JP2017019845A5 - - Google Patents
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- Publication number
- JP2017019845A5 JP2017019845A5 JP2016176303A JP2016176303A JP2017019845A5 JP 2017019845 A5 JP2017019845 A5 JP 2017019845A5 JP 2016176303 A JP2016176303 A JP 2016176303A JP 2016176303 A JP2016176303 A JP 2016176303A JP 2017019845 A5 JP2017019845 A5 JP 2017019845A5
- Authority
- JP
- Japan
- Prior art keywords
- active pharmaceutical
- pharmaceutical ingredient
- solvent
- api
- fluticasone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 20
- 239000008186 active pharmaceutical agent Substances 0.000 claims 16
- 239000002904 solvent Substances 0.000 claims 6
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 4
- 229960001664 mometasone Drugs 0.000 claims 4
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical group C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims 4
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims 3
- 238000001694 spray drying Methods 0.000 claims 3
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 2
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 claims 2
- LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 claims 2
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 2
- 229940092705 beclomethasone Drugs 0.000 claims 2
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims 2
- 229960004436 budesonide Drugs 0.000 claims 2
- 229960003728 ciclesonide Drugs 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- XTULMSXFIHGYFS-VLSRWLAYSA-N fluticasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4[C@@H](F)C[C@H]3[C@@H]2C[C@H]1C)C(=O)SCF)C(=O)C1=CC=CO1 XTULMSXFIHGYFS-VLSRWLAYSA-N 0.000 claims 2
- 229960000289 fluticasone propionate Drugs 0.000 claims 2
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 2
- 229960002848 formoterol Drugs 0.000 claims 2
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims 2
- GWVOFXBLSFFSEG-UHFFFAOYSA-N furan-2-carboxylic acid;hydrate Chemical compound O.OC(=O)C1=CC=CO1 GWVOFXBLSFFSEG-UHFFFAOYSA-N 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- 229960001888 ipratropium Drugs 0.000 claims 2
- OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 229960002052 salbutamol Drugs 0.000 claims 2
- 229960004017 salmeterol Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229960000195 terbutaline Drugs 0.000 claims 2
- 229960000257 tiotropium bromide Drugs 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- SMNDYUVBFMFKNZ-UHFFFAOYSA-N 2-furoic acid Chemical compound OC(=O)C1=CC=CO1 SMNDYUVBFMFKNZ-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
- 229960002537 betamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims 1
- 229960004648 betamethasone acetate Drugs 0.000 claims 1
- AKUJBENLRBOFTD-QZIXMDIESA-N betamethasone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(C)=O)(O)[C@@]1(C)C[C@@H]2O AKUJBENLRBOFTD-QZIXMDIESA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000009826 distribution Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 229960002714 fluticasone Drugs 0.000 claims 1
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- MFBMYAOAMQLLPK-FZNHGJLXSA-N hydrocortisone aceponate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(C)=O)(OC(=O)CC)[C@@]1(C)C[C@@H]2O MFBMYAOAMQLLPK-FZNHGJLXSA-N 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 238000003754 machining Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229960005018 salmeterol xinafoate Drugs 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 229940110309 tiotropium Drugs 0.000 claims 1
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims 1
- MQLXPRBEAHBZTK-SEINRUQRSA-M tiotropium bromide hydrate Chemical compound O.[Br-].C[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 MQLXPRBEAHBZTK-SEINRUQRSA-M 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT105058 | 2010-04-21 | ||
| PT105058A PT105058B (pt) | 2010-04-21 | 2010-04-21 | Processo para processamento de partículas de ingredientes activos farmacêuticos |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013505534A Division JP6347608B2 (ja) | 2010-04-21 | 2011-04-21 | 医薬品有効成分の粒子加工のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017019845A JP2017019845A (ja) | 2017-01-26 |
