CY1124684T1 - Μεθοδοι και συστηματα για την επεξεργασια μιας κυτταρικης καλλιεργειας - Google Patents
Μεθοδοι και συστηματα για την επεξεργασια μιας κυτταρικης καλλιεργειαςInfo
- Publication number
- CY1124684T1 CY1124684T1 CY20211100884T CY211100884T CY1124684T1 CY 1124684 T1 CY1124684 T1 CY 1124684T1 CY 20211100884 T CY20211100884 T CY 20211100884T CY 211100884 T CY211100884 T CY 211100884T CY 1124684 T1 CY1124684 T1 CY 1124684T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cell culture
- methods
- processing
- systems
- filtration
- Prior art date
Links
- 238000004113 cell culture Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000001914 filtration Methods 0.000 abstract 3
- 238000009295 crossflow filtration Methods 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/12—Purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Water Supply & Treatment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361878502P | 2013-09-16 | 2013-09-16 | |
| PCT/US2014/055897 WO2015039115A1 (en) | 2013-09-16 | 2014-09-16 | Methods and systems for processing a cell culture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124684T1 true CY1124684T1 (el) | 2022-07-22 |
Family
ID=51660627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100884T CY1124684T1 (el) | 2013-09-16 | 2021-10-13 | Μεθοδοι και συστηματα για την επεξεργασια μιας κυτταρικης καλλιεργειας |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20150158907A1 (enExample) |
| EP (1) | EP3047013B1 (enExample) |
| JP (4) | JP6925127B2 (enExample) |
| KR (3) | KR102369211B1 (enExample) |
| CN (2) | CN105722967B (enExample) |
| AU (4) | AU2014318420B2 (enExample) |
| BR (2) | BR122021001466B1 (enExample) |
| CA (1) | CA2924332C (enExample) |
| CY (1) | CY1124684T1 (enExample) |
| DK (1) | DK3047013T3 (enExample) |
| EA (2) | EA035665B1 (enExample) |
| ES (1) | ES2891728T3 (enExample) |
| HU (1) | HUE055888T2 (enExample) |
| IL (1) | IL244552B (enExample) |
| MX (2) | MX384020B (enExample) |
| SG (2) | SG10201803601SA (enExample) |
| WO (1) | WO2015039115A1 (enExample) |
Families Citing this family (65)
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|---|---|---|---|---|
| EP2958988A2 (en) | 2013-02-22 | 2015-12-30 | Genzyme Corporation | Microcarrier perfusion culturing methods and uses thereof |
| HUE042094T2 (hu) | 2013-02-22 | 2019-06-28 | Genzyme Corp | Mikrokarrier-perfúziós tenyésztési eljárások és alkalmazásuk |
| CA3140009C (en) | 2014-05-13 | 2023-09-05 | Amgen Inc. | Process control systems and methods for use with filters and filtration processes |
| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| DK3209765T3 (da) * | 2014-10-24 | 2022-11-28 | Genzyme Corp | Integreret kontinuerlig isolering af fluidumstrømninger fra sterile procesbeholdere |
| CA2971861C (en) | 2014-12-22 | 2024-02-13 | Genzyme Corporation | Methods of culturing a mammalian cell |
| JP6457338B2 (ja) * | 2015-05-28 | 2019-01-23 | 株式会社日立製作所 | 液体還流容器、細胞濃縮装置及び細胞濃縮システム |
| US11719704B2 (en) | 2015-12-30 | 2023-08-08 | Momenta Pharmaceuticals, Inc. | Methods related to biologics |
| ITUB20160272A1 (it) * | 2016-01-22 | 2017-07-22 | Univ Degli Studi Di Palermo | Bioreattore a perfusione autosufficiente monouso per crescite cellulari 3D |
| WO2017160739A1 (en) | 2016-03-14 | 2017-09-21 | Pendo TECH | Processing system for multiple tangential flow filtration stations in bioprocessing applications |
| EP3443064A1 (en) * | 2016-04-15 | 2019-02-20 | Boehringer Ingelheim International GmbH | Cell retention device and method |
| WO2018015386A1 (en) * | 2016-07-19 | 2018-01-25 | The Automation Partnership (Cambridge) Limited | Reversible liquid filtration system |
| CN109415673B (zh) * | 2016-07-19 | 2022-09-06 | 自动化合作关系（剑桥）有限公司 | 液体过滤和泵系统 |
| CN106047707B (zh) * | 2016-08-03 | 2018-11-13 | 广州赛泊泰生物技术有限公司 | 贴壁/悬浮型细胞培养单元、装置、系统及方法 |
| TWI675696B (zh) | 2017-06-01 | 2019-11-01 | 美商Ｅｍｄ密理博公司 | 用於灌注應用之切向流過濾裝置 |
| TWI889045B (zh) * | 2017-10-16 | 2025-07-01 | 美商再生元醫藥公司 | 灌注生物反應器及相關使用方法 |
| CN111417713B (zh) * | 2017-11-22 | 2024-04-26 | 康宁股份有限公司 | 灌注生物反应器系统及灌注细胞培养方法 |
| US11414639B2 (en) | 2018-02-09 | 2022-08-16 | Global Life Sciences Solutions Usa Llc | Bioprocessing vessel |
| US12077743B2 (en) | 2018-02-09 | 2024-09-03 | Global Life Sciences Solutions Usa Llc | Apparatus for fluid line management in a bioprocessing system |
