JP2016538830A5 - - Google Patents

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Publication number
JP2016538830A5
JP2016538830A5 JP2016521314A JP2016521314A JP2016538830A5 JP 2016538830 A5 JP2016538830 A5 JP 2016538830A5 JP 2016521314 A JP2016521314 A JP 2016521314A JP 2016521314 A JP2016521314 A JP 2016521314A JP 2016538830 A5 JP2016538830 A5 JP 2016538830A5
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JP
Japan
Prior art keywords
cell
car
item
bcma
sequence
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JP2016521314A
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English (en)
Japanese (ja)
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JP2016538830A (ja
JP6632073B2 (ja
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Priority claimed from GBGB1317929.6A external-priority patent/GB201317929D0/en
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Publication of JP2016538830A5 publication Critical patent/JP2016538830A5/ja
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Publication of JP6632073B2 publication Critical patent/JP6632073B2/ja
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JP2016521314A 2013-10-10 2014-10-10 キメラ抗原受容体 Active JP6632073B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1317929.6 2013-10-10
GBGB1317929.6A GB201317929D0 (en) 2013-10-10 2013-10-10 Chimeric antigen receptor
PCT/GB2014/053058 WO2015052538A1 (en) 2013-10-10 2014-10-10 Chimeric antigen receptor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019002499A Division JP2019052190A (ja) 2013-10-10 2019-01-10 キメラ抗原受容体

Publications (3)

Publication Number Publication Date
JP2016538830A JP2016538830A (ja) 2016-12-15
JP2016538830A5 true JP2016538830A5 (cg-RX-API-DMAC7.html) 2017-09-21
JP6632073B2 JP6632073B2 (ja) 2020-01-15

Family

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JP2016521314A Active JP6632073B2 (ja) 2013-10-10 2014-10-10 キメラ抗原受容体
JP2019002499A Withdrawn JP2019052190A (ja) 2013-10-10 2019-01-10 キメラ抗原受容体

Family Applications After (1)

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JP2019002499A Withdrawn JP2019052190A (ja) 2013-10-10 2019-01-10 キメラ抗原受容体

Country Status (16)

