JP2017048187A5 - - Google Patents
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- Publication number
- JP2017048187A5 JP2017048187A5 JP2016173482A JP2016173482A JP2017048187A5 JP 2017048187 A5 JP2017048187 A5 JP 2017048187A5 JP 2016173482 A JP2016173482 A JP 2016173482A JP 2016173482 A JP2016173482 A JP 2016173482A JP 2017048187 A5 JP2017048187 A5 JP 2017048187A5
- Authority
- JP
- Japan
- Prior art keywords
- immunostimulatory oligonucleotides
- cholesterol
- vaccine
- leucylamino
- dda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 10
- 229940107161 Cholesterol Drugs 0.000 claims description 5
- 235000012000 cholesterol Nutrition 0.000 claims description 5
- 239000000427 antigen Substances 0.000 claims description 3
- 102000038129 antigens Human genes 0.000 claims description 3
- 108091007172 antigens Proteins 0.000 claims description 3
- 229920000272 Oligonucleotide Polymers 0.000 claims 3
- 230000003308 immunostimulating Effects 0.000 claims 3
- 229960005486 vaccines Drugs 0.000 claims 3
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2S,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-4-[(2R,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 229920001888 polyacrylic acid Polymers 0.000 claims 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
Description
抗原とＣｐＧ、および抗原とＣｐＧ＋コレステロールの同時送達は、電気泳動におけるＣｐＧの移動度の遅延を示さなかった。ＵＶによって定量した際、遊離ＣｐＧと比較して同じ量のＣｐＧがＣｐＧ＋コレステロールの上清中で観察された。これは、ＣｐＧとコレステロールとの強い会合が存在しないことを示唆している。
Claims (1)
- １つまたは複数の抗原および１つまたは複数の免疫賦活性オリゴヌクレオチドおよび、追加の脂質なしで、コレステロールミクロスフェアを含むワクチンであって、ワクチンはＱｕｉｌ Ａ、ＤＤＡ、Ｃａｒｂｏｐｏｌ（登録商標）、およびＮ−（２−デオキシ−２−Ｌ−ロイシルアミノ−ｂ−Ｄ−グルコピラノシル）−Ｎ−オクタデシルドデカノイルアミドヒドロアセテートを含まず、前記１つまたは複数の免疫賦活性オリゴヌクレオチドはＯＲＮおよびＣｐＧ ＯＤＮからなる群から選択され、前記コレステロールおよび前記１つまたは複数の免疫賦活性オリゴヌクレオチドは一緒に混合されている、ワクチン。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34924410P | 2010-05-28 | 2010-05-28 | |
| US61/349,244 | 2010-05-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013513022A Division JP6034285B2 (ja) | 2010-05-28 | 2011-05-27 | 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017048187A JP2017048187A (ja) | 2017-03-09 |
| JP2017048187A5 true JP2017048187A5 (ja) | 2017-04-13 |
| JP6133482B2 JP6133482B2 (ja) | 2017-05-24 |
Family
ID=44626939
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013513022A Active JP6034285B2 (ja) | 2010-05-28 | 2011-05-27 | 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用 |
| JP2011118735A Withdrawn JP2011251963A (ja) | 2010-05-28 | 2011-05-27 | 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用 |
| JP2016173482A Active JP6133482B2 (ja) | 2010-05-28 | 2016-09-06 | 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013513022A Active JP6034285B2 (ja) | 2010-05-28 | 2011-05-27 | 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用 |
| JP2011118735A Withdrawn JP2011251963A (ja) | 2010-05-28 | 2011-05-27 | 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10456463B2 (ja) |
| EP (1) | EP2575878B1 (ja) |
| JP (3) | JP6034285B2 (ja) |
| KR (1) | KR101528021B1 (ja) |
| CN (1) | CN103025351B (ja) |
| AU (2) | AU2011259718B2 (ja) |
| BR (1) | BR112012030337B1 (ja) |
| CA (1) | CA2800158C (ja) |
| CL (1) | CL2012003299A1 (ja) |
| DK (1) | DK2575878T3 (ja) |
| ES (1) | ES2683316T3 (ja) |
| HR (1) | HRP20181039T1 (ja) |
| HU (1) | HUE038894T2 (ja) |
| LT (1) | LT2575878T (ja) |
| MX (1) | MX347471B (ja) |
| NZ (1) | NZ603527A (ja) |
| PL (1) | PL2575878T3 (ja) |
| PT (1) | PT2575878T (ja) |
| RS (1) | RS57428B1 (ja) |
| SI (1) | SI2575878T1 (ja) |
| WO (1) | WO2011148356A1 (ja) |
| ZA (1) | ZA201208837B (ja) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8552165B2 (en) * | 2008-12-09 | 2013-10-08 | Heather Davis | Immunostimulatory oligonucleotides |
| WO2010067262A1 (en) * | 2008-12-09 | 2010-06-17 | Pfizer Inc. | Immunostimulatory oligonucleotides |
