|
US2851458A
(en)
|
1955-06-08 |
1958-09-09 |
Burroughs Wellcome Co |
Diquaternary compounds and the manufacture thereof
|
|
US4678500A
(en)
|
1984-06-29 |
1987-07-07 |
E. I. Du Pont De Nemours And Company |
Herbicidal 2,6-disubstituted benzylsulfonamides and benzenesulfamates
|
|
US5177075A
(en)
|
1988-08-19 |
1993-01-05 |
Warner-Lambert Company |
Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process
|
|
US4942163A
(en)
|
1989-03-07 |
1990-07-17 |
E. I. Du Pont De Nemours And Company |
1(2H)-isoquinolinones and 1-isoquinolineamines as cancer chemotherapeutic agents
|
|
DE69839887D1
(de)
|
1997-10-02 |
2008-09-25 |
Eisai R&D Man Co Ltd |
Kondensierte pyridinderivate
|
|
US6878714B2
(en)
|
2001-01-12 |
2005-04-12 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
EP1396488A1
(en)
|
2001-05-23 |
2004-03-10 |
Mitsubishi Pharma Corporation |
Fused heterocyclic compound and medicinal use thereof
|
|
EP1427415B1
(en)
|
2001-09-21 |
2009-08-12 |
Brystol-Myers Squibb Company |
Lactam-containing compounds and derivatives thereof as factor xa inhibitors
|
|
MY140680A
(en)
|
2002-05-20 |
2010-01-15 |
Bristol Myers Squibb Co |
Hepatitis c virus inhibitors
|
|
AU2003255149A1
(en)
|
2002-07-24 |
2004-02-09 |
Kyorin Pharmaceutical Co., Ltd. |
4-(substituted aryl)-5-hydroxyisoquinolinone derivative
|
|
CN100390164C
(zh)
|
2002-10-01 |
2008-05-28 |
三菱制药株式会社 |
异喹啉化合物及其医药用途
|
|
WO2004037805A1
(en)
|
2002-10-23 |
2004-05-06 |
Glenmark Pharmaceuticals Ltd. |
Novel tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
|
|
CA2507027C
(en)
*
|
2002-11-22 |
2012-05-08 |
Mitsubishi Pharma Corporation |
Isoquinoline compounds and medicinal use thereof
|
|
EP1572660B1
(en)
|
2002-12-20 |
2011-01-26 |
X-Ceptor Therapeutics, Inc. |
Isoquinolinone derivatives and their use as therapeutic agents
|
|
EP1629000B1
(en)
|
2003-04-16 |
2009-02-18 |
Bristol-Myers Squibb Company |
Macrocyclic isoquinoline peptide inhibitors of hepatitis c virus
|
|
TW200536830A
(en)
|
2004-02-06 |
2005-11-16 |
Chugai Pharmaceutical Co Ltd |
1-(2H)-isoquinolone derivative
|
|
WO2005075432A1
(ja)
|
2004-02-06 |
2005-08-18 |
Chugai Seiyaku Kabushiki Kaisha |
１−（２ｈ）−イソキノロン誘導体およびその抗ガン剤としての使用
|
|
WO2005113540A1
(ja)
|
2004-05-20 |
2005-12-01 |
Mitsubishi Pharma Corporation |
イソキノリン化合物及びその医薬用途
|
|
CA2584485C
(en)
|
2004-10-20 |
2013-12-31 |
Resverlogix Corp. |
Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
|
|
ES2611604T3
(es)
|
2004-10-22 |
2017-05-09 |
Janssen Pharmaceutica Nv |
Inhibidores de la c fms quinasa
|
|
DE602005010744D1
(de)
|
2004-12-16 |
2008-12-11 |
Hoffmann La Roche |
Piperazinylpyridinderivate als mittel gegen adipositas
|
|
TWI389897B
(zh)
|
2005-02-22 |
2013-03-21 |
Chugai Pharmaceutical Co Ltd |