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US (4) US10160794B2 (cg-RX-API-DMAC7.html)
EP (1) EP3055326B1 (cg-RX-API-DMAC7.html)
JP (2) JP6632073B2 (cg-RX-API-DMAC7.html)
KR (1) KR20160067177A (cg-RX-API-DMAC7.html)
CN (1) CN105658671B (cg-RX-API-DMAC7.html)
AU (1) AU2014333564B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016007805A2 (cg-RX-API-DMAC7.html)
CA (1) CA2926560A1 (cg-RX-API-DMAC7.html)
CL (1) CL2016000734A1 (cg-RX-API-DMAC7.html)
ES (1) ES2918626T3 (cg-RX-API-DMAC7.html)
GB (1) GB201317929D0 (cg-RX-API-DMAC7.html)
IL (1) IL244784A0 (cg-RX-API-DMAC7.html)
MX (1) MX2016004362A (cg-RX-API-DMAC7.html)
RU (2) RU2019102382A (cg-RX-API-DMAC7.html)
SG (1) SG11201602414SA (cg-RX-API-DMAC7.html)
WO (1) WO2015052538A1 (cg-RX-API-DMAC7.html)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201317928D0 (en) * 2013-10-10 2013-11-27 Ucl Business Plc Molecule
GB201317929D0 (en) * 2013-10-10 2013-11-27 Ucl Business Plc Chimeric antigen receptor
CA2939411A1 (en) 2014-02-27 2015-09-03 Ucl Business Plc Ligand
US11385233B2 (en) 2015-03-05 2022-07-12 Autolus Limited Methods of depleting malignant T-cells
US20230027993A1 (en) 2014-03-05 2023-01-26 Autolus Limited Methods
GB201403972D0 (en) 2014-03-06 2014-04-23 Ucl Business Plc Chimeric antigen receptor
CA2945620C (en) 2014-04-14 2022-12-06 Cellectis Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy
CA2973529A1 (en) 2015-01-26 2016-08-04 Cellectis Cll1-specific multi-chain chimeric antigen receptor
SG11201707089WA (en) 2015-04-13 2017-10-30 Pfizer Chimeric antigen receptors targeting b-cell maturation antigen
GB201507115D0 (en) * 2015-04-27 2015-06-10 Ucl Business Plc Nucleic Acid Construct
GB201507111D0 (en) * 2015-04-27 2015-06-10 Ucl Business Plc Nucleic acid construct
GB201507108D0 (en) 2015-04-27 2015-06-10 Ucl Business Plc Nucleic acid construct
CN114634943A (zh) 2015-05-18 2022-06-17 T细胞受体治疗公司 使用融合蛋白对tcr重编程的组合物和方法
MA42895A (fr) * 2015-07-15 2018-05-23 Juno Therapeutics Inc Cellules modifiées pour thérapie cellulaire adoptive
RS60030B1 (sr) 2015-08-03 2020-04-30 Engmab Sarl Monoklonska antitela protiv humanog antigena sazrevanja b ćelija (bcma)
CN105384825B (zh) 2015-08-11 2018-06-01 南京传奇生物科技有限公司 一种基于单域抗体的双特异性嵌合抗原受体及其应用
EP3408297A2 (en) 2016-01-29 2018-12-05 Med Manor Organics, (P) Ltd A chimeric antigen receptor specific to b-cell maturation antigen, a recombinant expression vector and a method thereof
JP7194022B2 (ja) 2016-05-20 2022-12-21 イーライ リリー アンド カンパニー Notch阻害剤とPD-1またはPD-L1阻害剤との併用療法
CA3026778A1 (en) * 2016-06-07 2017-12-14 Max-Delbruck-Centrum Fur Molekulare Medizin In Der Helmholtz-Gemeinschaft Chimeric antigen receptor and car-t cells that bind bcma
EP3494138A1 (en) 2016-08-02 2019-06-12 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
GB2564823B8 (en) 2016-10-07 2022-06-29 Tcr2 Therapeutics Inc Compositions and methods for TCR reprogramming using fusion proteins
EP4295918A3 (en) 2016-11-02 2024-03-20 Bristol-Myers Squibb Company Bispecific antibody against bcma and cd3 and an immunological drug for combined use in treating multiple myeloma
JP2019535262A (ja) * 2016-11-11 2019-12-12 オートラス リミテッド キメラ抗原受容体
CA3044593A1 (en) 2016-11-22 2018-05-31 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
IL266892B2 (en) 2016-12-02 2025-10-01 Univ Southern California Artificial immune receptors and methods of using them
EP3568406A4 (en) * 2017-01-10 2020-10-21 The General Hospital Corporation T LYMPHOCYTES EXPRESSING A CHEMERICAL ANTIGENIC RECEPTOR
IL268349B2 (en) * 2017-02-17 2024-08-01 Hutchinson Fred Cancer Res Combination therapies for treatment of bcma-related cancers and autoimmune disorders
GB201709508D0 (en) * 2017-06-15 2017-08-02 Autolus Ltd Chimeric antigen receptor
AU2018311345A1 (en) * 2017-08-02 2020-02-27 Autolus Limited Cells expressing a chimeric antigen receptor or engineered TCR and comprising a nucleotide sequence which is selectively expressed
GB201716728D0 (en) 2017-10-12 2017-11-29 Autolus Ltd Cell
BR112020008638A2 (pt) 2017-11-01 2020-10-20 Juno Therapeutics Inc receptores de antígenos quiméricos específicos para antígenos de maturação de células b (bcma)
US11851679B2 (en) 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
BR112020008812A2 (pt) 2017-11-06 2020-10-27 Juno Therapeutics Inc combinação de terapia celular e um inibidor de gama secretase
CN109971715A (zh) * 2017-12-28 2019-07-05 深圳华大生命科学研究院 一种扩增特异性car-t细胞的培养方法
US20210054086A1 (en) * 2018-01-10 2021-02-25 The General Hospital Corporation Immune cells expressing a chimeric antigen receptor
CN116082518A (zh) * 2018-02-01 2023-05-09 南京驯鹿生物技术股份有限公司 一种结合bcma的嵌合抗原受体(car)及其应用
CA3094927A1 (en) * 2018-03-23 2019-09-26 Gavish-Galilee Bio Applications Ltd. Genetically reprogrammed tregs expressing membrane-bound il-10
GB201807693D0 (en) 2018-05-11 2018-06-27 Autolus Ltd Cell
BR112020024351A2 (pt) 2018-06-01 2021-02-23 Novartis Ag moléculas de ligação contra bcma e usos das mesmas
US20210230289A1 (en) 2018-06-12 2021-07-29 The Regents Of The University Of California Single-chain bispecific chimeric antigen receptors for the treatment of cancer
TWI838389B (zh) 2018-07-19 2024-04-11 美商再生元醫藥公司 雙特異性抗-BCMAx抗-CD3抗體及其用途
CA3113896A1 (en) 2018-09-27 2020-04-02 Autolus Limited Chimeric antigen receptor
SG11202104188VA (en) 2018-11-01 2021-05-28 Juno Therapeutics Inc Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen
TW202021981A (zh) 2018-11-01 2020-06-16 美商奇諾治療有限公司 G蛋白偶合受體c類第5群成員d(gprc5d)特異性嵌合抗原受體
WO2020120982A2 (en) 2018-12-14 2020-06-18 Autolus Limited Cell
GB201904160D0 (en) 2019-03-26 2019-05-08 Autolus Ltd Cell
CN113891718B (zh) * 2019-02-21 2025-01-28 杭州天康麦生物技术有限公司 人工免疫监视嵌合抗原受体(ai-car)及其表达细胞
US20220145325A1 (en) 2019-03-08 2022-05-12 Autolus Limited Compositions and methods comprising engineered chimeric antigen receptor and modulator of car
GB201903237D0 (en) 2019-03-08 2019-04-24 Autolus Ltd Method
CN121102493A (zh) 2019-03-21 2025-12-12 瑞泽恩制药公司 用于治疗过敏症的il-4/il-13途径抑制剂和浆细胞消融的组合
US20220186232A1 (en) * 2019-03-26 2022-06-16 Gavish-Galilee Bio Applications Ltd. Genetically reprogrammed tregs expressing cars
GB201904971D0 (en) 2019-04-08 2019-05-22 Autolus Ltd Cell
GB201906202D0 (en) 2019-05-02 2019-06-19 Autolus Ltd Cell
WO2020224606A1 (zh) 2019-05-07 2020-11-12 亘喜生物科技(上海)有限公司 靶向bcma的工程化免疫细胞及其用途
US20220202864A1 (en) 2019-05-07 2022-06-30 Gracell Biotechnologies (Shanghai) Co., Ltd. Bcma-targeting engineered immune cell and use thereof
KR102878895B1 (ko) 2019-05-21 2025-10-31 노파르티스 아게 Cd19 결합 분자 및 이의 용도
CN110592015A (zh) * 2019-09-27 2019-12-20 中国科学院西双版纳热带植物园 一种诱导增强cik细胞的滇重楼多糖组合物及其应用
JP2024500847A (ja) 2020-12-18 2024-01-10 センチュリー セラピューティクス,インコーポレイテッド 適合可能な受容体特異性を有するキメラ抗原受容体システム
WO2024031091A2 (en) 2022-08-05 2024-02-08 Juno Therapeutics, Inc. Chimeric antigen receptors specific for gprc5d and bcma
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
US20250127728A1 (en) 2023-10-05 2025-04-24 Capstan Therapeutics, Inc. Constrained Ionizable Cationic Lipids and Lipid Nanoparticles
US20250242056A1 (en) 2024-01-26 2025-07-31 Regeneron Pharmaceuticals, Inc. Methods and compositions for using plasma cell depleting agents and/or b cell depleting agents to suppress host anti-aav antibody response and enable aav transduction and re-dosing
WO2025160340A2 (en) 2024-01-26 2025-07-31 Regeneron Pharmaceuticals, Inc. Combination immunosuppression for inhibiting an immune response and enabling immunogen administration and re-administration
WO2025184567A1 (en) 2024-03-01 2025-09-04 Regeneron Pharmaceuticals, Inc. Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
GB202403564D0 (en) 2024-03-12 2024-04-24 Autolus Ltd Method
WO2025217452A1 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
WO2025217454A2 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Ionizable cationic lipids and lipid nanoparticles

