JP2016531100A - 二重特異的なｃｄ３及びｃｄ１９抗原結合構築物 - Google Patents

二重特異的なｃｄ３及びｃｄ１９抗原結合構築物 Download PDF

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JP2016531100A
JP2016531100A JP2016525831A JP2016525831A JP2016531100A JP 2016531100 A JP2016531100 A JP 2016531100A JP 2016525831 A JP2016525831 A JP 2016525831A JP 2016525831 A JP2016525831 A JP 2016525831A JP 2016531100 A JP2016531100 A JP 2016531100A
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binding
antigen
cell
antigen binding
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スールジット ビーマラオ ディキシット
スールジット ビーマラオ ディキシット
フォン クロイデンシュタイン トマス スプレッター
フォン クロイデンシュタイン トマス スプレッター
ゴードン イウ コン エング
ゴードン イウ コン エング
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ザイムワークス，インコーポレイテッド
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JP2016525831A 2013-07-12 2014-07-11 二重特異的なｃｄ３及びｃｄ１９抗原結合構築物 Withdrawn JP2016531100A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361845948P 2013-07-12 2013-07-12
US61/845,948 2013-07-12
US201461927877P 2014-01-15 2014-01-15
US61/927,877 2014-01-15
US201461978719P 2014-04-11 2014-04-11
US61/978,719 2014-04-11
PCT/US2014/046436 WO2015006749A2 (en) 2013-07-12 2014-07-11 Bispecific cd3 and cd19 antigen binding contructs

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JP2016531100A true JP2016531100A (ja) 2016-10-06
JP2016531100A5 JP2016531100A5 (https=) 2017-08-17

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US (1) US20160355588A1 (https=)
EP (1) EP3019622A4 (https=)
JP (1) JP2016531100A (https=)
KR (1) KR20160029128A (https=)
CN (1) CN105531374A (https=)
AU (1) AU2014287011A1 (https=)
BR (1) BR112016000666A2 (https=)
CA (1) CA2917886A1 (https=)
MX (1) MX2016000272A (https=)
RU (1) RU2016104130A (https=)
WO (1) WO2015006749A2 (https=)

Cited By (2)

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JP2022513383A (ja) * 2019-03-19 2022-02-07 益科思特（北京）医葯科技▲發▼展有限公司 二重特異性抗体及びその作製方法と使用
JP2022518530A (ja) * 2019-01-28 2022-03-15 ウーシー バイオロジクス アイルランド リミティド 新規二重特異性ｃｄ３／ｃｄ２０ポリペプチド複合体

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AU2012222833B2 (en) 2011-03-03 2017-03-16 Zymeworks Inc. Multivalent heteromultimer scaffold design and constructs
BR112014010580B1 (pt) 2011-11-04 2021-01-12 Zymeworks, Inc. constructo de fc heteromultimérico isolado, composição, uso de um constructo de fc heteromultimérico isolado, composição de ácido nucléico e método para expressar o constructo de fc heteromultimérico isolado
EP2892924B1 (en) * 2012-06-14 2020-11-25 Therapix Biosciences Ltd. Humanized antibodies to cluster of differentiation 3 (cd3)
US9499634B2 (en) 2012-06-25 2016-11-22 Zymeworks Inc. Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
WO2014012082A2 (en) 2012-07-13 2014-01-16 Zymeworks Inc. Multivalent heteromultimer scaffold design an constructs
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
US9914785B2 (en) 2012-11-28 2018-03-13 Zymeworks Inc. Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
TWI635098B (zh) 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體
KR102332303B1 (ko) 2013-05-31 2021-11-26 자임워크스 인코포레이티드 감소되거나 침묵화된 효과기 기능을 갖는 이종다량체
ME03675B (me) * 2013-07-05 2020-10-20 Genmab As Humanizovana ili himerna anтi-cd3 antiтela
IL263466B2 (en) 2013-12-17 2023-10-01 Genentech Inc Anti-CD3 antibodies and methods of using them
RU2016132863A (ru) * 2014-01-15 2018-02-20 Займворкс Инк. БИСПЕЦИФИЧЕСКИЕ CD3 и CD19 АНТИГЕНСВЯЗЫВАЮЩИЕ КОНСТРУКЦИИ
BR112016018100A2 (pt) 2014-02-07 2018-02-20 Univ Mcmaster acoplador antigênico de células t trifuncional, métodos e usos do mesmo
TWI701042B (zh) * 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
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