BRPI0517204A - sulfato de levosalbutamol cristalino (forma i), sulfato de levosalbutamol cristalino (forma ii), sulfato de levosalbutamol cristalino (forma iii), processo para preparar a forma i do sulfato de levosalbutamol cristalino, processo para preparar a forma ii do sulfato de levosalbutamol cristalino, processo para preparar a forma iii do sulfato de levosalbutamol, composição farmacêutica, composto, combinação, pó seco para inalador, processo para preparar um pó seco para inalador, processo para preparar uma composição famacêutica, processo para fabricação de uma composição farmacêutica, método para tratamento de um mamìfero, e uso de uma combinação de salbutamol - Google Patents
sulfato de levosalbutamol cristalino (forma i), sulfato de levosalbutamol cristalino (forma ii), sulfato de levosalbutamol cristalino (forma iii), processo para preparar a forma i do sulfato de levosalbutamol cristalino, processo para preparar a forma ii do sulfato de levosalbutamol cristalino, processo para preparar a forma iii do sulfato de levosalbutamol, composição farmacêutica, composto, combinação, pó seco para inalador, processo para preparar um pó seco para inalador, processo para preparar uma composição famacêutica, processo para fabricação de uma composição farmacêutica, método para tratamento de um mamìfero, e uso de uma combinação de salbutamolInfo
- Publication number
- BRPI0517204A BRPI0517204A BRPI0517204-7A BRPI0517204A BRPI0517204A BR PI0517204 A BRPI0517204 A BR PI0517204A BR PI0517204 A BRPI0517204 A BR PI0517204A BR PI0517204 A BRPI0517204 A BR PI0517204A
- Authority
- BR
- Brazil
- Prior art keywords
- preparing
- pharmaceutical composition
- levosalbutamol sulfate
- crystalline
- sulfate
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C07C215/60—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SULFATO DE LEVOSALBUTAMOL CRISTALINO (FORMA I), SULFATO DE LEVOSALBUTAMOL CRISTALINO (FORMA II), SULFATO DE LEVOSALBUTAMOL CRISTALINO (FORMA III), PROCESSO PARA PREPARAR A FORMA I DO SULFATO DE LEVOSALBUTAMOL CRISTALINO, PROCESSO PARA PREPARAR A FORMA II DO SULFATO DE LEVOSALBUTAMOL CRISTALINO, PROCESSO PARA PREPARAR A FORMA III DO SULFATO DE LEVOSALBUTAMOL, COMPOSIçãO FARMACêUTICA, COMPOSTO, COMBINAçãO, Pó SECO PARA INALADOR, PROCESSO PARA PREPARAR UM Pó SECO PARA INALADOR, PROCESSO PARA PREPARAR UMA COMPOSIçAO FARMACêUTICA, PROCESSO PARA FABRICAçãO DE UMA COMPOSIçãO FARMACêUTICA, MéTODO PARA TRATAMENTO DE UM MAMìFERO E USO DE UMA COMBINAçãO DE SALBUTAMOL". A invenção provê três formas polimórficas do sulfato de levosalbutamol cristalino designado aqui como Forma (I) , Forma (II) e Forma (III) . A Forma I do sulfato de levosalbutamol cristalina é caracterizada por um padrão de pó XRD com picos em 10.8, 11.9, 13.0, 18.3, 28.5 <sym> 0.2 graus 2- Theta. A Forma II do sulfato de levosalbutamol cristalina é caracterizada por um padrão de pó XRD com picos em 8.7, 9.6, 15.2, 17.7, 19.1, 27.2, 30.7 <sym> 0.2 graus 2-Theta. A Forma III do sulfato de levosalbutamol cristalina é caracterizada por um padrão de pó XRD com picos em 5.5, 6.9, 7.3, 18.7 <sym> 0.2 graus 2-Theta. O processo para preparar as novas formas polimórficas e as composições farmacêuticas compreendendo-as também é provido. Uma composição farmacêutica compreende um isómero terapeuticamente eficaz do salbutamol ou um sal, solvato, éster, derivado ou polimorfo do mesmo, um glicocorticóide e um veículo farmaceuticamente aceitável ou um excipiente e, opcionalmente, um ou mais de outros agentes terapêuticos. Preferivelmente, a composição é uma formulação aerossol compreendendo o fármaco, um propelente e, opcionalmente, um ou mais de outros ingredientes, tais como um surfactante, co-solvente, ou agente avolumador. Alternativamente, suspensões DPI ou de inalação podem ser utilizadas.