JP2016530893A5 - - Google Patents
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- JP2016530893A5 JP2016530893A5 JP2016542875A JP2016542875A JP2016530893A5 JP 2016530893 A5 JP2016530893 A5 JP 2016530893A5 JP 2016542875 A JP2016542875 A JP 2016542875A JP 2016542875 A JP2016542875 A JP 2016542875A JP 2016530893 A5 JP2016530893 A5 JP 2016530893A5
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- JP
- Japan
- Prior art keywords
- conduit
- reservoir
- pump
- cell culture
- tff
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361878502P | 2013-09-16 | 2013-09-16 | |
| US61/878,502 | 2013-09-16 | ||
| PCT/US2014/055897 WO2015039115A1 (en) | 2013-09-16 | 2014-09-16 | Methods and systems for processing a cell culture |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020073759A Division JP7008746B2 (ja) | 2013-09-16 | 2020-04-17 | 細胞培養物を処理する方法およびシステム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530893A JP2016530893A (ja) | 2016-10-06 |
| JP2016530893A5 true JP2016530893A5 (enExample) | 2017-10-26 |
| JP6925127B2 JP6925127B2 (ja) | 2021-08-25 |
Family
ID=51660627
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016542875A Active JP6925127B2 (ja) | 2013-09-16 | 2014-09-16 | 細胞培養物を処理する方法およびシステム |
| JP2020073759A Active JP7008746B2 (ja) | 2013-09-16 | 2020-04-17 | 細胞培養物を処理する方法およびシステム |
| JP2022001359A Active JP7227406B2 (ja) | 2013-09-16 | 2022-01-07 | 細胞培養物を処理する方法およびシステム |
| JP2023017253A Active JP7685543B2 (ja) | 2013-09-16 | 2023-02-08 | 細胞培養物を処理する方法およびシステム |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020073759A Active JP7008746B2 (ja) | 2013-09-16 | 2020-04-17 | 細胞培養物を処理する方法およびシステム |
| JP2022001359A Active JP7227406B2 (ja) | 2013-09-16 | 2022-01-07 | 細胞培養物を処理する方法およびシステム |
| JP2023017253A Active JP7685543B2 (ja) | 2013-09-16 | 2023-02-08 | 細胞培養物を処理する方法およびシステム |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20150158907A1 (enExample) |
| EP (1) | EP3047013B1 (enExample) |
| JP (4) | JP6925127B2 (enExample) |
| KR (3) | KR20230142653A (enExample) |
| CN (2) | CN113444620B (enExample) |
| AU (4) | AU2014318420B2 (enExample) |
| BR (2) | BR112016005545B1 (enExample) |
| CA (1) | CA2924332C (enExample) |
| CY (1) | CY1124684T1 (enExample) |
| DK (1) | DK3047013T3 (enExample) |
| EA (2) | EA031652B1 (enExample) |
| ES (1) | ES2891728T3 (enExample) |
| HU (1) | HUE055888T2 (enExample) |
| IL (1) | IL244552B (enExample) |
| MX (2) | MX384020B (enExample) |
| SG (2) | SG11201601899TA (enExample) |
| WO (1) | WO2015039115A1 (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105209603A (zh) | 2013-02-22 | 2015-12-30 | 建新公司 | 微载体灌注培养方法及其用途 |
| CN105143443A (zh) | 2013-02-22 | 2015-12-09 | 建新公司 | 微载体灌注培养方法及其用途 |
| KR102707370B1 (ko) * | 2014-05-13 | 2024-09-13 | 암겐 인코포레이티드 | 필터 및 여과 공정과 함께 사용하기 위한 공정 제어 시스템 및 방법 |
| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| EP3209765B1 (en) | 2014-10-24 | 2022-09-07 | Genzyme Corporation | Integrated continuous isolation of fluid streams from sterile process vessels |
| KR102769649B1 (ko) | 2014-12-22 | 2025-02-19 | 젠자임 코포레이션 | 포유류 세포의 배양 방법 |
