DK3047013T3 - Fremgangsmåder og systemer til forarbejdning af en cellekultur - Google Patents

Fremgangsmåder og systemer til forarbejdning af en cellekultur Download PDF

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Publication number
DK3047013T3
DK3047013T3 DK14780959.4T DK14780959T DK3047013T3 DK 3047013 T3 DK3047013 T3 DK 3047013T3 DK 14780959 T DK14780959 T DK 14780959T DK 3047013 T3 DK3047013 T3 DK 3047013T3
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Prior art keywords
systems
methods
processing
cell culture
culture
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DK14780959.4T
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Danish (da)
English (en)
Inventor
Hang Zhou
Benjamin Wright
Marcella Yu
Jin Yin
Konstantin Konstantinov
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Genzyme Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Water Supply & Treatment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK14780959.4T 2013-09-16 2014-09-16 Fremgangsmåder og systemer til forarbejdning af en cellekultur DK3047013T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361878502P 2013-09-16 2013-09-16
PCT/US2014/055897 WO2015039115A1 (en) 2013-09-16 2014-09-16 Methods and systems for processing a cell culture

Publications (1)

Publication Number Publication Date
DK3047013T3 true DK3047013T3 (da) 2021-11-15

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ID=51660627

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DK14780959.4T DK3047013T3 (da) 2013-09-16 2014-09-16 Fremgangsmåder og systemer til forarbejdning af en cellekultur