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1356MU2004 | 2004-12-17 | ||
IN40MU2005 | 2005-01-14 | ||
IN343MU2005 | 2005-03-24 | ||
PCT/GB2005/004935 WO2006064283A1 (en) | 2004-12-17 | 2005-12-19 | Pharmaceutical compounds and compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0517204A true BRPI0517204A (pt) | 2008-09-30 |
Family
ID=36091333
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0517204-7A BRPI0517204A (pt) | 2004-12-17 | 2005-12-19 | sulfato de levosalbutamol cristalino (forma i), sulfato de levosalbutamol cristalino (forma ii), sulfato de levosalbutamol cristalino (forma iii), processo para preparar a forma i do sulfato de levosalbutamol cristalino, processo para preparar a forma ii do sulfato de levosalbutamol cristalino, processo para preparar a forma iii do sulfato de levosalbutamol, composição farmacêutica, composto, combinação, pó seco para inalador, processo para preparar um pó seco para inalador, processo para preparar uma composição famacêutica, processo para fabricação de uma composição farmacêutica, método para tratamento de um mamìfero, e uso de uma combinação de salbutamol |
Country Status (11)
Country | Link |
---|---|
US (1) | US20090263333A1 (pt) |
EP (2) | EP2311793A1 (pt) |
JP (1) | JP2008524195A (pt) |
KR (1) | KR20070100735A (pt) |
AU (1) | AU2005315337B2 (pt) |
BR (1) | BRPI0517204A (pt) |
CA (1) | CA2591406A1 (pt) |
IL (1) | IL183986A0 (pt) |
MX (1) | MX2007007378A (pt) |
NZ (1) | NZ555500A (pt) |
WO (1) | WO2006064283A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1809243T4 (da) | 2004-07-02 | 2022-09-05 | Boehringer Ingelheim Int | Aerosolsuspensionsformuleringer med tg 227 ea som drivmiddel |
DE102006017320A1 (de) * | 2006-04-11 | 2007-10-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel |
US20070282010A1 (en) | 2006-05-30 | 2007-12-06 | Bridge Pharma, Inc. | Methods of Accelerating Muscle Growth, Decreasing Fat Deposits and Improving Feed Efficiency in Livestock Animals |
CN101909652A (zh) * | 2007-11-07 | 2010-12-08 | 阿斯利康(瑞典)有限公司 | 含有抗坏血酸衍生物的干粉制剂 |
US7723392B2 (en) | 2007-12-03 | 2010-05-25 | Bridge Pharma, Inc. | Use of RR/SR-ractopamine |
PT105058B (pt) * | 2010-04-21 | 2013-04-17 | Hovione Farmaciencia S A | Processo para processamento de partículas de ingredientes activos farmacêuticos |
IT1399912B1 (it) * | 2010-04-29 | 2013-05-09 | Lundbeck Pharmaceuticals Italy S Pa | Processo di preparazione di ritodrina cloridrato. |
BR112014002593B1 (pt) * | 2011-08-02 | 2022-11-29 | Alfasigma S.p.A | Composição farmacêutica de avidina oxidada apropriada para inalação e kits relacionados |
WO2013140120A1 (en) * | 2012-03-22 | 2013-09-26 | Cipla Limited | Glycerol solvate forms of (r) - 2 - [ [ [3 -methyl -4 (2,2, 2 - trifluoroethoxy) pyridin- 2 - yl] methyl] sulphinyl] - 1h - ben zimidazole |
DK2897589T3 (en) | 2013-11-22 | 2018-03-12 | Teva Branded Pharmaceutical Prod R & D Inc | Inhalable drug |