1- (2H) -isoquinolinone derivatives
|
|
RU2404973C2
(ru)
|
2005-03-31 |
2010-11-27 |
Астеллас Фарма Инк. |
Производное соединение пропан-1,3-диона или его соль
|
|
JP5368792B2
(ja)
|
2005-07-29 |
2013-12-18 |
レスバーロジックス コーポレイション |
複合疾患の予防および処置のための薬学的組成物および挿入可能な医療用デバイスによるその送達
|
|
RU2008110955A
(ru)
|
2005-08-24 |
2009-09-27 |
Инотек Фармасьютикалз Корпорейшн (Us) |
Инденоизохинолиноновые аналоги и способы их применения
|
|
JP2009539963A
(ja)
*
|
2006-06-15 |
2009-11-19 |
クドス ファーマシューティカルズ リミテッド |
Ｐａｒｐ阻害剤
|
|
PL2090570T3
(pl)
|
2006-09-05 |
2012-03-30 |
Kyowa Hakko Kirin Co Ltd |
Pochodna imidazolu
|
|
US7772180B2
(en)
|
2006-11-09 |
2010-08-10 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
DK2118074T3
(en)
|
2007-02-01 |
2014-03-10 |
Resverlogix Corp |
Compounds for the prevention and treatment of cardiovascular diseases
|
|
FR2919286A1
(fr)
|
2007-07-27 |
2009-01-30 |
Sanofi Aventis Sa |
Derives de derives de 1-oxo-1,2-dihydroisoquinoleine-5- carboxamides et de 4-oxo-3,4-dihydroquinazoline-8- carboxamides,leur preparation et leur application en therapeutique.
|
|
US20090054392A1
(en)
|
2007-08-20 |
2009-02-26 |
Wyeth |
Naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system
|
|
WO2009027650A1
(en)
|
2007-08-24 |
2009-03-05 |
The Institute Of Cancer: Royal Cancer Hospital |
Materials and methods for exploiting synthetic lethality in brca-associated cancers
|
|
CN101854924A
(zh)
|
2007-11-05 |
2010-10-06 |
诺瓦提斯公司 |
测量wnt活化以及治疗wnt相关癌症的方法和组合物
|
|
DE102008019838A1
(de)
|
2008-04-19 |
2009-12-10 |
Boehringer Ingelheim International Gmbh |
Neue Arylsulfonylglycin-Derivate, deren Herstellung und deren Verwendung als Arzneimittel
|
|
KR101598397B1
(ko)
|
2008-04-22 |
2016-02-29 |
얀센 파마슈티카 엔.브이. |
퀴놀린 또는 이소퀴놀린 치환된 피2엑스7 안타고니스트
|
|
US8697685B2
(en)
|
2008-11-20 |
2014-04-15 |
Glaxosmithkline Llc |
Chemical compounds
|
|
CN102341382A
(zh)
|
2009-03-06 |
2012-02-01 |
弗·哈夫曼-拉罗切有限公司 |
抗病毒的杂环化合物
|
|
KR101709492B1
(ko)
|
2009-03-18 |
2017-02-23 |
리스버로직스 코퍼레이션 |
신규한 소염제
|
|
US9757368B2
(en)
|
2009-04-22 |
2017-09-12 |
Resverlogix Corp. |
Anti-inflammatory agents
|
|
TWI499418B
(zh)
|
2009-05-21 |
2015-09-11 |
Nerviano Medical Sciences Srl |
異喹啉－１（２ｈ）－酮衍生物
|
|
KR20120100913A
(ko)
|
2009-10-13 |
2012-09-12 |
엠에스데 오쓰 베.베. |
아세틸콜린 수용체에 관련된 질환의 치료를 위한 축합 아진 - 유도체
|
|
AU2011255218B2
(en)
|
2010-05-21 |
2015-03-12 |
Infinity Pharmaceuticals, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
|
CN102947274A
(zh)
|
2010-06-17 |
2013-02-27 |
诺瓦提斯公司 |
联苯基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物
|
|
KR20140051944A
(ko)
|
2011-07-13 |
2014-05-02 |
노파르티스 아게 |
탄키라제 억제제로서 사용하기 위한 4-피페리디닐 화합물
|
|
EP2731951B1
(en)
|
2011-07-13 |
2015-08-19 |
Novartis AG |
