BR112019024851A2 - agente para evitar ou tratar atrofia cerebral - Google Patents
agente para evitar ou tratar atrofia cerebral Download PDFInfo
- Publication number
- BR112019024851A2 BR112019024851A2 BR112019024851A BR112019024851A BR112019024851A2 BR 112019024851 A2 BR112019024851 A2 BR 112019024851A2 BR 112019024851 A BR112019024851 A BR 112019024851A BR 112019024851 A BR112019024851 A BR 112019024851A BR 112019024851 A2 BR112019024851 A2 BR 112019024851A2
- Authority
- BR
- Brazil
- Prior art keywords
- cerebral atrophy
- agent
- prevent
- treat cerebral
- benzothiophen
- Prior art date
Links
- 206010008096 Cerebral atrophy Diseases 0.000 title abstract 4
- HQNACSFBDBYLJP-UHFFFAOYSA-N 1-[3-[2-(1-benzothiophen-5-yl)ethoxy]propyl]azetidin-3-ol Chemical compound C1C(O)CN1CCCOCCC1=CC=C(SC=C2)C2=C1 HQNACSFBDBYLJP-UHFFFAOYSA-N 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000032683 aging Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Abstract
a presente invenção refere-se a um fármaco que evita o progresso de doença de alzheimer e um método para evitar progresso de doença de alzheimer. 1-(3-(2-(1-benzotiofen-5-il)etóxi)propil)azetidin-3-ol ou um sal do mesmo tem um efeito de suprimir atrofia cerebral e é útil como um agente para evitar ou tratar atrofia cerebral. a atrofia cerebral observada em envelhecimento ou doenças neurodegenerativas pode ser evitada ou tratada por administrar 1-(3-(2-(1-benzotiofen-5-il)etóxi)propil)azetidin-3-ol ou um sal do mesmo.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017109885 | 2017-06-02 | ||
JP2017128472 | 2017-06-30 | ||
JP2017145100 | 2017-07-27 | ||
PCT/JP2018/021223 WO2018221729A1 (ja) | 2017-06-02 | 2018-06-01 | 脳萎縮予防または治療剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019024851A2 true BR112019024851A2 (pt) | 2020-06-09 |
Family
ID=64455855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019024851A BR112019024851A2 (pt) | 2017-06-02 | 2018-06-01 | agente para evitar ou tratar atrofia cerebral |
Country Status (15)
Country | Link |
---|---|
US (1) | US11951092B2 (pt) |
EP (1) | EP3632431A4 (pt) |
JP (2) | JP7282028B2 (pt) |
KR (1) | KR20190137936A (pt) |
CN (3) | CN116492335A (pt) |
AU (1) | AU2018276638B2 (pt) |
BR (1) | BR112019024851A2 (pt) |
CA (1) | CA3067453C (pt) |
IL (1) | IL270922A (pt) |
MX (1) | MX2019014310A (pt) |
NZ (1) | NZ759585A (pt) |
RU (1) | RU2759727C2 (pt) |
SG (1) | SG11201911512SA (pt) |
WO (1) | WO2018221729A1 (pt) |
ZA (1) | ZA201907973B (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116492335A (zh) * | 2017-06-02 | 2023-07-28 | 富士胶片富山化学株式会社 | 脑萎缩预防或治疗剂 |
IL270910B2 (en) | 2017-06-02 | 2024-03-01 | Fujifilm Toyama Chemical Co Ltd | 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)aztidine-3-ol or a salt thereof for use in suppressing cerebral atrophy |
WO2018221728A1 (ja) | 2017-06-02 | 2018-12-06 | 富山化学工業株式会社 | アルツハイマー型認知症予防または治療剤 |
JP7256118B2 (ja) | 2017-06-02 | 2023-04-11 | 富士フイルム富山化学株式会社 | アミロイドβ蛋白質量減少剤 |