| JP6457338B2 (ja) * | 2015-05-28 | 2019-01-23 | 株式会社日立製作所 | 液体還流容器、細胞濃縮装置及び細胞濃縮システム |
| EP4310503A3 (en) | 2015-12-30 | 2024-03-20 | Momenta Pharmaceuticals, Inc. | Methods related to biologics |
| ITUB20160272A1 (it) * | 2016-01-22 | 2017-07-22 | Univ Degli Studi Di Palermo | Bioreattore a perfusione autosufficiente monouso per crescite cellulari 3D |
| WO2017160739A1 (en) * | 2016-03-14 | 2017-09-21 | Pendo TECH | Processing system for multiple tangential flow filtration stations in bioprocessing applications |
| WO2017180814A1 (en) * | 2016-04-15 | 2017-10-19 | Boehringer Ingelheim International Gmbh | Cell retention device and method |
| US11560539B2 (en) | 2016-07-19 | 2023-01-24 | The Automation Partnership (Cambridge) Limited | Reversible liquid filtration system |
| EP3487981B1 (en) | 2016-07-19 | 2022-06-08 | The Automation Partnership (Cambridge) Limited | Liquid filtration and pump system |
| CN106047707B (zh) * | 2016-08-03 | 2018-11-13 | 广州赛泊泰生物技术有限公司 | 贴壁/悬浮型细胞培养单元、装置、系统及方法 |
| TWI675696B (zh) | 2017-06-01 | 2019-11-01 | 美商Ｅｍｄ密理博公司 | 用於灌注應用之切向流過濾裝置 |
| HUE058924T2 (hu) * | 2017-10-16 | 2022-09-28 | Regeneron Pharma | Perfúziós eljárások |
| WO2019104071A1 (en) * | 2017-11-22 | 2019-05-31 | Corning Incorporated | Perfusion bioreactor system and perfusion cell culture method |
| US12077743B2 (en) | 2018-02-09 | 2024-09-03 | Global Life Sciences Solutions Usa Llc | Apparatus for fluid line management in a bioprocessing system |
| US12252682B2 (en) | 2018-02-09 | 2025-03-18 | Global Life Sciences Solutions Usa Llc | System and method for fluid flow management in a bioprocessing system |
| US11932842B2 (en) | 2018-02-09 | 2024-03-19 | Global Life Sciences Solutions Usa Llc | Bioprocessing apparatus |
| US10889792B2 (en) | 2018-02-09 | 2021-01-12 | Global Life Sciences Solutions Usa Llc | Cell expansion vessel systems and methods |
| US11414639B2 (en) | 2018-02-09 | 2022-08-16 | Global Life Sciences Solutions Usa Llc | Bioprocessing vessel |
| SG11202007439TA (en) * | 2018-02-09 | 2020-09-29 | Global Life Sciences Solutions Usa Llc | Systems and methods for bioprocessing |
| US11371007B2 (en) * | 2018-02-09 | 2022-06-28 | Global Life Sciences Solutions Usa Llc | System and method for fluid flow management in a bioprocessing system |
| US11920119B2 (en) | 2018-02-09 | 2024-03-05 | Global Life Sciences Solutions Usa Llc | Systems and methods for bioprocessing |
| CN110241012B (zh) * | 2018-03-09 | 2022-11-01 | 嘉和生物药业有限公司 | 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用 |
| TWI846694B (zh) | 2018-05-04 | 2024-07-01 | 美商健臻公司 | 具有過濾系統的灌注式生物反應器 |
| WO2019229764A1 (en) * | 2018-06-01 | 2019-12-05 | Gennova Biopharmaceuticals Limited | Process for production of recombinant tnk-tpa by packed-bed perfusion system |
| CN112584916A (zh) | 2018-08-29 | 2021-03-30 | 思拓凡瑞典有限公司 | 用于过滤的系统和其相关联的方法 |
| CN113286650A (zh) * | 2018-09-06 | 2021-08-20 | 动量制药公司 | 连续细胞培养方法 |
| WO2020058509A1 (en) * | 2018-09-21 | 2020-03-26 | Ge Healthcare Bio-Sciences Ab | Perfusion bioprocessing system and method of operating the same |