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE200000147A (et) * 1997-09-12 2001-02-15 Biogen, Incorporated April - uus kasvuefekte omav valk
UA74798C2 (uk) * 1999-10-06 2006-02-15 Байоджен Айдек Ма Інк. Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
SI1297013T1 (sl) * 2000-04-27 2007-06-30 Biogen Idec Inc Uporaba TACI kot protitumorskega sredstva
EP1309718A4 (en) * 2000-08-15 2004-08-25 Human Genome Sciences Inc NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT
EP1362061A2 (en) * 2001-02-20 2003-11-19 ZymoGenetics, Inc. Antibodies that bind both bcma and taci
CA2480745A1 (en) * 2002-04-09 2003-10-23 Biogen, Inc. Methods for treating tweak-related conditions
WO2004027026A2 (en) * 2002-09-19 2004-04-01 Biogen Idec Ma Inc. Improved methods for preparing highly active april ligand polypeptides
EP1836224A1 (en) * 2004-12-23 2007-09-26 Laboratoires Serono S.A. Bcma polypeptides and uses thereof
AT503861B1 (de) * 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw Verfahren zur manipulation von t-zell-rezeptoren
US20100105136A1 (en) 2006-10-09 2010-04-29 The General Hospital Corporation Chimeric t-cell receptors and t-cells targeting egfrviii on tumors
TWI679212B (zh) 2011-11-15 2019-12-11 美商安進股份有限公司 針對bcma之e3以及cd3的結合分子
EP2836239A1 (en) * 2012-04-11 2015-02-18 The United States of America, as Represented By the Secretary, Department of Health and Human Services Chimeric antigen receptors targeting b-cell maturation antigen
CN103145849B (zh) * 2013-02-18 2014-06-11 冯振卿 嵌合抗原受体及其用途
GB201317929D0 (en) * 2013-10-10 2013-11-27 Ucl Business Plc Chimeric antigen receptor
CA2939411A1 (en) 2014-02-27 2015-09-03 Ucl Business Plc Ligand
JP2019535262A (ja) 2016-11-11 2019-12-12 オートラス リミテッド キメラ抗原受容体
GB201709508D0 (en) 2017-06-15 2017-08-02 Autolus Ltd Chimeric antigen receptor
US20210054086A1 (en) * 2018-01-10 2021-02-25 The General Hospital Corporation Immune cells expressing a chimeric antigen receptor

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