JP2017537937A5 - - Google Patents
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- Publication number
- JP2017537937A5 JP2017537937A5 JP2017531389A JP2017531389A JP2017537937A5 JP 2017537937 A5 JP2017537937 A5 JP 2017537937A5 JP 2017531389 A JP2017531389 A JP 2017531389A JP 2017531389 A JP2017531389 A JP 2017531389A JP 2017537937 A5 JP2017537937 A5 JP 2017537937A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- compound
- alkylene
- alkyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462090267P | 2014-12-10 | 2014-12-10 | |
| US62/090,267 | 2014-12-10 | ||
| US201562117846P | 2015-02-18 | 2015-02-18 | |
| US62/117,846 | 2015-02-18 | ||
| PCT/US2015/064814 WO2016094570A1 (en) | 2014-12-10 | 2015-12-09 | Small molecule inhibitors of fibrosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537937A JP2017537937A (ja) | 2017-12-21 |
| JP2017537937A5 true JP2017537937A5 (OSRAM) | 2018-12-13 |
| JP6706023B2 JP6706023B2 (ja) | 2020-06-03 |
Family
ID=56108132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017531389A Active JP6706023B2 (ja) | 2014-12-10 | 2015-12-09 | 線維症の小分子阻害剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10336735B2 (OSRAM) |
| EP (1) | EP3250036B1 (OSRAM) |
| JP (1) | JP6706023B2 (OSRAM) |
| KR (1) | KR102548066B1 (OSRAM) |
| CN (1) | CN107404878B (OSRAM) |
| AU (1) | AU2015360583B2 (OSRAM) |
| CA (1) | CA2968874C (OSRAM) |
| ES (1) | ES2879963T3 (OSRAM) |
| WO (1) | WO2016094570A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11028078B2 (en) * | 2011-09-07 | 2021-06-08 | The Johns Hopkins University | Itraconazole analogs and use thereof |
| US11571431B2 (en) | 2013-12-04 | 2023-02-07 | Galmed Research And Development Ltd | Aramchol salts |
| EP3099679B1 (en) * | 2014-02-01 | 2020-05-20 | University of Connecticut | Itraconazole analogues and methods of use thereof |
| IL243707A0 (en) | 2016-01-20 | 2016-05-01 | Galmed Res And Dev Ltd | Treatment to regulate the microbiota in the intestine |
| US11197870B2 (en) | 2016-11-10 | 2021-12-14 | Galmed Research And Development Ltd | Treatment for hepatic fibrosis |
| US11390613B2 (en) | 2017-08-20 | 2022-07-19 | University Of Connecticut | Azole analogues and methods of use thereof |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| US12435067B2 (en) | 2019-08-09 | 2025-10-07 | University Of Connecticut | Truncated itraconazole analogues and methods of use thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267179A (en) | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| US4619931A (en) | 1983-02-28 | 1986-10-28 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| US4791111A (en) | 1985-12-23 | 1988-12-13 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties |
| WO1995014056A1 (en) | 1993-11-19 | 1995-05-26 | Shell Internationale Research Maatschappij B.V. | Polyketone polymer composition |
| US5521186A (en) | 1994-10-27 | 1996-05-28 | Janssen Pharmaceutica N.V. | Apolipoprotein-β synthesis inhibitors |
| TW457240B (en) | 1995-04-20 | 2001-10-01 | Janssen Pharmaceutica Nv | Novel triazolones as apolipoprotein-B synthesis inhibitors |
| EP0957101A1 (en) | 1998-05-14 | 1999-11-17 | Janssen Pharmaceutica N.V. | Water soluble azoles as broad-spectrum antifungals |
| EP1206265B1 (en) | 1999-06-30 | 2003-11-12 | Merck & Co., Inc. | Src kinase inhibitor compounds |
| US6414013B1 (en) | 2000-06-19 | 2002-07-02 | Pharmacia & Upjohn S.P.A. | Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention |
| AU2003243354A1 (en) | 2002-05-31 | 2003-12-19 | Transform Pharmaceuticals, Inc. | Novel conazole crystalline forms and related processes, pharmaceutical compositions and methods |
| EP1655295A1 (en) * | 2004-11-03 | 2006-05-10 | Schering Aktiengesellschaft | Anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
| JP2010502741A (ja) * | 2006-09-11 | 2010-01-28 | キュリス，インコーポレイテッド | Ｐｔｋインヒビターとしての亜鉛結合部分を含む置換２−インドリノン |
| CN101896472A (zh) | 2007-12-13 | 2010-11-24 | 锡耶纳生物技术股份公司 | Hedgehog途径拮抗剂及其治疗应用 |
| WO2010021681A2 (en) | 2008-08-18 | 2010-02-25 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| WO2011088404A1 (en) | 2010-01-15 | 2011-07-21 | Infinity Pharmaceuticals , Inc | Treatment of fibrotic conditions using hedgehog inhibitors |
| WO2012047762A2 (en) | 2010-10-08 | 2012-04-12 | Amplyx Pharmaceuticals, Inc. | Antifungal agents |
| WO2013036866A1 (en) * | 2011-09-07 | 2013-03-14 | The Johns Hopkins University | Itraconazole analogs and use thereof |
| CA2863224A1 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
| EP2922818B1 (en) | 2012-11-24 | 2018-09-05 | Hangzhou Dac Biotech Co., Ltd | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| PL3004106T3 (pl) | 2013-06-07 | 2018-01-31 | Rhizen Pharmaceuticals S A | Podwójne selektywne inhibitory kinaz pi3 delta i gamma |
| AU2014274830B2 (en) | 2013-06-07 | 2017-11-09 | The California Institute For Biomedical Research | Small molecule inhibitors of fibrosis |
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2015
- 2015-12-09 EP EP15867774.0A patent/EP3250036B1/en active Active
- 2015-12-09 CN CN201580075884.XA patent/CN107404878B/zh active Active
- 2015-12-09 US US15/534,225 patent/US10336735B2/en active Active
- 2015-12-09 CA CA2968874A patent/CA2968874C/en active Active
- 2015-12-09 ES ES15867774T patent/ES2879963T3/es active Active
- 2015-12-09 KR KR1020177018790A patent/KR102548066B1/ko active Active
- 2015-12-09 AU AU2015360583A patent/AU2015360583B2/en active Active
- 2015-12-09 WO PCT/US2015/064814 patent/WO2016094570A1/en not_active Ceased
- 2015-12-09 JP JP2017531389A patent/JP6706023B2/ja active Active