4-oxo-3,5,7,8-tetrahydro-4h-pyrano {4,3-d} pyrminidinyl compounds for use as tankyrase inhibitors
|
|
EP2731942B1
(en)
|
2011-07-13 |
2015-09-23 |
Novartis AG |
Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
|
|
AU2012342562B2
(en)
|
2011-11-25 |
2017-02-23 |
Nerviano Medical Sciences S.R.L. |
3-phenyl-isoquinolin-1(2H)-one derivatives as PARP-1 inhibitors
|
|
SG11201403538TA
(en)
|
2011-12-31 |
2014-09-26 |
Beigene Ltd |
Fused tetra or penta-cyclic pyridophthalazinones as parp inhibitors
|
|
NO2797921T3
(OSRAM)
|
2011-12-31 |
2018-02-03 |
|
|
|
CN104080773B
(zh)
|
2012-01-28 |
2016-12-28 |
默克专利股份公司 |
氮杂环化合物
|
|
WO2013116182A1
(en)
|
2012-01-31 |
2013-08-08 |
Boehringer Ingelheim International Gmbh |
Heterocyclic compounds as inhibitors of leukotriene production
|
|
KR20140121477A
(ko)
|
2012-02-09 |
2014-10-15 |
메르크 파텐트 게엠베하 |
Ｔａｎｋ 및 ｐａｒｐ 저해체로서의 테트라히드로-퀴나졸리논
|
|
US9340549B2
(en)
|
2012-03-05 |
2016-05-17 |
Amgen Inc. |
Oxazolidinone compounds and derivatives thereof
|
|
WO2013132253A1
(en)
*
|
2012-03-07 |
2013-09-12 |
Institute Of Cancer Research: Royal Cancer Hospital (The) |
3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
|
|
CN104169284B
(zh)
|
2012-03-28 |
2017-03-29 |
默克专利股份公司 |
双环吡嗪酮衍生物
|
|
US20130281397A1
(en)
|
2012-04-19 |
2013-10-24 |
Rvx Therapeutics Inc. |
Treatment of diseases by epigenetic regulation
|
|
JP6097820B2
(ja)
|
2012-05-04 |
2017-03-15 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ |
ピロロトリアジノン誘導体
|
|
WO2013177349A2
(en)
|
2012-05-25 |
2013-11-28 |
Glaxosmithkline Llc |
Quinazolinediones as tankyrase inhibitors
|
|
HK1202112A1
(en)
|
2012-06-07 |
2015-09-18 |
霍夫曼-拉罗奇有限公司 |
Pyrrolopyrimidone and pyrrolopyridone inhibitors of tankyrase
|
|
EP2858994A1
(en)
|
2012-06-07 |
2015-04-15 |
F. Hoffmann-La Roche AG |
Pyrazolopyrimidone and pyrazolopyridone inhibitors of tankyrase
|
|
WO2013189905A1
(en)
|
2012-06-20 |
2013-12-27 |
F. Hoffmann-La Roche Ag |
Pyrrolopyrazone inhibitors of tankyrase
|
|
EP2864335A1
(en)
|
2012-06-20 |
2015-04-29 |
F. Hoffmann-La Roche AG |
Pyranopyridone inhibitors of tankyrase
|
|
KR102083154B1
(ko)
|
2012-08-08 |
2020-03-02 |
메르크 파텐트 게엠베하 |
（아자―）이소퀴놀리논 유도체
|
|
EP2890696A1
(en)
|
2012-08-29 |
2015-07-08 |
Amgen, Inc. |
Quinazolinone compounds and derivatives thereof
|
|
WO2014045101A1
(en)
|
2012-09-21 |
2014-03-27 |
Cellzome Gmbh |
Tetrazolo quinoxaline derivatives as tankyrase inhibitors
|
|
AR092211A1
(es)
|
2012-09-24 |
2015-04-08 |
Merck Patent Ges Mit Beschränkter Haftung |
Derivados de hidropirrolopirrol
|
|
RU2650107C2
(ru)
|
2012-09-26 |
2018-04-09 |
Мерк Патент Гмбх |
Производные хиназолинона в качестве ингибиторов parp
|
|
WO2014087165A1
(en)
|
2012-12-06 |
2014-06-12 |
University Of Bath |
Tankyrase inhibitors
|