JP2016538584A5 - - Google Patents

Download PDF

Info

Publication number
JP2016538584A5
JP2016538584A5 JP2016521691A JP2016521691A JP2016538584A5 JP 2016538584 A5 JP2016538584 A5 JP 2016538584A5 JP 2016521691 A JP2016521691 A JP 2016521691A JP 2016521691 A JP2016521691 A JP 2016521691A JP 2016538584 A5 JP2016538584 A5 JP 2016538584A5
Authority
JP
Japan
Prior art keywords
biological sample
light
axis
along
fluorescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016521691A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016538584A (ja
JP6364074B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/059822 external-priority patent/WO2015054450A1/en
Publication of JP2016538584A publication Critical patent/JP2016538584A/ja
Publication of JP2016538584A5 publication Critical patent/JP2016538584A5/ja
Application granted granted Critical
Publication of JP6364074B2 publication Critical patent/JP6364074B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016521691A 2013-10-09 2014-10-09 マルチビュー・ライトシート顕微鏡検査法 Active JP6364074B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361888869P 2013-10-09 2013-10-09
US61/888,869 2013-10-09
PCT/US2014/059822 WO2015054450A1 (en) 2013-10-09 2014-10-09 Multiview light-sheet microscopy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018124403A Division JP6625696B2 (ja) 2013-10-09 2018-06-29 マルチビュー・ライトシート顕微鏡検査法

Publications (3)

Publication Number Publication Date
JP2016538584A JP2016538584A (ja) 2016-12-08
JP2016538584A5 true JP2016538584A5 (enExample) 2017-11-24
JP6364074B2 JP6364074B2 (ja) 2018-07-25

Family

ID=52776741

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016521691A Active JP6364074B2 (ja) 2013-10-09 2014-10-09 マルチビュー・ライトシート顕微鏡検査法
JP2018124403A Active JP6625696B2 (ja) 2013-10-09 2018-06-29 マルチビュー・ライトシート顕微鏡検査法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018124403A Active JP6625696B2 (ja) 2013-10-09 2018-06-29 マルチビュー・ライトシート顕微鏡検査法

Country Status (4)

