JP2016537345A5 - - Google Patents
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- JP2016537345A5 JP2016537345A5 JP2016529901A JP2016529901A JP2016537345A5 JP 2016537345 A5 JP2016537345 A5 JP 2016537345A5 JP 2016529901 A JP2016529901 A JP 2016529901A JP 2016529901 A JP2016529901 A JP 2016529901A JP 2016537345 A5 JP2016537345 A5 JP 2016537345A5
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- JP
- Japan
- Prior art keywords
- mtor inhibitor
- low
- use according
- mtor
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940124302 mTOR inhibitor Drugs 0.000 claims description 70
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims description 70
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical group C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims description 22
- 229960005167 everolimus Drugs 0.000 claims description 22
- 230000001965 increasing effect Effects 0.000 claims description 22
- 230000002434 immunopotentiative effect Effects 0.000 claims description 20
- 210000004027 cell Anatomy 0.000 claims description 18
- 230000028993 immune response Effects 0.000 claims description 18
- 210000003071 memory t lymphocyte Anatomy 0.000 claims description 15
- 239000012642 immune effector Substances 0.000 claims description 12
- 229940121354 immunomodulator Drugs 0.000 claims description 12
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims description 10
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims description 10
- 230000005764 inhibitory process Effects 0.000 claims description 10
- 101000971533 Homo sapiens Killer cell lectin-like receptor subfamily G member 1 Proteins 0.000 claims description 7
- 102100021457 Killer cell lectin-like receptor subfamily G member 1 Human genes 0.000 claims description 7
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 7
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims description 6
- 108091012583 BCL2 Proteins 0.000 claims description 6
- 102100027207 CD27 antigen Human genes 0.000 claims description 6
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 6
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims description 6
- 102100033467 L-selectin Human genes 0.000 claims description 6
- 230000003281 allosteric effect Effects 0.000 claims description 6
- 229940043355 kinase inhibitor Drugs 0.000 claims description 6
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims description 6
- 239000002243 precursor Substances 0.000 claims description 6
- 230000001737 promoting effect Effects 0.000 claims description 6
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 5
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims description 5
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims description 5
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 5
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims description 5
- 239000003060 catalysis inhibitor Substances 0.000 claims description 5
- 230000002708 enhancing effect Effects 0.000 claims description 5
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims description 5
- 229960002930 sirolimus Drugs 0.000 claims description 5
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims description 5
- 230000032683 aging Effects 0.000 claims description 4
- 230000003197 catalytic effect Effects 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 3
- 108090000695 Cytokines Proteins 0.000 claims description 3
- 230000004913 activation Effects 0.000 claims description 3
- 231100000433 cytotoxic Toxicity 0.000 claims description 3
- 230000001472 cytotoxic effect Effects 0.000 claims description 3
- JOGKUKXHTYWRGZ-UHFFFAOYSA-N dactolisib Chemical compound O=C1N(C)C2=CN=C3C=CC(C=4C=C5C=CC=CC5=NC=4)=CC3=C2N1C1=CC=C(C(C)(C)C#N)C=C1 JOGKUKXHTYWRGZ-UHFFFAOYSA-N 0.000 claims description 3
- 229950006418 dactolisib Drugs 0.000 claims description 3
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 230000006870 function Effects 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 230000001404 mediated effect Effects 0.000 claims description 3
- 230000036961 partial effect Effects 0.000 claims description 3
- 230000002062 proliferating effect Effects 0.000 claims description 3
- 230000009467 reduction Effects 0.000 claims description 3
- 230000028327 secretion Effects 0.000 claims description 3
- 230000001771 impaired effect Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 69
