JP2016536271A5 - - Google Patents

Info

Publication number

JP2016536271A5

JP2016536271A5 JP2016516087A JP2016516087A JP2016536271A5 JP 2016536271 A5 JP2016536271 A5 JP 2016536271A5 JP 2016516087 A JP2016516087 A JP 2016516087A JP 2016516087 A JP2016516087 A JP 2016516087A JP 2016536271 A5 JP2016536271 A5 JP 2016536271A5

Authority

JP

Japan

Prior art keywords

composition according

topical composition

antifungal agent

nanoparticles

topical

Prior art date

2014-09-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims description 34
• 230000000699 topical effect Effects 0.000 claims description 28
• 229940121375 antifungal agent Drugs 0.000 claims description 23
• 239000003429 antifungal agent Substances 0.000 claims description 23
• 239000002105 nanoparticle Substances 0.000 claims description 15
• 229920002413 Polyhexanide Polymers 0.000 claims description 11
• 229920000642 polymer Polymers 0.000 claims description 11
• VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims description 8
• 206010017533 Fungal infection Diseases 0.000 claims description 7
• 206010034016 Paronychia Diseases 0.000 claims description 6
• 206010017543 Fungal skin infection Diseases 0.000 claims description 5
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
• 239000000853 adhesive Substances 0.000 claims description 4
• 230000001070 adhesive effect Effects 0.000 claims description 4
• 238000000034 method Methods 0.000 claims description 4
• 229940079593 drug Drugs 0.000 claims description 3
• 239000003814 drug Substances 0.000 claims description 3
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
• XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims description 2
• VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims description 2
• APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims description 2
• 208000007163 Dermatomycoses Diseases 0.000 claims description 2
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 2
• APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims description 2
• 229960003942 amphotericin b Drugs 0.000 claims description 2
• 239000003963 antioxidant agent Substances 0.000 claims description 2
• 230000003078 antioxidant effect Effects 0.000 claims description 2
• YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 claims description 2
• 229940093265 berberine Drugs 0.000 claims description 2
• QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 claims description 2
• 239000011230 binding agent Substances 0.000 claims description 2
• 239000000872 buffer Substances 0.000 claims description 2
• 239000004202 carbamide Substances 0.000 claims description 2
• 239000006071 cream Substances 0.000 claims description 2
• 125000004122 cyclic group Chemical group 0.000 claims description 2
• 239000003995 emulsifying agent Substances 0.000 claims description 2
• 235000011187 glycerol Nutrition 0.000 claims description 2
• 229960004130 itraconazole Drugs 0.000 claims description 2
• 229960004125 ketoconazole Drugs 0.000 claims description 2
• 229960000988 nystatin Drugs 0.000 claims description 2
• VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 claims description 2
• 239000003921 oil Substances 0.000 claims description 2
• 239000002674 ointment Substances 0.000 claims description 2
• 239000002304 perfume Substances 0.000 claims description 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
• 239000000843 powder Substances 0.000 claims description 2
• 239000003755 preservative agent Substances 0.000 claims description 2
• 230000002335 preservative effect Effects 0.000 claims description 2
• 239000007921 spray Substances 0.000 claims description 2
• 230000002195 synergetic effect Effects 0.000 claims description 2
• 230000009885 systemic effect Effects 0.000 claims description 2
• DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims description 2
• 229960002722 terbinafine Drugs 0.000 claims description 2
• 241000238631 Hexapoda Species 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 239000004615 ingredient Substances 0.000 claims 1
• 208000031888 Mycoses Diseases 0.000 description 5
• BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
• 201000004647 tinea pedis Diseases 0.000 description 1