegrating tablet Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 239000007901 soft capsule Substances 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014091718 | 2014-04-25 | ||
| JP2014091718 | 2014-04-25 | ||
| JP2014147890 | 2014-07-18 | ||
| JP2014147890 | 2014-07-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514946A Division JP6165323B2 (ja) | 2014-04-25 | 2015-04-21 | アルツハイマー病の治療剤を含む、神経細胞の軸索の機能不全が関与する疾患の治療剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017165776A JP2017165776A (ja) | 2017-09-21 |
| JP2017165776A5 true JP2017165776A5 (OSRAM) | 2018-06-07 |
Family
ID=54332482
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514946A Active JP6165323B2 (ja) | 2014-04-25 | 2015-04-21 | アルツハイマー病の治療剤を含む、神経細胞の軸索の機能不全が関与する疾患の治療剤 |
| JP2017119963A Pending JP2017165776A (ja) | 2014-04-25 | 2017-06-19 | アルツハイマー病の治療剤を含む、神経細胞の軸索の機能不全が関与する疾患の治療剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514946A Active JP6165323B2 (ja) | 2014-04-25 | 2015-04-21 | アルツハイマー病の治療剤を含む、神経細胞の軸索の機能不全が関与する疾患の治療剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20170129915A1 (OSRAM) |
| JP (2) | JP6165323B2 (OSRAM) |
| TW (1) | TW201625268A (OSRAM) |
| WO (1) | WO2015163318A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108264535A (zh) * | 2016-12-30 | 2018-07-10 | 中国科学院上海药物研究所 | 一种抗抑郁化合物及其制备方法和应用 |
| BR112019024851A2 (pt) | 2017-06-02 | 2020-06-09 | Fujifilm Toyama Chemical Co Ltd | agente para evitar ou tratar atrofia cerebral |
| US11666551B2 (en) | 2017-06-02 | 2023-06-06 | Fujifilm Toyama Chemical Co., Ltd. | Agent for reducing amount of amyloid β protein |
| SG11201911515QA (en) | 2017-06-02 | 2020-01-30 | Fujifilm Toyama Chemical Co Ltd | Agent for preventing or treating spinocerebellar ataxia |
| JPWO2018221728A1 (ja) | 2017-06-02 | 2020-04-02 | 富士フイルム富山化学株式会社 | アルツハイマー型認知症予防または治療剤 |
| US11548878B2 (en) | 2017-10-30 | 2023-01-10 | Fujifilm Toyama Chemical Co., Ltd. | Emopamil binding protein binding agent and use thereof |
| CN109988218B (zh) * | 2017-12-29 | 2022-11-25 | 中国科学院上海药物研究所 | 一种菝葜皂苷元衍生物及其制备方法和应用 |
| WO2019129176A1 (zh) * | 2017-12-29 | 2019-07-04 | 中国科学院上海药物研究所 | 一种菝葜皂苷元衍生物及其制备方法和应用 |
| EP3572085A1 (en) | 2018-05-25 | 2019-11-27 | Neuro-Sys | Synergestic combination composition comprising a steroidal saponin, a first polyphenolic compound and optionnaly a second polyphenolic compound |
| CN109206472A (zh) * | 2018-09-27 | 2019-01-15 | 华东理工大学 | 薯蓣皂苷元衍生物、其药物组合物及其应用 |
| CN112142817B (zh) * | 2019-06-26 | 2021-10-22 | 中国科学院上海药物研究所 | 一种抗抑郁甾体化合物 |
| JP2025505820A (ja) * | 2022-02-18 | 2025-02-28 | ベイジン フィトベント ファーマシューティカル テクノロジー カンパニー，リミテッド | サルササポゲニン構造に基づく誘導体およびその医薬組成物の使用 |
| CN116621912A (zh) * | 2022-02-18 | 2023-08-22 | 北京清博汇能医药科技有限公司 | 基于菝契皂苷元结构的衍生物及其药物组合物的用途 |
| CN114805286B (zh) * | 2022-05-06 | 2023-06-16 | 深圳职业技术学院 | 一种萘并氧硫杂卓类衍生物的制备方法 |
| JPWO2024024395A1 (OSRAM) * | 2022-07-29 | 2024-02-01 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU746930B2 (en) * | 1998-04-24 | 2002-05-09 | New Chapter IP Pty Ltd | Therapeutic compositions |
| CA2479249A1 (en) * | 2002-03-15 | 2003-09-25 | Samaritan Pharmaceuticals, Inc. | Neuroprotective spirostenol pharmaceutical compositions |
| JP2008516972A (ja) * | 2004-10-14 | 2008-05-22 | ジョージタウン ユニバーシティー | 神経保護作用を有するスピロステノールの薬学的組成物 |
| JP2007016013A (ja) * | 2005-06-10 | 2007-01-25 | Kanebo Cosmetics Inc | 更年期の皮膚改善用経口組成物 |
| US20090123575A1 (en) * | 2007-11-12 | 2009-05-14 | Thomas Lake | Blended Compositions for Treatment of Alzheimer's Disease and Other Amyloidoses |
| JP2012031153A (ja) * | 2010-06-29 | 2012-02-16 | Takara Bio Inc | 脂肪燃焼促進剤 |
| WO2013149580A1 (en) * | 2012-04-03 | 2013-10-10 | Chiming Che | Timosaponin compounds |
-
2015
- 2015-04-21 US US15/306,576 patent/US20170129915A1/en not_active Abandoned
- 2015-04-21 WO PCT/JP2015/062094 patent/WO2015163318A1/ja not_active Ceased
- 2015-04-21 JP JP2016514946A patent/JP6165323B2/ja active Active
- 2015-04-24 TW TW104113201A patent/TW201625268A/zh unknown
-
2017
- 2017-06-19 JP JP2017119963A patent/JP2017165776A/ja active Pending
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