TN2016000259A1 (en) | 2016-06-27 | 2017-10-06 | Rekik Raouf | Salbutamol (albuterol) eye protective medicament. |
WO2019031902A2 (ko) | 2017-08-11 | 2019-02-14 | (주)아모레퍼시픽 | (r)-n-[1-(3,5-다이플루오로-4-메테인설폰일아미노-페닐)-에틸]-3-(2-프로필-6-트라이플루오로메틸-피리딘-3-일)-아크릴아마이드를 함유하는 약학 조성물 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
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CY1291A (en) | 1980-02-15 | 1985-10-18 | Glaxo Group Ltd | Androstane 17 beta carbothioates |
US5362755A (en) | 1990-01-05 | 1994-11-08 | Sepracor, Inc. | Method for treating asthma using optically pure (R)-albuterol |
IL104068A (en) * | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Pharmaceutical preparations in a spray without surfactant containing 1, 1, 1, 2 tetrafluoroethane or 1,1,2,3,3 petafluor N propane as propellant |
US5545745A (en) | 1994-05-23 | 1996-08-13 | Sepracor, Inc. | Enantioselective preparation of optically pure albuterol |
US6013245A (en) * | 1995-01-26 | 2000-01-11 | Glaxo Group Limited | Aerosol formulation containing beclomethasone dipropionate and 1,1,1,2,3,3,3-heptafluoro-n-propane as propellant |
SK284448B6 (sk) * | 1995-04-14 | 2005-04-01 | Glaxo Wellcome Inc. | Merací dávkovací inhalátor |
SE9700135D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
CN1144582C (zh) * | 2000-11-28 | 2004-04-07 | 中国药科大学 | 治疗呼吸系统疾病的无氟里昂药用气雾剂 |
GB0030171D0 (en) * | 2000-12-11 | 2001-01-24 | Cipla Ltd | Process for preparing isomers of salbutamol |
NO315264B1 (no) * | 2001-01-23 | 2003-08-11 | Tomra Systems Asa | Deteksjonssystem |
US6702997B2 (en) * | 2001-10-26 | 2004-03-09 | Dey, L.P. | Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma |
CN100432044C (zh) | 2002-09-13 | 2008-11-12 | 苏州君宁新药开发中心有限公司 | 左旋沙丁胺醇制备新工艺 |
DK2292584T3 (en) | 2002-12-10 | 2017-05-01 | Sunovion Pharmaceuticals Inc | Pharmaceutical composition comprising levalbuterol L-hemitartrate salt as aerosol formulation |
-
2005
- 2005-12-19 AU AU2005315337A patent/AU2005315337B2/en not_active Ceased
- 2005-12-19 JP JP2007546199A patent/JP2008524195A/ja active Pending
- 2005-12-19 CA CA002591406A patent/CA2591406A1/en not_active Abandoned
- 2005-12-19 KR KR1020077016000A patent/KR20070100735A/ko active IP Right Grant
- 2005-12-19 BR BRPI0517204-7A patent/BRPI0517204A/pt not_active IP Right Cessation
- 2005-12-19 EP EP10184848A patent/EP2311793A1/en not_active Withdrawn
- 2005-12-19 NZ NZ555500A patent/NZ555500A/en not_active IP Right Cessation
- 2005-12-19 US US11/721,866 patent/US20090263333A1/en not_active Abandoned
- 2005-12-19 WO PCT/GB2005/004935 patent/WO2006064283A1/en active Application Filing
- 2005-12-19 MX MX2007007378A patent/MX2007007378A/es active IP Right Grant
- 2005-12-19 EP EP05843722A patent/EP1828100A1/en not_active Withdrawn
-
2007
- 2007-06-17 IL IL183986A patent/IL183986A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2005315337B2 (en) | 2012-07-05 |
US20090263333A1 (en) | 2009-10-22 |
AU2005315337A1 (en) | 2006-06-22 |
EP2311793A1 (en) | 2011-04-20 |
WO2006064283A1 (en) | 2006-06-22 |
NZ555500A (en) | 2010-09-30 |
KR20070100735A (ko) | 2007-10-11 |
JP2008524195A (ja) | 2008-07-10 |
IL183986A0 (en) | 2007-10-31 |
CA2591406A1 (en) | 2006-06-22 |
MX2007007378A (es) | 2007-08-14 |
EP1828100A1 (en) | 2007-09-05 |
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Legal Events
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014. |