CN114072217A - 组合式层析装置、无缝连接层析方法和生物制剂的纯化方法 - Google Patents
组合式层析装置、无缝连接层析方法和生物制剂的纯化方法 Download PDFInfo
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Abstract
本发明提供一种组合式层析装置、无缝连接层析方法和生物制剂的纯化方法。组合式层析装置包括至少两个基础层析设备和至少两个层析柱，每一个所述基础层析设备至少与一个所述层析柱的进口和出口连接，其中，至少一个所述基础层析设备的出口阀(Vc)能够选择性地连接另一个所述基础层析设备，或者，至少一个所述基础层析设备的出口阀(Vc)能够选择性地连接与另一个所述基础层析设备相连的所述层析柱的进口。根据本发明的组合式层析装置将多个基础层析设备组合使用，实现多个层析过程同时进行，可以免去中间产品而直接得到最终产品。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910574122 | 2019-06-28 | ||
| CN2019105741224 | 2019-06-28 | ||
| PCT/CN2019/120929 WO2020258706A1 (zh) | 2019-06-28 | 2019-11-26 | 组合式层析装置、无缝连接层析方法和生物制剂的纯化方法 |
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| CN114072217A true CN114072217A (zh) | 2022-02-18 |
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| CN114478688B (zh) * | 2022-02-17 | 2024-03-22 | 李红臣 | 一种蛋白质提取纯化方法 |
Citations (10)
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| US20140299547A1 (en) * | 2013-04-08 | 2014-10-09 | Chromacon Ag | Chromatographic purification method |
| CN204275566U (zh) * | 2014-12-05 | 2015-04-22 | 北京佰纯润宇生物科技有限公司 | 基于单个七通阀实现双柱正反流及旁路功能的层析系统 |
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| CN105107230A (zh) * | 2015-09-09 | 2015-12-02 | 南月英 | 一种层析仪改装用于灌流培养纯化的方法 |
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| CN106353440A (zh) * | 2015-07-13 | 2017-01-25 | 帕尔公司 | 多柱色谱法的优化操作结合能力 |
| CN107485891A (zh) * | 2017-07-20 | 2017-12-19 | 上海药明生物技术有限公司 | 改良的层析装置及其用于连续流层析的方法 |
| WO2019001778A1 (en) * | 2017-06-26 | 2019-01-03 | Ge Healthcare Bioprocess R&D Ab | PER PLASMID PERIODIC CONTAMINOGRAPHIC CHROMATOGRAPHY SEPARATION |
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| WO2004011681A1 (en) * | 2002-07-26 | 2004-02-05 | Applera Corporation | Microfluidic device including purification column with excess diluent, and method |
| CN104458953B (zh) * | 2014-12-05 | 2016-10-05 | 北京佰纯润宇生物科技有限公司 | 基于三位七通阀实现层析柱正反流及旁路功能的层析系统 |
| CN105203675B (zh) * | 2015-08-18 | 2017-03-01 | 苏州赛谱仪器有限公司 | 连续进样层析装置 |
-
2019
- 2019-11-26 WO PCT/CN2019/120929 patent/WO2020258706A1/zh active Application Filing
- 2019-11-26 CN CN201980097878.2A patent/CN114072217A/zh active Pending
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|---|---|---|---|---|
| EP2888595A1 (en) * | 2012-08-22 | 2015-07-01 | GE Healthcare Bio-Sciences AB | Versatile rotary valve |
| US20140299547A1 (en) * | 2013-04-08 | 2014-10-09 | Chromacon Ag | Chromatographic purification method |
| CN105722967A (zh) * | 2013-09-16 | 2016-06-29 | 建新公司 | 用于处理细胞培养物的方法和系统 |
| CN204275566U (zh) * | 2014-12-05 | 2015-04-22 | 北京佰纯润宇生物科技有限公司 | 基于单个七通阀实现双柱正反流及旁路功能的层析系统 |
| CN106353440A (zh) * | 2015-07-13 | 2017-01-25 | 帕尔公司 | 多柱色谱法的优化操作结合能力 |
| CN105107230A (zh) * | 2015-09-09 | 2015-12-02 | 南月英 | 一种层析仪改装用于灌流培养纯化的方法 |
| CN105688443A (zh) * | 2016-02-05 | 2016-06-22 | 北京创新通恒科技有限公司 | 一种色谱纯化分离系统及分离纯化方法 |
| CN205838893U (zh) * | 2016-07-08 | 2016-12-28 | 福建省微生物研究所 | 一种环孢菌素同系物的分离纯化装置 |
| WO2019001778A1 (en) * | 2017-06-26 | 2019-01-03 | Ge Healthcare Bioprocess R&D Ab | PER PLASMID PERIODIC CONTAMINOGRAPHIC CHROMATOGRAPHY SEPARATION |
| CN107485891A (zh) * | 2017-07-20 | 2017-12-19 | 上海药明生物技术有限公司 | 改良的层析装置及其用于连续流层析的方法 |
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