| WO2020088180A1 (en) * | 2018-11-02 | 2020-05-07 | Wuxi Biologics (Shanghai) Co., Ltd. | Cell culture process by intensified perfusion with continuous harvest and without cell bleeding |
| US10647954B1 (en) | 2018-11-15 | 2020-05-12 | Flaskworks, Llc | Dendritic cell generating apparatus and method |
| KR20210131323A (ko) | 2018-12-31 | 2021-11-02 | 모멘타 파머슈티컬스 인코포레이티드 | 우스테키누맙 생성 방법 |
| ES2983667T3 (es) * | 2019-01-25 | 2024-10-24 | Becton Dickinson Co | Métodos y aparatos para extraer de manera selectiva los constituyentes de muestras biológicas |
| CN113748199B (zh) * | 2019-03-26 | 2024-10-25 | 株式会社美加细胞 | 细胞悬浮液处理装置 |
| AU2020253327B2 (en) * | 2019-04-01 | 2025-04-10 | Boehringer Ingelheim International Gmbh | Integrated and continuous recombinant protein manufacturing |
| CN114072217A (zh) * | 2019-06-28 | 2022-02-18 | 信达生物制药(苏州)有限公司 | 组合式层析装置、无缝连接层析方法和生物制剂的纯化方法 |
| US11566217B2 (en) | 2019-08-13 | 2023-01-31 | Flaskworks, Llc | Duty cycle for cell culture systems |
| JP2022552724A (ja) | 2019-10-21 | 2022-12-19 | フラスクワークス， エルエルシー | 細胞培養のためのシステムおよび方法 |
| WO2021174657A1 (zh) * | 2020-03-06 | 2021-09-10 | 尚玉宽 | 灌流模块及灌流培养系统 |
| EP3878542A1 (en) * | 2020-03-11 | 2021-09-15 | Bayer AG | Filter membranes as antifoam level safeguards |
| KR102230957B1 (ko) * | 2020-05-18 | 2021-03-23 | 경북대학교 산학협력단 | Ev 여과장치 |
| WO2022011145A1 (en) * | 2020-07-08 | 2022-01-13 | Vascular Perfusion Solutions, Inc. | Reciprocating pressure perfusion system and methods |
| EP4182427A1 (en) * | 2020-07-15 | 2023-05-24 | Global Life Sciences Solutions USA LLC | Bioprocessing perfusion system having a plurality of filters and method of operating the same |
| CN114058505B (zh) * | 2020-07-30 | 2024-10-01 | 环球生命科技咨询美国有限责任公司 | 新型灌流培养用高密度微载体截留装置和使用方法 |
| US20220119759A1 (en) * | 2020-10-19 | 2022-04-21 | Emd Millipore Corporation | Cascade Tangential Flow Filtration Systems for Perfusion of Cell Culture |
| US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12151024B2 (en) | 2021-01-22 | 2024-11-26 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| CN112831416B (zh) * | 2021-01-29 | 2025-01-10 | 上海睿钰生物科技有限公司 | 一种体外生命维持灌流培养系统及其控制方法 |
| US11673083B2 (en) | 2021-04-16 | 2023-06-13 | Repligen Corporation | Filtration system with selective flow reversal |
| EP4330367A1 (en) * | 2021-04-29 | 2024-03-06 | Univercells Technologies SA | Systems and methods for the continuous production and purification of biologics |
| EP4370647A1 (en) | 2021-07-15 | 2024-05-22 | Just-Evotec Biologics, Inc. | Bidirectional tangential flow filtration (tff) perfusion system |
| US12285419B2 (en) | 2021-10-14 | 2025-04-29 | Pacira Pharmaceuticals, Inc. | Bupivacaine multivesicular liposome formulations and uses thereof |
| EP4174164A1 (en) * | 2021-10-21 | 2023-05-03 | Alit Biotech (Shanghai) Co., Ltd. | Biological filtration systems and controlling methods thereof |
| US20240209301A1 (en) * | 2021-10-21 | 2024-06-27 | Alit Biotech (Shanghai) Co., Ltd. | Biological filtration systems and controlling methods thereof |
| US12522797B2 (en) | 2022-04-12 | 2026-01-13 | Sartorius Stedim Biotech Gmbh | Multiport device for connecting a loop to one port of a bioreactor, and perfusion or concentrated fed-batch setup for performing an upstream process of cell culture |