| JP2017019845A5 true JP2017019845A5 (cg-RX-API-DMAC7.html) | 2017-03-02 |
| JP6857467B2 JP6857467B2 (ja) | 2021-04-14 |
Family
ID=44194836
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013505534A Active JP6347608B2 (ja) | 2010-04-21 | 2011-04-21 | 医薬品有効成分の粒子加工のための方法 |
| JP2016176303A Active JP6857467B2 (ja) | 2010-04-21 | 2016-09-09 | 医薬品有効成分の粒子加工のための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013505534A Active JP6347608B2 (ja) | 2010-04-21 | 2011-04-21 | 医薬品有効成分の粒子加工のための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9956144B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2560620B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6347608B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102970978B (cg-RX-API-DMAC7.html) |
| BR (1) | BR112012026941A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2796978C (cg-RX-API-DMAC7.html) |
| IL (1) | IL222596B (cg-RX-API-DMAC7.html) |
| MX (1) | MX338594B (cg-RX-API-DMAC7.html) |
| PL (1) | PL2560620T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT105058B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2597790C2 (cg-RX-API-DMAC7.html) |
| SG (1) | SG185003A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011131947A2 (cg-RX-API-DMAC7.html) |
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| BRPI0517204A (pt) * | 2004-12-17 | 2008-09-30 | Cipla Ltd | sulfato de levosalbutamol cristalino (forma i), sulfato de levosalbutamol cristalino (forma ii), sulfato de levosalbutamol cristalino (forma iii), processo para preparar a forma i do sulfato de levosalbutamol cristalino, processo para preparar a forma ii do sulfato de levosalbutamol cristalino, processo para preparar a forma iii do sulfato de levosalbutamol, composição farmacêutica, composto, combinação, pó seco para inalador, processo para preparar um pó seco para inalador, processo para preparar uma composição famacêutica, processo para fabricação de uma composição farmacêutica, método para tratamento de um mamìfero, e uso de uma combinação de salbutamol |
| WO2006073154A1 (ja) | 2005-01-07 | 2006-07-13 | Eisai R&D Management Co., Ltd. | 医薬組成物及びその製造方法 |
| US20060193818A1 (en) * | 2005-02-25 | 2006-08-31 | Southall Michael D | Compositions containing amines and use thereof |
| DE102005011786A1 (de) | 2005-03-11 | 2006-09-14 | Pharmasol Gmbh | Verfahren zur Herstellung ultrafeiner Submicron-Suspensionen |
| GB0523576D0 (en) | 2005-11-18 | 2005-12-28 | Theradeas Ltd | Drug composition and its use in therapy |
| US20070178051A1 (en) | 2006-01-27 | 2007-08-02 | Elan Pharma International, Ltd. | Sterilized nanoparticulate glucocorticosteroid formulations |
| JP4879349B2 (ja) | 2007-07-31 | 2012-02-22 | 大塚製薬株式会社 | アリピプラゾール懸濁液及び凍結乾燥製剤の製造方法 |
| EP2050437A1 (en) | 2007-10-15 | 2009-04-22 | Laboratoires SMB | Improved pharmaceutical dry powder compositions for inhalation. |
| EP2156823A1 (en) * | 2008-08-14 | 2010-02-24 | Pharmatex Italia Srl | Process for the preparation of sterile powdered pharmeceutical compounds in the form of micro and nanoparticles |
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2010
- 2010-04-21 PT PT105058A patent/PT105058B/pt active IP Right Grant
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2011
- 2011-04-21 SG SG2012078614A patent/SG185003A1/en unknown
- 2011-04-21 CA CA2796978A patent/CA2796978C/en active Active
- 2011-04-21 CN CN201180024407.2A patent/CN102970978B/zh active Active
- 2011-04-21 RU RU2012149459/15A patent/RU2597790C2/ru active
- 2011-04-21 JP JP2013505534A patent/JP6347608B2/ja active Active
- 2011-04-21 PL PL11718765T patent/PL2560620T3/pl unknown
- 2011-04-21 WO PCT/GB2011/000631 patent/WO2011131947A2/en not_active Ceased
- 2011-04-21 MX MX2012012215A patent/MX338594B/es active IP Right Grant
- 2011-04-21 BR BR112012026941A patent/BR112012026941A2/pt not_active Application Discontinuation
- 2011-04-21 US US13/642,397 patent/US9956144B2/en active Active
- 2011-04-21 EP EP11718765.8A patent/EP2560620B1/en active Active
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2012
- 2012-10-21 IL IL222596A patent/IL222596B/en active IP Right Grant
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2016
- 2016-09-09 JP JP2016176303A patent/JP6857467B2/ja active Active
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