JP7227914B2 (ja) | 2017-10-30 | 2023-02-22 | 富士フイルム富山化学株式会社 | エモパミル結合タンパク質結合剤およびその利用 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2001514024A (ja) | 1997-09-05 | 2001-09-11 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 50個のヒト分泌タンパク質 |
GB9824207D0 (en) | 1998-11-04 | 1998-12-30 | Zeneca Ltd | Neurological disorders |
KR100956990B1 (ko) | 2001-10-19 | 2010-05-11 | 토야마 케미칼 컴퍼니 리미티드 | 알킬에테르유도체 또는 그 염 |
ES2379948T3 (es) * | 2002-06-14 | 2012-05-07 | Toyama Chemical Co., Ltd. | Composición medicinal que comprende Tacrine o Donepezil para mejorar la función cerebral |
MXPA05011125A (es) | 2003-04-17 | 2005-12-14 | Toyama Chemical Co Ltd | Remedio preventivo para enfermedades del nervio retiniano que contienen derivados de eter de alquilo o sales de los mismos. |
PL2011796T3 (pl) * | 2006-04-26 | 2015-03-31 | Toyama Chemical Co Ltd | Induktor neurogenezy lub środek terapeutyczny do stosowania w neuropatii zawierający pochodną eteru alkilowego lub jej sól |
US8119625B2 (en) * | 2006-04-26 | 2012-02-21 | Toyama Chemical Co., Ltd. | Neurogenesis inducer or neuropathy therapeutic agent comprising alkyl ether derivative or salt thereof |
EA017842B1 (ru) | 2008-03-04 | 2013-03-29 | Вернэлис (Р&Д) Лтд. | Производные азетидина и их применение |
FR2934596B1 (fr) | 2008-07-30 | 2015-04-10 | Trophos | Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation |
JP2012523437A (ja) | 2009-04-13 | 2012-10-04 | セラヴァンス, インコーポレーテッド | 認知障害の治療のための5−ht4受容体アゴニスト化合物 |
JP5808319B2 (ja) | 2009-05-11 | 2015-11-10 | フォルム ファーマシューティカルズ、インコーポレイテッド | アセチルコリンエステラーゼ阻害剤と組み合わせた特定のα7ニコチン酸受容体を用いた認知障害の治療 |
WO2011057199A1 (en) | 2009-11-06 | 2011-05-12 | Adenios, Inc. | Compositions for treating cns disorders |
US9872914B2 (en) | 2012-02-22 | 2018-01-23 | Toyama Chemical Co., Ltd. | Solid pharmaceutical composition containing 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salt thereof |
JP6397407B2 (ja) | 2012-07-19 | 2018-09-26 | ドレクセル ユニバーシティ | 細胞タンパク質ホメオスタシスを調節するためのシグマ受容体リガンド |
EP2903980B1 (en) | 2012-10-01 | 2017-07-19 | F. Hoffmann-La Roche AG | Benzimidazoles as cns active agents |
EP3100725B1 (en) * | 2014-01-31 | 2020-05-06 | FUJIFILM Toyama Chemical Co., Ltd. | Post nerve injury rehabilitation effect-enhancing agent comprising an alkyl ether derivative or a salt thereof |
WO2015163318A1 (ja) | 2014-04-25 | 2015-10-29 | レジリオ株式会社 | アルツハイマー病の治療剤を含む、神経細胞の軸索の機能不全が関与する疾患の治療剤 |
WO2015188368A1 (en) | 2014-06-13 | 2015-12-17 | Merck Sharp & Dohme Corp. | Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles |
WO2016051799A1 (ja) | 2014-10-01 | 2016-04-07 | 学校法人同志社 | 2-アミノヒドロキノン誘導体及びタウ凝集阻害剤 |
MY191590A (en) | 2015-02-02 | 2022-06-30 | Ucb Biopharma Sprl | 9h-pyrrolo-dipyridine derivatives |
US20160324851A1 (en) | 2015-05-07 | 2016-11-10 | Axovant Sciences, Ltd. | Methods of treating a neurodegenerative disease |
JP6761413B2 (ja) | 2015-06-11 | 2020-09-23 | 富士フイルム富山化学株式会社 | シグマ受容体結合剤 |
