JP2017105790A5 - - Google Patents
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- JP2017105790A5 JP2017105790A5 JP2017004063A JP2017004063A JP2017105790A5 JP 2017105790 A5 JP2017105790 A5 JP 2017105790A5 JP 2017004063 A JP2017004063 A JP 2017004063A JP 2017004063 A JP2017004063 A JP 2017004063A JP 2017105790 A5 JP2017105790 A5 JP 2017105790A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- prg4
- composition according
- effective amount
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 101710127913 Proteoglycan 4 Proteins 0.000 claims 9
- 102100028965 Proteoglycan 4 Human genes 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 101001123332 Homo sapiens Proteoglycan 4 Proteins 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 229960004676 antithrombotic agent Drugs 0.000 claims 1
- 210000000746 body region Anatomy 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 239000005482 chemotactic factor Substances 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 210000004207 dermis Anatomy 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 102000054055 human PRG4 Human genes 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002188 osteogenic effect Effects 0.000 claims 1
- 206010033675 panniculitis Diseases 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 229930002330 retinoic acid Natural products 0.000 claims 1
- 230000036558 skin tension Effects 0.000 claims 1
- 230000036548 skin texture Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 210000004304 subcutaneous tissue Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 229960001727 tretinoin Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18052509P | 2009-05-22 | 2009-05-22 | |
| US61/180,525 | 2009-05-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014241399A Division JP6159704B2 (ja) | 2009-05-22 | 2014-11-28 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018200467A Division JP2019048824A (ja) | 2009-05-22 | 2018-10-25 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017105790A JP2017105790A (ja) | 2017-06-15 |
| JP2017105790A5 true JP2017105790A5 (https=) | 2017-10-26 |
| JP6483164B2 JP6483164B2 (ja) | 2019-03-13 |
Family
ID=43126811
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012512085A Pending JP2012527485A (ja) | 2009-05-22 | 2010-05-24 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
| JP2014241399A Expired - Fee Related JP6159704B2 (ja) | 2009-05-22 | 2014-11-28 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
| JP2017004063A Expired - Fee Related JP6483164B2 (ja) | 2009-05-22 | 2017-01-13 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
| JP2018200467A Pending JP2019048824A (ja) | 2009-05-22 | 2018-10-25 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012512085A Pending JP2012527485A (ja) | 2009-05-22 | 2010-05-24 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
| JP2014241399A Expired - Fee Related JP6159704B2 (ja) | 2009-05-22 | 2014-11-28 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018200467A Pending JP2019048824A (ja) | 2009-05-22 | 2018-10-25 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9730865B2 (https=) |
| EP (1) | EP2432492B1 (https=) |
| JP (4) | JP2012527485A (https=) |
| CN (1) | CN102711796A (https=) |
| CA (2) | CA2762989C (https=) |
| ES (1) | ES2532526T3 (https=) |
| WO (1) | WO2010135736A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2762989C (en) | 2009-05-22 | 2021-04-13 | Benjamin Sullivan | Prg4 for treatment of oral cavity boundary lubrication disorders |
| WO2011091000A2 (en) * | 2010-01-19 | 2011-07-28 | Singularis, Inc. | Oral care compositions and methods |
| WO2015060935A1 (en) | 2013-10-22 | 2015-04-30 | Lubris, Llc | Control of rheological properties of mixed hyaluronate/lubricin solutions |
