JP2017052962A5 - - Google Patents
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- Publication number
- JP2017052962A5 JP2017052962A5 JP2016214773A JP2016214773A JP2017052962A5 JP 2017052962 A5 JP2017052962 A5 JP 2017052962A5 JP 2016214773 A JP2016214773 A JP 2016214773A JP 2016214773 A JP2016214773 A JP 2016214773A JP 2017052962 A5 JP2017052962 A5 JP 2017052962A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- aminooxy
- oligosaccharide
- reactive group
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 31
- -1 aminooxy compound Chemical class 0.000 claims 20
- 229920001542 oligosaccharide Polymers 0.000 claims 20
- 150000002482 oligosaccharides Chemical class 0.000 claims 20
- 125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 claims 11
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000006239 protecting group Chemical group 0.000 claims 5
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical group CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 239000003054 catalyst Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 3
- DUIOPKIIICUYRZ-UHFFFAOYSA-N semicarbazide Chemical compound NNC(N)=O DUIOPKIIICUYRZ-UHFFFAOYSA-N 0.000 claims 3
- 150000001266 acyl halides Chemical class 0.000 claims 2
- 150000001350 alkyl halides Chemical class 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 150000008064 anhydrides Chemical class 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- BRWIZMBXBAOCCF-UHFFFAOYSA-N hydrazinecarbothioamide Chemical compound NNC(N)=S BRWIZMBXBAOCCF-UHFFFAOYSA-N 0.000 claims 2
- 239000012948 isocyanate Substances 0.000 claims 2
- 150000002513 isocyanates Chemical class 0.000 claims 2
- 150000002540 isothiocyanates Chemical class 0.000 claims 2
- UWROMLKEISLXAJ-UHFFFAOYSA-N (aminooxyamino)thiourea Chemical compound NONNC(N)=S UWROMLKEISLXAJ-UHFFFAOYSA-N 0.000 claims 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical group ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 150000001540 azides Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000002128 sulfonyl halide group Chemical group 0.000 claims 1
- WSRAUHOGHHXDJT-UHFFFAOYSA-N CC(C)(C)OC(NOCC(NN)=O)=O Chemical compound CC(C)(C)OC(NOCC(NN)=O)=O WSRAUHOGHHXDJT-UHFFFAOYSA-N 0.000 description 1
- LISGDTPBJHWLKP-UHFFFAOYSA-N CC(C)(C)OC(NOCC(Oc(c(F)c(cc1F)F)c1F)=O)=O Chemical compound CC(C)(C)OC(NOCC(Oc(c(F)c(cc1F)F)c1F)=O)=O LISGDTPBJHWLKP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88547107P | 2007-01-18 | 2007-01-18 | |
| US60/885,471 | 2007-01-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014204593A Division JP6039625B2 (ja) | 2007-01-18 | 2014-10-03 | アミノオキシ基を含むオリゴ糖およびその複合体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018044959A Division JP2018109194A (ja) | 2007-01-18 | 2018-03-13 | アミノオキシ基を含むオリゴ糖およびその複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017052962A JP2017052962A (ja) | 2017-03-16 |
| JP2017052962A5 true JP2017052962A5 (OSRAM) | 2017-06-08 |
| JP6309592B2 JP6309592B2 (ja) | 2018-04-11 |
Family
ID=39473250
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009546533A Active JP5999867B2 (ja) | 2007-01-18 | 2008-01-18 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2014204593A Active JP6039625B2 (ja) | 2007-01-18 | 2014-10-03 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2016214773A Active JP6309592B2 (ja) | 2007-01-18 | 2016-11-02 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2018044959A Pending JP2018109194A (ja) | 2007-01-18 | 2018-03-13 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2020134331A Pending JP2020185011A (ja) | 2007-01-18 | 2020-08-07 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2022113593A Pending JP2022137232A (ja) | 2007-01-18 | 2022-07-15 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2024207922A Pending JP2025029023A (ja) | 2007-01-18 | 2024-11-29 | アミノオキシ基を含むオリゴ糖およびその複合体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009546533A Active JP5999867B2 (ja) | 2007-01-18 | 2008-01-18 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2014204593A Active JP6039625B2 (ja) | 2007-01-18 | 2014-10-03 | アミノオキシ基を含むオリゴ糖およびその複合体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018044959A Pending JP2018109194A (ja) | 2007-01-18 | 2018-03-13 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2020134331A Pending JP2020185011A (ja) | 2007-01-18 | 2020-08-07 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2022113593A Pending JP2022137232A (ja) | 2007-01-18 | 2022-07-15 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2024207922A Pending JP2025029023A (ja) | 2007-01-18 | 2024-11-29 | アミノオキシ基を含むオリゴ糖およびその複合体 |