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US (2) US20150158907A1 (enExample)
EP (1) EP3047013B1 (enExample)
JP (4) JP6925127B2 (enExample)
KR (3) KR102369211B1 (enExample)
CN (2) CN105722967B (enExample)
AU (4) AU2014318420B2 (enExample)
BR (2) BR122021001466B1 (enExample)
CA (1) CA2924332C (enExample)
CY (1) CY1124684T1 (enExample)
DK (1) DK3047013T3 (enExample)
EA (2) EA035665B1 (enExample)
ES (1) ES2891728T3 (enExample)
HU (1) HUE055888T2 (enExample)
IL (1) IL244552B (enExample)
MX (2) MX384020B (enExample)
SG (2) SG10201803601SA (enExample)
WO (1) WO2015039115A1 (enExample)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2958988A2 (en) 2013-02-22 2015-12-30 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
HUE042094T2 (hu) 2013-02-22 2019-06-28 Genzyme Corp Mikrokarrier-perfúziós tenyésztési eljárások és alkalmazásuk
CA3140009C (en) 2014-05-13 2023-09-05 Amgen Inc. Process control systems and methods for use with filters and filtration processes
TWI743024B (zh) 2014-06-06 2021-10-21 美商健臻公司 灌注培養方法及其用途
TWI776235B (zh) 2014-06-09 2022-09-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
DK3209765T3 (da) * 2014-10-24 2022-11-28 Genzyme Corp Integreret kontinuerlig isolering af fluidumstrømninger fra sterile procesbeholdere
CA2971861C (en) 2014-12-22 2024-02-13 Genzyme Corporation Methods of culturing a mammalian cell
JP6457338B2 (ja) * 2015-05-28 2019-01-23 株式会社日立製作所 液体還流容器、細胞濃縮装置及び細胞濃縮システム
US11719704B2 (en) 2015-12-30 2023-08-08 Momenta Pharmaceuticals, Inc. Methods related to biologics
ITUB20160272A1 (it) * 2016-01-22 2017-07-22 Univ Degli Studi Di Palermo Bioreattore a perfusione autosufficiente monouso per crescite cellulari 3D
WO2017160739A1 (en) 2016-03-14 2017-09-21 Pendo TECH Processing system for multiple tangential flow filtration stations in bioprocessing applications
EP3443064A1 (en) * 2016-04-15 2019-02-20 Boehringer Ingelheim International GmbH Cell retention device and method
WO2018015386A1 (en) * 2016-07-19 2018-01-25 The Automation Partnership (Cambridge) Limited Reversible liquid filtration system
CN109415673B (zh) * 2016-07-19 2022-09-06 自动化合作关系（剑桥）有限公司 液体过滤和泵系统
CN106047707B (zh) * 2016-08-03 2018-11-13 广州赛泊泰生物技术有限公司 贴壁/悬浮型细胞培养单元、装置、系统及方法
TWI675696B (zh) 2017-06-01 2019-11-01 美商Ｅｍｄ密理博公司 用於灌注應用之切向流過濾裝置
TWI889045B (zh) * 2017-10-16 2025-07-01 美商再生元醫藥公司 灌注生物反應器及相關使用方法
CN111417713B (zh) * 2017-11-22 2024-04-26 康宁股份有限公司 灌注生物反应器系统及灌注细胞培养方法
US11414639B2 (en) 2018-02-09 2022-08-16 Global Life Sciences Solutions Usa Llc Bioprocessing vessel
US12077743B2 (en) 2018-02-09 2024-09-03 Global Life Sciences Solutions Usa Llc Apparatus for fluid line management in a bioprocessing system
WO2019155030A1 (en) * 2018-02-09 2019-08-15 General Electric Company Bioprocessing apparatus
US12252682B2 (en) 2018-02-09 2025-03-18 Global Life Sciences Solutions Usa Llc System and method for fluid flow management in a bioprocessing system
US11920119B2 (en) 2018-02-09 2024-03-05 Global Life Sciences Solutions Usa Llc Systems and methods for bioprocessing
US11371007B2 (en) * 2018-02-09 2022-06-28 Global Life Sciences Solutions Usa Llc System and method for fluid flow management in a bioprocessing system
US11932842B2 (en) 2018-02-09 2024-03-19 Global Life Sciences Solutions Usa Llc Bioprocessing apparatus
CN110241012B (zh) * 2018-03-09 2022-11-01 嘉和生物药业有限公司 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
US20210214702A1 (en) * 2018-06-01 2021-07-15 Gennova Biopharmaceuticals Limited Process for production of recombinant tnk-tpa by packed-bed perfusion system
CN112584916A (zh) * 2018-08-29 2021-03-30 思拓凡瑞典有限公司 用于过滤的系统和其相关联的方法
AU2019336148B2 (en) * 2018-09-06 2025-08-14 Momenta Pharmaceuticals, Inc. Methods of continuous cell culture
EP3852904A1 (en) * 2018-09-21 2021-07-28 Cytiva Sweden AB Perfusion bioprocessing system and method of operating the same
US20220364034A1 (en) * 2018-11-02 2022-11-17 WuXi Biologics Ireland Limited Cell culture process by intensified perfusion with continuous harvest and without cell bleeding
US10647954B1 (en) 2018-11-15 2020-05-12 Flaskworks, Llc Dendritic cell generating apparatus and method
IL284374B2 (en) 2018-12-31 2025-10-01 Momenta Pharmaceuticals Inc Methods for producing ozatekinumab
BR112021014233A2 (pt) * 2019-01-25 2021-09-28 Becton, Dickinson And Company Métodos e aparelhos para extrair seletivamente constituintes de amostras biológicas
EP3947627A1 (en) * 2019-04-01 2022-02-09 Boehringer Ingelheim International GmbH Integrated and continuous recombinant protein manufacturing
WO2020258706A1 (zh) * 2019-06-28 2020-12-30 信达生物制药(苏州)有限公司 组合式层析装置、无缝连接层析方法和生物制剂的纯化方法
US11566217B2 (en) 2019-08-13 2023-01-31 Flaskworks, Llc Duty cycle for cell culture systems
JP2022552724A (ja) 2019-10-21 2022-12-19 フラスクワークス， エルエルシー 細胞培養のためのシステムおよび方法