| EP4268943A1 (en) | 2022-04-27 | 2023-11-01 | Levitronix GmbH | A device for tangential flow filtration of a fluid |
| US20260176561A1 (en) * | 2022-10-26 | 2026-06-25 | National Resilience, Inc. | Bioreactor Systems and Methods of Operating Same |
| EP4768564A1 (en) | 2023-09-27 | 2026-07-01 | FUJIFILM Corporation | APPARATUS AND METHOD FOR PROCESSING A CELL CULTURE SOLUTION, AND METHOD FOR PRODUCING THE PRODUCT |
| US20250129321A1 (en) * | 2023-10-20 | 2025-04-24 | Cellares Corporation | Systems, devices, and methods for fluid control in a cell processing system |
| WO2025122785A1 (en) * | 2023-12-05 | 2025-06-12 | Massachusetts Institute Of Technology | Magnetic resonance relaxometry bioreactor monitoring |
| WO2025134151A1 (en) * | 2023-12-20 | 2025-06-26 | Omnibrx Biotechnologies Private Limited | An apparatus for cell retention and method thereof |
| GB202407177D0 (en) * | 2024-05-20 | 2024-07-03 | Ivy Farm Tech Limited | Perfusion cell culture apparatus |
| CN122514587A (zh) * | 2024-02-01 | 2026-08-04 | 国立大学法人东京科学大学 | 细胞培养装置以及使用其的细胞培养方法 |
| US12280149B1 (en) | 2024-05-20 | 2025-04-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12251472B1 (en) | 2024-05-20 | 2025-03-18 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12156940B1 (en) | 2024-05-20 | 2024-12-03 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60804A (ja) * | 1983-06-20 | 1985-01-05 | Poritetsukusu:Kk | ウルトラフイルタ装置 |
| JPS6188872A (ja) * | 1984-10-09 | 1986-05-07 | Snow Brand Milk Prod Co Ltd | 高濃度連続培養方法及び装置 |
| US4885087A (en) * | 1986-11-26 | 1989-12-05 | Kopf Henry B | Apparatus for mass transfer involving biological/pharmaceutical media |
| US6022742A (en) * | 1986-11-26 | 2000-02-08 | Kopf; Henry B. | Culture device and method |
| US5030346A (en) * | 1988-01-15 | 1991-07-09 | Henry Filters, Inc. | Pump for filtration system |
| US5401650A (en) * | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
| JPH0531335A (ja) * | 1991-07-30 | 1993-02-09 | Toto Ltd | 分離膜洗浄方法 |
| US6544424B1 (en) | 1999-12-03 | 2003-04-08 | Refined Technology Company | Fluid filtration system |
| JP3547715B2 (ja) * | 2001-03-06 | 2004-07-28 | 榮 新垣 | ベクター精製用装置及び方法 |
| JP4567446B2 (ja) * | 2002-06-19 | 2010-10-20 | ノースウエスト バイオセラピューティクス，インコーポレイティド | 白血球富化のための平行流濾過デバイスおよび方法 |
| US7875448B2 (en) * | 2004-01-12 | 2011-01-25 | Single Use Brx, Llc | Bioreactor systems and disposable bioreactor |
| PL1720972T3 (pl) * | 2004-03-05 | 2014-06-30 | Dpx Holdings Bv | Proces hodowli komórek poprzez ciągłą perfuzję i zmienny przepływ styczny |
| EP1963367A4 (en) * | 2005-12-06 | 2009-05-13 | Amgen Inc | POLISHING STEPS IN MULTI-STAGE PROTEIN PURIFICATION TREATMENTS |
| GB0606144D0 (en) * | 2006-03-28 | 2006-05-10 | Ge Healthcare Bio Sciences Ab | Automated crossflow filtration method and system |
| FI2343362T4 (fi) * | 2006-07-14 | 2024-07-04 | Patheon Holdings I B V | Parannettu menetelmä solujen viljelyä varten |
| FR2925923B1 (fr) * | 2007-12-28 | 2009-12-18 | Michelin Soc Tech | Procede et dispositif de fabrication d'un cable a deux couches du type gomme in situ |
