JP2016529218A5 - - Google Patents
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- Publication number
- JP2016529218A5 JP2016529218A5 JP2016522860A JP2016522860A JP2016529218A5 JP 2016529218 A5 JP2016529218 A5 JP 2016529218A5 JP 2016522860 A JP2016522860 A JP 2016522860A JP 2016522860 A JP2016522860 A JP 2016522860A JP 2016529218 A5 JP2016529218 A5 JP 2016529218A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- solvate
- hydrate
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CPTWVPNVJXMMAV-UHFFFAOYSA-N CC(CC1)(CCC1NS(c(cc1)ccc1-c(c(C#N)c1)ccc1F)(=O)=O)O Chemical compound CC(CC1)(CCC1NS(c(cc1)ccc1-c(c(C#N)c1)ccc1F)(=O)=O)O CPTWVPNVJXMMAV-UHFFFAOYSA-N 0.000 description 1
- ZUUDKJLERCGKNN-UHFFFAOYSA-N CC(CC1)(CCC1NS(c(cc1)ccc1-c(ccc(C#N)c1)c1F)(=O)=O)O Chemical compound CC(CC1)(CCC1NS(c(cc1)ccc1-c(ccc(C#N)c1)c1F)(=O)=O)O ZUUDKJLERCGKNN-UHFFFAOYSA-N 0.000 description 1
- QHCZIGWQXAUGTL-UHFFFAOYSA-N CC(CC1)(CCC1NS(c1ccc(-c(c(F)c2)ccc2F)c(F)c1)(=O)=O)O Chemical compound CC(CC1)(CCC1NS(c1ccc(-c(c(F)c2)ccc2F)c(F)c1)(=O)=O)O QHCZIGWQXAUGTL-UHFFFAOYSA-N 0.000 description 1
- CPTWVPNVJXMMAV-MSEWRSJXSA-N C[C@](CC1)(CC[C@@H]1NS(c(cc1)ccc1-c(c(C#N)c1)ccc1F)(=O)=O)O Chemical compound C[C@](CC1)(CC[C@@H]1NS(c(cc1)ccc1-c(c(C#N)c1)ccc1F)(=O)=O)O CPTWVPNVJXMMAV-MSEWRSJXSA-N 0.000 description 1
- SIXCIFGYNGVAPI-WEHONNDLSA-N C[C@]1(CC[C@@H](CNS(c(cc2)ccc2-c(c(C#N)c2)ccc2Cl)(=O)=O)CC1)O Chemical compound C[C@]1(CC[C@@H](CNS(c(cc2)ccc2-c(c(C#N)c2)ccc2Cl)(=O)=O)CC1)O SIXCIFGYNGVAPI-WEHONNDLSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1311361.8 | 2013-06-26 | ||
| GBGB1311361.8A GB201311361D0 (en) | 2013-06-26 | 2013-06-26 | Compounds and their therapeutic use |
| PCT/GB2014/051921 WO2014207445A1 (en) | 2013-06-26 | 2014-06-24 | N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and their therapeutic use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016529218A JP2016529218A (ja) | 2016-09-23 |
| JP2016529218A5 true JP2016529218A5 (https=) | 2017-07-13 |
| JP6360555B2 JP6360555B2 (ja) | 2018-07-18 |
Family
ID=48998987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016522860A Active JP6360555B2 (ja) | 2013-06-26 | 2014-06-24 | Ｎ−（４−ヒドロキシ−４−メチル−シクロヘキシル）−４−フェニル−ベンゼンスルホンアミド及びｎ−（４−ヒドロキシ−４−メチル−シクロヘキシル）−４−（２−ピリジル）ベンゼンスルホンアミド、並びにそれらの治療的使用 |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US9624167B2 (https=) |
| EP (1) | EP3013799B1 (https=) |
| JP (1) | JP6360555B2 (https=) |
| KR (1) | KR102151299B1 (https=) |
| CN (1) | CN105492426B (https=) |
| AU (1) | AU2014300745B2 (https=) |
| BR (1) | BR112015031527B1 (https=) |
| CA (1) | CA2915075C (https=) |
| CY (1) | CY1119438T1 (https=) |
| DK (1) | DK3013799T3 (https=) |
| EA (1) | EA028077B1 (https=) |
| ES (1) | ES2641758T3 (https=) |
| GB (1) | GB201311361D0 (https=) |
| HR (1) | HRP20171611T1 (https=) |
| HU (1) | HUE034983T2 (https=) |
| IL (1) | IL243103B (https=) |
| LT (1) | LT3013799T (https=) |
| ME (1) | ME02834B (https=) |
| MX (1) | MX374328B (https=) |
| NZ (1) | NZ715192A (https=) |
| PL (1) | PL3013799T3 (https=) |
| PT (1) | PT3013799T (https=) |
| RS (1) | RS56256B1 (https=) |
| SG (1) | SG11201510646SA (https=) |
| SI (1) | SI3013799T1 (https=) |
| SM (1) | SMT201700503T1 (https=) |
| WO (1) | WO2014207445A1 (https=) |
| ZA (1) | ZA201600202B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0817207D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
| GB201311361D0 (en) | 2013-06-26 | 2013-08-14 | Pimco 2664 Ltd | Compounds and their therapeutic use |