| US20150141328A1 (en) * | 2013-11-18 | 2015-05-21 | The Schepens Eye Research Institute | Stimulation of human meibomian gland function |
| EP3074022B1 (en) * | 2013-11-26 | 2022-03-30 | Lubris LLC | Compositions and methods for inhibiting intercellular interactions |
| EP2896429B1 (en) * | 2014-01-20 | 2018-07-18 | COR S.a.r.l. | Skin Protector |
| RU2017129880A (ru) | 2015-01-26 | 2019-03-04 | ЛУБРИС ЭлЭлСи | Применение prg4 в качестве противовоспалительного средства |
| MA42148A (fr) * | 2015-05-19 | 2018-04-04 | Lubris Llc | Utilisation de prg4 pour améliorer l'acuité visuelle dynamique et les aberrations d'ordre supérieur |
| WO2016207299A1 (en) * | 2015-06-23 | 2016-12-29 | Fertin Pharma A/S | Chewing gum composition for use in alleviation of xerostomia induced by radiotherapy treatment |
| CN105055949A (zh) * | 2015-08-10 | 2015-11-18 | 孙霞 | 一种治疗小儿口腔溃疡的中药 |
| CN108157358A (zh) * | 2018-03-02 | 2018-06-15 | 沈阳汇翼宁消毒科技有限公司 | 一种消毒液及其制备方法 |
| BR112020025148A2 (pt) * | 2018-06-21 | 2021-03-09 | Lubris Llc | Lubricina para uso na cicatrização de feridas |
| WO2020097345A1 (en) * | 2018-11-08 | 2020-05-14 | The Schepens Eye Research Institute, Inc. | Therapeutic approaches for tissue reconstruction and wound healing treatment |
| WO2020136606A1 (en) | 2018-12-29 | 2020-07-02 | 3M Innovative Properties Company | Oral articles and methods of use |
| EP3902523A1 (en) | 2018-12-29 | 2021-11-03 | 3M Innovative Properties Company | Oral articles and methods of use |
| BR112021024266A2 (pt) | 2019-06-14 | 2022-01-11 | Procter & Gamble | Composições para tratamento bucal sem enxágue |
| WO2020248232A1 (en) * | 2019-06-14 | 2020-12-17 | The Procter & Gamble Company | Leave-on oral care compositions |
| EP3982913A1 (en) | 2019-06-14 | 2022-04-20 | The Procter & Gamble Company | Leave-on oral care compositions |
| WO2020248239A1 (en) * | 2019-06-14 | 2020-12-17 | The Procter & Gamble Company | Leave-on oral care compositions |
| EP3982912A1 (en) | 2019-06-14 | 2022-04-20 | The Procter & Gamble Company | Leave-on oral care compositions |
| JP7272214B2 (ja) * | 2019-09-24 | 2023-05-12 | 日油株式会社 | デンタルプラーク・ステイン付着防止剤および口腔用組成物 |
| CN111944595B (zh) * | 2020-08-21 | 2022-08-09 | 健尔康医疗科技股份有限公司 | 一种医用外科器械用润滑剂及其制备和使用方法 |
| KR20250152087A (ko) * | 2023-10-10 | 2025-10-22 | 파인·바이오메디컬 유겐가이샤 | 순환액 및 윤활성 조정제 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1981002977A1 (en) * | 1980-04-25 | 1981-10-29 | Orthana Kemisk Fab As | Sterilized,preserved,stable mucine-containing solutions and sterilization method |
| US4938963A (en) * | 1988-11-22 | 1990-07-03 | Parnell Pharmaceuticals, Inc. | Method and composition for treating xerostomia |
| US6433142B1 (en) | 1989-08-08 | 2002-08-13 | Genetics Institute, Llc | Megakaryocyte stimulating factors |
| US5326558A (en) | 1989-08-08 | 1994-07-05 | Genetics Institute, Inc. | Megakaryocytopoietic factor |
| US6743774B1 (en) | 1999-04-23 | 2004-06-01 | Rhode Island Hospital | Tribonectins |
| US7001881B1 (en) | 1999-04-23 | 2006-02-21 | Rhode Island Hospital | Tribonectins |
| US6960562B2 (en) | 1999-04-23 | 2005-11-01 | Rhode Island Hospital, A Lifespan Partner | Tribonectin polypeptides and uses thereof |
| GB2361870A (en) * | 2000-05-03 | 2001-11-07 | Zia Hashmi | Treating xerostomia |
| EP1347993A2 (en) * | 2000-12-29 | 2003-10-01 | Glaxo Group Limited | Superficial zone protein and methods of making and using same |
| US7071228B2 (en) * | 2002-10-23 | 2006-07-04 | Parks L Dean | Method of treating musculoskeletal and connective tissue inflammations |
| US7415381B2 (en) | 2003-01-09 | 2008-08-19 | Rhode Island Hospital, A Lifespan Partner | Joint friction sensing |
| RO120171B1 (ro) * | 2003-05-23 | 2005-10-28 | Ioan Nedelcu | Produse cosmetice şi pentru igienă, procedeu de obţinere şi procedeu de aplicare a acestora |
