JP2016539147A5 - - Google Patents
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- Publication number
- JP2016539147A5 JP2016539147A5 JP2016536235A JP2016536235A JP2016539147A5 JP 2016539147 A5 JP2016539147 A5 JP 2016539147A5 JP 2016536235 A JP2016536235 A JP 2016536235A JP 2016536235 A JP2016536235 A JP 2016536235A JP 2016539147 A5 JP2016539147 A5 JP 2016539147A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- ptsa
- acetic anhydride
- acetic
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361912794P | 2013-12-06 | 2013-12-06 | |
| US61/912,794 | 2013-12-06 | ||
| US201461969932P | 2014-03-25 | 2014-03-25 | |
| US61/969,932 | 2014-03-25 | ||
| PCT/EP2014/076885 WO2015082719A1 (en) | 2013-12-06 | 2014-12-08 | Alternative acetylation process in the synthesis of non-ionic xray contrast agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019125133A Division JP2019206536A (ja) | 2013-12-06 | 2019-07-04 | 非イオン性ｘ線造影剤の合成における代替アセチル化方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539147A JP2016539147A (ja) | 2016-12-15 |
| JP2016539147A5 true JP2016539147A5 (enExample) | 2020-09-24 |
| JP6783140B2 JP6783140B2 (ja) | 2020-11-11 |
Family
ID=52014106
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536235A Active JP6783140B2 (ja) | 2013-12-06 | 2014-12-08 | 非イオン性ｘ線造影剤の合成における代替アセチル化方法 |
| JP2019125133A Pending JP2019206536A (ja) | 2013-12-06 | 2019-07-04 | 非イオン性ｘ線造影剤の合成における代替アセチル化方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019125133A Pending JP2019206536A (ja) | 2013-12-06 | 2019-07-04 | 非イオン性ｘ線造影剤の合成における代替アセチル化方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9688614B2 (enExample) |
| EP (1) | EP3077366B1 (enExample) |
| JP (2) | JP6783140B2 (enExample) |
| CN (1) | CN105764882B (enExample) |
| ES (1) | ES2638645T3 (enExample) |
| WO (1) | WO2015082719A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109912445A (zh) * | 2019-02-26 | 2019-06-21 | 兄弟科技股份有限公司 | 碘海醇杂质f的合成方法及其在碘海醇杂质g、杂质h和杂质m合成中的应用 |
| GB202004773D0 (en) * | 2020-03-31 | 2020-05-13 | Ge Healthcare As | Continuous crystallisation method |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
| JP3254746B2 (ja) * | 1992-08-28 | 2002-02-12 | 住友化学工業株式会社 | 末端アセチレン化合物およびその製造法 |
| CN1078201C (zh) * | 1995-11-20 | 2002-01-23 | 江苏省原子医学研究所 | 一种碘海醇的制备方法 |
| AU2001276750A1 (en) * | 2000-08-08 | 2002-02-25 | Daiichi Pharmaceutical Co., Ltd. | Processes for preparation of bicyclic compounds and intermediates therefor |
| US20110021821A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Continuous acetylation process in synthesis of non-ionic x-ray contrast agents |
| US7863484B1 (en) * | 2009-07-21 | 2011-01-04 | Ge Healthcare As | Method for reducing aminoisophthalic acid bisamide related impurities in preparation of non-ionic X-ray contrast agents |
| US20110021822A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents |
| US7754920B1 (en) | 2009-07-21 | 2010-07-13 | Ge Healthcare As | Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents |
| EP2277859A1 (en) * | 2009-07-21 | 2011-01-26 | GE Healthcare AS | Acetylation using reduced concentration of acetic acid anhydride for synthesizing non-ionic X-ray contrast agents |
| EP2277851A1 (en) | 2009-07-21 | 2011-01-26 | GE Healthcare AS | Acetylation using reduced volume of acetic acid anhydride for synthesizing non-ionic X-ray contrast agents |
-
2014
- 2014-12-08 EP EP14809013.7A patent/EP3077366B1/en active Active
- 2014-12-08 WO PCT/EP2014/076885 patent/WO2015082719A1/en not_active Ceased
- 2014-12-08 JP JP2016536235A patent/JP6783140B2/ja active Active
- 2014-12-08 US US15/100,683 patent/US9688614B2/en active Active
- 2014-12-08 ES ES14809013.7T patent/ES2638645T3/es active Active
- 2014-12-08 CN CN201480066349.3A patent/CN105764882B/zh active Active
-
2019
- 2019-07-04 JP JP2019125133A patent/JP2019206536A/ja active Pending
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