JP2016537379A - 増強された防腐剤 - Google Patents
増強された防腐剤 Download PDFInfo
- Publication number
- JP2016537379A JP2016537379A JP2016532576A JP2016532576A JP2016537379A JP 2016537379 A JP2016537379 A JP 2016537379A JP 2016532576 A JP2016532576 A JP 2016532576A JP 2016532576 A JP2016532576 A JP 2016532576A JP 2016537379 A JP2016537379 A JP 2016537379A
- Authority
- JP
- Japan
- Prior art keywords
- zinc
- pyrithione
- biocide
- composition
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003755 preservative agent Substances 0.000 title claims description 18
- 239000003139 biocide Substances 0.000 claims abstract description 102
- 230000003115 biocidal effect Effects 0.000 claims abstract description 98
- 239000000203 mixture Substances 0.000 claims abstract description 97
- -1 amine salt Chemical class 0.000 claims abstract description 67
- FGVVTMRZYROCTH-UHFFFAOYSA-N pyridine-2-thiol N-oxide Chemical compound [O-][N+]1=CC=CC=C1S FGVVTMRZYROCTH-UHFFFAOYSA-N 0.000 claims abstract description 65
- 229960002026 pyrithione Drugs 0.000 claims abstract description 61
- 150000001412 amines Chemical class 0.000 claims abstract description 43
- 239000003623 enhancer Substances 0.000 claims abstract description 32
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 29
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229920006395 saturated elastomer Polymers 0.000 claims description 63
- GUUULVAMQJLDSY-UHFFFAOYSA-N 4,5-dihydro-1,2-thiazole Chemical compound C1CC=NS1 GUUULVAMQJLDSY-UHFFFAOYSA-N 0.000 claims description 31
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 22
- 125000004122 cyclic group Chemical group 0.000 claims description 19
- 230000002335 preservative effect Effects 0.000 claims description 12
- 229920002873 Polyethylenimine Polymers 0.000 claims description 11
- 150000003752 zinc compounds Chemical class 0.000 claims description 11
- 239000011787 zinc oxide Substances 0.000 claims description 11
- 125000000623 heterocyclic group Chemical group 0.000 claims description 10
- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical group C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 claims description 8
- 150000003751 zinc Chemical class 0.000 claims description 7
- RJSZFSOFYVMDIC-UHFFFAOYSA-N tert-butyl n,n-dimethylcarbamate Chemical compound CN(C)C(=O)OC(C)(C)C RJSZFSOFYVMDIC-UHFFFAOYSA-N 0.000 claims description 6
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 6
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 claims description 6
- ZRIILUSQBDFVNY-UHFFFAOYSA-N 4-dodecylmorpholine Chemical compound CCCCCCCCCCCCN1CCOCC1 ZRIILUSQBDFVNY-UHFFFAOYSA-N 0.000 claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 5
- 229910052791 calcium Inorganic materials 0.000 claims description 5
- 239000011575 calcium Substances 0.000 claims description 5
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 claims description 5
- JRBPAEWTRLWTQC-UHFFFAOYSA-N dodecylamine Chemical compound CCCCCCCCCCCCN JRBPAEWTRLWTQC-UHFFFAOYSA-N 0.000 claims description 5
- 229910052749 magnesium Inorganic materials 0.000 claims description 5
- 239000011777 magnesium Substances 0.000 claims description 5
- YWFWDNVOPHGWMX-UHFFFAOYSA-N n,n-dimethyldodecan-1-amine Chemical compound CCCCCCCCCCCCN(C)C YWFWDNVOPHGWMX-UHFFFAOYSA-N 0.000 claims description 5
- 229910052700 potassium Inorganic materials 0.000 claims description 5
- 239000011591 potassium Substances 0.000 claims description 5
- 239000011667 zinc carbonate Substances 0.000 claims description 5
- 235000004416 zinc carbonate Nutrition 0.000 claims description 5
- 229910000010 zinc carbonate Inorganic materials 0.000 claims description 5
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 claims description 5
- 229940007718 zinc hydroxide Drugs 0.000 claims description 5
- 229910021511 zinc hydroxide Inorganic materials 0.000 claims description 5
- 229940043810 zinc pyrithione Drugs 0.000 claims description 5
- 150000007522 mineralic acids Chemical class 0.000 claims description 4
- NYNKJVPRTLBJNQ-UHFFFAOYSA-N n'-(3-aminopropyl)-n'-dodecylpropane-1,3-diamine Chemical compound CCCCCCCCCCCCN(CCCN)CCCN NYNKJVPRTLBJNQ-UHFFFAOYSA-N 0.000 claims description 4
- 150000007524 organic acids Chemical class 0.000 claims description 4
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 4
- 229960001763 zinc sulfate Drugs 0.000 claims description 4
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 4
- RDWXSJCICPOOKO-UHFFFAOYSA-N 2-methyl-1,2-benzothiazol-3-one Chemical compound C1=CC=C2C(=O)N(C)SC2=C1 RDWXSJCICPOOKO-UHFFFAOYSA-N 0.000 claims description 3
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 3
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 3
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 3
- 239000005083 Zinc sulfide Substances 0.000 claims description 3
- 229910052797 bismuth Inorganic materials 0.000 claims description 3
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 claims description 3