EP3878542A1 (en) * 2020-03-11 2021-09-15 Bayer AG Filter membranes as antifoam level safeguards
KR102230957B1 (ko) * 2020-05-18 2021-03-23 경북대학교 산학협력단 Ev 여과장치
CA3185235C (en) * 2020-07-08 2024-05-07 Israel Jessop Reciprocating pressure perfusion system for perfusing tissue outside the body
CN115803422A (zh) * 2020-07-15 2023-03-14 环球生命科技咨询美国有限责任公司 具有多个过滤器的生物加工灌注系统及其操作方法
CN114058505B (zh) * 2020-07-30 2024-10-01 环球生命科技咨询美国有限责任公司 新型灌流培养用高密度微载体截留装置和使用方法
US20220119759A1 (en) * 2020-10-19 2022-04-21 Emd Millipore Corporation Cascade Tangential Flow Filtration Systems for Perfusion of Cell Culture
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12151024B2 (en) 2021-01-22 2024-11-26 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
CN112831416B (zh) * 2021-01-29 2025-01-10 上海睿钰生物科技有限公司 一种体外生命维持灌流培养系统及其控制方法
US11673083B2 (en) 2021-04-16 2023-06-13 Repligen Corporation Filtration system with selective flow reversal
CN115261223A (zh) * 2021-04-29 2022-11-01 尤尼沃尔塞尔斯技术股份公司 用于连续生产和纯化生物制剂的系统和方法
EP4370647A1 (en) 2021-07-15 2024-05-22 Just-Evotec Biologics, Inc. Bidirectional tangential flow filtration (tff) perfusion system
WO2023064464A1 (en) 2021-10-14 2023-04-20 Pacira Pharmaceuticals, Inc. Bupivacaine multivesicular liposome formulations and uses thereof
EP4174164A1 (en) * 2021-10-21 2023-05-03 Alit Biotech (Shanghai) Co., Ltd. Biological filtration systems and controlling methods thereof
US12522797B2 (en) 2022-04-12 2026-01-13 Sartorius Stedim Biotech Gmbh Multiport device for connecting a loop to one port of a bioreactor, and perfusion or concentrated fed-batch setup for performing an upstream process of cell culture
EP4268943A1 (en) 2022-04-27 2023-11-01 Levitronix GmbH A device for tangential flow filtration of a fluid
WO2024092004A1 (en) * 2022-10-26 2024-05-02 National Resilience, Inc. Bioreactor systems and methods of operating same
WO2025122785A1 (en) * 2023-12-05 2025-06-12 Massachusetts Institute Of Technology Magnetic resonance relaxometry bioreactor monitoring
WO2025134151A1 (en) * 2023-12-20 2025-06-26 Omnibrx Biotechnologies Private Limited An apparatus for cell retention and method thereof
GB202407177D0 (en) * 2024-05-20 2024-07-03 Ivy Farm Tech Limited Perfusion cell culture apparatus
WO2025164695A1 (ja) * 2024-02-01 2025-08-07 国立大学法人東京科学大学 細胞培養装置及びそれを用いた細胞培養方法
US12156940B1 (en) 2024-05-20 2024-12-03 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12251472B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12280149B1 (en) 2024-05-20 2025-04-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60804A (ja) * 1983-06-20 1985-01-05 Poritetsukusu:Kk ウルトラフイルタ装置
JPS6188872A (ja) * 1984-10-09 1986-05-07 Snow Brand Milk Prod Co Ltd 高濃度連続培養方法及び装置
US4885087A (en) * 1986-11-26 1989-12-05 Kopf Henry B Apparatus for mass transfer involving biological/pharmaceutical media
US6022742A (en) * 1986-11-26 2000-02-08 Kopf; Henry B. Culture device and method
US5030346A (en) * 1988-01-15 1991-07-09 Henry Filters, Inc. Pump for filtration system
US5401650A (en) * 1990-10-24 1995-03-28 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-galactosidase A
JPH0531335A (ja) * 1991-07-30 1993-02-09 Toto Ltd 分離膜洗浄方法
US6544424B1 (en) 1999-12-03 2003-04-08 Refined Technology Company Fluid filtration system
JP3547715B2 (ja) * 2001-03-06 2004-07-28 榮 新垣 ベクター精製用装置及び方法
DK3173141T3 (da) * 2002-06-19 2019-11-25 Northwest Biotherapeutics Inc Tangentialflowfiltreringsenhed og fremgangsmåder til berigelse af leukocytter
US7875448B2 (en) * 2004-01-12 2011-01-25 Single Use Brx, Llc Bioreactor systems and disposable bioreactor
KR101050585B1 (ko) * 2004-03-05 2011-07-19 디에스엠 아이피 어셋츠 비.브이. 연속식 살포 및 교호 접선 흐름에 의한 세포 배양 방법
CA2632519A1 (en) * 2005-12-06 2007-07-05 Amgen Inc. Polishing steps used in multi-step protein purification processes
GB0606144D0 (en) * 2006-03-28 2006-05-10 Ge Healthcare Bio Sciences Ab Automated crossflow filtration method and system
PT2634243T (pt) * 2006-07-14 2017-12-18 Patheon Holdings I B V Método para melhorar a cultura de células
FR2925923B1 (fr) * 2007-12-28 2009-12-18 Michelin Soc Tech Procede et dispositif de fabrication d'un cable a deux couches du type gomme in situ
JP5003614B2 (ja) * 2008-07-03 2012-08-15 株式会社日立プラントテクノロジー 生体細胞の分離方法及び培養装置
US9446354B2 (en) * 2010-08-25 2016-09-20 Repligen Corporation Device, system and process for modification or concentration of cell-depleted fluid
CN103415610B (zh) * 2011-03-18 2016-10-19 通用电气健康护理生物科学股份公司 用于培养细胞的弹性袋
EP2804943A1 (en) * 2012-01-18 2014-11-26 Bayer HealthCare LLC Perfusion bioreactor systems and methods of operating the same
JP6239532B2 (ja) * 2012-02-20 2017-11-29 バイエル、アクチエンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 細胞を保持し再循環させるための一方向分離器
US9663753B2 (en) 2012-09-27 2017-05-30 Ge Healthcare Bio-Sciences Ab Tangential flow perfusion system

