JP2017114876A5 - - Google Patents
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- Publication number
- JP2017114876A5 JP2017114876A5 JP2017018192A JP2017018192A JP2017114876A5 JP 2017114876 A5 JP2017114876 A5 JP 2017114876A5 JP 2017018192 A JP2017018192 A JP 2017018192A JP 2017018192 A JP2017018192 A JP 2017018192A JP 2017114876 A5 JP2017114876 A5 JP 2017114876A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- nitrogen
- oxygen
- sulfur
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4319708P | 2008-04-08 | 2008-04-08 | |
| US61/043,197 | 2008-04-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015038239A Division JP2015134793A (ja) | 2008-04-08 | 2015-02-27 | トリテルペンであるサポニン、その合成法および使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019000534A Division JP6770596B2 (ja) | 2008-04-08 | 2019-01-07 | トリテルペンであるサポニン、その合成法および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017114876A JP2017114876A (ja) | 2017-06-29 |
| JP2017114876A5 true JP2017114876A5 (OSRAM) | 2017-10-12 |
| JP6786410B2 JP6786410B2 (ja) | 2020-11-18 |
Family
ID=40875147
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011504157A Expired - Fee Related JP5706815B2 (ja) | 2008-04-08 | 2009-04-08 | トリテルペンであるサポニン、その合成法および使用 |
| JP2015038239A Withdrawn JP2015134793A (ja) | 2008-04-08 | 2015-02-27 | トリテルペンであるサポニン、その合成法および使用 |
| JP2017018192A Active JP6786410B2 (ja) | 2008-04-08 | 2017-02-03 | トリテルペンであるサポニン、その合成法および使用 |
| JP2019000534A Active JP6770596B2 (ja) | 2008-04-08 | 2019-01-07 | トリテルペンであるサポニン、その合成法および使用 |
| JP2020117691A Pending JP2020169206A (ja) | 2008-04-08 | 2020-07-08 | トリテルペンであるサポニン、その合成法および使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011504157A Expired - Fee Related JP5706815B2 (ja) | 2008-04-08 | 2009-04-08 | トリテルペンであるサポニン、その合成法および使用 |
| JP2015038239A Withdrawn JP2015134793A (ja) | 2008-04-08 | 2015-02-27 | トリテルペンであるサポニン、その合成法および使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019000534A Active JP6770596B2 (ja) | 2008-04-08 | 2019-01-07 | トリテルペンであるサポニン、その合成法および使用 |
| JP2020117691A Pending JP2020169206A (ja) | 2008-04-08 | 2020-07-08 | トリテルペンであるサポニン、その合成法および使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US8283456B2 (OSRAM) |
| EP (3) | EP3868771A1 (OSRAM) |
| JP (5) | JP5706815B2 (OSRAM) |
| KR (6) | KR102453184B1 (OSRAM) |
| CN (2) | CN104710487A (OSRAM) |
| AU (1) | AU2009233757B2 (OSRAM) |
| CA (3) | CA3096084C (OSRAM) |
| ES (1) | ES2827804T3 (OSRAM) |
| HK (1) | HK1211591A1 (OSRAM) |
| IL (4) | IL208535A (OSRAM) |
| WO (1) | WO2009126737A2 (OSRAM) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3096084C (en) | 2008-04-08 | 2022-12-20 | Sloan-Kettering Institute For Cancer Research | Triterpene saponins, methods of synthesis, and uses thereof |
| CN102068446B (zh) * | 2011-01-10 | 2013-08-21 | 武汉道一堂医药研究院 | 三萜皂苷化合物在制备抗病原微生物药物中的应用 |
| AU2013204005B2 (en) * | 2012-05-23 | 2015-04-16 | Oncology Research International Limited | Improved synthesis |
| EP3792272A1 (en) | 2013-01-04 | 2021-03-17 | OBI Pharma, Inc. | Vaccines with higher carbohydrate antigen density and novel saponin adjuvant |
| US10806119B2 (en) | 2013-06-05 | 2020-10-20 | Yeda Research And Development Co. Ltd. | Plant with altered content of steroidal alkaloids |
| KR20160055861A (ko) | 2013-09-17 | 2016-05-18 | 오비아이 파머 인코퍼레이티드 | 암치료에서 면역반응을 유도하기 위한 탄수화물 백신의 조성물 |
| ES2887400T3 (es) * | 2014-05-30 | 2021-12-22 | Memorial Sloan Kettering Cancer Center | Análogos mínimos de saponina, síntesis y uso de los mismos |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| KR20180050339A (ko) | 2015-09-04 | 2018-05-14 | 오비아이 파머 인코퍼레이티드 | 글리칸 어레이 및 사용 방법 |
| IL293848B2 (en) * | 2015-11-06 | 2025-02-01 | Adjuvance Tech Inc | Triterpene saponin analogues, methods for their production, compositions containing them and uses thereof |