| US9314519B2 (en) * | 2012-08-21 | 2016-04-19 | Intervet Inc. | Liquid stable virus vaccines |
| EP2996719B1 (en) * | 2013-05-14 | 2019-06-26 | Zoetis Services LLC | Novel vaccine compositions comprising immunostimulatory oligonucleotides |
| AU2014292926B2 (en) | 2013-07-25 | 2020-03-05 | Exicure Operating Company | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| CA2924526A1 (en) * | 2013-09-19 | 2015-03-26 | Paul Joseph Dominowski | Water-in-oil emulsions comprising immunostimulatory oligonucleotides |
| US20160256540A1 (en) | 2013-10-17 | 2016-09-08 | Zoetis Services Llc | Methods And Compositions For Treatment Of S. Equi Infection |
| EP4241853A3 (en) * | 2013-11-26 | 2023-11-22 | Zoetis Services LLC | Compositions for induction of immune response |
| PL3164113T3 (pl) | 2014-06-04 | 2019-09-30 | Exicure, Inc. | Wielowartościowe dostarczanie modulatorów immunologicznych w liposomowych kolistych kwasach nukleinowych do zastosowań profilaktycznych lub terapeutycznych |
| US10456459B2 (en) * | 2015-07-20 | 2019-10-29 | Zoetis Services Llc | Liposomal adjuvant compositions |
| PL3325015T3 (pl) * | 2015-07-20 | 2021-10-25 | Zoetis Services Llc | Liposomowe kompozycje adiuwantowe |
| EP3348269B1 (en) | 2015-09-09 | 2023-11-15 | Tsinghua University | Mevalonate pathway inhibitor as highly-effective vaccine adjuvant |
| CN107149671B (zh) * | 2016-03-03 | 2021-02-05 | 郭文江 | 一种药物组合物及其应用 |
| US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
| US11433131B2 (en) | 2017-05-11 | 2022-09-06 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (SNAs) |
| CN111447949A (zh) * | 2017-12-15 | 2020-07-24 | 拜耳动物保健有限责任公司 | 免疫刺激寡核苷酸 |
| MX2022000525A (es) * | 2019-07-12 | 2022-04-20 | Res Found Dev | Vacunas contra la ehrlichia y composiciones inmunogenicas. |
| IT202100014747A1 (it) * | 2021-06-07 | 2022-12-07 | Consiglio Nazionale Ricerche | Derivati sterolici come nuovi ligandi del recettore dectina-1 nel trattamento terapeutico di patologie correlate a tale recettore |
| CN115645417A (zh) * | 2022-10-17 | 2023-01-31 | 武汉轻工大学 | 鹅去氧胆酸在制备治疗或预防猪病毒性腹泻的药物或饲料添加剂中的应用 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| EP0092574B1 (en) | 1981-10-23 | 1992-04-29 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and methods of making same |
| US5023243A (en) | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| DE4321946A1 (de) | 1993-07-01 | 1995-01-12 | Hoechst Ag | Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| ES2267100T5 (es) * | 1994-07-15 | 2011-04-08 | The University Of Iowa Research Foundation | Oligonucleótidos inmunomoduladores. |
| GB9718901D0 (en) * | 1997-09-05 | 1997-11-12 | Smithkline Beecham Biolog | Vaccine |
| ES2257068T3 (es) | 1998-08-10 | 2006-07-16 | Antigenics Inc. | Mezclas de adyuvantes de cpg y saponinas y metodos de empleo de las mismas. |
| FR2783170B1 (fr) * | 1998-09-11 | 2004-07-16 | Pasteur Merieux Serums Vacc | Emulsion immunostimulante |
| GB9921146D0 (en) * | 1999-09-07 | 1999-11-10 | Smithkline Beecham Biolog | Novel composition |
| CA2386019C (en) | 1999-09-27 | 2011-06-21 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
| US6949520B1 (en) | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
| CN1301572A (zh) * | 1999-10-28 | 2001-07-04 | 上海生物制品研究所 | 用于疫苗的佐剂组合物 |
| US7129222B2 (en) * | 2000-03-10 | 2006-10-31 | Dynavax Technologies Corporation | Immunomodulatory formulations and methods for use thereof |
| IL160157A0 (en) | 2001-08-17 | 2004-07-25 | Coley Pharm Group Inc | Combination motif immune stimulation oligonucleotides with improved activity |
| GB0123580D0 (en) | 2001-10-01 | 2001-11-21 | Glaxosmithkline Biolog Sa | Vaccine |
| RU2322258C2 (ru) * | 2001-11-07 | 2008-04-20 | Цитос Байотекнолоджи Аг | Антигенные матрицы для лечения заболевания костей |
| WO2003066649A1 (en) * | 2002-02-04 | 2003-08-14 | Biomira Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