- QHNCWVQDOPICKC-UHFFFAOYSA-N copper;1-hydroxypyridine-2-thione Chemical compound [Cu].ON1C=CC=CC1=S.ON1C=CC=CC1=S QHNCWVQDOPICKC-UHFFFAOYSA-N 0.000 claims description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052737 gold Inorganic materials 0.000 claims description 3
- 239000010931 gold Substances 0.000 claims description 3
- 229910052744 lithium Inorganic materials 0.000 claims description 3
- 229910052748 manganese Inorganic materials 0.000 claims description 3
- 239000011572 manganese Substances 0.000 claims description 3
- NCCHARWOCKOHIH-UHFFFAOYSA-N n-methylbenzamide Chemical compound CNC(=O)C1=CC=CC=C1 NCCHARWOCKOHIH-UHFFFAOYSA-N 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
- JPMIIZHYYWMHDT-UHFFFAOYSA-N octhilinone Chemical compound CCCCCCCCN1SC=CC1=O JPMIIZHYYWMHDT-UHFFFAOYSA-N 0.000 claims description 3
- 229910052709 silver Inorganic materials 0.000 claims description 3
- 239000004332 silver Substances 0.000 claims description 3
- XNRNJIIJLOFJEK-UHFFFAOYSA-N sodium;1-oxidopyridine-2-thione Chemical group [Na+].[O-]N1C=CC=CC1=S XNRNJIIJLOFJEK-UHFFFAOYSA-N 0.000 claims description 3
- 229910052712 strontium Inorganic materials 0.000 claims description 3
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 3
- 125000005750 substituted cyclic group Chemical group 0.000 claims description 3
- 239000011592 zinc chloride Substances 0.000 claims description 3
- 235000005074 zinc chloride Nutrition 0.000 claims description 3
- 229910052984 zinc sulfide Inorganic materials 0.000 claims description 3
- DRDVZXDWVBGGMH-UHFFFAOYSA-N zinc;sulfide Chemical compound [S-2].[Zn+2] DRDVZXDWVBGGMH-UHFFFAOYSA-N 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 2
- BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 claims 4
- UAYWVJHJZHQCIE-UHFFFAOYSA-L zinc iodide Chemical compound I[Zn]I UAYWVJHJZHQCIE-UHFFFAOYSA-L 0.000 claims 4
- 235000014692 zinc oxide Nutrition 0.000 claims 4
- PUSPAPGHKSLKKH-UHFFFAOYSA-N 2-methyl-1,2-thiazolidin-3-one Chemical compound CN1SCCC1=O PUSPAPGHKSLKKH-UHFFFAOYSA-N 0.000 claims 2
- UBWLNECWELYOIE-UHFFFAOYSA-N 4,4-dichloro-2-octyl-1,2-thiazolidin-3-one Chemical compound CCCCCCCCN1SCC(Cl)(Cl)C1=O UBWLNECWELYOIE-UHFFFAOYSA-N 0.000 claims 2
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims 2
- 239000004110 Zinc silicate Substances 0.000 claims 2
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims 2
- MFGZXPGKKJMZIY-UHFFFAOYSA-N ethyl 5-amino-1-(4-sulfamoylphenyl)pyrazole-4-carboxylate Chemical compound NC1=C(C(=O)OCC)C=NN1C1=CC=C(S(N)(=O)=O)C=C1 MFGZXPGKKJMZIY-UHFFFAOYSA-N 0.000 claims 2
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims 2
- BIKXLKXABVUSMH-UHFFFAOYSA-N trizinc;diborate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]B([O-])[O-].[O-]B([O-])[O-] BIKXLKXABVUSMH-UHFFFAOYSA-N 0.000 claims 2
- MJIBOYFUEIDNPI-HBNMXAOGSA-L zinc 5-[2,3-dihydroxy-5-[(2R,3R,4S,5R,6S)-4,5,6-tris[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]-2-[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxymethyl]oxan-3-yl]oxycarbonylphenoxy]carbonyl-3-hydroxybenzene-1,2-diolate Chemical compound [Zn++].Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c([O-])c([O-])c2)c1 MJIBOYFUEIDNPI-HBNMXAOGSA-L 0.000 claims 2
- 239000004246 zinc acetate Substances 0.000 claims 2
- 229940043825 zinc carbonate Drugs 0.000 claims 2
- 229960001939 zinc chloride Drugs 0.000 claims 2
- 239000011746 zinc citrate Substances 0.000 claims 2
- 235000006076 zinc citrate Nutrition 0.000 claims 2
- 229940068475 zinc citrate Drugs 0.000 claims 2
- 239000011576 zinc lactate Substances 0.000 claims 2
- 235000000193 zinc lactate Nutrition 0.000 claims 2
- 229940050168 zinc lactate Drugs 0.000 claims 2
- 229960001296 zinc oxide Drugs 0.000 claims 2
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 claims 2
- 229910000165 zinc phosphate Inorganic materials 0.000 claims 2
- XSMMCTCMFDWXIX-UHFFFAOYSA-N zinc silicate Chemical compound [Zn+2].[O-][Si]([O-])=O XSMMCTCMFDWXIX-UHFFFAOYSA-N 0.000 claims 2
- 235000019352 zinc silicate Nutrition 0.000 claims 2
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims 2
- 229940006174 zinc valerate Drugs 0.000 claims 2
- VRGNUPCISFMPEM-ZVGUSBNCSA-L zinc;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VRGNUPCISFMPEM-ZVGUSBNCSA-L 0.000 claims 2
- LPEBYPDZMWMCLZ-CVBJKYQLSA-L zinc;(z)-octadec-9-enoate Chemical compound [Zn+2].CCCCCCCC\C=C/CCCCCCCC([O-])=O.CCCCCCCC\C=C/CCCCCCCC([O-])=O LPEBYPDZMWMCLZ-CVBJKYQLSA-L 0.000 claims 2
- ZPEJZWGMHAKWNL-UHFFFAOYSA-L zinc;oxalate Chemical compound [Zn+2].[O-]C(=O)C([O-])=O ZPEJZWGMHAKWNL-UHFFFAOYSA-L 0.000 claims 2
- BUDAIZWUWHWZPQ-UHFFFAOYSA-L zinc;pentanoate Chemical compound [Zn+2].CCCCC([O-])=O.CCCCC([O-])=O BUDAIZWUWHWZPQ-UHFFFAOYSA-L 0.000 claims 2
- XDWXRAYGALQIFG-UHFFFAOYSA-L zinc;propanoate Chemical compound [Zn+2].CCC([O-])=O.CCC([O-])=O XDWXRAYGALQIFG-UHFFFAOYSA-L 0.000 claims 2
- PEUPCBAALXHYHP-UHFFFAOYSA-L zinc;selenite Chemical compound [Zn+2].[O-][Se]([O-])=O PEUPCBAALXHYHP-UHFFFAOYSA-L 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 1