| US11041017B2 (en) | 2016-03-29 | 2021-06-22 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| AU2017252128B2 (en) | 2016-04-22 | 2024-06-06 | Obi Pharma, Inc. | Cancer immunotherapy by immune activation or immune modulation via Globo series antigens |
| KR20230117482A (ko) | 2016-07-27 | 2023-08-08 | 오비아이 파머 인코퍼레이티드 | 면역원성/치료 글리칸 조성물 및 그의 용도 |
| CN110062767B (zh) | 2016-07-29 | 2023-07-11 | 台湾浩鼎生技股份有限公司 | 人抗体、药物组合物和方法 |
| TWI822055B (zh) | 2016-11-21 | 2023-11-11 | 台灣浩鼎生技股份有限公司 | 共軛生物分子、醫藥組成物及方法 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| KR20190137808A (ko) * | 2017-04-13 | 2019-12-11 | 아쥬반스 테크놀로지스 인코포레이티드 | 트리테르펜 사포닌, 중간체 및 보조제 배합물 |
| SG11201909584QA (en) * | 2017-04-25 | 2019-11-28 | Adjuvance Technologies Inc | Triterpene saponin analogues |
| EP3615039A4 (en) * | 2017-04-25 | 2021-01-13 | Adjuvance Technologies, Inc. | TRITERPENIC SAPONIN ANALOGUES |
| KR20200098476A (ko) | 2017-10-16 | 2020-08-20 | 아쥬반스 테크놀로지스 인코포레이티드 | 트리테르펜 사포닌 유사체 |
| US11548908B2 (en) | 2017-12-29 | 2023-01-10 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| WO2019183159A1 (en) * | 2018-03-20 | 2019-09-26 | The Uab Research Foundation | Saponin-based vaccine adjuvants |
| WO2020006176A1 (en) | 2018-06-27 | 2020-01-02 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
| WO2020049572A1 (en) | 2018-09-06 | 2020-03-12 | Yeda Research And Development Co. Ltd. | Cellulose-synthase-like enzymes and uses thereof |
| WO2020055503A1 (en) | 2018-09-14 | 2020-03-19 | Massachusetts Institute Of Technology | Nanoparticle vaccine adjuvant and methods of use thereof |
| CN118373810A (zh) | 2018-12-27 | 2024-07-23 | 糖模拟物有限公司 | 抑制c-糖苷的半乳凝素-3 |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| US20220409721A1 (en) * | 2019-11-05 | 2022-12-29 | Adjuvance Technologies, Inc. | Varicella zoster |
| US20230128815A1 (en) * | 2020-03-23 | 2023-04-27 | Adjuvance Technologies, Inc. | Adjuvant compounds, salt forms, and formulations |
| US20250282811A1 (en) * | 2021-10-02 | 2025-09-11 | Desert King Chile S.A | A 3-o-monodesmosidic saponins extract, stable at physiological ph, method for preparing it from a quillaja plant extract cultured with a microbial consortium, uses and such microbial consortium |
| EP4190359A1 (en) | 2021-12-03 | 2023-06-07 | Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE | Saponin-based adjuvants and vaccines |
| WO2023114570A1 (en) | 2021-12-19 | 2023-06-22 | Massachusetts Institute Of Technology | Compositions and methods for long-lasting germinal center responses to a priming immunization |
| EP4466278A1 (en) | 2022-01-19 | 2024-11-27 | Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE | Saponin-based adjuvants and vaccines |
| WO2024218268A1 (en) | 2023-04-20 | 2024-10-24 | Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune | Saponin derivatives as adjuvants and photoaffinity probes |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6112695A (ja) * | 1984-06-28 | 1986-01-21 | Rikagaku Kenkyusho | シアル酸誘導体 |
| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US5583112A (en) | 1987-05-29 | 1996-12-10 | Cambridge Biotech Corporation | Saponin-antigen conjugates and the use thereof |
| JPH09169648A (ja) * | 1995-12-22 | 1997-06-30 | Nippon Shinyaku Co Ltd | 医薬組成物 |
| US6231859B1 (en) | 1996-12-02 | 2001-05-15 | Aquila Biopharmaceuticals, Inc. | Saponin adjuvant compositions |
| DE69637435T2 (de) * | 1996-12-02 | 2009-02-19 | Antigenics Inc. | Saponin-zusammensetzungen und deren verwendung |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| ES2235330T3 (es) | 1997-05-20 | 2005-07-01 | Galenica Pharmaceuticals, Inc. | Analogos de saponionas triterpenicas que tienen actividad ayuvante. |
| EP0988053A1 (en) * | 1997-06-11 | 2000-03-29 | Aquila Biopharmaceuticals, Inc. | Purified saponins as oral adjuvants |
| US6262029B1 (en) | 1998-08-14 | 2001-07-17 | Galenica Pharmaceuticals, Inc. | Chemically modified saponins and the use thereof as adjuvants |