Country Link
US (1) US10539772B2 (enExample)
EP (1) EP3055728B1 (enExample)
JP (2) JP6364074B2 (enExample)
WO (1) WO2015054450A1 (enExample)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014531908A (ja) 2011-10-14 2014-12-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 構造アッセンブリによる配列決定
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
US10138509B2 (en) 2013-03-12 2018-11-27 President And Fellows Of Harvard College Method for generating a three-dimensional nucleic acid containing matrix
DE102013112596B4 (de) * 2013-11-15 2023-12-28 Carl Zeiss Microscopy Gmbh Anordnung zur Lichtblattmikroskopie
WO2016007839A1 (en) 2014-07-11 2016-01-14 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
ES2567379B1 (es) * 2014-10-21 2017-02-03 Universidad Carlos Iii De Madrid Microscopio y procedimiento para la generación de imágenes 3D de una colección demuestras
DE102014116174A1 (de) * 2014-11-06 2016-05-12 Carl Zeiss Microscopy Gmbh Verfahren zur Erzeugung eines Bildes einer Probe
US10795144B2 (en) * 2014-12-06 2020-10-06 Howard Hughes Medical Institute Microscopy with structured plane illumination and point accumulation for imaging and nanoscale topography
CA2977073A1 (en) 2015-02-23 2016-09-01 Li-Cor, Inc. Fluorescence biopsy specimen imager and methods
JP6552881B2 (ja) * 2015-06-12 2019-07-31 オリンパス株式会社 顕微鏡および顕微鏡画像取得方法
CN107709968A (zh) 2015-06-26 2018-02-16 利康公司 荧光活检样本成像仪及方法
ITUB20154591A1 (it) * 2015-10-12 2017-04-12 Crestoptics S R L Apparato di microscopia confocale e relativo procedimento di acquisizione ed elaborazione di immagini
US10802262B2 (en) * 2015-10-29 2020-10-13 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for imaging a biological sample
JP6882282B2 (ja) * 2015-11-03 2021-06-02 プレジデント アンド フェローズ オブ ハーバード カレッジ 三次元核酸含有マトリックスの立体撮像のための方法と装置
CN113063755A (zh) * 2015-11-17 2021-07-02 韩国科学技术院 利用混沌波传感器的样品特性探测装置
DE102016204653B4 (de) * 2016-03-21 2022-12-22 Carl Zeiss Microscopy Gmbh Die Erfindung betrifft ein Lichtblattmikroskop sowie ein Verfahren zum Betreiben eines Lichtblattmikroskops
DE102016105798A1 (de) * 2016-03-30 2017-10-05 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Verfahren zum Erzeugen eines Mikroskopbildes
LU93022B1 (de) 2016-04-08 2017-11-08 Leica Microsystems Verfahren und Mikroskop zum Untersuchen einer Probe
EP3446098A1 (en) 2016-04-21 2019-02-27 Li-Cor, Inc. Multimodality multi-axis 3-d imaging
EP4613756A3 (en) 2016-04-25 2025-11-12 President And Fellows Of Harvard College Hybridization chain reaction methods for in situ molecular detection
DE102016108384B3 (de) * 2016-05-04 2017-11-09 Leica Microsystems Cms Gmbh Vorrichtung und Verfahren zur lichtblattartigen Beleuchtung einer Probe
US10495554B2 (en) * 2016-05-25 2019-12-03 The Board Of Trustees Of The Leland Stanford Junior University Method and system for imaging and analysis of a biological specimen
WO2017223378A1 (en) 2016-06-23 2017-12-28 Li-Cor, Inc. Complementary color flashing for multichannel image presentation
US11320640B2 (en) * 2016-06-24 2022-05-03 Howard Hughes Medical Institute Automated adjustment of light sheet geometry in a microscope
EP3497502B1 (de) * 2016-08-15 2022-10-26 Leica Microsystems CMS GmbH Lichtblattmikroskop
EP4273594A3 (en) 2016-09-09 2024-01-10 The University of North Carolina at Chapel Hill Tilted illumination systems for fluoresence microscopes
EP3296723A1 (en) * 2016-09-14 2018-03-21 ASML Netherlands B.V. Illumination source for an inspection apparatus, inspection apparatus and inspection method
US10690898B2 (en) * 2016-09-15 2020-06-23 Molecular Devices (Austria) GmbH Light-field microscope with selective-plane illumination
US11506877B2 (en) * 2016-11-10 2022-11-22 The Trustees Of Columbia University In The City Of New York Imaging instrument having objective axis and light sheet or light beam projector axis intersecting at less than 90 degrees
WO2018098162A1 (en) 2016-11-23 2018-05-31 Li-Cor, Inc. Motion-adaptive interactive imaging method
JP2018105936A (ja) * 2016-12-22 2018-07-05 オリンパス株式会社 顕微鏡、設定支援方法
CN110100175A (zh) * 2017-02-02 2019-08-06 伊斯梅卡半导体控股公司 用于检查部件的组件和方法
US11156822B2 (en) 2017-04-24 2021-10-26 Igor Lyuboshenko Selective plane illumination microscopy with multiple illumination units scanning an object in sync with a digital camera rolling shutter
US10768400B2 (en) 2017-04-24 2020-09-08 Igor Lyuboshenko Varying an illumination path of a selective plane illumination microscopy
US10365464B1 (en) 2017-04-24 2019-07-30 Igor Lyuboshenko Extending optical microscopes to provide selective plane illumination microscopy
US12474561B2 (en) 2017-04-24 2025-11-18 Igor Lyuboshenko Automatic correction of spherical aberration in selective plane illumination microscopy
EP3616158A1 (en) 2017-04-25 2020-03-04 Li-Cor, Inc. Top-down and rotational side view biopsy specimen imager and methods
JP7014794B2 (ja) * 2017-07-11 2022-02-01 浜松ホトニクス株式会社 試料観察装置及び試料観察方法
EP3454105A1 (en) * 2017-09-08 2019-03-13 Igor Lyuboshenko Varying an illumination path of a selective plane illumination microscopy
CN107884379A (zh) * 2017-12-18 2018-04-06 北京赛尔怡美科技有限公司 光片照明成像装置
CN111869205B (zh) * 2018-01-19 2022-06-10 Pcms控股公司 具有变化位置的多焦平面
CN108334688B (zh) * 2018-01-29 2022-04-01 南京理工大学 基于matlab的旋转功能梯度厚板动力学行为计算方法
WO2019152216A1 (en) * 2018-02-01 2019-08-08 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Systems and methods for robust background correction and/or emitter localization for super-resolution localization microscopy
CN112005100B (zh) * 2018-03-12 2024-09-20 查珀尔希尔北卡罗来纳大学 用于荧光显微镜的光盘显微术
CN112020641B (zh) 2018-03-12 2024-04-16 查珀尔希尔北卡罗来纳大学 用于增加收集的镜像显微术
US12153227B2 (en) 2018-03-12 2024-11-26 The University Of North Carolina At Chapel Hill Light disc microscopy for fluorescence microscopes
US11477434B2 (en) 2018-03-23 2022-10-18 Pcms Holdings, Inc. Multifocal plane based method to produce stereoscopic viewpoints in a DIBR system (MFP-DIBR)
CN108956562B (zh) * 2018-06-11 2020-05-22 浙江大学 一种基于重定位的光切片荧光显微成像方法和装置
WO2020010018A1 (en) 2018-07-05 2020-01-09 Pcms Holdings, Inc. Method and system for near-eye focal plane overlays for 3d perception of content on 2d displays
DE102018215833B4 (de) * 2018-09-18 2020-04-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Optische Anordnung für fluoreszenzmikroskopische Anwendungen
DE102018215831B4 (de) * 2018-09-18 2020-04-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Optische Anordnung für fluoreszenzmikroskopische Anwendungen
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
WO2020161826A1 (ja) 2019-02-06 2020-08-13 オリンパス株式会社 撮像装置
US11187659B2 (en) * 2019-03-28 2021-11-30 The Regents Of The University Of California Systems for fluorescence light sheet microscopy of large samples in high refractive index solutions
EP3796065B1 (en) * 2019-09-20 2025-02-19 Leica Microsystems CMS GmbH Light sheet microscope with exchangeable optical elements
CN111521608A (zh) * 2020-04-27 2020-08-11 中国科学院广州生物医药与健康研究院 一种超分辨率显微成像方法及显微镜
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
KR102451422B1 (ko) * 2020-11-24 2022-10-07 울산과학기술원 초고해상도 이미지와 고속 광시야 이미지를 동시에 획득하는 방법 및 장치
EP4036628A1 (en) * 2021-01-22 2022-08-03 Viventis Microscopy Sàrl Microscope for imaging a sample
DE102021107821B4 (de) * 2021-03-29 2023-05-11 Universität Kassel, Körperschaft des öffentlichen Rechts Lichtblatt-fluoreszenzmikroskop und verfahren zur tomographischen darstellung
US12443023B2 (en) * 2021-05-14 2025-10-14 Igor Lyuboshenko Light sheet microscope having streamlined field of view changes
JPWO2022249583A1 (enExample) * 2021-05-26 2022-12-01
EP4134724A1 (en) * 2021-08-13 2023-02-15 European Molecular Biology Laboratory Inverted light-sheet microscope
WO2023049164A1 (en) * 2021-09-22 2023-03-30 Howard Hughes Medical Institute Multiscale multiview light-sheet imaging
CN114236801B (zh) * 2021-10-25 2024-01-05 北京京东方技术开发有限公司 光片生成装置及具有其的显微镜系统
WO2024068455A1 (en) * 2022-09-26 2024-04-04 Consiglio Nazionale Delle Ricerche System and method for multicolor light sheet microscopy
WO2024178045A1 (en) * 2023-02-21 2024-08-29 The Board Of Regents Of The University Of Texas System Systems, methods, and devices providing fluorescence microscopy confocally sectioned images