- MGIYRDNGCNKGJU-UHFFFAOYSA-N isothiazolinone Chemical compound O=C1C=CSN1 MGIYRDNGCNKGJU-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 description 28
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 19
- 239000000047 product Substances 0.000 description 17
- 125000003342 alkenyl group Chemical group 0.000 description 15
- 125000004103 aminoalkyl group Chemical group 0.000 description 14
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 14
- 239000002245 particle Substances 0.000 description 13
- 125000003545 alkoxy group Chemical group 0.000 description 11
- 125000000304 alkynyl group Chemical group 0.000 description 11
- 230000000845 anti-microbial effect Effects 0.000 description 11
- 150000003839 salts Chemical class 0.000 description 10
- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 9
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- UEFCKYIRXORTFI-UHFFFAOYSA-N 1,2-thiazolidin-3-one Chemical class O=C1CCSN1 UEFCKYIRXORTFI-UHFFFAOYSA-N 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 239000012467 final product Substances 0.000 description 5
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 5
- 239000003973 paint Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 4
- 239000004166 Lanolin Substances 0.000 description 4
- 239000003945 anionic surfactant Substances 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 4
- 235000019438 castor oil Nutrition 0.000 description 4
- 229940008099 dimethicone Drugs 0.000 description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 4
- 235000019388 lanolin Nutrition 0.000 description 4
- 229940039717 lanolin Drugs 0.000 description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 4
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 4
- YBBJKCMMCRQZMA-UHFFFAOYSA-N pyrithione Chemical group ON1C=CC=CC1=S YBBJKCMMCRQZMA-UHFFFAOYSA-N 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 235000013162 Cocos nucifera Nutrition 0.000 description 3
- 244000060011 Cocos nucifera Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
- 244000044822 Simmondsia californica Species 0.000 description 3
- 235000004433 Simmondsia californica Nutrition 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 239000004599 antimicrobial Substances 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000002054 inoculum Substances 0.000 description 3
- 229940091250 magnesium supplement Drugs 0.000 description 3
- 150000002780 morpholines Chemical class 0.000 description 3
- ONHFWHCMZAJCFB-UHFFFAOYSA-N myristamine oxide Chemical compound CCCCCCCCCCCCCC[N+](C)(C)[O-] ONHFWHCMZAJCFB-UHFFFAOYSA-N 0.000 description 3
- UTTVXKGNTWZECK-UHFFFAOYSA-N n,n-dimethyloctadecan-1-amine oxide Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)[O-] UTTVXKGNTWZECK-UHFFFAOYSA-N 0.000 description 3
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 150000003512 tertiary amines Chemical class 0.000 description 3
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 2
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 2
- PORQOHRXAJJKGK-UHFFFAOYSA-N 4,5-dichloro-2-n-octyl-3(2H)-isothiazolone Chemical compound CCCCCCCCN1SC(Cl)=C(Cl)C1=O PORQOHRXAJJKGK-UHFFFAOYSA-N 0.000 description 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 2
- 235000010919 Copernicia prunifera Nutrition 0.000 description 2
- 244000180278 Copernicia prunifera Species 0.000 description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- 235000001950 Elaeis guineensis Nutrition 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
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- YYRMITYYFKZLLJ-UHFFFAOYSA-N n,n-dimethylhexan-1-amine oxide Chemical compound CCCCCC[N+](C)(C)[O-] YYRMITYYFKZLLJ-UHFFFAOYSA-N 0.000 description 1
- XZEZLJBGDNUAQX-UHFFFAOYSA-N n,n-dimethylnonan-1-amine oxide Chemical compound CCCCCCCCC[N+](C)(C)[O-] XZEZLJBGDNUAQX-UHFFFAOYSA-N 0.000 description 1
- DLPZOAYAGDEIHC-UHFFFAOYSA-N n,n-dimethylpentadecan-1-amine oxide Chemical compound CCCCCCCCCCCCCCC[N+](C)(C)[O-] DLPZOAYAGDEIHC-UHFFFAOYSA-N 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N n-hexadecanoic acid Natural products CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- ONLRKTIYOMZEJM-UHFFFAOYSA-N n-methylmethanamine oxide Chemical compound C[NH+](C)[O-] ONLRKTIYOMZEJM-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 description 1
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- 150000007978 oxazole derivatives Chemical class 0.000 description 1
- 150000002917 oxazolidines Chemical class 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
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- 239000002304 perfume Substances 0.000 description 1
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- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229940068988 potassium aspartate Drugs 0.000 description 1
- ONQDVAFWWYYXHM-UHFFFAOYSA-M potassium lauryl sulfate Chemical compound [K+].CCCCCCCCCCCCOS([O-])(=O)=O ONQDVAFWWYYXHM-UHFFFAOYSA-M 0.000 description 1
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- 235000010241 potassium sorbate Nutrition 0.000 description 1
