JP2017158561A5 - - Google Patents
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- JP2017158561A5 JP2017158561A5 JP2017077422A JP2017077422A JP2017158561A5 JP 2017158561 A5 JP2017158561 A5 JP 2017158561A5 JP 2017077422 A JP2017077422 A JP 2017077422A JP 2017077422 A JP2017077422 A JP 2017077422A JP 2017158561 A5 JP2017158561 A5 JP 2017158561A5
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- 239000000203 mixture Substances 0.000 claims 7
- 230000003110 anti-inflammatory Effects 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 200000000018 inflammatory disease Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 201000004624 dermatitis Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 108010001801 Tumor Necrosis Factor-alpha Proteins 0.000 description 2
- 239000000262 estrogen Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
Description
その結果、ペプチド配列番号１〜５、配列番号７、配列番号９、配列番号１０、配列番号１２、配列番号１３、配列番号１５、配列番号１７〜２７、配列番号２９、配列番号３０、配列番号３２〜５３、配列番号５５〜６０、配列番号６７、配列番号６８、配列番号７０、配列番号７２〜８２、配列番号８４〜９２、配列番号９４、配列番号９９〜１１２、配列番号１１４、配列番号１２７〜１４４、配列番号１４６、配列番号１４８、配列番号１４９、配列番号１５１、及び配列番号１５３〜１６１が、対照群であるＬＰＳのみを処理したグループに比べ、ＴＮＦ−αを減少させるようであった。
また、配列番号１〜５、配列番号７、配列番号９、配列番号１０、配列番号１２、配列番号１３、配列番号１５、配列番号１７〜２３、配列番号２５〜２７、配列番号２９、配列番号３０、配列番号３３〜４３、配列番号１５６、配列番号１５７及び配列番号１５９が、ＬＰＳ及びエストロゲンで処理したグループに比べ、ＴＮＦ−αの発現レベルを減少させるペプチドであると選別された。
また、配列番号１〜５、配列番号７、配列番号９、配列番号１０、配列番号１２、配列番号１３、配列番号１５、配列番号１７〜２３、配列番号２５〜２７、配列番号２９、配列番号３０、配列番号３３〜４３、配列番号１５６、配列番号１５７及び配列番号１５９が、ＬＰＳ及びエストロゲンで処理したグループに比べ、ＴＮＦ−αの発現レベルを減少させるペプチドであると選別された。
Claims (5)
- （ａ）配列番号４８又は１０６のアミノ酸配列、または
（ｂ）（ａ）に規定されたアミノ酸配列と少なくとも９０％の配列同一性を有するアミノ酸配列
から成るペプチドを活性成分として含む、抗炎症組成物。 - 皮膚炎症の改善用または予防用の化粧品組成物である、請求項１に記載の抗炎症組成物。
- 炎症性疾患の治療または予防のための医薬組成物である、請求項１に記載の抗炎症組成物。
- 炎症の治療または予防のための食品組成物である、請求項１に記載の抗炎症組成物。
- 請求項１〜４のうちいずれか１項に記載の組成物；及び
前記組成物の投与量、投与経路、投与回数及び適応症の少なくとも１つを含む指示書
を含む、炎症性疾患の治療用または予防用のキット。
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020120079096A KR20140012385A (ko) | 2012-07-20 | 2012-07-20 | 항염증 활성을 갖는 펩티드 및 이를 포함하는 염증질환 치료용 조성물 |
| KR10-2012-0079096 | 2012-07-20 | ||
| KR10-2012-0089161 | 2012-08-14 | ||
| KR10-2012-0089167 | 2012-08-14 | ||
| KR1020120089162A KR20140022698A (ko) | 2012-08-14 | 2012-08-14 | 텔로머라제 펩티드를 포함하는 염증 예방 또는 억제용 조성물 |
| KR20120089161 | 2012-08-14 | ||
| KR10-2012-0089162 | 2012-08-14 | ||
| KR1020120089167A KR20140022699A (ko) | 2012-08-14 | 2012-08-14 | 텔로머라제 펩티드를 포함하는 염증 예방 또는 억제용 조성물 |
| KR20120104144 | 2012-09-19 | ||
| KR10-2012-0104207 | 2012-09-19 | ||
| KR10-2012-0104144 | 2012-09-19 | ||
| KR20120104207 | 2012-09-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521997A Division JP6352911B2 (ja) | 2012-07-20 | 2013-03-15 | 抗炎症活性を有するペプチド、及びそれを含む組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019075635A Division JP6788062B2 (ja) | 2012-07-20 | 2019-04-11 | 抗炎症活性を有するペプチド、及びそれを含む組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017158561A JP2017158561A (ja) | 2017-09-14 |
| JP2017158561A5 true JP2017158561A5 (ja) | 2018-11-22 |
| JP6514259B2 JP6514259B2 (ja) | 2019-05-15 |
Family
ID=47882177
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521997A Active JP6352911B2 (ja) | 2012-07-20 | 2013-03-15 | 抗炎症活性を有するペプチド、及びそれを含む組成物 |
| JP2017077422A Active JP6514259B2 (ja) | 2012-07-20 | 2017-04-10 | 抗炎症活性を有するペプチド、及びそれを含む組成物 |
| JP2019075635A Active JP6788062B2 (ja) | 2012-07-20 | 2019-04-11 | 抗炎症活性を有するペプチド、及びそれを含む組成物 |
| JP2020181780A Active JP7128246B2 (ja) | 2012-07-20 | 2020-10-29 | 抗炎症活性を有するペプチド、及びそれを含む組成物 |