| JP5003614B2 (ja) * | 2008-07-03 | 2012-08-15 | 株式会社日立プラントテクノロジー | 生体細胞の分離方法及び培養装置 |
| US9446354B2 (en) * | 2010-08-25 | 2016-09-20 | Repligen Corporation | Device, system and process for modification or concentration of cell-depleted fluid |
| EP2686415B1 (en) * | 2011-03-18 | 2017-11-15 | GE Healthcare Bio-Sciences AB | Flexible bag for cultivation of cells |
| WO2013109520A1 (en) * | 2012-01-18 | 2013-07-25 | Bayer Healthcare Llc | Perfusion bioreactor systems and methods of operating the same |
| CN111893022A (zh) * | 2012-02-20 | 2020-11-06 | 拜耳股份公司 | 用于截留和返回细胞的一次性分离器 |
| EP2900804B1 (en) * | 2012-09-27 | 2019-09-18 | GE Healthcare Bio-Sciences AB | Tangential flow perfusion system |
-
2014
- 2014-09-16 ES ES14780959T patent/ES2891728T3/es active Active
- 2014-09-16 EA EA201690602A patent/EA031652B1/ru not_active IP Right Cessation
- 2014-09-16 BR BR112016005545-4A patent/BR112016005545B1/pt active IP Right Grant
- 2014-09-16 KR KR1020237033339A patent/KR20230142653A/ko not_active Ceased
- 2014-09-16 EA EA201892084A patent/EA035665B1/ru not_active IP Right Cessation
- 2014-09-16 CA CA2924332A patent/CA2924332C/en active Active
- 2014-09-16 KR KR1020227006373A patent/KR102749545B1/ko active Active
- 2014-09-16 KR KR1020167009570A patent/KR102369211B1/ko active Active
- 2014-09-16 WO PCT/US2014/055897 patent/WO2015039115A1/en not_active Ceased
- 2014-09-16 BR BR122021001466-3A patent/BR122021001466B1/pt active IP Right Grant
- 2014-09-16 MX MX2016003440A patent/MX384020B/es unknown
- 2014-09-16 SG SG11201601899TA patent/SG11201601899TA/en unknown
- 2014-09-16 DK DK14780959.4T patent/DK3047013T3/da active
- 2014-09-16 CN CN202110234907.4A patent/CN113444620B/zh active Active
- 2014-09-16 CN CN201480062402.2A patent/CN105722967B/zh active Active
- 2014-09-16 AU AU2014318420A patent/AU2014318420B2/en active Active
- 2014-09-16 SG SG10201803601SA patent/SG10201803601SA/en unknown
- 2014-09-16 JP JP2016542875A patent/JP6925127B2/ja active Active
- 2014-09-16 EP EP14780959.4A patent/EP3047013B1/en not_active Revoked
- 2014-09-16 HU HUE14780959A patent/HUE055888T2/hu unknown
-
2015
- 2015-02-20 US US14/627,674 patent/US20150158907A1/en not_active Abandoned
-
2016
- 2016-03-13 IL IL244552A patent/IL244552B/en active IP Right Grant
- 2016-03-16 MX MX2021007792A patent/MX2021007792A/es unknown
-
2020
- 2020-04-16 AU AU2020202568A patent/AU2020202568B2/en active Active
- 2020-04-17 JP JP2020073759A patent/JP7008746B2/ja active Active
-
2021
- 2021-05-14 US US17/321,128 patent/US20210269477A1/en not_active Abandoned
- 2021-10-13 CY CY20211100884T patent/CY1124684T1/el unknown
-
2022
- 2022-01-07 JP JP2022001359A patent/JP7227406B2/ja active Active
- 2022-08-25 AU AU2022221495A patent/AU2022221495A1/en not_active Abandoned
-
2023
- 2023-02-08 JP JP2023017253A patent/JP7685543B2/ja active Active
-
2024
- 2024-09-03 AU AU2024219335A patent/AU2024219335A1/en not_active Abandoned
-
2025
- 2025-09-11 US US19/326,519 patent/US20260049100A1/en active Pending
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