| NZ538628A (en) * | 2002-08-12 | 2008-06-30 | Dynavax Tech Corp | Immunomodulatory compositions, methods of making, and methods of use thereof |
| CA2524853A1 (en) * | 2003-05-07 | 2005-01-20 | Aventis Pasteur, Inc. | Method of enhanced immunogenicity to meningococcal vaccination |
| AP2006003530A0 (en) * | 2003-08-28 | 2006-02-28 | Immune Response Corp Inc | Immunogenic HIV compositions and related methods. |
| GB0323965D0 (en) * | 2003-10-13 | 2003-11-19 | Glaxosmithkline Biolog Sa | Immunogenic compositions |
| US20050175630A1 (en) * | 2003-12-23 | 2005-08-11 | Eyal Raz | Immunogenic compositions and methods of use thereof |
| WO2005107797A1 (en) * | 2004-03-09 | 2005-11-17 | Chiron Corporation | Influenza virus vaccines |
| CA2557443A1 (en) * | 2004-03-12 | 2005-09-29 | Hybridon, Inc. | Enhanced activity of hiv vaccine using a second generation immunomodulatory oligonucleotide |
| US20070129320A9 (en) * | 2004-07-18 | 2007-06-07 | Coley Pharmaceutical Group, Ltd. | Methods and compositions for inducing innate immune responses |
| EP1829887B1 (en) * | 2004-11-29 | 2011-08-24 | Changchun Huapu Biotechnology Co., Ltd. | Cpg single-strand deoxynucleotides for use as adjuvant |
| EP1849780A1 (en) * | 2006-04-21 | 2007-10-31 | De Staat der Nederlanden, vert. door de minister van VWS | Vaccine against nicotine addiction |
| WO2007139190A1 (ja) * | 2006-05-31 | 2007-12-06 | Toray Industries, Inc. | 免疫刺激オリゴヌクレオチド及びその医薬用途 |
| NZ575437A (en) | 2006-09-27 | 2012-02-24 | Coley Pharm Gmbh | Cpg oligonucleotide analogs containing hydrophobic t analogs with enhanced immunostimulatory activity |
| WO2008142509A2 (en) * | 2007-05-17 | 2008-11-27 | Coley Pharmaceutical Group, Inc. | Class a oligonucleotides with immunostimulatory potency |
| CA2710983A1 (en) * | 2007-12-27 | 2009-10-01 | The Ohio State University Research Foundation | Lipid nanoparticle compositions and methods of making and using the same |
| ES2569907T3 (es) | 2008-06-27 | 2016-05-13 | Zoetis Services Llc | Composiciones adyuvantes novedosas |
-
2011
- 2011-05-27 JP JP2013513022A patent/JP6034285B2/ja active Active
- 2011-05-27 CN CN201180036906.3A patent/CN103025351B/zh active Active
- 2011-05-27 MX MX2012013731A patent/MX347471B/es active IP Right Grant
- 2011-05-27 BR BR112012030337-6A patent/BR112012030337B1/pt active IP Right Grant
- 2011-05-27 KR KR1020127033947A patent/KR101528021B1/ko active IP Right Grant
- 2011-05-27 JP JP2011118735A patent/JP2011251963A/ja not_active Withdrawn
- 2011-05-27 DK DK11727536.2T patent/DK2575878T3/en active
- 2011-05-27 ES ES11727536.2T patent/ES2683316T3/es active Active
- 2011-05-27 LT LTEP11727536.2T patent/LT2575878T/lt unknown
- 2011-05-27 NZ NZ603527A patent/NZ603527A/en unknown
- 2011-05-27 WO PCT/IB2011/052347 patent/WO2011148356A1/en active Application Filing
- 2011-05-27 CA CA2800158A patent/CA2800158C/en active Active
- 2011-05-27 AU AU2011259718A patent/AU2011259718B2/en active Active
- 2011-05-27 SI SI201131538T patent/SI2575878T1/sl unknown
- 2011-05-27 PL PL11727536T patent/PL2575878T3/pl unknown
- 2011-05-27 PT PT11727536T patent/PT2575878T/pt unknown
- 2011-05-27 HU HUE11727536A patent/HUE038894T2/hu unknown
- 2011-05-27 EP EP11727536.2A patent/EP2575878B1/en active Active
- 2011-05-27 RS RS20180784A patent/RS57428B1/sr unknown
- 2011-05-27 US US13/699,997 patent/US10456463B2/en active Active
-
2012
- 2012-11-22 ZA ZA2012/08837A patent/ZA201208837B/en unknown
- 2012-11-26 CL CL2012003299A patent/CL2012003299A1/es unknown
-
2016
- 2016-05-31 AU AU2016203611A patent/AU2016203611B2/en active Active
- 2016-09-06 JP JP2016173482A patent/JP6133482B2/ja active Active
-
2018
- 2018-07-05 HR HRP20181039TT patent/HRP20181039T1/hr unknown
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