| SI3262028T1 (sl) * | 2014-12-17 | 2022-02-28 | Pimco 2664 Limited | N-(4-hidroksi-4-metil-cikloheksil)-4-fenil-benzensulfonamidne in N-(-4hidroksi-4-metil-cikloheksil)-4-(2-piridil)-benzensulfonamidne spojine in njihova terapevtska uporaba |
| GB201813312D0 (en) | 2018-08-15 | 2018-09-26 | Modern Biosciences Ltd | Compounds and their therapeutic use |
| GB201905520D0 (en) * | 2019-04-18 | 2019-06-05 | Modern Biosciences Ltd | Compounds and their therapeutic use |
| EP4431090A1 (en) | 2023-03-15 | 2024-09-18 | Istesso 1 Limited | Solfonamides acting as mitochondrial complex i modulator compounds |
| GB202308547D0 (en) | 2023-06-08 | 2023-07-26 | Istesso 2 Ltd | Tnf inhibitor combination therapies |
| GB202309515D0 (en) | 2023-06-23 | 2023-08-09 | Istesso 2 Ltd | JAK inhibitor and IL-6 inhibitor combination therapies |
| GB202315822D0 (en) | 2023-10-16 | 2023-11-29 | Istesso 3 Ltd | Anti-fibrotic combination therapeutics |
| GB202317050D0 (en) | 2023-11-07 | 2023-12-20 | Istesso 2 Ltd | Disease modifying anti-rheumatic drug combination therapies |
| EP4647071A1 (en) | 2024-05-10 | 2025-11-12 | Istesso Therapeutics Limited | Mitochondrial complex i modulator for use in the treatment of arthritis |
| GB202411554D0 (en) | 2024-08-06 | 2024-09-18 | Istesso 2 Ltd | NF-kB inhibitor combination therapies |
Family Cites Families (58)
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| GB597810A (en) | 1943-04-12 | 1948-02-04 | Gen Printing Ink Corp | Improvements in or relating to derivatives of diphenyl |
| DE1046220B (de) | 1956-04-21 | 1958-12-11 | Bayer Ag | Verfahren zur Herstellung von Monoazofarbstoffen und deren Metallkomplexverbindungen |
| US4119784A (en) | 1977-07-01 | 1978-10-10 | American Cyanamid Company | Anionic substituted sulfonamido biphenyls |
| DE3000519A1 (de) | 1979-02-01 | 1980-08-14 | Byk Gulden Lomberg Chem Fab | Sulfonamido-alkansaeuren, ihre verwendung und herstellung sowie sie enthaltende arzneimittel |
| DE3535167A1 (de) | 1985-10-02 | 1987-04-09 | Boehringer Mannheim Gmbh | Neue sulfonyl-phenyl(alkyl)amine, verfahren zu ihrer herstellung sowie arzneimittel |
| IL118325A0 (en) | 1995-05-25 | 1996-10-31 | Pont Merck And Pharmaceutical | Integrin receptor antagonists and pharmaceutical compositions containing them |
| SK56798A3 (en) | 1995-10-30 | 1998-12-02 | Smithkline Beecham Corp | Protease inhibitors, pharmaceutical composition containing them and their use |
| US5760028A (en) | 1995-12-22 | 1998-06-02 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
| JP2001527513A (ja) | 1996-03-15 | 2001-12-25 | デュポン ファーマシューティカルズ カンパニー | スピロ環インテグリン阻害剤 |
| EP0939629A4 (en) | 1996-07-22 | 2002-07-17 | Monsanto Co | THIOL SULFONAMIDE METALLOPROTEASE INHIBITORS |
| AU731737B2 (en) | 1996-10-16 | 2001-04-05 | Wyeth Holdings Corporation | The preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| WO1998023608A1 (en) | 1996-11-27 | 1998-06-04 | Dupont Pharmaceuticals Company | Novel integrin receptor antagonists |
| WO1998043962A1 (en) | 1997-03-28 | 1998-10-08 | Du Pont Pharmaceuticals Company | Heterocyclic integrin inhibitor prodrugs |
| CA2289602A1 (en) | 1997-05-08 | 1998-11-12 | William Edward Bondinell | Protease inhibitors |
| DE59802394D1 (de) | 1997-05-09 | 2002-01-24 | Hoechst Ag | Substituierte Diaminocarbonsäuren |
| DE19719621A1 (de) | 1997-05-09 | 1998-11-12 | Hoechst Ag | Sulfonylaminocarbonsäuren |
| US6291425B1 (en) | 1999-09-01 | 2001-09-18 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage |
| IL137423A0 (en) | 1998-01-23 | 2001-07-24 | Aventis Pharma Gmbh | Novel sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion |
| RU2208609C2 (ru) | 1998-02-04 | 2003-07-20 | Новартис Аг | Сульфониламинопроизводные, которые ингибируют разлагающие матрикс металлопротеиназы |
| JPH11246527A (ja) | 1998-03-02 | 1999-09-14 | Shionogi & Co Ltd | Ｍｍｐ−８阻害剤 |
| DE19815547C1 (de) | 1998-04-07 | 1999-12-02 | Joachim Schmidt | Haftmittel für Zahnprothesen |
| EP0960882A1 (en) | 1998-05-19 | 1999-12-01 | Hoechst Marion Roussel Deutschland GmbH | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists |
| RU2002128015A (ru) | 2000-03-21 | 2004-02-27 | Дзе Проктер Энд Гэмбл Компани (US) | Содержащие карбоциклическую боковую цепь n-замещенные ингибиторы металлопротеаз |
| US6723733B2 (en) | 2000-05-19 | 2004-04-20 | Guilford Pharmaceuticals, Inc. | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses |
| WO2002060867A2 (en) | 2001-01-29 | 2002-08-08 | Insight Strategy And Marketing Ltd | Carbazole derivatives and their uses as heparanase inhibitors |
| JPWO2002074298A1 (ja) | 2001-03-21 | 2004-07-08 | 小野薬品工業株式会社 | Ｉｌ−６産生阻害剤 |
| JP2004535390A (ja) | 2001-05-07 | 2004-11-25 | スミスクライン・ビーチャム・コーポレイション | スルホンアミド |
| MXPA04001253A (es) | 2001-08-09 | 2004-06-03 | Ono Pharmaceutical Co | Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo. |
| GB0126157D0 (en) | 2001-10-31 | 2002-01-02 | Univ Aberdeen | Therapeutic compounds |
| TW200305396A (en) | 2002-03-27 | 2003-11-01 | Shionogi & Co | Cartilage extracellular matrix degradation |
| WO2004022561A1 (en) | 2002-09-04 | 2004-03-18 | Schering Corporation | Pyrazolopyrimidines as cyclin-dependent kinase inhibitors |
| DE10251170A1 (de) | 2002-10-31 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| WO2004073619A2 (en) | 2003-02-14 | 2004-09-02 | Smithkline Beecham Corporation | Ccr8 antagonists |
| ATE380025T1 (de) | 2003-05-07 | 2007-12-15 | Univ Aberdeen | Ketone und reduzierte ketone als therapeutische mittel zur behandlung von knochenerkrankungen |
| WO2004106290A1 (ja) | 2003-05-14 | 2004-12-09 | Kissei Pharmaceutical Co., Ltd. | アミノアルコール誘導体、それを含有する医薬組成物およびそれらの用途 |
| AR046330A1 (es) | 2003-09-09 | 2005-12-07 | Japan Tobacco Inc | Inhibidor de dipeptidilpeptidasa iv |
| GB0324792D0 (en) | 2003-10-23 | 2003-11-26 | Sterix Ltd | Compound |
| AP2006003633A0 (en) | 2003-12-19 | 2006-06-30 | Pfizer | Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-BETA-hydroxysteroid dehydrogenase type 1 (11-BETA-HSD-1) for the treatment of diabetes and obesity |
| WO2005080367A1 (en) | 2004-02-12 | 2005-09-01 | Pharmagene Laboratories Limited | Ep2 receptor agonists |
| GB0405193D0 (en) | 2004-03-08 | 2004-04-21 | Medical Res Council | Compounds |
| US20080255240A1 (en) | 2004-05-05 | 2008-10-16 | Novo Nordisk A/S | Sulfonamide Derivatives |
| GB0412553D0 (en) | 2004-06-04 | 2004-07-07 | Univ Aberdeen | Therapeutic agents for the treatment of bone conditions |
| US7470722B2 (en) | 2004-06-10 | 2008-12-30 | Kalypsys, Inc. | Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease |
| EP1807391A4 (en) | 2004-10-29 | 2010-01-06 | Astrazeneca Ab | NOVEL SULFONAMIDE DERIVATIVES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR AND FOR THE TREATMENT OF INFLAMMATORY DISEASES |
| EP1659113A1 (en) | 2004-11-08 | 2006-05-24 | Evotec AG | Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1) |
| AU2006257646A1 (en) | 2005-06-16 | 2006-12-21 | Pfizer Inc. | N-(pyridin-2-YL)-sulfonamide derivatives |
| WO2007008541A2 (en) | 2005-07-08 | 2007-01-18 | Kalypsys, Inc. | Cellular cholesterol absorption modifiers |