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003185927A (ja) 2001-12-13 2003-07-03 Olympus Optical Co Ltd 走査型レーザー顕微鏡
DE10257423A1 (de) 2002-12-09 2004-06-24 Europäisches Laboratorium für Molekularbiologie (EMBL) Mikroskop
WO2009002225A2 (ru) 2007-06-25 2008-12-31 Closed Company 'molecular-Medicine Technologies' Многофункциональное устройство для диагностики и способ тестирования биологических объектов
DE102007045897A1 (de) 2007-09-26 2009-04-09 Carl Zeiss Microimaging Gmbh Verfahren zur mikroskopischen dreidimensionalen Abbildung einer Probe
DE102007063274B8 (de) 2007-12-20 2022-12-15 Albert-Ludwigs-Universität Freiburg Mikroskop
DE102008009216A1 (de) 2008-02-13 2009-08-20 Carl Zeiss Microimaging Gmbh Vorrichtung und Verfahren zum räumlich hochauflösenden Abbilden einer Struktur einer Probe
US9134521B2 (en) * 2008-07-30 2015-09-15 The Regents Of The University Of California Multidirectional selective plane illumination microscopy
DE102009044983A1 (de) 2009-09-24 2011-03-31 Carl Zeiss Microimaging Gmbh Mikroskop
DE102009044984A1 (de) 2009-09-24 2011-03-31 Carl Zeiss Microimaging Gmbh Mikroskop
WO2011059833A2 (en) 2009-10-29 2011-05-19 California Institute Of Technology Dual-mode raster point scanning/light sheet illumination microscope
JP4894907B2 (ja) 2009-11-17 2012-03-14 カシオ計算機株式会社 撮像装置、撮像処理方法及びプログラム
US8711211B2 (en) * 2010-06-14 2014-04-29 Howard Hughes Medical Institute Bessel beam plane illumination microscope
US10051240B2 (en) 2010-06-14 2018-08-14 Howard Hughes Medical Institute Structured plane illumination microscopy
WO2012027542A2 (en) 2010-08-25 2012-03-01 California Institute Of Technology Simultaneous orthogonal light sheet microscopy and computed optical tomography
DE102010060121C5 (de) 2010-10-22 2023-09-28 Leica Microsystems Cms Gmbh SPIM-Mikroskop mit sequenziellem Lightsheet
US10908403B2 (en) 2011-02-14 2021-02-02 European Molecular Biology Laboratory (Embl) Light-pad microscope for high-resolution 3D fluorescence imaging and 2D fluctuation spectroscopy
WO2012122027A2 (en) * 2011-03-04 2012-09-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Optomechanical module for converting a microscope to provide selective plane illumination microscopy
JP6037623B2 (ja) 2012-02-24 2016-12-07 オリンパス株式会社 レーザ走査型共焦点顕微鏡、及び、レーザ走査型共焦点顕微鏡の光学系のアライメント調整方法
ES2898616T3 (es) 2012-04-03 2022-03-08 Univ Court Univ St Andrews Imágenes de alta resolución de volúmenes extendidos
DE102012013163B4 (de) 2012-07-02 2022-08-25 Carl Zeiss Microscopy Gmbh Mikroskop und Verfahren zur Lichtscheibenmikroskopie