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- 150000003141 primary amines Chemical class 0.000 description 1
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 150000003216 pyrazines Chemical class 0.000 description 1
- USPWKWBDZOARPV-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1 USPWKWBDZOARPV-UHFFFAOYSA-N 0.000 description 1
- 150000003218 pyrazolidines Chemical class 0.000 description 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
- 150000004892 pyridazines Chemical class 0.000 description 1
- WHMDPDGBKYUEMW-UHFFFAOYSA-N pyridine-2-thiol Chemical compound SC1=CC=CC=N1 WHMDPDGBKYUEMW-UHFFFAOYSA-N 0.000 description 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- 150000003233 pyrroles Chemical class 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 229940066675 ricinoleate Drugs 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 231100000051 skin sensitiser Toxicity 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 229940045870 sodium palmitate Drugs 0.000 description 1
- 229940045871 sodium palmitoyl proline Drugs 0.000 description 1
- GJIFNLAZXVYJDI-FYZYNONXSA-M sodium;(2s)-1-hexadecanoylpyrrolidine-2-carboxylate Chemical compound [Na+].CCCCCCCCCCCCCCCC(=O)N1CCC[C@H]1C([O-])=O GJIFNLAZXVYJDI-FYZYNONXSA-M 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- PNGBYKXZVCIZRN-UHFFFAOYSA-M sodium;hexadecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCCCCCS([O-])(=O)=O PNGBYKXZVCIZRN-UHFFFAOYSA-M 0.000 description 1
- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical group OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 description 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 229940061629 trideceth-9 Drugs 0.000 description 1
- GVPDNFYOFKBFEN-UHFFFAOYSA-N trimethyl(octadecoxy)silane Chemical compound CCCCCCCCCCCCCCCCCCO[Si](C)(C)C GVPDNFYOFKBFEN-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- OZHBUVQCJMARBN-UHFFFAOYSA-N undecylamine-n,n-dimethyl-n-oxide Chemical compound CCCCCCCCCCC[N+](C)(C)[O-] OZHBUVQCJMARBN-UHFFFAOYSA-N 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- PCHQDTOLHOFHHK-UHFFFAOYSA-L zinc;hydrogen carbonate Chemical compound [Zn+2].OC([O-])=O.OC([O-])=O PCHQDTOLHOFHHK-UHFFFAOYSA-L 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
- C09D7/40—Additives
- C09D7/60—Additives non-macromolecular
- C09D7/63—Additives non-macromolecular organic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/04—Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/36—Sulfur-, selenium-, or tellurium-containing compounds
- C08K5/37—Thiols
- C08K5/378—Thiols containing heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/36—Sulfur-, selenium-, or tellurium-containing compounds
- C08K5/45—Heterocyclic compounds having sulfur in the ring
- C08K5/46—Heterocyclic compounds having sulfur in the ring with oxygen or nitrogen in the ring
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- Life Sciences & Earth Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Description
[0001]本願は、本明細書に援用する2013年11月19日出願の米国仮特許出願第61/906,224号に基づくものであり、これ対する優先権を主張するものである。
[0002]防腐剤は、塗料、コーキング材、スラリー、建築用製品、パーソナルケア、工業用、健康及び衛生用、医薬用、並びに木材保護を含めたコーティングなどの分野に、広い用途を有する。防腐剤は、単一の作用物質又は多数の作用物質のブレンドであることができる。
[0006]しかしながら、殺生物剤、とりわけイソチアゾリン殺生物剤は、生産及び製品中への組み込みに若干費用がかかる。さらに、より高濃度のイソチアゾリンは、潜在的な皮膚感作物質でありうる。したがって、現在、イソチアゾリンのような少なくとも1つの殺生物剤を低減した量で含有する一方、細菌及び他の微生物に対する効力を提供する、抗微生物性組成物及び防腐剤に対する必要性が存在する。
[0007]一般に、本開示は、殺生物特性を有する組成物を対象とする。本開示に従って、イソチアゾリンを含む第1の殺生物剤を、少なくとも1つの殺生物剤増強剤と組み合わせる。殺生物剤増強剤は強化剤として作用し、さまざまな微生物に対する第1の殺生物剤の有効性を増大させる。このようにして、組成物中に存在する第1の殺生物剤の量を減少させる一方、依然として強い抗微生物活性を提供することができる。
[0009]1つの態様では、殺生物剤増強剤は、以下:
R1は、直鎖、分岐鎖、若しくは環状のC6−40飽和又は不飽和基であり;そして
R2及びR3は、互いにそれぞれ独立して、Hであるか、直鎖、分岐鎖、若しくは環状のC1−40飽和又は不飽和基であり、或いはR2及びR3は、それらが結合している窒素原子と一緒に組み合わさって、置換されていてもよい環状又は複素環式基を形成する]を含む。
[0012]該組成物は、亜鉛化合物及び/又はポリエチレンイミンを含有することもできる。
[0014] 当業者は、本考察が代表的態様を記載しているに過ぎず、本開示のより広範な観点を限定するものではないことを理解すべきである。
[0030]1つの態様では、R1は、直鎖、分岐鎖、環状、若しくはそれらの任意の組み合わせのC1−40飽和又は不飽和基、例えばC1−20飽和又は不飽和基或いはC6−40飽和又は不飽和基、例えばC1−10飽和又は不飽和基或いはC6−22飽和又は不飽和基、例えばC1−5飽和又は不飽和基或いはC8−18飽和又は不飽和基であることができる。R1は、アルキル基、アルケニル基、アルキニル基、ヒドロキシアルキル基、アルコキシ基、又はアミノアルキル基であることができる。
[0043]R5基は、上記R2又はR3基と同様に定義される。例えば、R5は、直鎖、分岐鎖、環状、若しくはそれらの任意の組み合わせのC1−40飽和又は不飽和基、例えばC1−20飽和又は不飽和基、例えばC1−10飽和又は不飽和基、例えばC1−5飽和又は不飽和基であることができる。R5は、Hであるか、アルキル基、アルケニル基、アルキニル基、ヒドロキシアルキル基、アルコキシ基、又はアミノアルキル基であることができる。1つの態様では、R5は、ヒドロキシアルキル基、例えばC1−10ヒドロキシアルキル基、例えばC1−5ヒドロキシアルキル基、例えばヒドロキシエチル基であることができる。
[0049]アミンオキシドは、以下の一般式:
[0050]R7は、直鎖、分岐鎖、環状、若しくはそれらの任意の組み合わせのC6−40飽和又は不飽和基、例えばC6−22飽和又は不飽和基、例えばC6−18飽和又は不飽和基、例えばC10−C16飽和又は不飽和基であることができる。R7は、アルキル基、アルケニル基、又はアルキニル基であることができる。
[0057]1つの態様では、組成物は、少なくともドデシルジメチルアミンオキシド、テトラデシルジメチルアミンオキシド、及びヘキサデシルジメチルアミンオキシドの組み合わせを含むことができる。他の態様では、R1基が以下の鎖の分布を有するアミンオキシドの組み合わせを利用することができ、ここで、%はR1の全炭素鎖数に基づく:C10(0〜10%、例えば0〜5%)、C12(60〜80%、例えば65〜75%)、C14(20〜40%、例えば25〜35%)、C16(5〜15%、例えば5〜10%)、C18(0〜10%、例えば0〜5%)。アミンオキシドの全R1基の平均鎖長は、約10〜約20炭素、例えば約11〜約17炭素、例えば約12〜約14炭素であることができる。したがって、該アミンオキシドは、主としてC12アミンオキシド、例えばC12ジメチルアミンオキシドで構成されることができ、C12アミンオキシドは他のアミンオキシドより多量に存在する。
