CN105579028B - 抗真菌局部组合物及治疗方法 - Google Patents

抗真菌局部组合物及治疗方法 Download PDF

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Publication number
CN105579028B
CN105579028B CN201480052228.3A CN201480052228A CN105579028B CN 105579028 B CN105579028 B CN 105579028B CN 201480052228 A CN201480052228 A CN 201480052228A CN 105579028 B CN105579028 B CN 105579028B
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antifungal agent
composition
phmb
antifungal
terbinafine
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Chinese (zh)
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CN105579028A (zh
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约翰·瑞登
迈克尔·戴维斯
利亚姆·古德
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Blueberry Therapeutics Ltd
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Blueberry Therapeutics Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201480052228.3A 2013-09-25 2014-09-25 抗真菌局部组合物及治疗方法 Active CN105579028B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1317005.5 2013-09-25
GBGB1317005.5A GB201317005D0 (en) 2013-09-25 2013-09-25 Composition and methods of treatment
GB1320723.8 2013-11-25
GBGB1320723.8A GB201320723D0 (en) 2013-09-25 2013-11-25 Composition and methods of treatment
PCT/GB2014/052911 WO2015044669A1 (en) 2013-09-25 2014-09-25 Antifungal topical composition and methods of treatment

Publications (2)

Publication Number Publication Date
CN105579028A CN105579028A (zh) 2016-05-11
CN105579028B true CN105579028B (zh) 2020-03-20

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US (2) US11185511B2 (enExample)
EP (3) EP3854380A1 (enExample)
JP (2) JP6581569B2 (enExample)
CN (1) CN105579028B (enExample)
CY (1) CY1123414T1 (enExample)
DK (1) DK3049056T4 (enExample)
ES (2) ES2738662T5 (enExample)
GB (2) GB201317005D0 (enExample)
HR (1) HRP20191304T4 (enExample)
HU (1) HUE044589T2 (enExample)
LT (1) LT3049056T (enExample)
PL (1) PL3049056T5 (enExample)
PT (1) PT3049056T (enExample)
RS (1) RS59211B2 (enExample)
SI (1) SI3049056T2 (enExample)
SM (1) SMT201900437T1 (enExample)
WO (1) WO2015044669A1 (enExample)