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KR102749545B1 (ko) 2025-01-07
WO2015039115A1 (en) 2015-03-19
MX2016003440A (es) 2016-11-11
EP3047013A1 (en) 2016-07-27
CN113444620B (zh) 2024-03-29
AU2014318420A1 (en) 2016-04-14
AU2022221495A1 (en) 2022-09-22
KR20160055866A (ko) 2016-05-18
MX384020B (es) 2025-03-14
JP7227406B2 (ja) 2023-02-21
JP6925127B2 (ja) 2021-08-25
ES2891728T3 (es) 2022-01-31
KR20230142653A (ko) 2023-10-11
IL244552B (en) 2020-04-30
AU2014318420B2 (en) 2020-01-16
AU2020202568A1 (en) 2020-05-07
EA201892084A1 (ru) 2019-02-28
US20150158907A1 (en) 2015-06-11
EA031652B1 (ru) 2019-02-28
EA201690602A1 (ru) 2016-07-29
MX2021007792A (es) 2021-08-11
BR122021001466B1 (pt) 2021-10-13
JP2023058588A (ja) 2023-04-25
IL244552A0 (en) 2016-04-21
JP2016530893A (ja) 2016-10-06
JP2022050549A (ja) 2022-03-30
EA035665B1 (ru) 2020-07-23
HUE055888T2 (hu) 2022-01-28
KR102369211B1 (ko) 2022-03-03
CN105722967A (zh) 2016-06-29
AU2020202568B2 (en) 2022-06-02
BR112016005545B1 (pt) 2021-06-01
HK1222672A1 (zh) 2017-07-07
CA2924332C (en) 2023-03-14
US20210269477A1 (en) 2021-09-02
JP2020124204A (ja) 2020-08-20
CN105722967B (zh) 2021-03-19
JP7685543B2 (ja) 2025-05-29
SG10201803601SA (en) 2018-06-28
CY1124684T1 (el) 2022-07-22
CN113444620A (zh) 2021-09-28
JP7008746B2 (ja) 2022-01-25
KR20220031937A (ko) 2022-03-14
AU2024219335A1 (en) 2024-09-19
SG11201601899TA (en) 2016-04-28
EP3047013B1 (en) 2021-08-18
CA2924332A1 (en) 2015-03-19

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