JP2017048187A5 - - Google Patents
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- Publication number
- JP2017048187A5 JP2017048187A5 JP2016173482A JP2016173482A JP2017048187A5 JP 2017048187 A5 JP2017048187 A5 JP 2017048187A5 JP 2016173482 A JP2016173482 A JP 2016173482A JP 2016173482 A JP2016173482 A JP 2016173482A JP 2017048187 A5 JP2017048187 A5 JP 2017048187A5
- Authority
- JP
- Japan
- Prior art keywords
- immunostimulatory oligonucleotides
- cholesterol
- vaccine
- leucylamino
- dda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 10
- 229940107161 Cholesterol Drugs 0.000 claims description 5
- 235000012000 cholesterol Nutrition 0.000 claims description 5
- 239000000427 antigen Substances 0.000 claims description 3
- 102000038129 antigens Human genes 0.000 claims description 3
- 108091007172 antigens Proteins 0.000 claims description 3
- 229920000272 Oligonucleotide Polymers 0.000 claims 3
- 230000003308 immunostimulating Effects 0.000 claims 3
- 229960005486 vaccines Drugs 0.000 claims 3
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2S,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-4-[(2R,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 229920001888 polyacrylic acid Polymers 0.000 claims 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
Description
抗原とＣｐＧ、および抗原とＣｐＧ＋コレステロールの同時送達は、電気泳動におけるＣｐＧの移動度の遅延を示さなかった。ＵＶによって定量した際、遊離ＣｐＧと比較して同じ量のＣｐＧがＣｐＧ＋コレステロールの上清中で観察された。これは、ＣｐＧとコレステロールとの強い会合が存在しないことを示唆している。
Claims (1)
- １つまたは複数の抗原および１つまたは複数の免疫賦活性オリゴヌクレオチドおよび、追加の脂質なしで、コレステロールミクロスフェアを含むワクチンであって、ワクチンはＱｕｉｌ Ａ、ＤＤＡ、Ｃａｒｂｏｐｏｌ（登録商標）、およびＮ−（２−デオキシ−２−Ｌ−ロイシルアミノ−ｂ−Ｄ−グルコピラノシル）−Ｎ−オクタデシルドデカノイルアミドヒドロアセテートを含まず、前記１つまたは複数の免疫賦活性オリゴヌクレオチドはＯＲＮおよびＣｐＧ ＯＤＮからなる群から選択され、前記コレステロールおよび前記１つまたは複数の免疫賦活性オリゴヌクレオチドは一緒に混合されている、ワクチン。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34924410P | 2010-05-28 | 2010-05-28 | |
| US61/349,244 | 2010-05-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013513022A Division JP6034285B2 (ja) | 2010-05-28 | 2011-05-27 | 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017048187A JP2017048187A (ja) | 2017-03-09 |
| JP2017048187A5 true JP2017048187A5 (ja) | 2017-04-13 |
| JP6133482B2 JP6133482B2 (ja) | 2017-05-24 |
Family
ID=44626939
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013513022A Active JP6034285B2 (ja) | 2010-05-28 | 2011-05-27 | 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用 |
| JP2011118735A Withdrawn JP2011251963A (ja) | 2010-05-28 | 2011-05-27 | 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用 |
| JP2016173482A Active JP6133482B2 (ja) | 2010-05-28 | 2016-09-06 | 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013513022A Active JP6034285B2 (ja) | 2010-05-28 | 2011-05-27 | 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用 |
| JP2011118735A Withdrawn JP2011251963A (ja) | 2010-05-28 | 2011-05-27 | 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10456463B2 (ja) |
| EP (1) | EP2575878B1 (ja) |
| JP (3) | JP6034285B2 (ja) |
| KR (1) | KR101528021B1 (ja) |
| CN (1) | CN103025351B (ja) |
| AU (2) | AU2011259718B2 (ja) |
| BR (1) | BR112012030337B1 (ja) |
| CA (1) | CA2800158C (ja) |
| CL (1) | CL2012003299A1 (ja) |
| DK (1) | DK2575878T3 (ja) |
| ES (1) | ES2683316T3 (ja) |
| HR (1) | HRP20181039T1 (ja) |
| HU (1) | HUE038894T2 (ja) |
| LT (1) | LT2575878T (ja) |
| MX (1) | MX347471B (ja) |
| NZ (1) | NZ603527A (ja) |
| PL (1) | PL2575878T3 (ja) |
| PT (1) | PT2575878T (ja) |
| RS (1) | RS57428B1 (ja) |
| SI (1) | SI2575878T1 (ja) |
| WO (1) | WO2011148356A1 (ja) |