[0066]1つの態様では、該組成物はさらに、1種以上の界面活性剤を含有することができる。スルフェート部分を有する好適なアニオン性界面活性剤としては、式RSO4M[式中、Rは、鎖の主鎖に約10〜約18原子を含有する鎖であり、Mは、アンモニウムなどのカチオン;トリエタノールアミンなどのアルカノールアミン;ナトリウム及びカリウムなどの一価金属;並びにマグネシウム及びカルシウムなどの多価金属である]により表されるスルフェートが挙げられる。1つの態様では、スルフェート部分を有するアニオン性界面活性剤は、Rが10〜18炭素原子、好ましくは10〜16炭素原子、より好ましくは10〜14炭素原子を有するアルキルである、アルキル硫酸塩である。Rは直鎖又は分岐鎖であることができる。Rが直鎖であると有利である。1つの態様では、Rはオクチル基である。
[0070]好適なアニオン性界面活性剤(ii)は、アルキルアリールスルホン酸又はその塩であり、ここで、アルキル部分は約10〜約18炭素原子を含有し、アリール部分はベンジル又は置換ベンジル基を含有する。1つの態様では、アルキルアリールスルホン酸は、式
[0075]好適な乳化剤は、例えば、脂肪酸の塩、例えばステアリン酸ナトリウム若しくはパルミチン酸ナトリウム、有機セッケン、例えばモノ−、ジ−、若しくはトリエタノールアミノエート(triethanolaminoeate)、硫酸化若しくはスルホン化化合物、例えばラウリル硫酸ナトリウム若しくはセチルスルホン酸ナトリウム、サポニン、ラメポン(lamepons)のような、アニオン性物質;第四級アンモニウム塩のようなカチオン性物質;脂肪族アルコール、飽和若しくは不飽和脂肪酸を伴う脂肪酸エステル、脂肪酸のポリオキシエチレンエステル若しくはポリオキシエチレンエーテル、エチレンオキシド及びプロピレンオキシド若しくはプロピレングリコール由来のポリマーのような、非イオン性物質;ホスファチドのような両性物質;ゼラチン、カゼインアルキルアミドベタイン、アルキルベタイン、及びアンホグリシネート(amphoglycinate)のようなタンパク質;アルキルホスフェート、アルキルポリオキシエチレンホスフェート、若しくは対応する酸、シリコーン誘導体、例えばアルキルジメチコンコポリオールである。
実施例
[0080]以下の実施例で用いる略語:
BIT=1,2ベンズイソチアゾリン−3−オン
ZnPT=亜鉛ピリチオン
BBIT=n−ブチルベンズイソチアゾリン
DDA=1−ドデシルアミン
微生物:緑膿菌 ATCC 15442
MIC設定:96ウェルのマイクロタイタープレート最小発育阻止濃度(MIC)試験を、試験生体に好適なブロス中で実施した。滅菌水で段階希釈した活性物質を調製し、効力範囲に応じて開始濃度を変動させた。2倍濃度の好適なブロス中に調製した接種材料を各ウェルに加え、細菌の最終濃度を約5×105に調整した。
[0086]当業者であれば、添付の特許請求の範囲においてより詳細に記載する本発明の精神及び範囲から逸脱することなく、本発明へのこれら及び他の修正及び変動を実施することができる。加えて、さまざまな態様の観点は、全体的にも部分的にも交換できることを理解すべきである。さらに、当業者であれば、上記記載は一例に過ぎず、添付の特許請求の範囲においてさらに記載される本発明を限定するものではないことを理解するであろう。
Claims (24)
- 殺生物特性を有する組成物であって:
イソチアゾリンを含む第1の殺生物剤;
ピリチオンを含む第2の殺生物剤;及び
アミン、アミン塩、アミンオキシド、又はそれらの混合物を含み、該アミン、アミン塩、又はアミンオキシドは、少なくとも6炭素原子、例えば少なくとも8炭素原子の炭素鎖長を有する殺生物剤増強剤、
を含む、前記組成物。 - 第1の殺生物剤及び第2の殺生物剤が、組成物中に約1:200〜約10:1の重量比で存在する、請求項1に定義した組成物。
- 第1の殺生物剤及び殺生物剤増強剤が、組成物中に約1:600〜約2:1の重量比で存在する、請求項1又は2に定義した組成物。
- アミン、アミン塩、又はアミンオキシドをそれぞれ含む少なくとも2つの殺生物剤増強剤を含有する、請求項1〜3のいずれかに定義した組成物。
- 有機酸の亜鉛塩、無機酸の亜鉛塩、酸化亜鉛、水酸化亜鉛、又はそれらの混合物を含む亜鉛化合物をさらに含む、請求項1〜4のいずれかに定義した組成物。
- ポリエチレンイミンをさらに含む、請求項1〜5のいずれかに定義した組成物。
- 第1の殺生物剤が、1,2−ベンズイソチアゾリン−3−オン;5−クロロ−2−メチル−2H−イソチアゾリン−3−オン;2−メチル−2H−イソチアゾリン−3−オン;2−オクチル−3(2H)−イソチアゾロン;ジクロロ−n−オクチル−2H−イソチアゾリン−3−オン;N−メチル−1,2−ベンズイソチアゾリン−3−オン;2,2−ジチオビス(N−メチルベンズアミド);N−ブチル−1,2−ベンズイソチアゾリン−3−オン;又はそれらの混合物を含む、請求項1〜6のいずれかに定義した組成物。
- 第2の殺生物剤が、ナトリウムピリチオン、ビスマスピリチオン、カリウムピリチオン、リチウムピリチオン、アンモニウムピリチオン、亜鉛ピリチオン、銅ピリチオン、カルシウムピリチオン、マグネシウムピリチオン、ストロンチウムピリチオン、銀ピリチオン、金ピリチオン、マンガンピリチオン、有機アミンピリチオン、又はそれらの混合物を含む、請求項1〜7のいずれかに定義した組成物。
- 殺生物剤増強剤が、1−ドデシルアミン、ココジメチルアミンオキシド、4−ドデシルモルホリン、ラウリルジメチルアミン、ビス(3−アミノプロピル)ドデシルアミン、又はそれらの混合物を含む、請求項1〜8のいずれかに定義した組成物。
- 亜鉛化合物が、酢酸亜鉛、ホウ酸亜鉛、酸化亜鉛、炭酸亜鉛、塩化亜鉛、硫酸亜鉛、水酸化亜鉛、クエン酸亜鉛、フッ化亜鉛、ヨウ化亜鉛、乳酸亜鉛、オレイン酸亜鉛、シュウ酸亜鉛、リン酸亜鉛、プロピオン酸亜鉛、サリチル酸亜鉛、亜セレン酸亜鉛、ケイ酸亜鉛、ステアリン酸亜鉛、硫化亜鉛、タンニン酸亜鉛、酒石酸亜鉛、吉草酸亜鉛、及びそれらの混合物を含む、請求項5に定義した組成物。
- ポリエチレンイミンが分岐構造を有する、請求項6に定義した組成物。
- 殺生物剤増強剤が:
R1は、直鎖、分岐鎖、若しくは環状のC6−40飽和又は不飽和基であり;そして
R2及びR3は、互いにそれぞれ独立して、Hであるか、直鎖、分岐鎖、若しくは環状のC1−40飽和又は不飽和基であり、或いはR2及びR3は、それらが結合している窒素原子と一緒に組み合わさって、置換されていてもよい環状又は複素環式基を形成する]
を含む、請求項1〜11のいずれかに定義した組成物。 - 表面をコーティングするための製品であって:
ベース組成物;並びに
イソチアゾリンを含む第1の殺生物剤;ピリチオンを含む第2の殺生物剤;及びアミン、アミン塩、アミンオキシド、又はそれらの混合物を含み、該アミン、アミン塩、又はアミンオキシドは、少なくとも6炭素原子、例えば少なくとも8炭素原子の炭素鎖長を有する殺生物剤増強剤、を含む防腐剤、ここで、第1の殺生物剤は、製品中に最大約50ppmの濃度で存在する、
を含む、前記製品。 - 第1の殺生物剤及び第2の殺生物剤が、組成物中に約1:10〜約1:4の重量比で存在する、請求項13に定義した製品。
- 第1の殺生物剤及び殺生物剤増強剤が、組成物中に約1:100〜約1:2の重量比で存在する、請求項13又は14に定義した製品。
- 組成物が、アミン、アミン塩、又はアミンオキシドをそれぞれ含む少なくとも2つの殺生物剤増強剤を含有する、請求項13〜15のいずれかに定義した製品。
- 有機酸の亜鉛塩、無機酸の亜鉛塩、酸化亜鉛、水酸化亜鉛、又はそれらの混合物を含む亜鉛化合物をさらに含む、請求項13〜16のいずれかに定義した製品。
- 組成物がポリエチレンイミンをさらに含む、請求項13〜17のいずれかに定義した製品。
- 第1の殺生物剤が、1,2−ベンズイソチアゾリン−3−オン;5−クロロ−2−メチル−2H−イソチアゾリン−3−オン;2−メチル−2H−イソチアゾリン−3−オン;2−オクチル−3(2H)−イソチアゾロン;ジクロロ−n−オクチル−2H−イソチアゾリン−3−オン;N−メチル−1,2−ベンズイソチアゾリン−3−オン;2,2−ジチオビス(N−メチルベンズアミド);N−ブチル−1,2−ベンズイソチアゾリン−3−オン;及びそれらの混合物を含む、請求項13〜18のいずれかに定義した製品。
- 第2の殺生物剤が、ナトリウムピリチオン、ビスマスピリチオン、カリウムピリチオン、リチウムピリチオン、アンモニウムピリチオン、亜鉛ピリチオン、銅ピリチオン、カルシウムピリチオン、マグネシウムピリチオン、ストロンチウムピリチオン、銀ピリチオン、金ピリチオン、マンガンピリチオン、有機アミンピリチオン、及びそれらの混合物を含む、請求項13〜19のいずれかに定義した製品。
- 殺生物剤増強剤が、1−ドデシルアミン、ココジメチルアミンオキシド、4−ドデシルモルホリン、ラウリルジメチルアミン、ビス(3−アミノプロピル)ドデシルアミン、及びそれらの混合物を含む、請求項13〜20のいずれかに定義した製品。
- 亜鉛化合物が、酢酸亜鉛、ホウ酸亜鉛、酸化亜鉛、炭酸亜鉛、塩化亜鉛、硫酸亜鉛、水酸化亜鉛、クエン酸亜鉛、フッ化亜鉛、ヨウ化亜鉛、乳酸亜鉛、オレイン酸亜鉛、シュウ酸亜鉛、リン酸亜鉛、プロピオン酸亜鉛、サリチル酸亜鉛、亜セレン酸亜鉛、ケイ酸亜鉛、ステアリン酸亜鉛、硫化亜鉛、タンニン酸亜鉛、酒石酸亜鉛、吉草酸亜鉛、及びそれらの混合物を含む、請求項17に定義した製品。
- ポリエチレンイミンが分岐構造を有する、請求項18に定義した製品。
- 殺生物剤増強剤が:
R1は、直鎖、分岐鎖、若しくは環状のC6−40飽和又は不飽和基であり;そして
R2及びR3は、互いにそれぞれ独立して、Hであるか、直鎖、分岐鎖、若しくは環状のC1−40飽和又は不飽和基であり、或いはR2及びR3は、それらが結合している窒素原子と一緒に組み合わさって、置換されていてもよい環状又は複素環式基を形成する]
を含む、請求項13〜23のいずれかに定義した製品。
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Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02221205A (ja) * | 1988-12-22 | 1990-09-04 | Rohm & Haas Co | 2―n―オクチル―3―イソチアゾロンと市販のある種の殺生物剤とを含む相乗作用的殺微生物性複合剤 |
JPH02221203A (ja) * | 1988-12-22 | 1990-09-04 | Rohm & Haas Co | 殺微生物剤組成物 |
GB2230190A (en) * | 1989-03-28 | 1990-10-17 | Ici Plc | Compositions containing an isothiazolin(thi)one derivative and a 2-mercaptopyridine-1-oxide derivative |
EP0482328A1 (de) * | 1990-10-19 | 1992-04-29 | SchàLke & Mayr Gmbh | Flüssige 1,2-Benzisothiazolin-3-on-Zubereitung |
JPH05246808A (ja) * | 1991-11-26 | 1993-09-24 | Rohm & Haas Co | 2−メチル−3−イソチアゾロン及びある種の市販殺生物剤を含む相乗殺微生物性配合物 |
JPH08217607A (ja) * | 1995-02-09 | 1996-08-27 | Permachem Asia Ltd | 工業用防腐剤組成物 |
