CN105764882B - 合成非离子x射线造影剂的备选乙酰化方法 - Google Patents

合成非离子x射线造影剂的备选乙酰化方法 Download PDF

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Publication number
CN105764882B
CN105764882B CN201480066349.3A CN201480066349A CN105764882B CN 105764882 B CN105764882 B CN 105764882B CN 201480066349 A CN201480066349 A CN 201480066349A CN 105764882 B CN105764882 B CN 105764882B
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compound
ptsa
added
slurry
acetylation
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Chinese (zh)
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CN105764882A (zh
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I.D.萨努姆
T.哈兰德
R.卡莱贝格
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GE Healthcare AS
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GE Healthcare AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
CN201480066349.3A 2013-12-06 2014-12-08 合成非离子x射线造影剂的备选乙酰化方法 Active CN105764882B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361912794P 2013-12-06 2013-12-06
US61/912794 2013-12-06
US201461969932P 2014-03-25 2014-03-25
US61/969932 2014-03-25
PCT/EP2014/076885 WO2015082719A1 (en) 2013-12-06 2014-12-08 Alternative acetylation process in the synthesis of non-ionic xray contrast agents

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CN105764882A CN105764882A (zh) 2016-07-13
CN105764882B true CN105764882B (zh) 2018-03-30

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US (1) US9688614B2 (enExample)
EP (1) EP3077366B1 (enExample)
JP (2) JP6783140B2 (enExample)
CN (1) CN105764882B (enExample)
ES (1) ES2638645T3 (enExample)
WO (1) WO2015082719A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109912445A (zh) * 2019-02-26 2019-06-21 兄弟科技股份有限公司 碘海醇杂质f的合成方法及其在碘海醇杂质g、杂质h和杂质m合成中的应用
GB202004773D0 (en) * 2020-03-31 2020-05-13 Ge Healthcare As Continuous crystallisation method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4250113A (en) * 1976-06-11 1981-02-10 Nyegaard & Co. A/S Chemical compounds
US7754920B1 (en) * 2009-07-21 2010-07-13 Ge Healthcare As Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
EP2277851A1 (en) * 2009-07-21 2011-01-26 GE Healthcare AS Acetylation using reduced volume of acetic acid anhydride for synthesizing non-ionic X-ray contrast agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3254746B2 (ja) * 1992-08-28 2002-02-12 住友化学工業株式会社 末端アセチレン化合物およびその製造法
CN1078201C (zh) * 1995-11-20 2002-01-23 江苏省原子医学研究所 一种碘海醇的制备方法
AU2001276750A1 (en) * 2000-08-08 2002-02-25 Daiichi Pharmaceutical Co., Ltd. Processes for preparation of bicyclic compounds and intermediates therefor
US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
EP2277859A1 (en) * 2009-07-21 2011-01-26 GE Healthcare AS Acetylation using reduced concentration of acetic acid anhydride for synthesizing non-ionic X-ray contrast agents
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US7863484B1 (en) * 2009-07-21 2011-01-04 Ge Healthcare As Method for reducing aminoisophthalic acid bisamide related impurities in preparation of non-ionic X-ray contrast agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4250113A (en) * 1976-06-11 1981-02-10 Nyegaard & Co. A/S Chemical compounds
US7754920B1 (en) * 2009-07-21 2010-07-13 Ge Healthcare As Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
EP2277851A1 (en) * 2009-07-21 2011-01-26 GE Healthcare AS Acetylation using reduced volume of acetic acid anhydride for synthesizing non-ionic X-ray contrast agents

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Publication number Publication date
EP3077366B1 (en) 2017-08-09
JP2016539147A (ja) 2016-12-15
US20160304438A1 (en) 2016-10-20
CN105764882A (zh) 2016-07-13
EP3077366A1 (en) 2016-10-12
WO2015082719A1 (en) 2015-06-11
ES2638645T3 (es) 2017-10-23
JP6783140B2 (ja) 2020-11-11
JP2019206536A (ja) 2019-12-05
US9688614B2 (en) 2017-06-27

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