JP2019500374A5 - - Google Patents
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- Publication number
- JP2019500374A5 JP2019500374A5 JP2018533649A JP2018533649A JP2019500374A5 JP 2019500374 A5 JP2019500374 A5 JP 2019500374A5 JP 2018533649 A JP2018533649 A JP 2018533649A JP 2018533649 A JP2018533649 A JP 2018533649A JP 2019500374 A5 JP2019500374 A5 JP 2019500374A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- pharmaceutically acceptable
- alkyl
- solvate
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 16
- 239000012453 solvate Substances 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 15
- 239000000651 prodrug Substances 0.000 claims 15
- 229940002612 prodrug Drugs 0.000 claims 15
- 125000004452 carbocyclyl group Chemical group 0.000 claims 12
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 125000000547 substituted alkyl group Chemical group 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000003107 substituted aryl group Chemical group 0.000 claims 7
- 125000001188 haloalkyl group Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 3
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 3
- 125000005884 carbocyclylalkyl group Chemical group 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000004306 triazinyl group Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021103372A JP2021167323A (ja) | 2015-12-23 | 2021-06-22 | グルココルチコイド受容体の阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562387282P | 2015-12-23 | 2015-12-23 | |
| US62/387,282 | 2015-12-23 | ||
| PCT/US2016/068431 WO2017112902A1 (en) | 2015-12-23 | 2016-12-22 | Inhibitors of glucocorticoid receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021103372A Division JP2021167323A (ja) | 2015-12-23 | 2021-06-22 | グルココルチコイド受容体の阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019500374A JP2019500374A (ja) | 2019-01-10 |
| JP2019500374A5 true JP2019500374A5 (OSRAM) | 2020-01-30 |
| JP6906525B2 JP6906525B2 (ja) | 2021-07-21 |
Family
ID=59091239
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018533649A Expired - Fee Related JP6906525B2 (ja) | 2015-12-23 | 2016-12-22 | グルココルチコイド受容体の阻害剤 |
| JP2021103372A Ceased JP2021167323A (ja) | 2015-12-23 | 2021-06-22 | グルココルチコイド受容体の阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021103372A Ceased JP2021167323A (ja) | 2015-12-23 | 2021-06-22 | グルココルチコイド受容体の阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11124537B2 (OSRAM) |
| EP (1) | EP3394078A4 (OSRAM) |
| JP (2) | JP6906525B2 (OSRAM) |
| CN (1) | CN108699102A (OSRAM) |
| AU (2) | AU2016377702B2 (OSRAM) |
| CA (1) | CA3009522A1 (OSRAM) |
| WO (1) | WO2017112902A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108699102A (zh) * | 2015-12-23 | 2018-10-23 | 欧瑞克制药公司 | 糖皮质激素受体抑制剂 |
| US11110103B2 (en) | 2015-12-23 | 2021-09-07 | Oric Pharmaceuticals, Inc. | Inhibitors of glucocorticoid receptor |
| AU2016379417B2 (en) | 2015-12-23 | 2020-09-24 | Oric Pharmaceuticals, Inc. | Inhibitors of glucocorticoid receptor |
| DK3523315T3 (da) * | 2016-10-07 | 2021-05-03 | Oric Pharmaceuticals Inc | Inhibitor af glucocorticoidreceptor |
| WO2019200217A1 (en) | 2018-04-13 | 2019-10-17 | Board Of Regents, The University Of Texas System | Compounds and methods for selective proteolysis of glucocorticoid receptors |
| EP4192460A4 (en) * | 2020-08-04 | 2024-10-23 | Oric Pharmaceuticals, Inc. | USES OF COMBINATIONS OF GLUCOCORTICOID RECEPTOR (GR) ANTAGONIST AND ANDROGEN RECEPTOR (AR) DEGRADING AGENT |
| WO2022046870A1 (en) * | 2020-08-31 | 2022-03-03 | The Trustees Of Indiana University | Methods to prevent high-grade serous ovarian cancer and breast cancer by administering antiprogestins |
| WO2023000135A1 (en) * | 2021-07-19 | 2023-01-26 | Context Biopharma Inc. | Processes of making onapristone and intermediates thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2528434B1 (fr) | 1982-06-11 | 1985-07-19 | Roussel Uclaf | Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament |
| ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
| FR2522328B1 (fr) | 1982-03-01 | 1986-02-14 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments |
| JP2785023B2 (ja) * | 1987-12-30 | 1998-08-13 | ルセル―ユクラフ | １７α位置を置換された１７β―ＯＨ―１９―ノルステロイドの新誘導体、その製造方法、その薬剤としての使用及びそれを含有する製薬組成物 |
| JPH02188599A (ja) * | 1988-11-16 | 1990-07-24 | Roussel Uclaf | ３―ケト―デルタ―４，９―１９―ノルステロイドから誘導される新物質及びそれらよりなる薬剤 |
| DE3921059A1 (de) | 1989-06-23 | 1991-01-10 | Schering Ag | 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