- 239000000427 antigen Substances 0.000 description 16
- 102000036639 antigens Human genes 0.000 description 16
- 108091007433 antigens Proteins 0.000 description 16
- 239000000203 mixture Substances 0.000 description 16
- 206010028980 Neoplasm Diseases 0.000 description 13
- 201000011510 cancer Diseases 0.000 description 12
- 229960005486 vaccine Drugs 0.000 description 10
- 206010022000 influenza Diseases 0.000 description 9
- 239000002552 dosage form Substances 0.000 description 8
- 238000011282 treatment Methods 0.000 description 7
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 4
- 238000013268 sustained release Methods 0.000 description 4
- 239000012730 sustained-release form Substances 0.000 description 4
- 239000012646 vaccine adjuvant Substances 0.000 description 4
- 229940124931 vaccine adjuvant Drugs 0.000 description 4
- 238000002649 immunization Methods 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 108010013238 70-kDa Ribosomal Protein S6 Kinases Proteins 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 206010012289 Dementia Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
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- 230000002829 reductive effect Effects 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000024806 Brain atrophy Diseases 0.000 description 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 description 1
- 208000006029 Cardiomegaly Diseases 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010052337 Diastolic dysfunction Diseases 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 208000023105 Huntington disease Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 206010049565 Muscle fatigue Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 206010040799 Skin atrophy Diseases 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010071436 Systolic dysfunction Diseases 0.000 description 1
- 206010064930 age-related macular degeneration Diseases 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 238000010322 bone marrow transplantation Methods 0.000 description 1
- 229940022399 cancer vaccine Drugs 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000002659 cell therapy Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000006999 cognitive decline Effects 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 238000011393 cytotoxic chemotherapy Methods 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000010370 hearing loss Effects 0.000 description 1
- 231100000888 hearing loss Toxicity 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 201000005787 hematologic cancer Diseases 0.000 description 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229960003971 influenza vaccine Drugs 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
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- 231100000857 poor renal function Toxicity 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
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- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361903636P | 2013-11-13 | 2013-11-13 | |
| US61/903,636 | 2013-11-13 | ||
| US201462027121P | 2014-07-21 | 2014-07-21 | |
| US62/027,121 | 2014-07-21 | ||
| US201462052629P | 2014-09-19 | 2014-09-19 | |
| US62/052,629 | 2014-09-19 | ||
| US201462076142P | 2014-11-06 | 2014-11-06 | |
| US62/076,142 | 2014-11-06 | ||
| PCT/US2014/065408 WO2015073644A1 (en) | 2013-11-13 | 2014-11-13 | Mtor inhibitors for enhancing the immune response |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020009002A Division JP2020097589A (ja) | 2013-11-13 | 2020-01-23 | 免疫応答を増強するためのｍＴＯＲ阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016537345A JP2016537345A (ja) | 2016-12-01 |
| JP2016537345A5 true JP2016537345A5 (https=) | 2017-12-21 |
Family
ID=53057999
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016529901A Withdrawn JP2016537345A (ja) | 2013-11-13 | 2014-11-13 | 免疫応答を増強するためのｍＴＯＲ阻害剤 |
| JP2020009002A Withdrawn JP2020097589A (ja) | 2013-11-13 | 2020-01-23 | 免疫応答を増強するためのｍＴＯＲ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020009002A Withdrawn JP2020097589A (ja) | 2013-11-13 | 2020-01-23 | 免疫応答を増強するためのｍＴＯＲ阻害剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20150140036A1 (https=) |
| EP (1) | EP3068435A1 (https=) |
| JP (2) | JP2016537345A (https=) |
| KR (1) | KR20160084438A (https=) |
| CN (1) | CN105899232A (https=) |