JPH11506103A (ja) * | 1995-05-30 | 1999-06-02 | バックマン・ラボラトリーズ・インターナショナル・インコーポレーテッド | N−アルキルヘテロ環化合物を用いた殺菌効果の活性化 |
JP2003500373A (ja) * | 1999-05-24 | 2003-01-07 | ロンザ インコーポレイテッド | イソチアゾロン/アミンオキシド木材防腐剤 |
JP3368892B2 (ja) * | 1998-06-18 | 2003-01-20 | 泰雄 福谷 | 水溶性切削液 |
JP2003238319A (ja) * | 2002-01-31 | 2003-08-27 | Rohm & Haas Co | 相乗的殺微生物配合物 |
JP2004524263A (ja) * | 2000-08-21 | 2004-08-12 | トール ゲーエムベーハー | 相乗作用のある殺生剤組成物 |
JP2004315507A (ja) * | 2003-04-07 | 2004-11-11 | Rohm & Haas Co | 殺微生物組成物 |
JP2010502707A (ja) * | 2006-09-08 | 2010-01-28 | アーチ・ウッド・プロテクション・インコーポレーテッド | イソチアゾリン−3−オン含有抗菌組成物 |
JP2010095517A (ja) * | 2008-09-18 | 2010-04-30 | Permachem Asia Ltd | 工業用殺菌剤 |
US20110171279A1 (en) * | 2009-11-02 | 2011-07-14 | Ndsu Research Foundation | Polyethylenimine biocides |
US20120172404A1 (en) * | 2009-10-02 | 2012-07-05 | L'Air Liquide Societe Anonyme Pour L'Etude Et L'Explotation Des Procedes George | Antimicrobially effective use solutions comprising combinations of isothiazolones and amines |
US20120189603A1 (en) * | 2009-10-02 | 2012-07-26 | L"Air Liquide, Societe Anonyme Pour L'etude Et L' Exploitation Des Procedes George | Storage-stable, synergistic microbicidal concentrates containing an isothiazolone, an amine and an oxidizing agent |
US20120247364A1 (en) * | 2011-03-28 | 2012-10-04 | Helen Margaret Hyde | Wet State Preservation of Mineral Slurries |
Family Cites Families (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2809971A (en) | 1955-11-22 | 1957-10-15 | Olin Mathieson | Heavy-metal derivatives of 1-hydroxy-2-pyridinethiones and method of preparing same |
US2786847A (en) | 1956-07-23 | 1957-03-26 | Reilly Tar & Chem Corp | 2-mercapto, alkanol pyridine-nu-oxides |
US3159640A (en) | 1963-04-23 | 1964-12-01 | Olin Mathieson | Process for preparing 2-mercaptopyridine-nu oxide |
US3590035A (en) | 1967-12-21 | 1971-06-29 | Procter & Gamble | Process for preparing pyridine n-oxide carbanion salts |
US3773770A (en) | 1968-09-30 | 1973-11-20 | Procter & Gamble | Process for preparing pyridine n-oxide carbanion salts and derivatives thereof |
US3589999A (en) | 1968-10-25 | 1971-06-29 | Ionics | Deionization process |
JPS6041979B2 (ja) | 1976-01-30 | 1985-09-19 | 有限会社野々川商事 | 水性懸濁液の製造方法 |
US4161526A (en) | 1978-07-20 | 1979-07-17 | Sterling Drug Inc. | Zinc salt prevention or removal of discoloration in pyrithione, pyrithione salt and dipyrithione compositions |
US4301162A (en) | 1978-07-31 | 1981-11-17 | Nippon Gohsei Kagaku Kogyo Kabushiki Kaisha | Antibacterial and antifungal composition |
DE3263149D1 (en) | 1981-10-21 | 1985-05-23 | Beecham Group Plc | Topical antimicrobial compositions |
US4482715A (en) | 1982-02-26 | 1984-11-13 | Olin Corporation | Process for the prevention or reduction of discoloration of sodium or zinc pyrithione |
US4396766A (en) | 1982-04-28 | 1983-08-02 | Olin Corporation | Process for producing sodium and zinc pyrithione |
US4581351A (en) | 1982-11-23 | 1986-04-08 | Sutton Laboratories, Inc. | Composition of matter containing imidazolidinyl urea and pyrithione and its derivatives |
DE3422510A1 (de) | 1984-06-16 | 1985-12-19 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von ueber o,o'-methylenethergruppen verknuepften phenolresolethern und deren verwendung |
US4565856A (en) | 1984-10-12 | 1986-01-21 | Olin Corporation | Pyrithione-containing bioactive polymers and their use in paint and wood preservative products |
US4596864A (en) | 1984-10-12 | 1986-06-24 | Olin Corporation | Pyrithione-containing bioactive polymers and their use in paint and wood preservative products |
JPH0711696B2 (ja) | 1987-02-20 | 1995-02-08 | 富士写真フイルム株式会社 | ハロゲン化銀カラ−写真感光材料の処理方法 |
US4818436A (en) | 1987-08-31 | 1989-04-04 | Olin Corporation | Process and composition for providing reduced discoloration of pyrithiones |
US4957658A (en) | 1987-08-31 | 1990-09-18 | Olin Corporation | Process and composition for providing reduced discoloration caused by the presence of pyrithione and ferric ion in water-based paints and paint bases |
US4888368A (en) | 1988-05-12 | 1989-12-19 | Dow Corning Corporation | Method of inhibiting the discoloration of emulsions and discoloration resistant emulsion compositions |
US5401757A (en) | 1988-05-20 | 1995-03-28 | Zeneca Limited | Synergistic fungicidal composition and use |
US5131939A (en) * | 1988-12-22 | 1992-07-21 | Rohm And Haas Company | Synergistic microbicidal combinations containing 2-n-octyl-3-isothiazolone and certain commercial biocides |
US4935061A (en) | 1989-01-17 | 1990-06-19 | Olin Corporation | Process and composition for providing reduced discoloration caused by the presence of pyrithione and ferric ion in water-based paints and paint bases |
US5057153A (en) | 1990-05-03 | 1991-10-15 | Olin Corporation | Paint containing high levels of a pyrithione salt plus a copper salt |
EP0499817B1 (en) | 1991-01-30 | 1995-05-17 | Dai Nippon Toryo Co., Ltd. | Antifouling coating composition |
US5098473A (en) | 1991-03-04 | 1992-03-24 | Olin Corporation | Process for stabilizing zinc pyrithione plus cuprous oxide in paint |