Similar Documents

Publication Publication Date Title
JP2016538584A5 (enExample)
US9810896B2 (en) Microscope device and microscope system
US10007100B2 (en) Light sheet illumination microscope and light sheet illumination method
US8254020B2 (en) Objective-coupled selective plane illumination microscopy
JP6417262B2 (ja) シート照明顕微鏡
JP2018520388A (ja) 複数の対象面を同時にイメージングする光シート顕微鏡
KR101609029B1 (ko) 광 전달 매질의 투과 특성을 측정하는 방법 및 이를 이용한 이미지 획득 장치
JP2017167535A (ja) ライトフィールド顕微鏡および照明方法
US10191263B2 (en) Scanning microscopy system
JP2019530006A (ja) 選択的平面照明を伴う明視野顕微鏡
WO2019086550A8 (en) Confocal scanning imaging systems with micro optical element arrays and methods of specimen imaging
JP2008502929A (ja) 反射または透過赤外光による微細構造の検査装置または検査方法
US9217665B2 (en) Viewing-angle imaging using lenslet array
US9820652B2 (en) Multi-photon microscope having an excitation-beam array
US11237374B2 (en) Optical arrangement and method for imaging a sample
US20160313548A1 (en) Method for capturing image of three-dimensional structure of specimen and microscopic device
CN105874317A (zh) 用于借助于光学投影断层扫描术研究样品的方法和设备
JP5311195B2 (ja) 顕微鏡装置
JP2016024210A (ja) 位相変調素子調整システムおよび位相変調素子調整方法
JP2012133368A5 (enExample)
US20170336610A1 (en) Resolution enhancement for light sheet microscopy systems and methods
JP5311196B2 (ja) 顕微鏡装置
CN104677872A (zh) 多光子激发多向照明显微成像系统
JP2012228544A5 (enExample)
JP2018194634A (ja) ライトフィールド顕微鏡