JP2017105790A5 - - Google Patents
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- JP2017105790A5 JP2017105790A5 JP2017004063A JP2017004063A JP2017105790A5 JP 2017105790 A5 JP2017105790 A5 JP 2017105790A5 JP 2017004063 A JP2017004063 A JP 2017004063A JP 2017004063 A JP2017004063 A JP 2017004063A JP 2017105790 A5 JP2017105790 A5 JP 2017105790A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- prg4
- composition according
- effective amount
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 102100019040 PRG4 Human genes 0.000 claims 10
- 101700020998 PRG4 Proteins 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 3
- 210000000088 Lip Anatomy 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 210000003467 Cheek Anatomy 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 210000004207 Dermis Anatomy 0.000 claims 1
- 229940088597 Hormone Drugs 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 210000004304 Subcutaneous Tissue Anatomy 0.000 claims 1
- SHGAZHPCJJPHSC-NWVFGJFESA-N Tretinoin Chemical compound OC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NWVFGJFESA-N 0.000 claims 1
- 229960001727 Tretinoin Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agents Drugs 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 210000000746 body regions Anatomy 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 239000005482 chemotactic factor Substances 0.000 claims 1
- 229960005188 collagen Drugs 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000002188 osteogenic Effects 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 229930002330 retinoic acid Natural products 0.000 claims 1
- 230000036558 skin tension Effects 0.000 claims 1
- 230000036548 skin texture Effects 0.000 claims 1
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Claims (13)
- 皮膚科学的に許容される粘稠溶液中に、配列番号１のアミノ酸配列と少なくとも９５％の一次アミノ酸配列の相同性を有するプロテオグリカン４（ＰＲＧ４）の有効量を含む、患者の顔又はヒトの体の選択された領域の組織ボリューム、皮膚の緊張感、肌理、及び張りを満たし又は回復させるための医薬組成物。
- 前記ＰＲＧ４は、配列番号１のアミノ酸配列を含む、請求項１に記載の医薬組成物。
- 前記選択された体の領域が、眼窩周辺領域、唇、頬領域、鼻唇溝、口唇−下顎溝、首、又は手である、請求項１に記載の医薬組成物。
- 更に、皮膚科学的有効量のヒアルロン酸又はコラーゲンと組み合わせてなる、請求項１に記載の医薬組成物。
- 更に、皮膚科学的有効量のカルボキシメチルセルロース、ポリエチレングリコール及び／又はポリエチレンオキシドと組み合わせてなる、請求項１に記載の医薬組成物。
- 更に、抗血栓薬、抗炎症薬、ホルモン、走化性因子、鎮痛薬、増殖因子、サイトカイン、骨形成因子及び麻酔薬からなる群から選択される薬物と組み合わせてなる、請求項１に記載の医薬組成物。
- 更に、レチノイン酸と組み合わせてなる、請求項１に記載の医薬組成物。
- 更に、重水素減少水と組み合わせてなる、請求項１に記載の医薬組成物。
- 前記組成物は注射により、真皮又は皮下組織に投与される、請求項１に記載の医薬組成物。
- 前記ＰＲＧ４は組み換えＰＲＧ４である、請求項１に記載の医薬組成物。
- 前記ＰＲＧ４の濃度が１０〜１０，０００μｇ／ｍＬである、請求項１に記載の医薬組成物。
- 前記ＰＲＧ４はヒトＰＲＧ４である、請求項１に記載の医薬組成物。
- 前記ＰＲＧ４が、単離又は精製された天然ＰＲＧ４タンパク質である、請求項１に記載の医薬組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18052509P | 2009-05-22 | 2009-05-22 | |
| US61/180,525 | 2009-05-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014241399A Division JP6159704B2 (ja) | 2009-05-22 | 2014-11-28 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018200467A Division JP2019048824A (ja) | 2009-05-22 | 2018-10-25 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017105790A JP2017105790A (ja) | 2017-06-15 |
| JP2017105790A5 true JP2017105790A5 (ja) | 2017-10-26 |
| JP6483164B2 JP6483164B2 (ja) | 2019-03-13 |
Family
ID=43126811
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012512085A Pending JP2012527485A (ja) | 2009-05-22 | 2010-05-24 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
| JP2014241399A Expired - Fee Related JP6159704B2 (ja) | 2009-05-22 | 2014-11-28 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
| JP2017004063A Active JP6483164B2 (ja) | 2009-05-22 | 2017-01-13 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
| JP2018200467A Pending JP2019048824A (ja) | 2009-05-22 | 2018-10-25 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012512085A Pending JP2012527485A (ja) | 2009-05-22 | 2010-05-24 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