Country Status (21)
| Country | Link |
|---|---|
| US (6) | US8759501B2 (OSRAM) |
| EP (5) | EP3597655B1 (OSRAM) |
| JP (7) | JP5999867B2 (OSRAM) |
| CN (2) | CN101631794B (OSRAM) |
| CA (1) | CA2675968C (OSRAM) |
| CY (2) | CY1119954T1 (OSRAM) |
| DK (3) | DK2457919T3 (OSRAM) |
| ES (3) | ES2744574T3 (OSRAM) |
| FI (1) | FIC20220047I1 (OSRAM) |
| FR (1) | FR22C1061I2 (OSRAM) |
| HR (3) | HRP20130744T1 (OSRAM) |
| HU (3) | HUE036140T2 (OSRAM) |
| IL (3) | IL243117B2 (OSRAM) |
| LT (3) | LT2457920T (OSRAM) |
| LU (1) | LUC00290I2 (OSRAM) |
| NL (1) | NL301210I2 (OSRAM) |
| NO (2) | NO2457920T3 (OSRAM) |
| PL (3) | PL2457920T3 (OSRAM) |
| PT (3) | PT2121713E (OSRAM) |
| SI (2) | SI2457919T1 (OSRAM) |
| WO (1) | WO2008089403A2 (OSRAM) |
Families Citing this family (23)
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| PT2121713E (pt) * | 2007-01-18 | 2013-06-25 | Genzyme Corp | Oligossacáridos compreendendo um grupo aminooxi e seus conjugados |
| BRPI0815324A2 (pt) * | 2007-08-20 | 2015-07-14 | Protalix Ltd | "conjugado protêico que contém sacarídeos, processo de separação do conjugado protêico que contém sacarídeos, composição farmacêutica do conjugado protêico que contém sacarídeos, uso do conjugado protêico que contém sacarídeos e composto do conjugado protêico que contém sacarídeos" |
| EP2465542B1 (en) | 2008-12-16 | 2015-01-21 | Genzyme Corporation | Oligosaccharide-protein conjugates |
| CA2766614C (en) | 2009-07-03 | 2018-06-19 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Compounds targeting the cation-independent mannose 6-phosphate receptor |
| CN104530182A (zh) * | 2009-07-27 | 2015-04-22 | 利普森技术有限公司 | 非凝血蛋白的糖基多唾液酸化 |
| CA2769244A1 (en) | 2009-07-27 | 2011-02-03 | Lipoxen Technologies Limited | Glycopolysialylation of non-blood coagulation proteins |
| US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
| EP2585108A4 (en) * | 2010-06-24 | 2016-04-13 | Univ Kansas | CONJUGATES WITH AN N-OXIM BINDING AND ASSOCIATED METHODS |
| WO2012082635A1 (en) * | 2010-12-13 | 2012-06-21 | Ancora Pharmaceuticals, Inc. | Synthetic oligosaccharide group a streptococcus |
| DK2665814T3 (en) | 2011-01-20 | 2017-09-11 | Protalix Ltd | NUCLEIC ACID CONSTRUCTION FOR EXPRESSION OF ALPHA-GALACTOSIDASE IN PLANTS AND PLANT CELLS |
| HK1220980A1 (zh) | 2013-02-20 | 2017-05-19 | Valerion Therapeutics, Llc | 用於治疗庞贝氏症的方法和组合物 |
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| CA3010205A1 (en) | 2015-12-30 | 2017-07-06 | Amicus Therapeutics, Inc. | Augmented acid alpha-glucosidase for the treatment of pompe disease |
| EP3624831B1 (en) | 2017-05-15 | 2023-03-29 | Amicus Therapeutics, Inc. | Recombinant human acid alpha-glucosidase |
| TWI821227B (zh) | 2017-12-22 | 2023-11-11 | 美商健臻公司 | 胺甲喋呤誘發的免疫耐受性之生物標記 |
| KR20210081324A (ko) | 2018-08-02 | 2021-07-01 | 다인 세라퓨틱스, 인크. | 근육 표적화 복합체 및 안면견갑상완 근육 이영양증을 치료하기 위한 그의 용도 |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| AU2019377869A1 (en) * | 2018-11-08 | 2021-05-27 | Kaleido Biosciences, Inc. | Oligosaccharide compositions and methods of use thereof |
| CN115335081A (zh) | 2020-02-07 | 2022-11-11 | 诺华股份有限公司 | 靶向血浆蛋白降解 |
| IL295415A (en) | 2020-02-08 | 2022-10-01 | Genzyme Corp | Compositions and methods for treating pompe disease |
| WO2021257409A1 (en) | 2020-06-14 | 2021-12-23 | Genzyme Corporation | Compositions and methods for treating late-onset pompe disease |
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| PT2121713E (pt) | 2007-01-18 | 2013-06-25 | Genzyme Corp | Oligossacáridos compreendendo um grupo aminooxi e seus conjugados |
| EP2465542B1 (en) | 2008-12-16 | 2015-01-21 | Genzyme Corporation | Oligosaccharide-protein conjugates |
-
2008
- 2008-01-18 PT PT87279105T patent/PT2121713E/pt unknown
- 2008-01-18 EP EP19177425.6A patent/EP3597655B1/en active Active
- 2008-01-18 LT LTEP11188506.7T patent/LT2457920T/lt unknown
- 2008-01-18 ES ES11188504T patent/ES2744574T3/es active Active
- 2008-01-18 ES ES11188506.7T patent/ES2656314T3/es active Active
- 2008-01-18 SI SI200832088T patent/SI2457919T1/sl unknown
- 2008-01-18 DK DK11188504.2T patent/DK2457919T3/da active
- 2008-01-18 EP EP08727910.5A patent/EP2121713B1/en active Active
- 2008-01-18 PL PL11188506T patent/PL2457920T3/pl unknown
- 2008-01-18 CA CA2675968A patent/CA2675968C/en not_active Expired - Fee Related
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