| TW200720261A (en) | 2005-08-31 | 2007-06-01 | Sankyo Co | Phenylene derivatives |
| CN102775396B (zh) | 2005-11-08 | 2014-10-08 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的杂环调控剂 |
| DK1984344T3 (da) | 2005-12-29 | 2013-01-14 | Lexicon Pharmaceuticals Inc | Multicykliske aminosyrederivater og fremgangsmåder til anvendelse heraf |
| US7560597B2 (en) | 2007-03-08 | 2009-07-14 | The University Court Of The University Of Aberdeen | 2′,4′-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds and their use as therapeutic agents |
| GB0705400D0 (en) | 2007-03-21 | 2007-05-02 | Univ Aberdeen | Therapeutic compounds andm their use |
| WO2010025235A1 (en) | 2008-08-29 | 2010-03-04 | Regents Of The University Of Michigan | Selective ligands for the dopamine 3 (d3) receptor and methods of using the same |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| GB0817207D0 (en) * | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
| GB0817208D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | Therapeutic apsap compounds and their use |
| GB201311361D0 (en) | 2013-06-26 | 2013-08-14 | Pimco 2664 Ltd | Compounds and their therapeutic use |
| SI3262028T1 (sl) | 2014-12-17 | 2022-02-28 | Pimco 2664 Limited | N-(4-hidroksi-4-metil-cikloheksil)-4-fenil-benzensulfonamidne in N-(-4hidroksi-4-metil-cikloheksil)-4-(2-piridil)-benzensulfonamidne spojine in njihova terapevtska uporaba |
-
2013
- 2013-06-26 GB GBGB1311361.8A patent/GB201311361D0/en not_active Ceased
-
2014
- 2014-06-24 BR BR112015031527-5A patent/BR112015031527B1/pt active IP Right Grant
- 2014-06-24 DK DK14735642.2T patent/DK3013799T3/en active
- 2014-06-24 LT LTEP14735642.2T patent/LT3013799T/lt unknown
- 2014-06-24 CN CN201480047140.2A patent/CN105492426B/zh active Active
- 2014-06-24 RS RS20170876A patent/RS56256B1/sr unknown
- 2014-06-24 US US14/899,422 patent/US9624167B2/en active Active
- 2014-06-24 SI SI201430364T patent/SI3013799T1/sl unknown
- 2014-06-24 HR HRP20171611TT patent/HRP20171611T1/hr unknown
- 2014-06-24 KR KR1020167002015A patent/KR102151299B1/ko active Active
- 2014-06-24 EP EP14735642.2A patent/EP3013799B1/en active Active
- 2014-06-24 SG SG11201510646SA patent/SG11201510646SA/en unknown
- 2014-06-24 ME MEP-2017-208A patent/ME02834B/me unknown
- 2014-06-24 EA EA201592308A patent/EA028077B1/ru unknown
- 2014-06-24 PT PT147356422T patent/PT3013799T/pt unknown
- 2014-06-24 WO PCT/GB2014/051921 patent/WO2014207445A1/en not_active Ceased
- 2014-06-24 ES ES14735642.2T patent/ES2641758T3/es active Active
- 2014-06-24 AU AU2014300745A patent/AU2014300745B2/en active Active
- 2014-06-24 MX MX2015016914A patent/MX374328B/es active IP Right Grant
- 2014-06-24 NZ NZ715192A patent/NZ715192A/en unknown
- 2014-06-24 CA CA2915075A patent/CA2915075C/en active Active
- 2014-06-24 SM SM20170503T patent/SMT201700503T1/it unknown
- 2014-06-24 JP JP2016522860A patent/JP6360555B2/ja active Active
- 2014-06-24 HU HUE14735642A patent/HUE034983T2/en unknown
- 2014-06-24 PL PL14735642T patent/PL3013799T3/pl unknown
-
2015
- 2015-12-14 IL IL243103A patent/IL243103B/en active IP Right Grant
-
2016
- 2016-01-11 ZA ZA2016/00202A patent/ZA201600202B/en unknown
-
2017
- 2017-04-11 US US15/484,256 patent/US9796670B2/en active Active
- 2017-10-11 CY CY20171101060T patent/CY1119438T1/el unknown
- 2017-10-17 US US15/786,021 patent/US10029979B2/en active Active
-
2018
- 2018-07-17 US US16/037,048 patent/US10233147B2/en active Active
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