| FR2651435A1 (fr) | 1989-09-07 | 1991-03-08 | Roussel Uclaf | Nouvelle utilisation de composes anti-progestomimetiques. |
| DE4018167A1 (de) | 1990-06-01 | 1991-12-05 | Schering Ag | Verfahren zur herstellung von 10(beta)-h-steroiden |
| DE4042007A1 (de) | 1990-12-22 | 1992-06-25 | Schering Ag | 6,7-modifizierte-11(beta)-aryl-4-estrene |
| US5741787A (en) | 1993-08-04 | 1998-04-21 | Akzo Nobel N.V. | Antiglucocorticoid steroids for the treatment of anxiety disorders |
| WO1995017192A1 (en) | 1993-12-22 | 1995-06-29 | The Salk Institute For Biological Studies | Methods for reducing multidrug resistance |
| SK282570B6 (sk) | 1995-02-02 | 2002-10-08 | Schering Aktiengesellschaft | Antagonisty progesterónu na výrobu liekov na ošetrenie dysfunkčného maternicového krvácania |
| IL118974A (en) | 1995-08-17 | 2001-09-13 | Akzo Nobel Nv | History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them |
| IL122740A (en) | 1997-01-15 | 2003-09-17 | Akzo Nobel Nv | 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them |
| CN1085078C (zh) | 1998-01-07 | 2002-05-22 | 沈志华 | 用于大月份引产的复合药物 |
| US6512130B1 (en) | 2000-09-05 | 2003-01-28 | Council Of Scientific And Industrial Research | Mifepristone analogue, process for the preparation thereof and use thereof |
| EP1285927A3 (de) * | 2001-08-16 | 2005-06-29 | Schering Aktiengesellschaft | Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems |
| US7250408B2 (en) * | 2002-12-16 | 2007-07-31 | Bayer Schering Pharma Ag | Glucocorticoid receptor antagonists for prophylaxis and therapy of glucocorticoid-mediated hypogonadism, of sexual dysfunction and/or infertility |
| DK1989218T3 (da) * | 2006-02-17 | 2010-04-26 | Janssen Pharmaceutica Nv | 17-phosphor-steroidderivater, der er anvendelige som progesteronreceptormodulatorer |
| MX2008012492A (es) | 2006-03-29 | 2008-12-12 | Univ California | Compuestos de diariltiohidantoina. |
| PT2148681E (pt) | 2007-04-20 | 2016-06-17 | Preglem Sa | Moduladores seletivos da progesterona no tratamento da hemorragia uterina |
| US8658128B2 (en) | 2011-02-03 | 2014-02-25 | Pop Test Cortisol Llc | System and method for diagnosis and treatment |
| EP2545922A1 (en) | 2011-07-12 | 2013-01-16 | PregLem S.A. | Treatment of excessive menstrual bleeding associated with uterine fibroids |
| US20130029953A1 (en) * | 2011-07-28 | 2013-01-31 | Klaus Nickisch | Progesterone antagonists |
| US9289436B2 (en) | 2012-02-24 | 2016-03-22 | The University Of Chicago | Method of treatment of prostate cancer with androgen receptor and glucocorticoid receptor antagonists |
| EP2641602A1 (en) | 2012-03-23 | 2013-09-25 | PregLem S.A. | Method for treating gynecological diseases |
| US9096641B2 (en) | 2013-06-05 | 2015-08-04 | Evestra, Inc. | Imidazolyl progesterone antagonists |
| CA2933590C (en) | 2013-12-11 | 2023-10-03 | Sloan-Kettering Institute For Cancer Research | Glucocorticoid inhibitors for treatment of prostate cancer |
| CN104530166B (zh) | 2014-12-04 | 2016-08-24 | 陕西汉江药业集团股份有限公司 | 选择性还原4,6-共轭双烯-3-酮甾体化合物的方法 |
| CN108699102A (zh) | 2015-12-23 | 2018-10-23 | 欧瑞克制药公司 | 糖皮质激素受体抑制剂 |
| US11110103B2 (en) | 2015-12-23 | 2021-09-07 | Oric Pharmaceuticals, Inc. | Inhibitors of glucocorticoid receptor |
| AU2016379417B2 (en) | 2015-12-23 | 2020-09-24 | Oric Pharmaceuticals, Inc. | Inhibitors of glucocorticoid receptor |
| DK3523315T3 (da) | 2016-10-07 | 2021-05-03 | Oric Pharmaceuticals Inc | Inhibitor af glucocorticoidreceptor |
| US12233073B2 (en) | 2017-06-09 | 2025-02-25 | Regents Of The University Of Minnesota | Skin care formulations and skin cancer treatment |
| EP3773515A4 (en) | 2018-04-11 | 2022-03-23 | Oric Pharmaceuticals, Inc. | SOLID FORMS AND FORMULATIONS COMPRISING A GLUCOCORTICOID RECEPTOR ANTAGONIST AND THEIR USES |
-
2016
- 2016-12-22 CN CN201680082458.3A patent/CN108699102A/zh active Pending
- 2016-12-22 AU AU2016377702A patent/AU2016377702B2/en not_active Ceased
- 2016-12-22 CA CA3009522A patent/CA3009522A1/en active Pending
- 2016-12-22 EP EP16880121.5A patent/EP3394078A4/en not_active Withdrawn
- 2016-12-22 WO PCT/US2016/068431 patent/WO2017112902A1/en not_active Ceased
- 2016-12-22 US US16/065,626 patent/US11124537B2/en not_active Expired - Fee Related
- 2016-12-22 JP JP2018533649A patent/JP6906525B2/ja not_active Expired - Fee Related
-
2021
- 2021-03-31 AU AU2021202019A patent/AU2021202019B2/en not_active Ceased
- 2021-06-22 JP JP2021103372A patent/JP2021167323A/ja not_active Ceased
- 2021-08-17 US US17/404,493 patent/US20210395295A1/en not_active Abandoned