US11304928B2 (en) | 2015-12-25 | 2022-04-19 | Fujifilm Toyama Chemical Co., Ltd. | Tablet comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salt thereof |
CN116492335A (zh) * | 2017-06-02 | 2023-07-28 | 富士胶片富山化学株式会社 | 脑萎缩预防或治疗剂 |
IL270910B2 (en) | 2017-06-02 | 2024-03-01 | Fujifilm Toyama Chemical Co Ltd | 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)aztidine-3-ol or a salt thereof for use in suppressing cerebral atrophy |
WO2018221728A1 (ja) | 2017-06-02 | 2018-12-06 | 富山化学工業株式会社 | アルツハイマー型認知症予防または治療剤 |
EP3636261A4 (en) | 2017-06-02 | 2020-06-10 | FUJIFILM Toyama Chemical Co., Ltd. | AGENT FOR PREVENTING OR TREATING TAUOPATHY |
JP7256118B2 (ja) | 2017-06-02 | 2023-04-11 | 富士フイルム富山化学株式会社 | アミロイドβ蛋白質量減少剤 |
JP7227914B2 (ja) | 2017-10-30 | 2023-02-22 | 富士フイルム富山化学株式会社 | エモパミル結合タンパク質結合剤およびその利用 |
-
2018
- 2018-06-01 CN CN202310474317.8A patent/CN116492335A/zh active Pending
- 2018-06-01 JP JP2019521348A patent/JP7282028B2/ja active Active
- 2018-06-01 SG SG11201911512SA patent/SG11201911512SA/en unknown
- 2018-06-01 CN CN201880035394.0A patent/CN110709078A/zh active Pending
- 2018-06-01 NZ NZ759585A patent/NZ759585A/en unknown
- 2018-06-01 WO PCT/JP2018/021223 patent/WO2018221729A1/ja active Application Filing
- 2018-06-01 BR BR112019024851A patent/BR112019024851A2/pt unknown
- 2018-06-01 KR KR1020197035347A patent/KR20190137936A/ko not_active IP Right Cessation
- 2018-06-01 RU RU2019138166A patent/RU2759727C2/ru active
- 2018-06-01 MX MX2019014310A patent/MX2019014310A/es unknown
- 2018-06-01 CN CN202310470444.0A patent/CN116473962A/zh active Pending
- 2018-06-01 EP EP18810520.9A patent/EP3632431A4/en active Pending
- 2018-06-01 CA CA3067453A patent/CA3067453C/en active Active
- 2018-06-01 US US16/617,739 patent/US11951092B2/en active Active
- 2018-06-01 AU AU2018276638A patent/AU2018276638B2/en active Active
-
2019
- 2019-11-25 IL IL270922A patent/IL270922A/en unknown
- 2019-11-29 ZA ZA2019/07973A patent/ZA201907973B/en unknown
-
2023
- 2023-02-15 JP JP2023021443A patent/JP2023053337A/ja not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
SG11201911512SA (en) | 2020-01-30 |
RU2019138166A3 (pt) | 2021-07-09 |
KR20190137936A (ko) | 2019-12-11 |
AU2018276638A1 (en) | 2019-12-19 |
EP3632431A1 (en) | 2020-04-08 |
CA3067453C (en) | 2021-11-23 |
US20200215030A1 (en) | 2020-07-09 |
EP3632431A4 (en) | 2020-06-03 |
MX2019014310A (es) | 2022-06-10 |
RU2019138166A (ru) | 2021-07-09 |
ZA201907973B (en) | 2022-03-30 |
IL270922A (en) | 2020-01-30 |
WO2018221729A1 (ja) | 2018-12-06 |
NZ759585A (en) | 2022-02-25 |
CA3067453A1 (en) | 2018-12-06 |
US11951092B2 (en) | 2024-04-09 |
JPWO2018221729A1 (ja) | 2020-04-09 |
CN116473962A (zh) | 2023-07-25 |
RU2759727C2 (ru) | 2021-11-17 |
JP7282028B2 (ja) | 2023-05-26 |
CN110709078A (zh) | 2020-01-17 |
AU2018276638B2 (en) | 2021-04-08 |
CN116492335A (zh) | 2023-07-28 |
JP2023053337A (ja) | 2023-04-12 |
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