| JP2014241399A Expired - Fee Related JP6159704B2 (ja) | 2009-05-22 | 2014-11-28 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018200467A Pending JP2019048824A (ja) | 2009-05-22 | 2018-10-25 | Ｐｒｇ４及びその治療調節作用の応用及び使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9730865B2 (ja) |
| EP (1) | EP2432492B1 (ja) |
| JP (4) | JP2012527485A (ja) |
| CN (1) | CN102711796A (ja) |
| CA (2) | CA2762989C (ja) |
| ES (1) | ES2532526T3 (ja) |
| WO (1) | WO2010135736A2 (ja) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9730865B2 (en) | 2009-05-22 | 2017-08-15 | Lubris, Llc | Application and uses of PRG4 and therapeutic modulation thereof |
| US11213566B2 (en) * | 2010-01-19 | 2022-01-04 | Lubris Llc | Oral care compositions and methods |
| WO2015060935A1 (en) | 2013-10-22 | 2015-04-30 | Lubris, Llc | Control of rheological properties of mixed hyaluronate/lubricin solutions |
| US20150141328A1 (en) * | 2013-11-18 | 2015-05-21 | The Schepens Eye Research Institute | Stimulation of human meibomian gland function |
| AU2014354859B2 (en) | 2013-11-26 | 2020-04-09 | Lubris Llc | Compositions and methods for inhibiting intercellular interactions |
| EP2896429B1 (en) | 2014-01-20 | 2018-07-18 | COR S.a.r.l. | Skin Protector |
| CN113908257A (zh) | 2015-01-26 | 2022-01-11 | 卢布里斯有限责任公司 | Prg4作为抗炎剂的应用 |
| PL3300482T3 (pl) * | 2015-05-19 | 2022-01-03 | Lubris Llc | Zastosowanie prg4 do poprawy dynamicznej ostrości wzroku i aberracji wyższego rzędu |
| US10695292B2 (en) | 2015-06-23 | 2020-06-30 | Fertin Pharma A/S | Chewing gum composition for use in alleviation of xerostomia induced by radiotherapy treatment |
| CN105055949A (zh) * | 2015-08-10 | 2015-11-18 | 孙霞 | 一种治疗小儿口腔溃疡的中药 |
| CN108157358A (zh) * | 2018-03-02 | 2018-06-15 | 沈阳汇翼宁消毒科技有限公司 | 一种消毒液及其制备方法 |
| AU2019290206A1 (en) * | 2018-06-21 | 2021-01-07 | Lubris Llc | Lubricin for use in wound healing |
| WO2020248232A1 (en) * | 2019-06-14 | 2020-12-17 | The Procter & Gamble Company | Leave-on oral care compositions |
| WO2020248239A1 (en) * | 2019-06-14 | 2020-12-17 | The Procter & Gamble Company | Leave-on oral care compositions |
| CN113950319A (zh) | 2019-06-14 | 2022-01-18 | 宝洁公司 | 免洗型口腔护理组合物 |
| CN114040743A (zh) * | 2019-06-14 | 2022-02-11 | 宝洁公司 | 免洗型口腔护理组合物 |
| MX2021015126A (es) | 2019-06-14 | 2022-01-24 | Procter & Gamble | Composiciones para el cuidado bucal para usar y no enjuagar. |
| JP7272214B2 (ja) * | 2019-09-24 | 2023-05-12 | 日油株式会社 | デンタルプラーク・ステイン付着防止剤および口腔用組成物 |
| CN111944595B (zh) * | 2020-08-21 | 2022-08-09 | 健尔康医疗科技股份有限公司 | 一种医用外科器械用润滑剂及其制备和使用方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1981002977A1 (en) * | 1980-04-25 | 1981-10-29 | Orthana Kemisk Fab As | Sterilized,preserved,stable mucine-containing solutions and sterilization method |
| US4938963A (en) * | 1988-11-22 | 1990-07-03 | Parnell Pharmaceuticals, Inc. | Method and composition for treating xerostomia |
| US5326558A (en) | 1989-08-08 | 1994-07-05 | Genetics Institute, Inc. | Megakaryocytopoietic factor |
| US6433142B1 (en) | 1989-08-08 | 2002-08-13 | Genetics Institute, Llc | Megakaryocyte stimulating factors |
| US7001881B1 (en) | 1999-04-23 | 2006-02-21 | Rhode Island Hospital | Tribonectins |
| US6743774B1 (en) | 1999-04-23 | 2004-06-01 | Rhode Island Hospital | Tribonectins |
| US6960562B2 (en) | 1999-04-23 | 2005-11-01 | Rhode Island Hospital, A Lifespan Partner | Tribonectin polypeptides and uses thereof |
| GB2361870A (en) * | 2000-05-03 | 2001-11-07 | Zia Hashmi | Treating xerostomia |
| US20030180948A1 (en) * | 2000-12-29 | 2003-09-25 | Hutchins Jeff T. | Superficial zone protein and methods of making and using same |
| US7071228B2 (en) * | 2002-10-23 | 2006-07-04 | Parks L Dean | Method of treating musculoskeletal and connective tissue inflammations |
| US7415381B2 (en) | 2003-01-09 | 2008-08-19 | Rhode Island Hospital, A Lifespan Partner | Joint friction sensing |