US5160527A (en) | 1991-05-24 | 1992-11-03 | Rohm And Haas Company | Stabilized metal salt/3-isothiazolone combinations |
US5137569A (en) | 1991-10-10 | 1992-08-11 | Olin Corporation | Process for stabilizing zinc pyrithione plus cuprous oxide in paint |
US5227156A (en) | 1992-04-14 | 1993-07-13 | Amway Corporation | Use of zinc compounds to stabilize a thiazolinone preservative in an anti-dandruff shampoo |
US5185033A (en) | 1992-09-01 | 1993-02-09 | Olin Corporation | Gel-free paint containing copper pyrithione or pyrithione disulfide plus cuprous oxide |
US5232493A (en) | 1992-09-01 | 1993-08-03 | Olin Corporation | Process for stabilizing zinc pyrithione plus cuprous oxide in paint |
US5246489A (en) | 1992-09-04 | 1993-09-21 | Olin Corporation | Process for generating copper pyrithione in-situ in a paint formulation |
SE500299C2 (sv) | 1992-11-25 | 1994-05-30 | Berol Nobel Ab | En vattenhaltig, alkalisk metallbearbetningsvätska innehållande en primär amin |
CA2146549C (en) | 1992-12-01 | 2005-01-04 | Karl F. Roenigk | Durable antimicrobial agents |
US5314719A (en) | 1993-03-18 | 1994-05-24 | Foster Products Corporation | Fungicidal protective coating for air handling equipment |
US5298061A (en) | 1993-05-14 | 1994-03-29 | Olin Corporation | Gel-free paint containing zinc pyrithione, cuprous oxide, and amine treated rosin |
US5342437A (en) | 1993-10-15 | 1994-08-30 | Olin Corporation | Gel-free paint containing zinc pyrithione cuprous oxide and carboxylic acid |
US5939203A (en) | 1995-02-03 | 1999-08-17 | Arch Chemicals, Inc. | Discoloration prevention in pyrithione-containing coating compositions |
US5562995A (en) | 1995-02-03 | 1996-10-08 | Olin Corporation | Discoloration prevention in pyrithione-containing coating compositions |
US5518774A (en) | 1995-06-26 | 1996-05-21 | Olin Corporation | In-can and dry coating antimicrobial |
DK1185400T3 (da) | 1999-05-24 | 2006-05-29 | Lonza Ag | Kobber/aminoxid-træbeskyttelsesmidler |
PT1185399E (pt) | 1999-05-24 | 2005-04-29 | Lonza Ag | Composicao de conservacao de madeira que compreende um oxido de amina e um biocida contendo iodo |
US6783947B1 (en) | 1999-09-09 | 2004-08-31 | Dade Behring Marburg Gmbh | Protecting groups for biological labeling |
JP4587137B2 (ja) | 2000-03-31 | 2010-11-24 | 第一ビル管理株式会社 | 抗菌組成物 |
EP1294547A1 (en) | 2000-05-24 | 2003-03-26 | Lonza Inc. | Amine oxide wood preservatives |
AU5864401A (en) | 2000-06-02 | 2001-12-17 | Avecia Inc | Treatment of circulating water systems |
US6583181B1 (en) | 2000-11-22 | 2003-06-24 | Lonza Inc. | Antimicrobial quaternary ammonium compositions with reduced ocular irritation |
WO2002069716A1 (en) | 2001-03-01 | 2002-09-12 | Lonza Inc. | Combination of an iodopropynyl derivative with a ketone acid or its salt and/or with an aromatic carboxylic acid or its salt |
FR2821746B1 (fr) | 2001-03-12 | 2004-12-03 | Oreal | Utilisation de complexes formes par l'association d'un derive de la tropolone et d'un sel metallique divalent comme agents de lutte contre les etats desquamatifs du cuir chevelu |
DK1469729T3 (en) | 2002-01-18 | 2016-01-25 | Lonza Ag | VIRUS KILLING DISINFECTANT |
US6893752B2 (en) | 2002-06-28 | 2005-05-17 | United States Gypsum Company | Mold-resistant gypsum panel and method of making same |
US7473474B2 (en) | 2003-02-25 | 2009-01-06 | Quick-Med Technologies, Inc. | Antifungal gypsum board |
US20040213751A1 (en) | 2003-03-18 | 2004-10-28 | Schwartz James Robert | Augmentation of pyrithione activity or a polyvalent metal salt of pyrithione activity by zinc-containing layered material |
US7056582B2 (en) | 2003-04-17 | 2006-06-06 | Usg Interiors, Inc. | Mold resistant acoustical panel |
US20050129937A1 (en) | 2003-12-16 | 2005-06-16 | Eastman Kodak Company | Antimicrobial web for application to a surface |
US20060171976A1 (en) | 2005-02-01 | 2006-08-03 | National Gypsum | Mold resistant gypsum wallboard |
DE102005008184A1 (de) | 2005-02-23 | 2006-08-31 | Lanxess Deutschland Gmbh | Antimikrobiell ausgerüstete Gipsbauplatten |
WO2007025734A1 (en) | 2005-08-31 | 2007-03-08 | Lafarge Platres | Wallboard with antifungal properties and method of making same |
KR101230109B1 (ko) | 2006-01-25 | 2013-02-05 | 쓰리엠 이노베이티브 프로퍼티즈 캄파니 | 항미생물성 공기정화용 필터 |
US9723842B2 (en) | 2006-05-26 | 2017-08-08 | Arch Chemicals, Inc. | Isothiazolinone biocides enhanced by zinc ions |
CN101528043A (zh) * | 2006-09-08 | 2009-09-09 | 奥麒木材保护有限公司 | 含异噻唑啉-3-酮的抗菌组合物 |
DE102006045065A1 (de) * | 2006-09-21 | 2008-03-27 | Schülke & Mayr GmbH | Mikrobizide Zubereitung auf der Basis von 1,2-Benzisothiazolin-3-on |
WO2008091794A2 (en) | 2007-01-26 | 2008-07-31 | Dow Global Technologies Inc. | Mold-resistant wallboard |
JP4903745B2 (ja) | 2007-05-08 | 2012-03-28 | ローム アンド ハース カンパニー | 安定化された流体 |
WO2008155979A1 (ja) | 2007-06-19 | 2008-12-24 | Yoshino Gypsum Co., Ltd. | 防カビ性を有する石膏ボード |
CN101883485A (zh) * | 2007-10-02 | 2010-11-10 | 世界矿物公司 | 经由包括功能颗粒载体材料的表面处理的方法而增强的保留能力和由其制得的功能颗粒载体材料 |
WO2009104973A1 (en) * | 2008-02-22 | 2009-08-27 | Tapuae Partnership | Encapsulated wood preservatives |
