JP2017018106A5 - - Google Patents
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- JP2017018106A5 JP2017018106A5 JP2016142281A JP2016142281A JP2017018106A5 JP 2017018106 A5 JP2017018106 A5 JP 2017018106A5 JP 2016142281 A JP2016142281 A JP 2016142281A JP 2016142281 A JP2016142281 A JP 2016142281A JP 2017018106 A5 JP2017018106 A5 JP 2017018106A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 52
- 239000000427 antigen Substances 0.000 claims description 42
- 102000036639 antigens Human genes 0.000 claims description 42
- 108091007433 antigens Proteins 0.000 claims description 42
- 239000008194 pharmaceutical composition Substances 0.000 claims description 30
- 102000013691 Interleukin-17 Human genes 0.000 claims description 25
- 108050003558 Interleukin-17 Proteins 0.000 claims description 25
- 241000282414 Homo sapiens Species 0.000 claims description 23
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 14
- 239000000710 homodimer Substances 0.000 claims description 13
- 208000027866 inflammatory disease Diseases 0.000 claims description 11
- 206010003246 arthritis Diseases 0.000 claims description 8
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 7
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 7
- 208000005777 Lupus Nephritis Diseases 0.000 claims description 7
- 201000004681 Psoriasis Diseases 0.000 claims description 7
- 208000006673 asthma Diseases 0.000 claims description 7
- 201000006417 multiple sclerosis Diseases 0.000 claims description 7
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 101000998146 Homo sapiens Interleukin-17A Proteins 0.000 claims description 5
- 102000053162 human IL17A Human genes 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 31
- 239000000833 heterodimer Substances 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 206010046851 Uveitis Diseases 0.000 claims 4
- 206010000269 abscess Diseases 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 4
- 210000000106 sweat gland Anatomy 0.000 claims 4
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 description 35
- 108090000623 proteins and genes Proteins 0.000 description 35
- 150000001413 amino acids Chemical class 0.000 description 6
- 108090001005 Interleukin-6 Proteins 0.000 description 5
- 102000004889 Interleukin-6 Human genes 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 230000001575 pathological effect Effects 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 101001027327 Bos taurus Growth-regulated protein homolog alpha Proteins 0.000 description 3
- 102000016950 Chemokine CXCL1 Human genes 0.000 description 3
- 238000010367 cloning Methods 0.000 description 3
- 239000013604 expression vector Substances 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 description 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 description 2
- 108090000978 Interleukin-4 Proteins 0.000 description 2
- 102000004388 Interleukin-4 Human genes 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 241000024188 Andala Species 0.000 description 1
- 102000009024 Epidermal Growth Factor Human genes 0.000 description 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 description 1
- 101000959820 Homo sapiens Interferon alpha-1/13 Proteins 0.000 description 1
- 101000998151 Homo sapiens Interleukin-17F Proteins 0.000 description 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 1
- 102100040019 Interferon alpha-1/13 Human genes 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 102000000589 Interleukin-1 Human genes 0.000 description 1
- 102000013462 Interleukin-12 Human genes 0.000 description 1
- 108010065805 Interleukin-12 Proteins 0.000 description 1
- 102100033096 Interleukin-17D Human genes 0.000 description 1
- 102000003810 Interleukin-18 Human genes 0.000 description 1
- 108090000171 Interleukin-18 Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102000000588 Interleukin-2 Human genes 0.000 description 1
- 102000013264 Interleukin-23 Human genes 0.000 description 1
- 108010065637 Interleukin-23 Proteins 0.000 description 1
- 108010066979 Interleukin-27 Proteins 0.000 description 1
- 108010002386 Interleukin-3 Proteins 0.000 description 1
- 102000000646 Interleukin-3 Human genes 0.000 description 1
- 108090001007 Interleukin-8 Proteins 0.000 description 1
- 102000004890 Interleukin-8 Human genes 0.000 description 1
- 241000282567 Macaca fascicularis Species 0.000 description 1
- 241000282560 Macaca mulatta Species 0.000 description 1
- 101000998150 Mus musculus Interleukin-17F Proteins 0.000 description 1
- 101710098940 Pro-epidermal growth factor Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 102100040247 Tumor necrosis factor Human genes 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 239000013599 cloning vector Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- -1 gIFN Proteins 0.000 description 1
- 102000056946 human IL17F Human genes 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 241001515942 marmosets Species 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361762406P | 2013-02-08 | 2013-02-08 | |
| US61/762,406 | 2013-02-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556599A Division JP6084708B2 (ja) | 2013-02-08 | 2014-02-07 | 抗ｉｌ−１７ａ抗体ならびに自己免疫性および炎症性障害の処置におけるその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017018106A JP2017018106A (ja) | 2017-01-26 |
| JP2017018106A5 true JP2017018106A5 (enExample) | 2017-03-09 |
| JP6266710B2 JP6266710B2 (ja) | 2018-01-24 |
Family
ID=50239702
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556599A Active JP6084708B2 (ja) | 2013-02-08 | 2014-02-07 | 抗ｉｌ−１７ａ抗体ならびに自己免疫性および炎症性障害の処置におけるその使用 |
| JP2016142281A Active JP6266710B2 (ja) | 2013-02-08 | 2016-07-20 | 抗ｉｌ−１７ａ抗体ならびに自己免疫性および炎症性障害の処置におけるその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556599A Active JP6084708B2 (ja) | 2013-02-08 | 2014-02-07 | 抗ｉｌ−１７ａ抗体ならびに自己免疫性および炎症性障害の処置におけるその使用 |
Country Status (38)
Families Citing this family (66)
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| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| LT2953969T (lt) * | 2013-02-08 | 2019-12-10 | Novartis Ag | Anti-il-17a antikūnai ir jų panaudojimas autoimuninių ir uždegiminių ligų gydymui |
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| CN106474470B (zh) * | 2015-08-28 | 2020-05-22 | 江苏恒瑞医药股份有限公司 | 一种抗il-17a抗体的组合物 |
| CN116059350A (zh) * | 2015-10-27 | 2023-05-05 | Ucb生物制药有限责任公司 | 使用抗-il-17a/f抗体的治疗方法 |
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