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US11110071B2 (en) * 2015-06-19 2021-09-07 Global Health Solutions Llc Petrolatum-based PHMB compositions and methods of treatment for onychomycosis
US12290599B2 (en) 2015-06-19 2025-05-06 Global Health Solutions Llc Oil-based wound care compositions and methods
GB201511799D0 (en) * 2015-07-06 2015-08-19 Blueberry Therapeutics Ltd Composition and methods of treatment
EP3393518B1 (en) * 2015-12-23 2024-10-30 Aarhus Universitet Antifungal agent
AU2017236423A1 (en) * 2016-03-24 2018-11-15 Locate Bio Limited Scaffolding material, methods and uses
GB201605127D0 (en) * 2016-03-25 2016-05-11 Blueberry Therapeutics Ltd Composition and methods of treatment
JP6310977B2 (ja) * 2016-09-07 2018-04-11 株式会社日本総合研究所 爪用シール及びシールシート
WO2018162271A1 (en) 2017-03-05 2018-09-13 Rita Dobmeyer Nanoparticles for the treatment of macular degeneration
GB201710491D0 (en) * 2017-06-30 2017-08-16 Blueberry Therapeutics Ltd Composition and methods of treatment
KR102060138B1 (ko) * 2018-05-30 2019-12-27 연세대학교 산학협력단 안구용 마이크로니들 주사의 제조방법
GB201810923D0 (en) * 2018-07-03 2018-08-15 Blueberry Therapeutics Ltd Compositions and method of treatment
GB201810925D0 (en) * 2018-07-03 2018-08-15 Blueberry Therapeutics Ltd Compositions and methods of treatment
US12115139B2 (en) * 2018-08-15 2024-10-15 Todd Alan Weinfield Treatment methods and processes for an infected nail
EP3911306B1 (en) * 2019-01-16 2023-12-20 Global Health Solutions, LLC Petrolatum-based phmb compositions and methods of treatment for onychomycosis
GB201908229D0 (en) * 2019-06-10 2019-07-24 Univ College Cork National Univ Of Ireland Microneedles and methods for the manufacture thereof
CN110898075B (zh) * 2019-12-27 2021-08-03 温海 聚六亚甲基双胍在制备抑制和/或杀灭犬小孢子菌的药物中的应用
CN111067897A (zh) * 2020-01-20 2020-04-28 中山大学 一种抗真菌的组合物及其应用
KR20230031188A (ko) * 2020-02-26 2023-03-07 바이오써젠 에이에스 치료적 폴리엔 마크롤리드의 제약 조성물 및 그의 사용 방법
CN111588689B (zh) * 2020-06-20 2023-08-11 温州医科大学 一种角膜微创可溶性微针贴片及其制备方法与应用
CN112168845A (zh) * 2020-11-13 2021-01-05 郑虹 一种用于治疗手足癣的药物软膏及其制备方法
JP7883713B2 (ja) * 2021-02-02 2026-07-02 国立大学法人 鹿児島大学 ナノ粒子組成物、抗菌抗かび抗ウイルス剤、抗菌抗かび抗ウイルス塗料、抗菌抗かび抗ウイルス剤調製キット及びナノ粒子組成物の製造方法
DE102021118997A1 (de) * 2021-07-22 2023-01-26 Lts Lohmann Therapie-Systeme Ag. Mikronadelarray mit Antiseptika
CN113567217A (zh) * 2021-07-27 2021-10-29 肖波 一种妇科荧光染色液
WO2023154464A1 (en) * 2022-02-11 2023-08-17 Fairleigh Dickinson University Locally administered compositions and methods of use thereof
KR102597564B1 (ko) * 2023-03-03 2023-11-03 장병모 조갑 및 피부 백선의 예방 또는 치료용 약학적 조성물
CN117563121A (zh) * 2023-11-30 2024-02-20 北京化工大学 一种用于治疗趾间型足癣的集成式可分离微针装置

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CN101227940A (zh) * 2005-07-25 2008-07-23 纳米技术维多利亚有限公司 微阵列装置

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US20220133640A1 (en) 2022-05-05
US12161764B2 (en) 2024-12-10
PL3049056T3 (pl) 2019-10-31
JP6581569B2 (ja) 2019-09-25
SI3049056T2 (sl) 2022-08-31
JP7028836B2 (ja) 2022-03-02
EP3501498B1 (en) 2020-11-25
HRP20191304T1 (hr) 2019-10-18
DK3049056T3 (da) 2019-07-29
SI3049056T1 (sl) 2019-11-29
CN105579028A (zh) 2016-05-11
PL3049056T5 (pl) 2022-09-12
ES2738662T3 (es) 2020-01-24
US11185511B2 (en) 2021-11-30
EP3854380A1 (en) 2021-07-28
LT3049056T (lt) 2019-08-26
EP3049056B2 (en) 2022-06-01
RS59211B1 (sr) 2019-10-31
HRP20191304T4 (hr) 2022-07-22
RS59211B2 (sr) 2022-07-29
EP3049056A1 (en) 2016-08-03
WO2015044669A1 (en) 2015-04-02
US20160206567A1 (en) 2016-07-21
EP3049056B1 (en) 2019-04-24
PT3049056T (pt) 2019-07-25
CY1123414T1 (el) 2022-03-24
SMT201900437T1 (it) 2019-09-09
DK3049056T4 (da) 2022-08-01
ES2859518T3 (es) 2021-10-04
HUE044589T2 (hu) 2019-11-28
EP3501498A1 (en) 2019-06-26
JP2016536271A (ja) 2016-11-24
JP2019218393A (ja) 2019-12-26
GB201320723D0 (en) 2014-01-08
ES2738662T5 (es) 2022-09-21
GB201317005D0 (en) 2013-11-06

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