| AU (3) | AU2014348657A1 (https=) |
| BR (1) | BR112016010716A8 (https=) |
| CA (1) | CA2929181A1 (https=) |
| EA (1) | EA201690987A1 (https=) |
| MX (1) | MX2016006316A (https=) |
| TW (1) | TWI679976B (https=) |
| WO (1) | WO2015073644A1 (https=) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9259399B2 (en) | 2007-11-07 | 2016-02-16 | Cornell University | Targeting CDK4 and CDK6 in cancer therapy |
| US20120156134A1 (en) | 2007-12-20 | 2012-06-21 | Shayne Squires | Compositions and methods for detecting or eliminating senescent cells to diagnose or treat disease |
| ES2660418T3 (es) | 2008-07-16 | 2018-03-22 | Pharmacyclics Llc | Inhibidores de la tirosina quinasa de Bruton para el tratamiento de tumores sólidos |
| CN107898791A (zh) | 2010-06-03 | 2018-04-13 | 药品循环有限责任公司 | 布鲁顿酪氨酸激酶(btk)抑制剂的应用 |
| US20140189897A1 (en) | 2011-06-21 | 2014-07-03 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
| US9138436B2 (en) | 2011-07-13 | 2015-09-22 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
| KR20140119023A (ko) | 2011-12-13 | 2014-10-08 | 버크 인스티튜트 포 리서치 온 에이징 | 의료 요법을 개선하는 방법 |
| US20150064137A1 (en) | 2012-04-17 | 2015-03-05 | Kythera Biopharmaceuticals, Inc. | Use of engineered viruses to specifically kill senescent cells |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
| US9901080B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells |
| US9901081B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse for determining the role of senescent cells in cancer |
| US9415050B2 (en) | 2013-08-12 | 2016-08-16 | Pharmacyclics Llc | Methods for the treatment of HER2 amplified cancer |
| CN105899232A (zh) | 2013-11-13 | 2016-08-24 | 诺华股份有限公司 | 用于增强免疫应答的mTOR抑制剂 |
| US20190269675A1 (en) | 2014-01-28 | 2019-09-05 | Buck Institute for Research and Aging | Treatment of parkinson's disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents |
| US20170216286A1 (en) | 2014-01-28 | 2017-08-03 | Mayo Foundation For Medical Education And Research | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid |
| US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
| AU2015211021B2 (en) | 2014-01-28 | 2020-07-02 | Buck Institute For Research On Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
| WO2015143400A1 (en) | 2014-03-20 | 2015-09-24 | Pharmacyclics, Inc. | Phospholipase c gamma 2 and resistance associated mutations |
| WO2016014530A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
| SG10201913765YA (en) | 2014-07-21 | 2020-03-30 | Novartis Ag | Treatment of cancer using a cd33 chimeric antigen receptor |
| CA2958200A1 (en) | 2014-08-14 | 2016-02-18 | Novartis Ag | Treatment of cancer using a gfr alpha-4 chimeric antigen receptor |
| KR20170068504A (ko) | 2014-10-08 | 2017-06-19 | 노파르티스 아게 | 키메라 항원 수용체 요법에 대한 치료 반응성을 예측하는 바이오마커 및 그의 용도 |
| JP2017536347A (ja) * | 2014-10-17 | 2017-12-07 | ノバルティス アーゲー | セリチニブとｅｇｆｒ阻害剤の組合せ |
| US11083725B2 (en) | 2014-10-24 | 2021-08-10 | St. Jude Children's Research Hospital | Coordinated metabolic reprogramming in response to productive viral infections |
| WO2016066608A1 (en) * | 2014-10-28 | 2016-05-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of pulmonary cell senescence and peripheral aging |
| SG11201708516YA (en) | 2015-04-17 | 2017-11-29 | David Maxwell Barrett | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
| HK1245095A1 (zh) * | 2015-05-20 | 2018-08-24 | Novartis Ag | 依维莫司(everolimus)与达托里昔布(dactolisib)的医药组合 |
| MX376083B (es) | 2015-06-04 | 2025-03-07 | Pfizer | Formas de dosificacion solidas de palbociclib. |
| JP2018522028A (ja) * | 2015-07-31 | 2018-08-09 | ファーマサイクリックス エルエルシー | ブルトン型チロシンキナーゼ阻害剤の組み合わせ及びそれらの使用 |
| JP6905163B2 (ja) | 2015-09-03 | 2021-07-21 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | サイトカイン放出症候群を予測するバイオマーカー |
| KR20180081501A (ko) * | 2015-09-24 | 2018-07-16 | 드렉셀유니버시티 | 진피 장애를 치료하거나 예방하는 신규한 조성물 및 방법 |
| EP3391057B1 (en) * | 2015-12-16 | 2020-04-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Diagnostic markers of immunosenescence and methods for determining the susceptibility to nosocomial infections |
| US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| KR101796684B1 (ko) * | 2016-05-19 | 2017-11-10 | 건국대학교 산학협력단 | 케라틴 8 인산화 억제제를 포함하는 황반변성 예방 또는 치료용 약학 조성물 및 황반변성 치료제의 스크리닝 방법 |
| EP3518923A4 (en) * | 2016-09-28 | 2020-06-17 | Abraxis BioScience, LLC | METHOD FOR TREATING MITOCHONDRIAL AND METABOLIC DISORDERS |