| ZA (1) | ZA201208837B (ja) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2376107T3 (pl) * | 2008-12-09 | 2014-09-30 | Coley Pharm Group Inc | Oligonukleotydy immunostymulujące |
| US8552165B2 (en) * | 2008-12-09 | 2013-10-08 | Heather Davis | Immunostimulatory oligonucleotides |
| US9314519B2 (en) * | 2012-08-21 | 2016-04-19 | Intervet Inc. | Liquid stable virus vaccines |
| ES2894138T3 (es) * | 2013-05-14 | 2022-02-11 | Zoetis Services Llc | Composiciones de vacuna novedosas que comprenden oligonucleótidos inmunoestimulantes |
| ES2750608T3 (es) | 2013-07-25 | 2020-03-26 | Exicure Inc | Construcciones esféricas a base de ácido nucleico como agentes inmunoestimulantes para uso profiláctico y terapéutico |
| AU2014321369B2 (en) * | 2013-09-19 | 2020-04-16 | Zoetis Services Llc | Oil-based adjuvants |
| MX2016004961A (es) | 2013-10-17 | 2016-06-28 | Zoetis Services Llc | Procedimientos y composiciones para el tratamiento de infecciones por s. equi. |
| US11318200B2 (en) * | 2013-11-26 | 2022-05-03 | Zoetis Services Llc | Methods and compositions for induction of immune response |
| TR201908550T4 (tr) | 2014-06-04 | 2019-07-22 | Exicure Inc | Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi. |
| US10456459B2 (en) * | 2015-07-20 | 2019-10-29 | Zoetis Services Llc | Liposomal adjuvant compositions |
| RS62015B1 (sr) * | 2015-07-20 | 2021-07-30 | Zoetis Services Llc | Kompozicije lipozomalnog adjuvansa |
| CN114848656A (zh) | 2015-09-09 | 2022-08-05 | 清华大学 | 作为高效的疫苗佐剂的甲羟戊酸通路的抑制剂 |
| CN107149671B (zh) * | 2016-03-03 | 2021-02-05 | 郭文江 | 一种药物组合物及其应用 |
| US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| WO2019115385A1 (en) * | 2017-12-15 | 2019-06-20 | Bayer Animal Health Gmbh | Immunostimulatory compositions |
| BR112022000347A2 (pt) * | 2019-07-12 | 2022-04-12 | Res Found Dev | Vacinas de ehrlichia e composições imunogênicas |
| IT202100014747A1 (it) * | 2021-06-07 | 2022-12-07 | Consiglio Nazionale Ricerche | Derivati sterolici come nuovi ligandi del recettore dectina-1 nel trattamento terapeutico di patologie correlate a tale recettore |
| CN115645417A (zh) * | 2022-10-17 | 2023-01-31 | 武汉轻工大学 | 鹅去氧胆酸在制备治疗或预防猪病毒性腹泻的药物或饲料添加剂中的应用 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5023243A (en) | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| JP2547714B2 (ja) | 1981-10-23 | 1996-10-23 | モルキユラ− バイオシステムズ インコ−ポレテツド | オリゴヌクレオチド治療剤及びその製法 |
| DE4321946A1 (de) | 1993-07-01 | 1995-01-12 | Hoechst Ag | Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| EP1167379A3 (en) * | 1994-07-15 | 2004-09-08 | University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| GB9718901D0 (en) * | 1997-09-05 | 1997-11-12 | Smithkline Beecham Biolog | Vaccine |
| DE69929444T2 (de) | 1998-08-10 | 2006-09-28 | Antigenics Inc., Woburn | Cpg-zusammensetzungen, saponin-adjuvantien und verfahren zu deren verwendung |
| FR2783170B1 (fr) * | 1998-09-11 | 2004-07-16 | Pasteur Merieux Serums Vacc | Emulsion immunostimulante |
| GB9921146D0 (en) * | 1999-09-07 | 1999-11-10 | Smithkline Beecham Biolog | Novel composition |
| US6949520B1 (en) | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
| JP2003510290A (ja) | 1999-09-27 | 2003-03-18 | コーリー ファーマシューティカル グループ，インコーポレイテッド | 免疫刺激核酸誘導インターフェロンに関する方法 |
| CN1301572A (zh) * | 1999-10-28 | 2001-07-04 | 上海生物制品研究所 | 用于疫苗的佐剂组合物 |
| US7129222B2 (en) * | 2000-03-10 | 2006-10-31 | Dynavax Technologies Corporation | Immunomodulatory formulations and methods for use thereof |
| ATE411054T1 (de) | 2001-08-17 | 2008-10-15 | Coley Pharm Gmbh | Kombinations-motif-immunstimulierende oligonukleotide mit verbesserter wirkung |
| GB0123580D0 (en) | 2001-10-01 | 2001-11-21 | Glaxosmithkline Biolog Sa | Vaccine |