GB2459691B (en) | 2008-04-30 | 2013-05-22 | Arch Timber Protection Ltd | Formulations |
US20090298805A1 (en) | 2008-06-03 | 2009-12-03 | Polson George A | Topical pyrithione compositions and methods for treatment of nail fungus |
EP2183970A1 (en) | 2008-10-08 | 2010-05-12 | Lonza, Inc. | Mold-inhibiting method and composition |
SG174543A1 (en) | 2009-03-26 | 2011-10-28 | Lonza Ag | Salts of dehydroacetic acid as a pyrithione stabilizer in plastics |
KR101416156B1 (ko) | 2009-08-05 | 2014-07-09 | 다우 글로벌 테크놀로지스 엘엘씨 | 상승적 항균 조성물 |
WO2011056667A2 (en) | 2009-10-28 | 2011-05-12 | Guthery Eugene B | Rosacea topical skin treatment method and formulation |
US8541493B2 (en) | 2010-02-19 | 2013-09-24 | Arch Chemicals, Inc. | Synthesis of zinc acrylate copolymer from acid functional copolymer, zinc pyrithione, and copper compound |
JP5364935B2 (ja) | 2010-11-09 | 2013-12-11 | ダウ グローバル テクノロジーズ エルエルシー | フルメツラムまたはジクロスラムとジンクピリチオンとの相乗的組み合わせ |
JP5529834B2 (ja) | 2010-12-22 | 2014-06-25 | ダウ グローバル テクノロジーズ エルエルシー | グリホサート化合物とzptとの相乗的組み合わせ |
US8685908B2 (en) | 2011-02-28 | 2014-04-01 | The Procter & Gamble Company | Bar soap comprising pyrithione sources |
US20120219610A1 (en) | 2011-02-28 | 2012-08-30 | Smith Iii Edward Dewey | Bar Compositions Comprising Platelet Zinc Pyrithione |
EP2717886B1 (en) | 2011-06-08 | 2021-09-01 | Chelation Partners Incorporated | Metal chelating compositions and methods for controlling the growth or activities of a living cell or organism |
US20130109664A1 (en) | 2011-10-28 | 2013-05-02 | James Robert Schwartz | Personal Care Compositions Comprising a Pyrithione and an Iron Chelator |
MX358464B (es) | 2012-07-31 | 2018-08-22 | Arch Chem Inc | Composición y método para impedir la decoloración de composiciones que contienen piritiona. |
CA2887240C (en) | 2012-10-12 | 2022-08-09 | Arch Chemicals, Inc. | Biocidal compositions comprising iron chelators |
-
2014
- 2014-11-18 JP JP2016532576A patent/JP6853039B2/ja active Active
- 2014-11-18 US US14/543,999 patent/US10721934B2/en active Active
- 2014-11-18 ES ES14809204T patent/ES2905266T3/es active Active
- 2014-11-18 CN CN201480062918.7A patent/CN105792653A/zh active Pending
- 2014-11-18 EP EP21169019.3A patent/EP3909428A1/en active Pending
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- 2014-11-18 EP EP14809204.2A patent/EP3071038B1/en active Active
-
2020
- 2020-06-05 JP JP2020098316A patent/JP2021035929A/ja not_active Withdrawn
Patent Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02221205A (ja) * | 1988-12-22 | 1990-09-04 | Rohm & Haas Co | 2―n―オクチル―3―イソチアゾロンと市販のある種の殺生物剤とを含む相乗作用的殺微生物性複合剤 |
JPH02221203A (ja) * | 1988-12-22 | 1990-09-04 | Rohm & Haas Co | 殺微生物剤組成物 |
GB2230190A (en) * | 1989-03-28 | 1990-10-17 | Ici Plc | Compositions containing an isothiazolin(thi)one derivative and a 2-mercaptopyridine-1-oxide derivative |
EP0482328A1 (de) * | 1990-10-19 | 1992-04-29 | SchàLke & Mayr Gmbh | Flüssige 1,2-Benzisothiazolin-3-on-Zubereitung |
JPH05246808A (ja) * | 1991-11-26 | 1993-09-24 | Rohm & Haas Co | 2−メチル−3−イソチアゾロン及びある種の市販殺生物剤を含む相乗殺微生物性配合物 |
JPH08217607A (ja) * | 1995-02-09 | 1996-08-27 | Permachem Asia Ltd | 工業用防腐剤組成物 |
JPH11506103A (ja) * | 1995-05-30 | 1999-06-02 | バックマン・ラボラトリーズ・インターナショナル・インコーポレーテッド | N−アルキルヘテロ環化合物を用いた殺菌効果の活性化 |
JP3368892B2 (ja) * | 1998-06-18 | 2003-01-20 | 泰雄 福谷 | 水溶性切削液 |
JP2003500373A (ja) * | 1999-05-24 | 2003-01-07 | ロンザ インコーポレイテッド | イソチアゾロン/アミンオキシド木材防腐剤 |
JP2004524263A (ja) * | 2000-08-21 | 2004-08-12 | トール ゲーエムベーハー | 相乗作用のある殺生剤組成物 |
JP2003238319A (ja) * | 2002-01-31 | 2003-08-27 | Rohm & Haas Co | 相乗的殺微生物配合物 |
JP2004315507A (ja) * | 2003-04-07 | 2004-11-11 | Rohm & Haas Co | 殺微生物組成物 |
JP2010502707A (ja) * | 2006-09-08 | 2010-01-28 | アーチ・ウッド・プロテクション・インコーポレーテッド | イソチアゾリン−3−オン含有抗菌組成物 |
JP2010095517A (ja) * | 2008-09-18 | 2010-04-30 | Permachem Asia Ltd | 工業用殺菌剤 |
US20120172404A1 (en) * | 2009-10-02 | 2012-07-05 | L'Air Liquide Societe Anonyme Pour L'Etude Et L'Explotation Des Procedes George | Antimicrobially effective use solutions comprising combinations of isothiazolones and amines |
US20120189603A1 (en) * | 2009-10-02 | 2012-07-26 | L"Air Liquide, Societe Anonyme Pour L'etude Et L' Exploitation Des Procedes George | Storage-stable, synergistic microbicidal concentrates containing an isothiazolone, an amine and an oxidizing agent |
US20110171279A1 (en) * | 2009-11-02 | 2011-07-14 | Ndsu Research Foundation | Polyethylenimine biocides |
US20120247364A1 (en) * | 2011-03-28 | 2012-10-04 | Helen Margaret Hyde | Wet State Preservation of Mineral Slurries |
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ES2905266T3 (es) | 2022-04-07 |
CN105792653A (zh) | 2016-07-20 |
EP3071038A1 (en) | 2016-09-28 |
CN112616848A (zh) | 2021-04-09 |
JP6853039B2 (ja) | 2021-03-31 |
EP3071038B1 (en) | 2021-12-15 |
US20150141393A1 (en) | 2015-05-21 |
WO2015077209A1 (en) | 2015-05-28 |
EP3909428A1 (en) | 2021-11-17 |
US10721934B2 (en) | 2020-07-28 |
JP2021035929A (ja) | 2021-03-04 |
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