| EP3523331A1 (en) | 2016-10-07 | 2019-08-14 | Novartis AG | Chimeric antigen receptors for the treatment of cancer |
| CN110114070A (zh) | 2016-11-23 | 2019-08-09 | 诺华公司 | 使用依维莫司(everolimus)、达托里昔布(dactolisib)或二者增强免疫反应的方法 |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| US10438189B2 (en) | 2017-02-22 | 2019-10-08 | Square, Inc. | Server-enabled chip card interface tamper detection |
| JP6482604B2 (ja) * | 2017-06-22 | 2019-03-13 | 教裕 南郷 | 外皮内溶解型ニードル及びニードル装置 |
| US20200230115A1 (en) * | 2017-07-24 | 2020-07-23 | University Of Cincinnati | Methods of treating influenza-associated viral pneumonia |
| TWI795462B (zh) * | 2017-11-17 | 2023-03-11 | 日商鹽野義製藥股份有限公司 | 光安定性及溶出性優異的醫藥製劑 |
| BR112020010579A2 (pt) * | 2017-11-30 | 2020-11-10 | Novartis Ag | receptor de antígeno quimérico de alvejamento de bcma e usos do mesmo |
| US10596165B2 (en) | 2018-02-12 | 2020-03-24 | resTORbio, Inc. | Combination therapies |
| US20210396739A1 (en) | 2018-05-01 | 2021-12-23 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| KR20210056331A (ko) * | 2018-07-23 | 2021-05-18 | 트랜슬레이트 바이오 인코포레이티드 | 전령 rna의 건조 분말 제형 |
| GB201813186D0 (en) * | 2018-08-13 | 2018-09-26 | Univ Central Lancashire | Solid dosage from production |
| WO2020055761A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| WO2021050743A1 (en) * | 2019-09-11 | 2021-03-18 | Yale University | Compositions and methods for treating slow-flow vascular malformations |
| IL292924A (en) | 2019-11-26 | 2022-07-01 | Novartis Ag | Chimeric antigen receptors cd19 and cd22 and their uses |
| CN114981298B (zh) | 2019-12-12 | 2024-08-20 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
| US20220079930A1 (en) * | 2020-02-04 | 2022-03-17 | Brain Cancer Research Institute | Therapeutic Cancer Immune Modulation by Treatment with mTOR Inhibitors |
| CN111214470A (zh) * | 2020-02-28 | 2020-06-02 | 北京澳丹斯生物科技有限公司 | 雷帕霉素及其衍生物在制备用于预防和治疗病毒引起的ade的药品的用途 |
| CN113679724B (zh) * | 2020-05-18 | 2023-04-07 | 中国科学院微生物研究所 | 一种流感病毒小分子抑制剂 |
| US11857551B1 (en) | 2020-07-10 | 2024-01-02 | Ting Therapeutics Llc | Methods for the prevention and treatment of hearing loss |
| TW202206093A (zh) * | 2020-08-12 | 2022-02-16 | 中國醫藥大學 | Ｓｅｍａ３ｄ拮抗劑用於預防或治療神經退化性疾病以及延長壽命之用途 |
| CN114306245A (zh) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | 无定形固体分散体的药物组合物及其制备方法 |
| US20240058349A1 (en) * | 2020-12-18 | 2024-02-22 | Northwestern University | Pi3k inhibitors for protection against glucocorticoid-induced atrophy |
| CN113082212A (zh) * | 2021-04-15 | 2021-07-09 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 包含mTOR抑制剂的药物组合物及其应用 |
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-
2014
- 2014-11-13 CN CN201480072942.9A patent/CN105899232A/zh active Pending
- 2014-11-13 AU AU2014348657A patent/AU2014348657A1/en not_active Abandoned
- 2014-11-13 EA EA201690987A patent/EA201690987A1/ru unknown
- 2014-11-13 EP EP14815965.0A patent/EP3068435A1/en not_active Ceased
- 2014-11-13 WO PCT/US2014/065408 patent/WO2015073644A1/en not_active Ceased
- 2014-11-13 TW TW103139447A patent/TWI679976B/zh not_active IP Right Cessation
- 2014-11-13 CA CA2929181A patent/CA2929181A1/en not_active Abandoned
- 2014-11-13 US US14/540,867 patent/US20150140036A1/en not_active Abandoned
- 2014-11-13 MX MX2016006316A patent/MX2016006316A/es unknown
- 2014-11-13 KR KR1020167015237A patent/KR20160084438A/ko not_active Withdrawn
- 2014-11-13 BR BR112016010716A patent/BR112016010716A8/pt not_active IP Right Cessation
- 2014-11-13 JP JP2016529901A patent/JP2016537345A/ja not_active Withdrawn
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2016
- 2016-10-12 US US15/292,088 patent/US10004803B2/en not_active Expired - Fee Related
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2017
- 2017-10-12 AU AU2017245411A patent/AU2017245411B2/en not_active Ceased
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2018
- 2018-06-25 US US16/017,173 patent/US10286069B2/en not_active Expired - Fee Related
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2019
- 2019-03-22 US US16/361,822 patent/US20200054742A1/en not_active Abandoned
- 2019-10-10 AU AU2019246853A patent/AU2019246853A1/en not_active Abandoned
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2020
- 2020-01-23 JP JP2020009002A patent/JP2020097589A/ja not_active Withdrawn
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