| RU2322258C2 (ru) * | 2001-11-07 | 2008-04-20 | Цитос Байотекнолоджи Аг | Антигенные матрицы для лечения заболевания костей |
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| JP2007516219A (ja) * | 2003-05-07 | 2007-06-21 | アヴェンティス パストゥール インコーポレイテッド | 髄膜炎菌ワクチン接種に対する免疫原性の増強の方法 |
| US20070253979A1 (en) * | 2003-08-28 | 2007-11-01 | Moss Ronald B | Immunogenic Hiv Compositions and Related Methods |
| GB0323965D0 (en) * | 2003-10-13 | 2003-11-19 | Glaxosmithkline Biolog Sa | Immunogenic compositions |
| US20050175630A1 (en) * | 2003-12-23 | 2005-08-11 | Eyal Raz | Immunogenic compositions and methods of use thereof |
| CA2559371C (en) * | 2004-03-09 | 2014-07-08 | Chiron Corporation | Influenza virus vaccines |
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| US20070129320A9 (en) * | 2004-07-18 | 2007-06-07 | Coley Pharmaceutical Group, Ltd. | Methods and compositions for inducing innate immune responses |
| JP2008521385A (ja) * | 2004-11-29 | 2008-06-26 | 長春華普生物技術有限公司 | アジュバントとしてのＣｐＧ含有一本鎖デオキシヌクレオチド |
| EP1849780A1 (en) * | 2006-04-21 | 2007-10-31 | De Staat der Nederlanden, vert. door de minister van VWS | Vaccine against nicotine addiction |
| PL2034015T3 (pl) * | 2006-05-31 | 2012-11-30 | Toray Industries | Immunostymulujący oligonukleotyd i jego zastosowanie farmaceutyczne |
| KR101251707B1 (ko) | 2006-09-27 | 2013-04-11 | 콜리 파마슈티칼 게엠베하 | 면역 자극 활성이 증강된 소수성 Ｔ 유사체를 함유하는 ＣｐＧ 올리고뉴클레오티드 유사체 |
| EP2160199A2 (en) * | 2007-05-17 | 2010-03-10 | Coley Pharmaceutical Group, Inc. | Class a oligonucleotides with immunostimulatory potency |
| WO2009120247A2 (en) * | 2007-12-27 | 2009-10-01 | The Ohio State University Research Foundation | Lipid nanoparticle compositions and methods of making and using the same |
| ES2728949T3 (es) | 2008-06-27 | 2019-10-29 | Zoetis Services Llc | Composiciones adyuvantes novedosas |
-
2011
- 2011-05-27 CN CN201180036906.3A patent/CN103025351B/zh active Active
- 2011-05-27 EP EP11727536.2A patent/EP2575878B1/en active Active
- 2011-05-27 KR KR1020127033947A patent/KR101528021B1/ko active IP Right Grant
- 2011-05-27 MX MX2012013731A patent/MX347471B/es active IP Right Grant
- 2011-05-27 LT LTEP11727536.2T patent/LT2575878T/lt unknown
- 2011-05-27 WO PCT/IB2011/052347 patent/WO2011148356A1/en active Application Filing
- 2011-05-27 JP JP2013513022A patent/JP6034285B2/ja active Active
- 2011-05-27 ES ES11727536.2T patent/ES2683316T3/es active Active
- 2011-05-27 BR BR112012030337-6A patent/BR112012030337B1/pt active IP Right Grant
- 2011-05-27 PL PL11727536T patent/PL2575878T3/pl unknown
- 2011-05-27 US US13/699,997 patent/US10456463B2/en active Active
- 2011-05-27 SI SI201131538T patent/SI2575878T1/sl unknown
- 2011-05-27 JP JP2011118735A patent/JP2011251963A/ja not_active Withdrawn
- 2011-05-27 HU HUE11727536A patent/HUE038894T2/hu unknown
- 2011-05-27 NZ NZ603527A patent/NZ603527A/en unknown
- 2011-05-27 RS RS20180784A patent/RS57428B1/sr unknown
- 2011-05-27 DK DK11727536.2T patent/DK2575878T3/en active
- 2011-05-27 AU AU2011259718A patent/AU2011259718B2/en active Active
- 2011-05-27 CA CA2800158A patent/CA2800158C/en active Active
- 2011-05-27 PT PT11727536T patent/PT2575878T/pt unknown
-
2012
- 2012-11-22 ZA ZA2012/08837A patent/ZA201208837B/en unknown
- 2012-11-26 CL CL2012003299A patent/CL2012003299A1/es unknown
-
2016
- 2016-05-31 AU AU2016203611A patent/AU2016203611B2/en active Active
- 2016-09-06 JP JP2016173482A patent/JP6133482B2/ja active Active
-
2018
- 2018-07-05 HR HRP20181039TT patent/HRP20181039T1/hr unknown
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