| WO2019155030A1 (en) * | 2018-02-09 | 2019-08-15 | General Electric Company | Bioprocessing apparatus |
| US12252682B2 (en) | 2018-02-09 | 2025-03-18 | Global Life Sciences Solutions Usa Llc | System and method for fluid flow management in a bioprocessing system |
| US11920119B2 (en) | 2018-02-09 | 2024-03-05 | Global Life Sciences Solutions Usa Llc | Systems and methods for bioprocessing |
| US11371007B2 (en) * | 2018-02-09 | 2022-06-28 | Global Life Sciences Solutions Usa Llc | System and method for fluid flow management in a bioprocessing system |
| US11932842B2 (en) | 2018-02-09 | 2024-03-19 | Global Life Sciences Solutions Usa Llc | Bioprocessing apparatus |
| CN110241012B (zh) * | 2018-03-09 | 2022-11-01 | 嘉和生物药业有限公司 | 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用 |
| TWI846694B (zh) * | 2018-05-04 | 2024-07-01 | 美商健臻公司 | 具有過濾系統的灌注式生物反應器 |
| US20210214702A1 (en) * | 2018-06-01 | 2021-07-15 | Gennova Biopharmaceuticals Limited | Process for production of recombinant tnk-tpa by packed-bed perfusion system |
| CN112584916A (zh) * | 2018-08-29 | 2021-03-30 | 思拓凡瑞典有限公司 | 用于过滤的系统和其相关联的方法 |
| AU2019336148B2 (en) * | 2018-09-06 | 2025-08-14 | Momenta Pharmaceuticals, Inc. | Methods of continuous cell culture |
| EP3852904A1 (en) * | 2018-09-21 | 2021-07-28 | Cytiva Sweden AB | Perfusion bioprocessing system and method of operating the same |
| US20220364034A1 (en) * | 2018-11-02 | 2022-11-17 | WuXi Biologics Ireland Limited | Cell culture process by intensified perfusion with continuous harvest and without cell bleeding |
| US10647954B1 (en) | 2018-11-15 | 2020-05-12 | Flaskworks, Llc | Dendritic cell generating apparatus and method |
| IL284374B2 (en) | 2018-12-31 | 2025-10-01 | Momenta Pharmaceuticals Inc | Methods for producing ozatekinumab |
| BR112021014233A2 (pt) * | 2019-01-25 | 2021-09-28 | Becton, Dickinson And Company | Métodos e aparelhos para extrair seletivamente constituintes de amostras biológicas |
| EP3947627A1 (en) * | 2019-04-01 | 2022-02-09 | Boehringer Ingelheim International GmbH | Integrated and continuous recombinant protein manufacturing |
| WO2020258706A1 (zh) * | 2019-06-28 | 2020-12-30 | 信达生物制药(苏州)有限公司 | 组合式层析装置、无缝连接层析方法和生物制剂的纯化方法 |
| US11566217B2 (en) | 2019-08-13 | 2023-01-31 | Flaskworks, Llc | Duty cycle for cell culture systems |
| JP2022552724A (ja) | 2019-10-21 | 2022-12-19 | フラスクワークス， エルエルシー | 細胞培養のためのシステムおよび方法 |
| EP3878542A1 (en) * | 2020-03-11 | 2021-09-15 | Bayer AG | Filter membranes as antifoam level safeguards |
| KR102230957B1 (ko) * | 2020-05-18 | 2021-03-23 | 경북대학교 산학협력단 | Ev 여과장치 |
| CA3185235C (en) * | 2020-07-08 | 2024-05-07 | Israel Jessop | Reciprocating pressure perfusion system for perfusing tissue outside the body |
| CN115803422A (zh) * | 2020-07-15 | 2023-03-14 | 环球生命科技咨询美国有限责任公司 | 具有多个过滤器的生物加工灌注系统及其操作方法 |
| CN114058505B (zh) * | 2020-07-30 | 2024-10-01 | 环球生命科技咨询美国有限责任公司 | 新型灌流培养用高密度微载体截留装置和使用方法 |
| US20220119759A1 (en) * | 2020-10-19 | 2022-04-21 | Emd Millipore Corporation | Cascade Tangential Flow Filtration Systems for Perfusion of Cell Culture |
| US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12151024B2 (en) | 2021-01-22 | 2024-11-26 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
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| CN112831416B (zh) * | 2021-01-29 | 2025-01-10 | 上海睿钰生物科技有限公司 | 一种体外生命维持灌流培养系统及其控制方法 |
| US11673083B2 (en) | 2021-04-16 | 2023-06-13 | Repligen Corporation | Filtration system with selective flow reversal |
| CN115261223A (zh) * | 2021-04-29 | 2022-11-01 | 尤尼沃尔塞尔斯技术股份公司 | 用于连续生产和纯化生物制剂的系统和方法 |
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| US9446354B2 (en) * | 2010-08-25 | 2016-09-20 | Repligen Corporation | Device, system and process for modification or concentration of cell-depleted fluid |
| CN103415610B (zh) * | 2011-03-18 | 2016-10-19 | 通用电气健康护理生物科学股份公司 | 用于培养细胞的弹性袋 |
| EP2804943A1 (en) * | 2012-01-18 | 2014-11-26 | Bayer HealthCare LLC | Perfusion bioreactor systems and methods of operating the same |
| JP6239532B2 (ja) * | 2012-02-20 | 2017-11-29 | バイエル、アクチエンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 細胞を保持し再循環させるための一方向分離器 |
| US9663753B2 (en) | 2012-09-27 | 2017-05-30 | Ge Healthcare Bio-Sciences Ab | Tangential flow perfusion system |
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2014
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