| US7457415B2 (en) | 1998-08-20 | 2008-11-25 | Akikaze Technologies, Llc | Secure information distribution system utilizing information segment scrambling |
| US6716428B1 (en) | 1999-10-06 | 2004-04-06 | The Ohio State University Research Foundation | Antigenic modification of polypeptides |
| US20040242502A1 (en) * | 2003-04-08 | 2004-12-02 | Galenica Pharmaceuticals, Inc. | Semi-synthetic saponin analogs with carrier and immune stimulatory activities for DNA and RNA vaccines |
| WO2006116876A1 (en) * | 2005-05-04 | 2006-11-09 | National Research Council Of Canada | Method for production of saponaria from microspores |
| CN100335073C (zh) * | 2005-08-19 | 2007-09-05 | 浙江大学 | 木鳖子含三萜皂甙成分提取物的制备方法 |
| CA3096084C (en) * | 2008-04-08 | 2022-12-20 | Sloan-Kettering Institute For Cancer Research | Triterpene saponins, methods of synthesis, and uses thereof |
| CN101322734B (zh) | 2008-07-22 | 2013-05-29 | 沈阳药科大学 | 具有抗炎免疫作用的轮叶党参总皂苷及其制备方法 |
| ES2887400T3 (es) * | 2014-05-30 | 2021-12-22 | Memorial Sloan Kettering Cancer Center | Análogos mínimos de saponina, síntesis y uso de los mismos |
-
2009
- 2009-04-08 CA CA3096084A patent/CA3096084C/en active Active
- 2009-04-08 EP EP20186996.3A patent/EP3868771A1/en active Pending
- 2009-04-08 KR KR1020217015136A patent/KR102453184B1/ko active Active
- 2009-04-08 KR KR1020197003429A patent/KR102085687B1/ko active Active
- 2009-04-08 WO PCT/US2009/039954 patent/WO2009126737A2/en not_active Ceased
- 2009-04-08 AU AU2009233757A patent/AU2009233757B2/en active Active
- 2009-04-08 CA CA2720771A patent/CA2720771C/en active Active
- 2009-04-08 JP JP2011504157A patent/JP5706815B2/ja not_active Expired - Fee Related
- 2009-04-08 EP EP18161023.9A patent/EP3357931B1/en active Active
- 2009-04-08 CN CN201510047889.3A patent/CN104710487A/zh active Pending
- 2009-04-08 KR KR1020167022654A patent/KR101825315B1/ko active Active
- 2009-04-08 CA CA2993582A patent/CA2993582C/en active Active
- 2009-04-08 CN CN200980116830.8A patent/CN102112484B/zh active Active
- 2009-04-08 KR KR1020187002556A patent/KR101947332B1/ko active Active
- 2009-04-08 KR KR1020107024935A patent/KR101651695B1/ko active Active
- 2009-04-08 US US12/420,803 patent/US8283456B2/en active Active
- 2009-04-08 KR KR1020207006108A patent/KR102256410B1/ko active Active
- 2009-04-08 ES ES18161023T patent/ES2827804T3/es active Active
- 2009-04-08 EP EP09731210.2A patent/EP2280987B1/en active Active
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2010
- 2010-10-07 IL IL208535A patent/IL208535A/en not_active IP Right Cessation
-
2012
- 2012-09-13 US US13/613,312 patent/US8889842B2/en active Active
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2014
- 2014-09-24 US US14/494,720 patent/US9718850B2/en active Active
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2015
- 2015-02-27 JP JP2015038239A patent/JP2015134793A/ja not_active Withdrawn
- 2015-03-02 IL IL237505A patent/IL237505A/en active IP Right Grant
- 2015-05-28 IL IL239051A patent/IL239051B/en active IP Right Grant
- 2015-12-17 HK HK15112457.4A patent/HK1211591A1/xx unknown
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2017
- 2017-02-03 JP JP2017018192A patent/JP6786410B2/ja active Active
- 2017-06-16 US US15/626,046 patent/US11447515B2/en active Active
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2019
- 2019-01-07 JP JP2019000534A patent/JP6770596B2/ja active Active
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2020
- 2020-07-08 JP JP2020117691A patent/JP2020169206A/ja active Pending
-
2021
- 2021-03-04 IL IL281261A patent/IL281261B2/en unknown
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2022
- 2022-09-19 US US17/947,716 patent/US12227535B2/en active Active
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2025
- 2025-02-18 US US19/056,443 patent/US20250188109A1/en active Pending
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