| WO2005000331A2 (en) | 2003-06-04 | 2005-01-06 | Mucosal Therapeutics, Inc. | Compositions for the treatment and prevention of degenerative joint disorders |
| DK1663291T3 (da) * | 2003-08-14 | 2012-07-02 | Wyeth Llc | Rekombinante lubricinmolekyler og anvendelser deraf |
| CA2558497A1 (en) | 2004-03-05 | 2005-09-15 | Synthes (U.S.A.) | Use of a mixture for the production of an agent for treating defective or degenerated cartilage in the production of natural cartilage replacement in vitro |
| US8034796B2 (en) * | 2004-04-07 | 2011-10-11 | The University Of Georgia Research Foundation, Inc. | Glucosamine and glucosamine/anti-inflammatory mutual prodrugs, compositions, and methods |
| WO2005102363A2 (en) | 2004-04-20 | 2005-11-03 | Mucosal Therapeutics Llc | Methods of promoting cartilage healing or cartilage integration |
| EP1778360A2 (en) | 2004-07-23 | 2007-05-02 | Mucosal Therapeutics LLC | Compositions and methods for viscosupplementation |
| BRPI0514037B8 (pt) | 2004-08-02 | 2021-05-25 | Glaxo Group Ltd | composição para o cuidado oral |
| WO2006060473A2 (en) * | 2004-12-03 | 2006-06-08 | Mucosal Therapeutics Llc | Methods of treatment of injured or diseased joints with lubricin compositions |
| US20070111327A1 (en) | 2005-05-05 | 2007-05-17 | Jay Gregory D | Methods of detecting lubricin |
| US8057458B2 (en) | 2006-10-30 | 2011-11-15 | Warsaw Orthopedic, Inc. | Method for treating facet pain |
| US20090068247A1 (en) | 2007-09-12 | 2009-03-12 | Mucosal Therapeutics | Biocompatible devices coated with a tribonectin and methods for their production |
| US20090104148A1 (en) | 2007-09-18 | 2009-04-23 | Jay Gregory D | Treatment and prevention of joint disease |
| HUE024146T2 (en) | 2008-05-07 | 2016-02-29 | Univ California | Medical filling and enrichment of eye surface lubrication |
| US8506944B2 (en) | 2008-05-07 | 2013-08-13 | The Regents Of The University Of California | Replenishment and enrichment of ocular surface lubrication |
| CN102239368A (zh) * | 2008-12-19 | 2011-11-09 | 考泰斯德事隆Cvs有限公司 | 车辆液体加热器 |
| US8980840B2 (en) | 2009-01-13 | 2015-03-17 | Schepens Eye Research Institute | Therapeutic modulation of vaginal epithelium boundary lubrication |
| CA2762989C (en) | 2009-05-22 | 2021-04-13 | Benjamin Sullivan | Prg4 for treatment of oral cavity boundary lubrication disorders |
| WO2011019963A2 (en) | 2009-08-13 | 2011-02-17 | Singularis, Inc. | Prg4 treatment for interstitial cystitis |
| WO2011091000A2 (en) | 2010-01-19 | 2011-07-28 | Singularis, Inc. | Oral care compositions and methods |
| US20130116186A1 (en) | 2011-10-04 | 2013-05-09 | Rhode Island Hospital, A Lifespan Partner | Lubricin injections to maintain cartilage health |
| WO2015060935A1 (en) | 2013-10-22 | 2015-04-30 | Lubris, Llc | Control of rheological properties of mixed hyaluronate/lubricin solutions |
-
2010
- 2010-05-24 CA CA2762989A patent/CA2762989C/en active Active
- 2010-05-24 WO PCT/US2010/035956 patent/WO2010135736A2/en not_active Ceased
- 2010-05-24 EP EP10778522.2A patent/EP2432492B1/en active Active
- 2010-05-24 ES ES10778522.2T patent/ES2532526T3/es active Active
- 2010-05-24 CN CN2010800337956A patent/CN102711796A/zh active Pending
- 2010-05-24 US US13/321,532 patent/US9730865B2/en active Active
- 2010-05-24 CA CA3110817A patent/CA3110817C/en active Active
- 2010-05-24 JP JP2012512085A patent/JP2012527485A/ja active Pending
-
2014
- 2014-11-28 JP JP2014241399A patent/JP6159704B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-13 JP JP2017004063A patent/JP6483164B2/ja not_active Expired - Fee Related
- 2017-08-14 US US15/676,433 patent/US10383796B2/en active Active
-
2018
- 2018-10-25 JP JP2018200467A patent/JP2019048824A/ja active Pending
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