| JP2022130519A Active JP7440581B2 (ja) | 2012-07-20 | 2022-08-18 | 抗炎症活性を有するペプチド、及びそれを含む組成物 |
| JP2024021407A Pending JP2024056904A (ja) | 2012-07-20 | 2024-02-15 | 抗炎症活性を有するペプチド、及びそれを含む組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521997A Active JP6352911B2 (ja) | 2012-07-20 | 2013-03-15 | 抗炎症活性を有するペプチド、及びそれを含む組成物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019075635A Active JP6788062B2 (ja) | 2012-07-20 | 2019-04-11 | 抗炎症活性を有するペプチド、及びそれを含む組成物 |
| JP2020181780A Active JP7128246B2 (ja) | 2012-07-20 | 2020-10-29 | 抗炎症活性を有するペプチド、及びそれを含む組成物 |
| JP2022130519A Active JP7440581B2 (ja) | 2012-07-20 | 2022-08-18 | 抗炎症活性を有するペプチド、及びそれを含む組成物 |
| JP2024021407A Pending JP2024056904A (ja) | 2012-07-20 | 2024-02-15 | 抗炎症活性を有するペプチド、及びそれを含む組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US20150125438A1 (ja) |
| EP (3) | EP3428182B1 (ja) |
| JP (6) | JP6352911B2 (ja) |
| KR (2) | KR20150031413A (ja) |
| CN (3) | CN109777791B (ja) |
| ES (2) | ES2693321T3 (ja) |
| TW (4) | TWI647311B (ja) |
| WO (1) | WO2014012683A1 (ja) |
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| US10967000B2 (en) | 2012-07-11 | 2021-04-06 | Gemvax & Kael Co., Ltd. | Cell-penetrating peptide, conjugate comprising same and composition comprising same |
| US20150125438A1 (en) | 2012-07-20 | 2015-05-07 | Sang Jae Kim | Anti-Inflammatory Peptides and Composition Comprising the Same |
| ES2802253T3 (es) | 2012-09-19 | 2021-01-18 | Gemvax & Kael Co Ltd | Péptido de penetración celular, conjugado que comprende el mismo y composición que comprende el conjugado |
| US9572900B2 (en) | 2012-09-19 | 2017-02-21 | Gemvax & Kael Co., Ltd. | Cell penetrating peptide, conjugate comprising same, and composition comprising conjugate |
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| RU2677277C2 (ru) | 2013-06-07 | 2019-01-16 | Джемвакс Энд Каэл Ко., Лтд. | Биологические маркеры, которые могут быть использованы в иммунотерапии рака |
| EP3011967B1 (en) | 2013-06-21 | 2020-06-17 | Gemvax & Kael Co., Ltd. | Hormone secretion regulator, composition containing same, and method for controlling hormone secretion using same |
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| KR102413243B1 (ko) | 2014-12-23 | 2022-06-27 | 주식회사 젬백스앤카엘 | 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물 |
| CN107405380B (zh) | 2015-02-27 | 2021-04-20 | 珍白斯凯尔有限公司 | 用于预防听觉损伤的肽及其包含该肽的组合物 |
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| KR101734529B1 (ko) | 2015-05-08 | 2017-05-11 | 건국대학교 산학협력단 | 패혈증 치료제의 스크리닝 방법 및 패혈증 치료용 약학 조성물 |
| ES2879641T3 (es) | 2015-05-26 | 2021-11-22 | Gemvax & Kael Co Ltd | Octapéptidos antiinflamatorias, antifibróticos y cicatrizantes de heridas y las composiciones que los contienen |
| ES2886946T3 (es) | 2015-07-02 | 2021-12-21 | Gemvax & Kael Co Ltd | Péptido con efecto antiviral y composición que lo contiene |
| US10858397B2 (en) | 2015-08-28 | 2020-12-08 | The Medical College Of Wisconsin, Inc. | Peptide inhibitors of telomerase translocation and therapeutic uses thereof |
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-
2013
- 2013-03-05 US US14/400,322 patent/US20150125438A1/en not_active Abandoned
- 2013-03-15 CN CN201910110866.0A patent/CN109777791B/zh active Active
- 2013-03-15 EP EP18187426.4A patent/EP3428182B1/en active Active
- 2013-03-15 JP JP2015521997A patent/JP6352911B2/ja active Active
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