| RO120171B1 (ro) * | 2003-05-23 | 2005-10-28 | Ioan Nedelcu | Produse cosmetice şi pentru igienă, procedeu de obţinere şi procedeu de aplicare a acestora |
| WO2005000331A2 (en) | 2003-06-04 | 2005-01-06 | Mucosal Therapeutics, Inc. | Compositions for the treatment and prevention of degenerative joint disorders |
| CN102924584A (zh) * | 2003-08-14 | 2013-02-13 | 惠氏公司 | 重组润滑素分子及其用途 |
| EP1740190A1 (de) | 2004-03-05 | 2007-01-10 | Synthes GmbH | Verwendung eines gemisches für die herstellung eines mittels zur behandlung von defektem oder degeneriertem knorpel in vivo und bei der herstellung von natürlichem knorpelersatz in vitro |
| US8034796B2 (en) * | 2004-04-07 | 2011-10-11 | The University Of Georgia Research Foundation, Inc. | Glucosamine and glucosamine/anti-inflammatory mutual prodrugs, compositions, and methods |
| WO2005102363A2 (en) | 2004-04-20 | 2005-11-03 | Mucosal Therapeutics Llc | Methods of promoting cartilage healing or cartilage integration |
| WO2006012492A2 (en) | 2004-07-23 | 2006-02-02 | Mucosal Therapeutics Llc | Compositions and methods for viscosupplementation |
| ATE466566T1 (de) | 2004-08-02 | 2010-05-15 | Glaxo Group Ltd | Neue zusammensetzung gegen xerostomie |
| WO2006060473A2 (en) | 2004-12-03 | 2006-06-08 | Mucosal Therapeutics Llc | Methods of treatment of injured or diseased joints with lubricin compositions |
| US20070111327A1 (en) | 2005-05-05 | 2007-05-17 | Jay Gregory D | Methods of detecting lubricin |
| US8057458B2 (en) | 2006-10-30 | 2011-11-15 | Warsaw Orthopedic, Inc. | Method for treating facet pain |
| US20090068247A1 (en) | 2007-09-12 | 2009-03-12 | Mucosal Therapeutics | Biocompatible devices coated with a tribonectin and methods for their production |
| US20090104148A1 (en) | 2007-09-18 | 2009-04-23 | Jay Gregory D | Treatment and prevention of joint disease |
| EP2285364B1 (en) | 2008-05-07 | 2015-01-21 | The Regents of The University of California | Therapeutic replenishment and enrichment of ocular surface lubrication |
| US8506944B2 (en) | 2008-05-07 | 2013-08-13 | The Regents Of The University Of California | Replenishment and enrichment of ocular surface lubrication |
| WO2010069355A1 (en) * | 2008-12-19 | 2010-06-24 | Kautex Textron Cvs Limited | Vehicular fluid heater |
| US8980840B2 (en) | 2009-01-13 | 2015-03-17 | Schepens Eye Research Institute | Therapeutic modulation of vaginal epithelium boundary lubrication |
| US9730865B2 (en) | 2009-05-22 | 2017-08-15 | Lubris, Llc | Application and uses of PRG4 and therapeutic modulation thereof |
| EP2464375B1 (en) | 2009-08-13 | 2017-06-14 | Lubris LLC | Prg4 treatment for interstitial cystitis |
| US11213566B2 (en) | 2010-01-19 | 2022-01-04 | Lubris Llc | Oral care compositions and methods |
| US20130116186A1 (en) | 2011-10-04 | 2013-05-09 | Rhode Island Hospital, A Lifespan Partner | Lubricin injections to maintain cartilage health |
| WO2015060935A1 (en) | 2013-10-22 | 2015-04-30 | Lubris, Llc | Control of rheological properties of mixed hyaluronate/lubricin solutions |
-
2010
- 2010-05-24 US US13/321,532 patent/US9730865B2/en active Active
- 2010-05-24 ES ES10778522.2T patent/ES2532526T3/es active Active
- 2010-05-24 CN CN2010800337956A patent/CN102711796A/zh active Pending
- 2010-05-24 EP EP10778522.2A patent/EP2432492B1/en active Active
- 2010-05-24 WO PCT/US2010/035956 patent/WO2010135736A2/en active Application Filing
- 2010-05-24 CA CA2762989A patent/CA2762989C/en active Active
- 2010-05-24 CA CA3110817A patent/CA3110817C/en active Active
- 2010-05-24 JP JP2012512085A patent/JP2012527485A/ja active Pending
-
2014
- 2014-11-28 JP JP2014241399A patent/JP6159704B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-13 JP JP2017004063A patent/JP6483164B2/ja active Active
- 2017-08-14 US US15/676,433 patent/US10383796B2/en active Active
-
2018
- 2018-10-25 JP JP2018200467A patent/JP2019048824A/ja active Pending
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